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THNSL2 (threonine synthase like 2)

Identity

Alias (NCBI)SOFAT
THS2
TSH2
HGNC (Hugo) THNSL2
HGNC Alias symbFLJ10916
TSH2
SOFAT
HGNC Alias namesecreted osteoclastogenic factor of activated T cells
HGNC Previous namethreonine synthase-like 2 (S. cerevisiae)
LocusID (NCBI) 55258
Atlas_Id 74678
Location 2p11.2  [Link to chromosome band 2p11]
Location_base_pair Starts at 88173139 and ends at 88186637 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C19orf43 (19p13.2) / THNSL2 (2p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)THNSL2   25602
Cards
Entrez_Gene (NCBI)THNSL2    threonine synthase like 2
AliasesSOFAT; THS2; TSH2
GeneCards (Weizmann)THNSL2
Ensembl hg19 (Hinxton)ENSG00000144115 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000144115 [Gene_View]  ENSG00000144115 [Sequence]  chr2:88173139-88186637 [Contig_View]  THNSL2 [Vega]
ICGC DataPortalENSG00000144115
TCGA cBioPortalTHNSL2
AceView (NCBI)THNSL2
Genatlas (Paris)THNSL2
SOURCE (Princeton)THNSL2
Genetics Home Reference (NIH)THNSL2
Genomic and cartography
GoldenPath hg38 (UCSC)THNSL2  -     chr2:88173139-88186637 +  2p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)THNSL2  -     2p11.2   [Description]    (hg19-Feb_2009)
GoldenPathTHNSL2 - 2p11.2 [CytoView hg19]  THNSL2 - 2p11.2 [CytoView hg38]
ImmunoBaseENSG00000144115
Genome Data Viewer NCBITHNSL2 [Mapview hg19]  
OMIM611261   
Gene and transcription
Genbank (Entrez)AI313402 AK001778 AK092823 AK095303 AK289486
RefSeq transcript (Entrez)NM_001244676 NM_001244678 NM_001384382 NM_001384383 NM_018271
Consensus coding sequences : CCDS (NCBI)THNSL2
Gene ExpressionTHNSL2 [ NCBI-GEO ]   THNSL2 [ EBI - ARRAY_EXPRESS ]   THNSL2 [ SEEK ]   THNSL2 [ MEM ]
Gene Expression Viewer (FireBrowse)THNSL2 [ Firebrowse - Broad ]
GenevisibleExpression of THNSL2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55258
GTEX Portal (Tissue expression)THNSL2
Human Protein AtlasENSG00000144115-THNSL2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86YJ6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86YJ6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86YJ6
Catalytic activity : Enzyme4.2.3.- [ Enzyme-Expasy ]   4.2.3.-4.2.3.- [ IntEnz-EBI ]   4.2.3.- [ BRENDA ]   4.2.3.- [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ86YJ6
Domains : Interpro (EBI)PLP-dep    Thr_synth_N    Thr_synth_N_sf    Thr_synthase-like    Trypto_synt_PLP_dependent   
Domain families : Pfam (Sanger)PALP (PF00291)    Thr_synth_N (PF14821)   
Domain families : Pfam (NCBI)pfam00291    pfam14821   
Conserved Domain (NCBI)THNSL2
SuperfamilyQ86YJ6
AlphaFold pdb e-kbQ86YJ6   
Human Protein Atlas [tissue]ENSG00000144115-THNSL2 [tissue]
HPRD07715
Protein Interaction databases
DIP (DOE-UCLA)Q86YJ6
IntAct (EBI)Q86YJ6
BioGRIDTHNSL2
STRING (EMBL)THNSL2
ZODIACTHNSL2
Ontologies - Pathways
QuickGOQ86YJ6
Ontology : AmiGOmolecular_function  threonine synthase activity  cytokine activity  cellular_component  extracellular space  signal transduction  biological_process  serine family amino acid catabolic process  serine family amino acid catabolic process  dephosphorylation  dephosphorylation  pyridoxal phosphate binding  pyridoxal phosphate binding  2-oxobutyrate biosynthetic process  2-oxobutyrate biosynthetic process  serine binding  
Ontology : EGO-EBImolecular_function  threonine synthase activity  cytokine activity  cellular_component  extracellular space  signal transduction  biological_process  serine family amino acid catabolic process  serine family amino acid catabolic process  dephosphorylation  dephosphorylation  pyridoxal phosphate binding  pyridoxal phosphate binding  2-oxobutyrate biosynthetic process  2-oxobutyrate biosynthetic process  serine binding  
NDEx NetworkTHNSL2
Atlas of Cancer Signalling NetworkTHNSL2
Wikipedia pathwaysTHNSL2
Orthology - Evolution
OrthoDB55258
GeneTree (enSembl)ENSG00000144115
Phylogenetic Trees/Animal Genes : TreeFamTHNSL2
Homologs : HomoloGeneTHNSL2
Homology/Alignments : Family Browser (UCSC)THNSL2
Gene fusions - Rearrangements
Fusion : QuiverTHNSL2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTHNSL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)THNSL2
dbVarTHNSL2
ClinVarTHNSL2
MonarchTHNSL2
1000_GenomesTHNSL2 
Exome Variant ServerTHNSL2
GNOMAD BrowserENSG00000144115
Varsome BrowserTHNSL2
ACMGTHNSL2 variants
VarityQ86YJ6
Genomic Variants (DGV)THNSL2 [DGVbeta]
DECIPHERTHNSL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTHNSL2 
Mutations
ICGC Data PortalTHNSL2 
TCGA Data PortalTHNSL2 
Broad Tumor PortalTHNSL2
OASIS PortalTHNSL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTHNSL2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTHNSL2
Mutations and Diseases : HGMDTHNSL2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTHNSL2
DgiDB (Drug Gene Interaction Database)THNSL2
DoCM (Curated mutations)THNSL2
CIViC (Clinical Interpretations of Variants in Cancer)THNSL2
Cancer3DTHNSL2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611261   
Orphanet
DisGeNETTHNSL2
MedgenTHNSL2
Genetic Testing Registry THNSL2
NextProtQ86YJ6 [Medical]
GENETestsTHNSL2
Target ValidationTHNSL2
Huge Navigator THNSL2 [HugePedia]
ClinGenTHNSL2
Clinical trials, drugs, therapy
MyCancerGenomeTHNSL2
Protein Interactions : CTDTHNSL2
Pharm GKB GenePA162405692
PharosQ86YJ6
Clinical trialTHNSL2
Miscellaneous
canSAR (ICR)THNSL2
HarmonizomeTHNSL2
DataMed IndexTHNSL2
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTHNSL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:25:28 CEST 2021

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