THBD (thrombomodulin)

2007-02-01  

Identity

HGNC
LOCATION
20p11.21
LOCUSID
ALIAS
AHUS6,BDCA-3,BDCA3,CD141,THPH12,THRM,TM

Other Information

Locus ID:

NCBI: 7056
MIM: 188040
HGNC: 11784
Ensembl: ENSG00000178726

Variants:

dbSNP: 7056
ClinVar: 7056
TCGA: ENSG00000178726
COSMIC: THBD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178726ENST00000377103P07204

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Complement and coagulation cascadesKEGGhsa04610
HemostasisREACTOMER-HSA-109582
Formation of Fibrin Clot (Clotting Cascade)REACTOMER-HSA-140877
Common Pathway of Fibrin Clot FormationREACTOMER-HSA-140875
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
AGE-RAGE signaling pathway in diabetic complicationsKEGGko04933
AGE-RAGE signaling pathway in diabetic complicationsKEGGhsa04933
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA451906warfarinChemicalClinicalAnnotationassociatedPD24602049

References

Pubmed IDYearTitleCitations
204791162010Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens.354
204791152010Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells.287
204791172010Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells.267
179824642007Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis.133
196257162009Thrombomodulin mutations in atypical hemolytic-uremic syndrome.131
196257162009Thrombomodulin mutations in atypical hemolytic-uremic syndrome.131
160436422005Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells.103
237410072013Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children.96
151785542004Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation.92
205131332010Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome.88

Citation

Dessen P

THBD (thrombomodulin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45938/thbd