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THBD (thrombomodulin)

Identity

Alias_symbol (synonym)CD141
Other aliasAHUS6
BDCA3
THPH12
THRM
TM
HGNC (Hugo) THBD
LocusID (NCBI) 7056
Atlas_Id 45938
Location 20p11.21  [Link to chromosome band 20p11]
Location_base_pair Starts at 23045633 and ends at 23049664 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)THBD   11784
LRG (Locus Reference Genomic)LRG_168
Cards
Entrez_Gene (NCBI)THBD  7056  thrombomodulin
AliasesAHUS6; BDCA3; CD141; THPH12; 
THRM; TM
GeneCards (Weizmann)THBD
Ensembl hg19 (Hinxton)ENSG00000178726 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000178726 [Gene_View]  chr20:23045633-23049664 [Contig_View]  THBD [Vega]
ICGC DataPortalENSG00000178726
TCGA cBioPortalTHBD
AceView (NCBI)THBD
Genatlas (Paris)THBD
WikiGenes7056
SOURCE (Princeton)THBD
Genetics Home Reference (NIH)THBD
Genomic and cartography
GoldenPath hg38 (UCSC)THBD  -     chr20:23045633-23049664 -  20p11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)THBD  -     20p11.21   [Description]    (hg19-Feb_2009)
EnsemblTHBD - 20p11.21 [CytoView hg19]  THBD - 20p11.21 [CytoView hg38]
Mapping of homologs : NCBITHBD [Mapview hg19]  THBD [Mapview hg38]
OMIM188040   612926   614486   
Gene and transcription
Genbank (Entrez)AI285986 AK091934 AK123557 BC035602 BC053357
RefSeq transcript (Entrez)NM_000361
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)THBD
Cluster EST : UnigeneHs.2030 [ NCBI ]
CGAP (NCI)Hs.2030
Alternative Splicing GalleryENSG00000178726
Gene ExpressionTHBD [ NCBI-GEO ]   THBD [ EBI - ARRAY_EXPRESS ]   THBD [ SEEK ]   THBD [ MEM ]
Gene Expression Viewer (FireBrowse)THBD [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7056
GTEX Portal (Tissue expression)THBD
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07204   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07204  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07204
Splice isoforms : SwissVarP07204
PhosPhoSitePlusP07204
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    C_TYPE_LECTIN_2 (PS50041)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)   
Domains : Interpro (EBI)C-type_lectin-like    C-type_lectin-like/link    CD141    cEGF    CTDL_fold    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    Growth_fac_rcpt_    Tme5_EGF-like   
Domain families : Pfam (Sanger)cEGF (PF12662)    EGF_CA (PF07645)    Lectin_C (PF00059)    Tme5_EGF_like (PF09064)   
Domain families : Pfam (NCBI)pfam12662    pfam07645    pfam00059    pfam09064   
Domain families : Smart (EMBL)CLECT (SM00034)  EGF (SM00181)  EGF_CA (SM00179)  
Conserved Domain (NCBI)THBD
DMDM Disease mutations7056
Blocks (Seattle)THBD
PDB (SRS)1ADX    1DQB    1DX5    1EGT    1FGD    1FGE    1HLT    1TMR    1ZAQ    2ADX    3GIS   
PDB (PDBSum)1ADX    1DQB    1DX5    1EGT    1FGD    1FGE    1HLT    1TMR    1ZAQ    2ADX    3GIS   
PDB (IMB)1ADX    1DQB    1DX5    1EGT    1FGD    1FGE    1HLT    1TMR    1ZAQ    2ADX    3GIS   
PDB (RSDB)1ADX    1DQB    1DX5    1EGT    1FGD    1FGE    1HLT    1TMR    1ZAQ    2ADX    3GIS   
Structural Biology KnowledgeBase1ADX    1DQB    1DX5    1EGT    1FGD    1FGE    1HLT    1TMR    1ZAQ    2ADX    3GIS   
SCOP (Structural Classification of Proteins)1ADX    1DQB    1DX5    1EGT    1FGD    1FGE    1HLT    1TMR    1ZAQ    2ADX    3GIS   
CATH (Classification of proteins structures)1ADX    1DQB    1DX5    1EGT    1FGD    1FGE    1HLT    1TMR    1ZAQ    2ADX    3GIS   
SuperfamilyP07204
Human Protein AtlasENSG00000178726
Peptide AtlasP07204
HPRD01764
IPIIPI00010737   IPI00902498   IPI00984907   
Protein Interaction databases
DIP (DOE-UCLA)P07204
IntAct (EBI)P07204
FunCoupENSG00000178726
BioGRIDTHBD
STRING (EMBL)THBD
ZODIACTHBD
Ontologies - Pathways
QuickGOP07204
Ontology : AmiGOreceptor activity  transmembrane signaling receptor activity  calcium ion binding  protein binding  extracellular space  vacuolar membrane  plasma membrane  integral component of plasma membrane  signal transduction  female pregnancy  blood coagulation  cell surface  response to X-ray  negative regulation of platelet activation  apicolateral plasma membrane  negative regulation of blood coagulation  response to lipopolysaccharide  leukocyte migration  response to cAMP  negative regulation of fibrinolysis  
Ontology : EGO-EBIreceptor activity  transmembrane signaling receptor activity  calcium ion binding  protein binding  extracellular space  vacuolar membrane  plasma membrane  integral component of plasma membrane  signal transduction  female pregnancy  blood coagulation  cell surface  response to X-ray  negative regulation of platelet activation  apicolateral plasma membrane  negative regulation of blood coagulation  response to lipopolysaccharide  leukocyte migration  response to cAMP  negative regulation of fibrinolysis  
Pathways : KEGGComplement and coagulation cascades   
NDEx NetworkTHBD
Atlas of Cancer Signalling NetworkTHBD
Wikipedia pathwaysTHBD
Orthology - Evolution
OrthoDB7056
GeneTree (enSembl)ENSG00000178726
Phylogenetic Trees/Animal Genes : TreeFamTHBD
HOVERGENP07204
HOGENOMP07204
Homologs : HomoloGeneTHBD
Homology/Alignments : Family Browser (UCSC)THBD
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTHBD [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)THBD
dbVarTHBD
ClinVarTHBD
1000_GenomesTHBD 
Exome Variant ServerTHBD
ExAC (Exome Aggregation Consortium)THBD (select the gene name)
Genetic variants : HAPMAP7056
Genomic Variants (DGV)THBD [DGVbeta]
DECIPHERTHBD [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTHBD 
Mutations
ICGC Data PortalTHBD 
TCGA Data PortalTHBD 
Broad Tumor PortalTHBD
OASIS PortalTHBD [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTHBD  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTHBD
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch THBD
DgiDB (Drug Gene Interaction Database)THBD
DoCM (Curated mutations)THBD (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)THBD (select a term)
intoGenTHBD
Cancer3DTHBD(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM188040    612926    614486   
Orphanet18810    23331   
MedgenTHBD
Genetic Testing Registry THBD
NextProtP07204 [Medical]
TSGene7056
GENETestsTHBD
Target ValidationTHBD
Huge Navigator THBD [HugePedia]
snp3D : Map Gene to Disease7056
BioCentury BCIQTHBD
ClinGenTHBD
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7056
Chemical/Pharm GKB GenePA36496
Clinical trialTHBD
Miscellaneous
canSAR (ICR)THBD (select the gene name)
Probes
Litterature
PubMed263 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTHBD
EVEXTHBD
GoPubMedTHBD
iHOPTHBD
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Sep 25 19:34:55 CEST 2017

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