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THNSL2 (threonine synthase like 2)

Identity

Alias_namesthreonine synthase-like 2 (S. cerevisiae)
Alias_symbol (synonym)FLJ10916
TSH2
SOFAT
Other aliasTHS2
HGNC (Hugo) THNSL2
LocusID (NCBI) 55258
Atlas_Id 74678
Location 2p11.2  [Link to chromosome band 2p11]
Location_base_pair Starts at 88170295 and ends at 88186637 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
C19orf43 (19p13.2) / THNSL2 (2p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)THNSL2   25602
Cards
Entrez_Gene (NCBI)THNSL2  55258  threonine synthase like 2
AliasesSOFAT; THS2; TSH2
GeneCards (Weizmann)THNSL2
Ensembl hg19 (Hinxton)ENSG00000144115 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000144115 [Gene_View]  chr2:88170295-88186637 [Contig_View]  THNSL2 [Vega]
ICGC DataPortalENSG00000144115
TCGA cBioPortalTHNSL2
AceView (NCBI)THNSL2
Genatlas (Paris)THNSL2
WikiGenes55258
SOURCE (Princeton)THNSL2
Genetics Home Reference (NIH)THNSL2
Genomic and cartography
GoldenPath hg38 (UCSC)THNSL2  -     chr2:88170295-88186637 +  2p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)THNSL2  -     2p11.2   [Description]    (hg19-Feb_2009)
EnsemblTHNSL2 - 2p11.2 [CytoView hg19]  THNSL2 - 2p11.2 [CytoView hg38]
Mapping of homologs : NCBITHNSL2 [Mapview hg19]  THNSL2 [Mapview hg38]
OMIM611261   
Gene and transcription
Genbank (Entrez)AI313402 AK001778 AK092823 AK095303 AK289486
RefSeq transcript (Entrez)NM_001244676 NM_001244678 NM_018271
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)THNSL2
Cluster EST : UnigeneHs.740434 [ NCBI ]
CGAP (NCI)Hs.740434
Alternative Splicing GalleryENSG00000144115
Gene ExpressionTHNSL2 [ NCBI-GEO ]   THNSL2 [ EBI - ARRAY_EXPRESS ]   THNSL2 [ SEEK ]   THNSL2 [ MEM ]
Gene Expression Viewer (FireBrowse)THNSL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55258
GTEX Portal (Tissue expression)THNSL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86YJ6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86YJ6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86YJ6
Splice isoforms : SwissVarQ86YJ6
Catalytic activity : Enzyme4.2.3.- [ Enzyme-Expasy ]   4.2.3.-4.2.3.- [ IntEnz-EBI ]   4.2.3.- [ BRENDA ]   4.2.3.- [ KEGG ]   
PhosPhoSitePlusQ86YJ6
Domains : Interpro (EBI)Thr_synth_N    Thr_synthase-like    TrpB-like_PLP-dep   
Domain families : Pfam (Sanger)PALP (PF00291)    Thr_synth_N (PF14821)   
Domain families : Pfam (NCBI)pfam00291    pfam14821   
Conserved Domain (NCBI)THNSL2
DMDM Disease mutations55258
Blocks (Seattle)THNSL2
SuperfamilyQ86YJ6
Human Protein AtlasENSG00000144115
Peptide AtlasQ86YJ6
HPRD07715
IPIIPI00395997   IPI00413065   IPI00448531   IPI00019452   IPI01021494   IPI01012140   IPI00926125   
Protein Interaction databases
DIP (DOE-UCLA)Q86YJ6
IntAct (EBI)Q86YJ6
FunCoupENSG00000144115
BioGRIDTHNSL2
STRING (EMBL)THNSL2
ZODIACTHNSL2
Ontologies - Pathways
QuickGOQ86YJ6
Ontology : AmiGOmolecular_function  threonine synthase activity  cytokine activity  cellular_component  extracellular space  biological_process  serine family amino acid catabolic process  threonine biosynthetic process  dephosphorylation  dephosphorylation  pyridoxal phosphate binding  2-oxobutyrate biosynthetic process  serine binding  
Ontology : EGO-EBImolecular_function  threonine synthase activity  cytokine activity  cellular_component  extracellular space  biological_process  serine family amino acid catabolic process  threonine biosynthetic process  dephosphorylation  dephosphorylation  pyridoxal phosphate binding  2-oxobutyrate biosynthetic process  serine binding  
NDEx NetworkTHNSL2
Atlas of Cancer Signalling NetworkTHNSL2
Wikipedia pathwaysTHNSL2
Orthology - Evolution
OrthoDB55258
GeneTree (enSembl)ENSG00000144115
Phylogenetic Trees/Animal Genes : TreeFamTHNSL2
HOVERGENQ86YJ6
HOGENOMQ86YJ6
Homologs : HomoloGeneTHNSL2
Homology/Alignments : Family Browser (UCSC)THNSL2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTHNSL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)THNSL2
dbVarTHNSL2
ClinVarTHNSL2
1000_GenomesTHNSL2 
Exome Variant ServerTHNSL2
ExAC (Exome Aggregation Consortium)THNSL2 (select the gene name)
Genetic variants : HAPMAP55258
Genomic Variants (DGV)THNSL2 [DGVbeta]
DECIPHERTHNSL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTHNSL2 
Mutations
ICGC Data PortalTHNSL2 
TCGA Data PortalTHNSL2 
Broad Tumor PortalTHNSL2
OASIS PortalTHNSL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTHNSL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTHNSL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch THNSL2
DgiDB (Drug Gene Interaction Database)THNSL2
DoCM (Curated mutations)THNSL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)THNSL2 (select a term)
intoGenTHNSL2
Cancer3DTHNSL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611261   
Orphanet
MedgenTHNSL2
Genetic Testing Registry THNSL2
NextProtQ86YJ6 [Medical]
TSGene55258
GENETestsTHNSL2
Target ValidationTHNSL2
Huge Navigator THNSL2 [HugePedia]
snp3D : Map Gene to Disease55258
BioCentury BCIQTHNSL2
ClinGenTHNSL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55258
Chemical/Pharm GKB GenePA162405692
Clinical trialTHNSL2
Miscellaneous
canSAR (ICR)THNSL2 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTHNSL2
EVEXTHNSL2
GoPubMedTHNSL2
iHOPTHNSL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:45:27 CEST 2017

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