Atlas of Genetics and Cytogenetics in Oncology and Haematology


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THOC1 (THO complex 1)

Identity

Alias (NCBI)HPR1
P84
P84N5
HGNC (Hugo) THOC1
HGNC Alias symbP84
HPR1
LocusID (NCBI) 9984
Atlas_Id 52285
Location 18p11.32  [Link to chromosome band 18p11]
Location_base_pair Starts at 214520 and ends at 268047 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
THOC1 (18p11.32) / SRP19 (5q22.2)THOC1 (18p11.32) / THOC1 (18p11.32)USP45 (6q16.2) / THOC1 (18p11.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)THOC1   19070
Cards
Entrez_Gene (NCBI)THOC1    THO complex 1
AliasesHPR1; P84; P84N5
GeneCards (Weizmann)THOC1
Ensembl hg19 (Hinxton)ENSG00000079134 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000079134 [Gene_View]  ENSG00000079134 [Sequence]  chr18:214520-268047 [Contig_View]  THOC1 [Vega]
ICGC DataPortalENSG00000079134
TCGA cBioPortalTHOC1
AceView (NCBI)THOC1
Genatlas (Paris)THOC1
SOURCE (Princeton)THOC1
Genetics Home Reference (NIH)THOC1
Genomic and cartography
GoldenPath hg38 (UCSC)THOC1  -     chr18:214520-268047 -  18p11.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)THOC1  -     18p11.32   [Description]    (hg19-Feb_2009)
GoldenPathTHOC1 - 18p11.32 [CytoView hg19]  THOC1 - 18p11.32 [CytoView hg38]
ImmunoBaseENSG00000079134
Genome Data Viewer NCBITHOC1 [Mapview hg19]  
OMIM606930   
Gene and transcription
Genbank (Entrez)AK055354 AK123530 AK225067 AK225709 AK314755
RefSeq transcript (Entrez)NM_005131
Consensus coding sequences : CCDS (NCBI)THOC1
Gene ExpressionTHOC1 [ NCBI-GEO ]   THOC1 [ EBI - ARRAY_EXPRESS ]   THOC1 [ SEEK ]   THOC1 [ MEM ]
Gene Expression Viewer (FireBrowse)THOC1 [ Firebrowse - Broad ]
GenevisibleExpression of THOC1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9984
GTEX Portal (Tissue expression)THOC1
Human Protein AtlasENSG00000079134-THOC1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96FV9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96FV9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96FV9
PhosPhoSitePlusQ96FV9
Domaine pattern : Prosite (Expaxy)DEATH_DOMAIN (PS50017)   
Domains : Interpro (EBI)DEATH-like_dom_sf    Death_domain    THO_THOC1   
Domain families : Pfam (Sanger)Death (PF00531)    efThoc1 (PF11957)   
Domain families : Pfam (NCBI)pfam00531    pfam11957   
Domain families : Smart (EMBL)DEATH (SM00005)  
Conserved Domain (NCBI)THOC1
PDB (RSDB)1WXP   
PDB Europe1WXP   
PDB (PDBSum)1WXP   
PDB (IMB)1WXP   
Structural Biology KnowledgeBase1WXP   
SCOP (Structural Classification of Proteins)1WXP   
CATH (Classification of proteins structures)1WXP   
SuperfamilyQ96FV9
AlphaFold pdb e-kbQ96FV9   
Human Protein Atlas [tissue]ENSG00000079134-THOC1 [tissue]
HPRD09498
Protein Interaction databases
DIP (DOE-UCLA)Q96FV9
IntAct (EBI)Q96FV9
BioGRIDTHOC1
STRING (EMBL)THOC1
ZODIACTHOC1
Ontologies - Pathways
QuickGOQ96FV9
Ontology : AmiGOregulation of DNA recombination  transcription export complex  THO complex  THO complex part of transcription export complex  THO complex part of transcription export complex  chromosome, telomeric region  DNA binding  RNA binding  protein binding  nucleus  nucleoplasm  cytoplasm  RNA processing  RNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  apoptotic process  signal transduction  RNA splicing  nuclear matrix  nuclear speck  mRNA 3'-end processing  replication fork processing  regulation of DNA-templated transcription, elongation  regulation of DNA-templated transcription, elongation  positive regulation of DNA-templated transcription, elongation  viral mRNA export from host cell nucleus  negative regulation of isotype switching to IgA isotypes  negative regulation of DNA damage checkpoint  
Ontology : EGO-EBIregulation of DNA recombination  transcription export complex  THO complex  THO complex part of transcription export complex  THO complex part of transcription export complex  chromosome, telomeric region  DNA binding  RNA binding  protein binding  nucleus  nucleoplasm  cytoplasm  RNA processing  RNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  apoptotic process  signal transduction  RNA splicing  nuclear matrix  nuclear speck  mRNA 3'-end processing  replication fork processing  regulation of DNA-templated transcription, elongation  regulation of DNA-templated transcription, elongation  positive regulation of DNA-templated transcription, elongation  viral mRNA export from host cell nucleus  negative regulation of isotype switching to IgA isotypes  negative regulation of DNA damage checkpoint  
Pathways : KEGGRNA transport    Spliceosome   
NDEx NetworkTHOC1
Atlas of Cancer Signalling NetworkTHOC1
Wikipedia pathwaysTHOC1
Orthology - Evolution
OrthoDB9984
GeneTree (enSembl)ENSG00000079134
Phylogenetic Trees/Animal Genes : TreeFamTHOC1
Homologs : HomoloGeneTHOC1
Homology/Alignments : Family Browser (UCSC)THOC1
Gene fusions - Rearrangements
Fusion : QuiverTHOC1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTHOC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)THOC1
dbVarTHOC1
ClinVarTHOC1
MonarchTHOC1
1000_GenomesTHOC1 
Exome Variant ServerTHOC1
GNOMAD BrowserENSG00000079134
Varsome BrowserTHOC1
ACMGTHOC1 variants
VarityQ96FV9
Genomic Variants (DGV)THOC1 [DGVbeta]
DECIPHERTHOC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTHOC1 
Mutations
ICGC Data PortalTHOC1 
TCGA Data PortalTHOC1 
Broad Tumor PortalTHOC1
OASIS PortalTHOC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTHOC1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTHOC1
Mutations and Diseases : HGMDTHOC1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTHOC1
DgiDB (Drug Gene Interaction Database)THOC1
DoCM (Curated mutations)THOC1
CIViC (Clinical Interpretations of Variants in Cancer)THOC1
Cancer3DTHOC1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606930   
Orphanet
DisGeNETTHOC1
MedgenTHOC1
Genetic Testing Registry THOC1
NextProtQ96FV9 [Medical]
GENETestsTHOC1
Target ValidationTHOC1
Huge Navigator THOC1 [HugePedia]
ClinGenTHOC1
Clinical trials, drugs, therapy
MyCancerGenomeTHOC1
Protein Interactions : CTDTHOC1
Pharm GKB GenePA134887435
PharosQ96FV9
Clinical trialTHOC1
Miscellaneous
canSAR (ICR)THOC1
HarmonizomeTHOC1
DataMed IndexTHOC1
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTHOC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:01 CEST 2021

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