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THBS4 (thrombospondin 4)

Identity

Other aliasTSP-4
TSP4
HGNC (Hugo) THBS4
LocusID (NCBI) 7060
Atlas_Id 42551
Location 5q14.1  [Link to chromosome band 5q14]
Location_base_pair Starts at 79991296 and ends at 80083284 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)THBS4   11788
Cards
Entrez_Gene (NCBI)THBS4  7060  thrombospondin 4
AliasesTSP-4; TSP4
GeneCards (Weizmann)THBS4
Ensembl hg19 (Hinxton)ENSG00000113296 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113296 [Gene_View]  chr5:79991296-80083284 [Contig_View]  THBS4 [Vega]
ICGC DataPortalENSG00000113296
TCGA cBioPortalTHBS4
AceView (NCBI)THBS4
Genatlas (Paris)THBS4
WikiGenes7060
SOURCE (Princeton)THBS4
Genetics Home Reference (NIH)THBS4
Genomic and cartography
GoldenPath hg38 (UCSC)THBS4  -     chr5:79991296-80083284 +  5q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)THBS4  -     5q14.1   [Description]    (hg19-Feb_2009)
EnsemblTHBS4 - 5q14.1 [CytoView hg19]  THBS4 - 5q14.1 [CytoView hg38]
Mapping of homologs : NCBITHBS4 [Mapview hg19]  THBS4 [Mapview hg38]
OMIM600715   
Gene and transcription
Genbank (Entrez)AK302842 AK313587 BC050456 DC310687 DC342285
RefSeq transcript (Entrez)NM_001306212 NM_001306213 NM_001306214 NM_003248
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)THBS4
Cluster EST : UnigeneHs.211426 [ NCBI ]
CGAP (NCI)Hs.211426
Alternative Splicing GalleryENSG00000113296
Gene ExpressionTHBS4 [ NCBI-GEO ]   THBS4 [ EBI - ARRAY_EXPRESS ]   THBS4 [ SEEK ]   THBS4 [ MEM ]
Gene Expression Viewer (FireBrowse)THBS4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7060
GTEX Portal (Tissue expression)THBS4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35443   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35443  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35443
Splice isoforms : SwissVarP35443
PhosPhoSitePlusP35443
Domaine pattern : Prosite (Expaxy)EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    TSP3 (PS51234)    TSP_CTER (PS51236)   
Domains : Interpro (EBI)ConA-like_dom    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF_Ca-bd_CS    Laminin_G    Thbs/COMP_coiled-coil    Thrombospondin_3-like_rpt    Thrombospondin_3_rpt    Thrombospondin_C    TSP_type-3_rpt   
Domain families : Pfam (Sanger)COMP (PF11598)    EGF_CA (PF07645)    TSP_3 (PF02412)    TSP_C (PF05735)   
Domain families : Pfam (NCBI)pfam11598    pfam07645    pfam02412    pfam05735   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  TSPN (SM00210)  
Conserved Domain (NCBI)THBS4
DMDM Disease mutations7060
Blocks (Seattle)THBS4
SuperfamilyP35443
Human Protein AtlasENSG00000113296
Peptide AtlasP35443
HPRD02836
IPIIPI00328550   IPI00966406   
Protein Interaction databases
DIP (DOE-UCLA)P35443
IntAct (EBI)P35443
FunCoupENSG00000113296
BioGRIDTHBS4
STRING (EMBL)THBS4
ZODIACTHBS4
Ontologies - Pathways
QuickGOP35443
Ontology : AmiGOpositive regulation of endothelial cell proliferation  integrin binding  calcium ion binding  protein binding  extracellular region  basement membrane  extracellular space  endoplasmic reticulum  response to unfolded protein  growth factor activity  heparin binding  negative regulation of angiogenesis  sarcoplasmic reticulum  extracellular matrix  regulation of tissue remodeling  response to endoplasmic reticulum stress  behavioral response to pain  tissue remodeling  positive regulation of peptidyl-tyrosine phosphorylation  myoblast migration  positive regulation of cell division  extracellular exosome  endothelial cell-cell adhesion  positive regulation of neutrophil chemotaxis  
Ontology : EGO-EBIpositive regulation of endothelial cell proliferation  integrin binding  calcium ion binding  protein binding  extracellular region  basement membrane  extracellular space  endoplasmic reticulum  response to unfolded protein  growth factor activity  heparin binding  negative regulation of angiogenesis  sarcoplasmic reticulum  extracellular matrix  regulation of tissue remodeling  response to endoplasmic reticulum stress  behavioral response to pain  tissue remodeling  positive regulation of peptidyl-tyrosine phosphorylation  myoblast migration  positive regulation of cell division  extracellular exosome  endothelial cell-cell adhesion  positive regulation of neutrophil chemotaxis  
Pathways : KEGGPhagosome    PI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction    Malaria   
NDEx NetworkTHBS4
Atlas of Cancer Signalling NetworkTHBS4
Wikipedia pathwaysTHBS4
Orthology - Evolution
OrthoDB7060
GeneTree (enSembl)ENSG00000113296
Phylogenetic Trees/Animal Genes : TreeFamTHBS4
HOVERGENP35443
HOGENOMP35443
Homologs : HomoloGeneTHBS4
Homology/Alignments : Family Browser (UCSC)THBS4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTHBS4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)THBS4
dbVarTHBS4
ClinVarTHBS4
1000_GenomesTHBS4 
Exome Variant ServerTHBS4
ExAC (Exome Aggregation Consortium)THBS4 (select the gene name)
Genetic variants : HAPMAP7060
Genomic Variants (DGV)THBS4 [DGVbeta]
DECIPHERTHBS4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTHBS4 
Mutations
ICGC Data PortalTHBS4 
TCGA Data PortalTHBS4 
Broad Tumor PortalTHBS4
OASIS PortalTHBS4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTHBS4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTHBS4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch THBS4
DgiDB (Drug Gene Interaction Database)THBS4
DoCM (Curated mutations)THBS4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)THBS4 (select a term)
intoGenTHBS4
Cancer3DTHBS4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600715   
Orphanet
MedgenTHBS4
Genetic Testing Registry THBS4
NextProtP35443 [Medical]
TSGene7060
GENETestsTHBS4
Target ValidationTHBS4
Huge Navigator THBS4 [HugePedia]
snp3D : Map Gene to Disease7060
BioCentury BCIQTHBS4
ClinGenTHBS4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7060
Chemical/Pharm GKB GenePA36500
Clinical trialTHBS4
Miscellaneous
canSAR (ICR)THBS4 (select the gene name)
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTHBS4
EVEXTHBS4
GoPubMedTHBS4
iHOPTHBS4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:59:16 CEST 2017

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