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THEMIS (thymocyte selection associated)

Identity

Alias_namesC6orf207
C6orf190
TSEPA
chromosome 6 open reading frame 207
chromosome 6 open reading frame 190
thymocyte selection pathway associated
Alias_symbol (synonym)bA325O24.4
FLJ40584
bA325O24.3
Other aliasGASP
SPOT
HGNC (Hugo) THEMIS
LocusID (NCBI) 387357
Atlas_Id 52829
Location 6q22.33  [Link to chromosome band 6q22]
Location_base_pair Starts at 127708194 and ends at 127855188 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MTHFD1L (6q25.1) / THEMIS (6q22.33)PTPRK (6q22.33) / THEMIS (6q22.33)MTHFD1L 6q25.1 / THEMIS 6q22.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(q22;q25) MTHFD1L/THEMIS


External links

Nomenclature
HGNC (Hugo)THEMIS   21569
Cards
Entrez_Gene (NCBI)THEMIS  387357  thymocyte selection associated
AliasesC6orf190; C6orf207; GASP; SPOT; 
TSEPA
GeneCards (Weizmann)THEMIS
Ensembl hg19 (Hinxton)ENSG00000172673 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172673 [Gene_View]  ENSG00000172673 [Sequence]  chr6:127708194-127855188 [Contig_View]  THEMIS [Vega]
ICGC DataPortalENSG00000172673
TCGA cBioPortalTHEMIS
AceView (NCBI)THEMIS
Genatlas (Paris)THEMIS
WikiGenes387357
SOURCE (Princeton)THEMIS
Genetics Home Reference (NIH)THEMIS
Genomic and cartography
GoldenPath hg38 (UCSC)THEMIS  -     chr6:127708194-127855188 -  6q22.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)THEMIS  -     6q22.33   [Description]    (hg19-Feb_2009)
EnsemblTHEMIS - 6q22.33 [CytoView hg19]  THEMIS - 6q22.33 [CytoView hg38]
Mapping of homologs : NCBITHEMIS [Mapview hg19]  THEMIS [Mapview hg38]
OMIM613607   
Gene and transcription
Genbank (Entrez)AK094863 AK097903 AK124031 AK128377 AK292046
RefSeq transcript (Entrez)NM_001010923 NM_001164685 NM_001164687 NM_001318531
RefSeq genomic (Entrez)NC_000006 NC_018917 NG_016226 NT_187556
Consensus coding sequences : CCDS (NCBI)THEMIS
Cluster EST : UnigeneHs.661756 [ NCBI ]
CGAP (NCI)Hs.661756
Alternative Splicing GalleryENSG00000172673
Gene ExpressionTHEMIS [ NCBI-GEO ]   THEMIS [ EBI - ARRAY_EXPRESS ]   THEMIS [ SEEK ]   THEMIS [ MEM ]
Gene Expression Viewer (FireBrowse)THEMIS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)387357
GTEX Portal (Tissue expression)THEMIS
Human Protein AtlasENSG00000172673-THEMIS [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N1K5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N1K5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N1K5
Splice isoforms : SwissVarQ8N1K5
PhosPhoSitePlusQ8N1K5
Domains : Interpro (EBI)CABIT_dom   
Domain families : Pfam (Sanger)CABIT (PF12736)   
Domain families : Pfam (NCBI)pfam12736   
Conserved Domain (NCBI)THEMIS
DMDM Disease mutations387357
Blocks (Seattle)THEMIS
SuperfamilyQ8N1K5
Human Protein Atlas [tissue]ENSG00000172673-THEMIS [tissue]
Peptide AtlasQ8N1K5
HPRD16662
IPIIPI00742863   IPI00943662   IPI00643888   IPI00944562   
Protein Interaction databases
DIP (DOE-UCLA)Q8N1K5
IntAct (EBI)Q8N1K5
FunCoupENSG00000172673
BioGRIDTHEMIS
STRING (EMBL)THEMIS
ZODIACTHEMIS
Ontologies - Pathways
QuickGOQ8N1K5
Ontology : AmiGOadaptive immune response  protein binding  nucleus  cytoplasm  cell-cell junction  COP9 signalosome  positive T cell selection  negative T cell selection  T cell receptor signaling pathway  
Ontology : EGO-EBIadaptive immune response  protein binding  nucleus  cytoplasm  cell-cell junction  COP9 signalosome  positive T cell selection  negative T cell selection  T cell receptor signaling pathway  
NDEx NetworkTHEMIS
Atlas of Cancer Signalling NetworkTHEMIS
Wikipedia pathwaysTHEMIS
Orthology - Evolution
OrthoDB387357
GeneTree (enSembl)ENSG00000172673
Phylogenetic Trees/Animal Genes : TreeFamTHEMIS
HOVERGENQ8N1K5
HOGENOMQ8N1K5
Homologs : HomoloGeneTHEMIS
Homology/Alignments : Family Browser (UCSC)THEMIS
Gene fusions - Rearrangements
Fusion : MitelmanMTHFD1L/THEMIS [6q25.1/6q22.33]  [t(6;6)(q22;q25)]  
Fusion PortalMTHFD1L 6q25.1 THEMIS 6q22.33 BRCA
Fusion : QuiverTHEMIS
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTHEMIS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)THEMIS
dbVarTHEMIS
ClinVarTHEMIS
1000_GenomesTHEMIS 
Exome Variant ServerTHEMIS
ExAC (Exome Aggregation Consortium)ENSG00000172673
GNOMAD BrowserENSG00000172673
Genetic variants : HAPMAP387357
Genomic Variants (DGV)THEMIS [DGVbeta]
DECIPHERTHEMIS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTHEMIS 
Mutations
ICGC Data PortalTHEMIS 
TCGA Data PortalTHEMIS 
Broad Tumor PortalTHEMIS
OASIS PortalTHEMIS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTHEMIS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTHEMIS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch THEMIS
DgiDB (Drug Gene Interaction Database)THEMIS
DoCM (Curated mutations)THEMIS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)THEMIS (select a term)
intoGenTHEMIS
Cancer3DTHEMIS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613607   
Orphanet
DisGeNETTHEMIS
MedgenTHEMIS
Genetic Testing Registry THEMIS
NextProtQ8N1K5 [Medical]
TSGene387357
GENETestsTHEMIS
Target ValidationTHEMIS
Huge Navigator THEMIS [HugePedia]
snp3D : Map Gene to Disease387357
BioCentury BCIQTHEMIS
ClinGenTHEMIS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD387357
Chemical/Pharm GKB GenePA165618330
Clinical trialTHEMIS
Miscellaneous
canSAR (ICR)THEMIS (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTHEMIS
EVEXTHEMIS
GoPubMedTHEMIS
iHOPTHEMIS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:53:52 CEST 2018

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