THOC1 (THO complex 1)

2011-07-01 Affiliation

Identity

HGNC

THOC1

LOCATION

18p11.32

LOCUSID

9984

ALIAS

HPR1,P84,P84N5

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9984
MIM: 606930
HGNC: 19070
Ensembl: ENSG00000079134

Variants:

dbSNP: 9984
ClinVar: 9984
TCGA: ENSG00000079134
COSMIC: THOC1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000079134	ENST00000261600	Q96FV9
ENSG00000079134	ENST00000579891	R4GMN4
ENSG00000079134	ENST00000580038	J3KT14
ENSG00000079134	ENST00000581116	J3KRD7
ENSG00000079134	ENST00000581269	J3QQZ3
ENSG00000079134	ENST00000584642	R4GN58
ENSG00000079134	ENST00000616322	A0A087WWS1
ENSG00000079134	ENST00000621904	A0A087WY84
ENSG00000079134	ENST00000631280	J3QQZ3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Spliceosome	KEGG	ko03040
Spliceosome	KEGG	hsa03040
RNA transport	KEGG	ko03013
RNA transport	KEGG	hsa03013
THC complex	KEGG	hsa_M00405
TREX complex	KEGG	hsa_M00406
THC complex	KEGG	M00405
TREX complex	KEGG	M00406
Gene Expression	REACTOME	R-HSA-74160
RNA Polymerase II Transcription	REACTOME	R-HSA-73857
RNA Polymerase II Transcription Termination	REACTOME	R-HSA-73856
Cleavage of Growing Transcript in the Termination Region	REACTOME	R-HSA-109688
Processing of Capped Intron-Containing Pre-mRNA	REACTOME	R-HSA-72203
mRNA 3'-end processing	REACTOME	R-HSA-72187
Transport of Mature Transcript to Cytoplasm	REACTOME	R-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing Transcript	REACTOME	R-HSA-159236

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
15998806	2005	Recruitment of the human TREX complex to mRNA during splicing.	174
22144908	2011	Genome instability and transcription elongation impairment in human cells depleted of THO/TREX.	84
15870275	2005	Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors.	35
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	27
17638875	2007	Cancer cells and normal cells differ in their requirements for Thoc1.	24
29074626	2017	Human THO-Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability.	24
21329510	2011	Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers.	23
17699767	2007	Cells with defective p53-p21-pRb pathway are susceptible to apoptosis induced by p84N5 via caspase-6.	12
18469354	2008	Relationships of hHpr1/p84/Thoc1 expression to clinicopathologic characteristics and prognosis in non-small cell lung cancer.	5
26545775	2015	Elevated expression of Thoc1 is associated with aggressive phenotype and poor prognosis in colorectal cancer.	5

Citation

Dessen P

THOC1 (THO complex 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-07-01

Online version: http://atlasgeneticsoncology.org/gene/52285/thoc1