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THEM4 (thioesterase superfamily member 4)

Identity

Alias_symbol (synonym)CTMP
Other alias
HGNC (Hugo) THEM4
LocusID (NCBI) 117145
Atlas_Id 49973
Location 1q21.3  [Link to chromosome band 1q21]
Location_base_pair Starts at 151870867 and ends at 151909885 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TGFB3 (14q24.3) / THEM4 (1q21.3)THEM4 (1q21.3) / DCST2 (1q21.3)THEM4 (1q21.3) / S100A10 (1q21.3)
THEM4 1q21.3 / DCST2 1q21.3THEM4 1q21.3 / S100A10 1q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)THEM4   17947
Cards
Entrez_Gene (NCBI)THEM4  117145  thioesterase superfamily member 4
AliasesCTMP
GeneCards (Weizmann)THEM4
Ensembl hg19 (Hinxton)ENSG00000159445 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000159445 [Gene_View]  chr1:151870867-151909885 [Contig_View]  THEM4 [Vega]
ICGC DataPortalENSG00000159445
TCGA cBioPortalTHEM4
AceView (NCBI)THEM4
Genatlas (Paris)THEM4
WikiGenes117145
SOURCE (Princeton)THEM4
Genetics Home Reference (NIH)THEM4
Genomic and cartography
GoldenPath hg38 (UCSC)THEM4  -     chr1:151870867-151909885 -  1q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)THEM4  -     1q21.3   [Description]    (hg19-Feb_2009)
EnsemblTHEM4 - 1q21.3 [CytoView hg19]  THEM4 - 1q21.3 [CytoView hg38]
Mapping of homologs : NCBITHEM4 [Mapview hg19]  THEM4 [Mapview hg38]
OMIM606388   
Gene and transcription
Genbank (Entrez)AF075119 AJ313515 AK024219 AK096211 AK130716
RefSeq transcript (Entrez)NM_053055 NM_176853
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)THEM4
Cluster EST : UnigeneHs.164070 [ NCBI ]
CGAP (NCI)Hs.164070
Alternative Splicing GalleryENSG00000159445
Gene ExpressionTHEM4 [ NCBI-GEO ]   THEM4 [ EBI - ARRAY_EXPRESS ]   THEM4 [ SEEK ]   THEM4 [ MEM ]
Gene Expression Viewer (FireBrowse)THEM4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)117145
GTEX Portal (Tissue expression)THEM4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5T1C6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5T1C6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5T1C6
Splice isoforms : SwissVarQ5T1C6
Catalytic activity : Enzyme3.1.2.2 [ Enzyme-Expasy ]   3.1.2.23.1.2.2 [ IntEnz-EBI ]   3.1.2.2 [ BRENDA ]   3.1.2.2 [ KEGG ]   
PhosPhoSitePlusQ5T1C6
Domains : Interpro (EBI)HotDog_dom    Thioestr_dom   
Domain families : Pfam (Sanger)4HBT (PF03061)   
Domain families : Pfam (NCBI)pfam03061   
Conserved Domain (NCBI)THEM4
DMDM Disease mutations117145
Blocks (Seattle)THEM4
PDB (SRS)4AE8    4GAH   
PDB (PDBSum)4AE8    4GAH   
PDB (IMB)4AE8    4GAH   
PDB (RSDB)4AE8    4GAH   
Structural Biology KnowledgeBase4AE8    4GAH   
SCOP (Structural Classification of Proteins)4AE8    4GAH   
CATH (Classification of proteins structures)4AE8    4GAH   
SuperfamilyQ5T1C6
Human Protein AtlasENSG00000159445
Peptide AtlasQ5T1C6
HPRD16215
IPIIPI00064739   IPI00843843   IPI00977034   
Protein Interaction databases
DIP (DOE-UCLA)Q5T1C6
IntAct (EBI)Q5T1C6
FunCoupENSG00000159445
BioGRIDTHEM4
STRING (EMBL)THEM4
ZODIACTHEM4
Ontologies - Pathways
QuickGOQ5T1C6
Ontology : AmiGOmitochondrion  mitochondrial inner membrane  mitochondrial intermembrane space  mitochondrial matrix  cytosol  cytosol  plasma membrane  fatty acid metabolic process  palmitoyl-CoA hydrolase activity  ruffle membrane  long-chain fatty-acyl-CoA biosynthetic process  protein kinase B signaling  acyl-CoA hydrolase activity  myristoyl-CoA hydrolase activity  regulation of mitochondrial membrane permeability involved in apoptotic process  
Ontology : EGO-EBImitochondrion  mitochondrial inner membrane  mitochondrial intermembrane space  mitochondrial matrix  cytosol  cytosol  plasma membrane  fatty acid metabolic process  palmitoyl-CoA hydrolase activity  ruffle membrane  long-chain fatty-acyl-CoA biosynthetic process  protein kinase B signaling  acyl-CoA hydrolase activity  myristoyl-CoA hydrolase activity  regulation of mitochondrial membrane permeability involved in apoptotic process  
Pathways : KEGGPI3K-Akt signaling pathway   
NDEx NetworkTHEM4
Atlas of Cancer Signalling NetworkTHEM4
Wikipedia pathwaysTHEM4
Orthology - Evolution
OrthoDB117145
GeneTree (enSembl)ENSG00000159445
Phylogenetic Trees/Animal Genes : TreeFamTHEM4
HOVERGENQ5T1C6
HOGENOMQ5T1C6
Homologs : HomoloGeneTHEM4
Homology/Alignments : Family Browser (UCSC)THEM4
Gene fusions - Rearrangements
Fusion : MitelmanTHEM4/DCST2 [1q21.3/1q21.3]  
Fusion : MitelmanTHEM4/S100A10 [1q21.3/1q21.3]  [t(1;1)(q21;q21)]  
Fusion: TCGATHEM4 1q21.3 DCST2 1q21.3 BRCA
Fusion: TCGATHEM4 1q21.3 S100A10 1q21.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTHEM4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)THEM4
dbVarTHEM4
ClinVarTHEM4
1000_GenomesTHEM4 
Exome Variant ServerTHEM4
ExAC (Exome Aggregation Consortium)THEM4 (select the gene name)
Genetic variants : HAPMAP117145
Genomic Variants (DGV)THEM4 [DGVbeta]
DECIPHERTHEM4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTHEM4 
Mutations
ICGC Data PortalTHEM4 
TCGA Data PortalTHEM4 
Broad Tumor PortalTHEM4
OASIS PortalTHEM4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTHEM4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTHEM4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch THEM4
DgiDB (Drug Gene Interaction Database)THEM4
DoCM (Curated mutations)THEM4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)THEM4 (select a term)
intoGenTHEM4
Cancer3DTHEM4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606388   
Orphanet
MedgenTHEM4
Genetic Testing Registry THEM4
NextProtQ5T1C6 [Medical]
TSGene117145
GENETestsTHEM4
Target ValidationTHEM4
Huge Navigator THEM4 [HugePedia]
snp3D : Map Gene to Disease117145
BioCentury BCIQTHEM4
ClinGenTHEM4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD117145
Chemical/Pharm GKB GenePA142670813
Clinical trialTHEM4
Miscellaneous
canSAR (ICR)THEM4 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTHEM4
EVEXTHEM4
GoPubMedTHEM4
iHOPTHEM4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:09:40 CEST 2017

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