Identity
HGNC
LOCATION
18p11.32
LOCUSID
ALIAS
HPR1,P84,P84N5
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9984
MIM: 606930
HGNC: 19070
Ensembl: ENSG00000079134
Variants:
dbSNP: 9984
ClinVar: 9984
TCGA: ENSG00000079134
COSMIC: THOC1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32669125 | 2020 | Knockdown of THOC1 reduces the proliferation of hepatocellular carcinoma and increases the sensitivity to cisplatin. | 15 |
| 32776944 | 2020 | THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis. | 14 |
| 32669125 | 2020 | Knockdown of THOC1 reduces the proliferation of hepatocellular carcinoma and increases the sensitivity to cisplatin. | 15 |
| 32776944 | 2020 | THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis. | 14 |
| 29074626 | 2017 | Human THO-Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability. | 71 |
| 29074626 | 2017 | Human THO-Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability. | 71 |
| 26545775 | 2015 | Elevated expression of Thoc1 is associated with aggressive phenotype and poor prognosis in colorectal cancer. | 11 |
| 26545775 | 2015 | Elevated expression of Thoc1 is associated with aggressive phenotype and poor prognosis in colorectal cancer. | 11 |
| 24682263 | 2014 | Thoc1 inhibits cell growth via induction of cell cycle arrest and apoptosis in lung cancer cells. | 7 |
| 25296641 | 2014 | The Thoc1 ribonucleoprotein and prostate cancer progression. | 11 |
| 24682263 | 2014 | Thoc1 inhibits cell growth via induction of cell cycle arrest and apoptosis in lung cancer cells. | 7 |
| 25296641 | 2014 | The Thoc1 ribonucleoprotein and prostate cancer progression. | 11 |
| 23460917 | 2013 | The Thoc1 encoded ribonucleoprotein is a substrate for the NEDD4-1 E3 ubiquitin protein ligase. | 3 |
| 23460917 | 2013 | The Thoc1 encoded ribonucleoprotein is a substrate for the NEDD4-1 E3 ubiquitin protein ligase. | 3 |
| 22952718 | 2012 | Transcriptional regulation of hTREX84 in human cancer cells. | 3 |
Citation
Dessen P
THOC1 (THO complex 1)
Atlas Genet Cytogenet Oncol Haematol. 2011-07-01
Online version: http://atlasgeneticsoncology.org/gene/52285/thoc1
