Atlas of Genetics and Cytogenetics in Oncology and Haematology


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THOC1 (THO complex 1)

Identity

Alias_symbol (synonym)P84
HPR1
Other aliasP84N5
HGNC (Hugo) THOC1
LocusID (NCBI) 9984
Atlas_Id 52285
Location 18p11.32  [Link to chromosome band 18p11]
Location_base_pair Starts at 214520 and ends at 268059 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
THOC1 (18p11.32) / SRP19 (5q22.2)THOC1 (18p11.32) / THOC1 (18p11.32)USP45 (6q16.2) / THOC1 (18p11.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)THOC1   19070
Cards
Entrez_Gene (NCBI)THOC1  9984  THO complex 1
AliasesHPR1; P84; P84N5
GeneCards (Weizmann)THOC1
Ensembl hg19 (Hinxton)ENSG00000079134 [Gene_View]  chr18:214520-268059 [Contig_View]  THOC1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000079134 [Gene_View]  chr18:214520-268059 [Contig_View]  THOC1 [Vega]
ICGC DataPortalENSG00000079134
TCGA cBioPortalTHOC1
AceView (NCBI)THOC1
Genatlas (Paris)THOC1
WikiGenes9984
SOURCE (Princeton)THOC1
Genetics Home Reference (NIH)THOC1
Genomic and cartography
GoldenPath hg19 (UCSC)THOC1  -     chr18:214520-268059 -  18p11.32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)THOC1  -     18p11.32   [Description]    (hg38-Dec_2013)
EnsemblTHOC1 - 18p11.32 [CytoView hg19]  THOC1 - 18p11.32 [CytoView hg38]
Mapping of homologs : NCBITHOC1 [Mapview hg19]  THOC1 [Mapview hg38]
OMIM606930   
Gene and transcription
Genbank (Entrez)AK055354 AK123530 AK225067 AK225709 AK314755
RefSeq transcript (Entrez)NM_005131
RefSeq genomic (Entrez)NC_000018 NC_018929 NT_010859 NW_004929409
Consensus coding sequences : CCDS (NCBI)THOC1
Cluster EST : UnigeneHs.712543 [ NCBI ]
CGAP (NCI)Hs.712543
Alternative Splicing GalleryENSG00000079134
Gene ExpressionTHOC1 [ NCBI-GEO ]   THOC1 [ EBI - ARRAY_EXPRESS ]   THOC1 [ SEEK ]   THOC1 [ MEM ]
Gene Expression Viewer (FireBrowse)THOC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9984
GTEX Portal (Tissue expression)THOC1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96FV9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96FV9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96FV9
Splice isoforms : SwissVarQ96FV9
PhosPhoSitePlusQ96FV9
Domaine pattern : Prosite (Expaxy)DEATH_DOMAIN (PS50017)   
Domains : Interpro (EBI)DEATH-like_dom    Death_domain    THO_THOC1   
Domain families : Pfam (Sanger)Death (PF00531)    efThoc1 (PF11957)   
Domain families : Pfam (NCBI)pfam00531    pfam11957   
Domain families : Smart (EMBL)DEATH (SM00005)  
Conserved Domain (NCBI)THOC1
DMDM Disease mutations9984
Blocks (Seattle)THOC1
PDB (SRS)1WXP   
PDB (PDBSum)1WXP   
PDB (IMB)1WXP   
PDB (RSDB)1WXP   
Structural Biology KnowledgeBase1WXP   
SCOP (Structural Classification of Proteins)1WXP   
CATH (Classification of proteins structures)1WXP   
SuperfamilyQ96FV9
Human Protein AtlasENSG00000079134
Peptide AtlasQ96FV9
HPRD09498
IPIIPI00305374   IPI00646620   IPI00944519   
Protein Interaction databases
DIP (DOE-UCLA)Q96FV9
IntAct (EBI)Q96FV9
FunCoupENSG00000079134
BioGRIDTHOC1
STRING (EMBL)THOC1
ZODIACTHOC1
Ontologies - Pathways
QuickGOQ96FV9
Ontology : AmiGOregulation of DNA recombination  transcription export complex  THO complex  THO complex part of transcription export complex  nuclear chromosome, telomeric region  DNA binding  RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  termination of RNA polymerase II transcription  RNA processing  RNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  apoptotic process  signal transduction  RNA splicing  nuclear matrix  nuclear speck  mRNA 3'-end processing  replication fork processing  regulation of DNA-templated transcription, elongation  positive regulation of DNA-templated transcription, elongation  intercellular bridge  viral mRNA export from host cell nucleus  negative regulation of isotype switching to IgA isotypes  negative regulation of DNA damage checkpoint  
Ontology : EGO-EBIregulation of DNA recombination  transcription export complex  THO complex  THO complex part of transcription export complex  nuclear chromosome, telomeric region  DNA binding  RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  termination of RNA polymerase II transcription  RNA processing  RNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  apoptotic process  signal transduction  RNA splicing  nuclear matrix  nuclear speck  mRNA 3'-end processing  replication fork processing  regulation of DNA-templated transcription, elongation  positive regulation of DNA-templated transcription, elongation  intercellular bridge  viral mRNA export from host cell nucleus  negative regulation of isotype switching to IgA isotypes  negative regulation of DNA damage checkpoint  
Pathways : KEGGRNA transport    Spliceosome   
NDEx NetworkTHOC1
Atlas of Cancer Signalling NetworkTHOC1
Wikipedia pathwaysTHOC1
Orthology - Evolution
OrthoDB9984
GeneTree (enSembl)ENSG00000079134
Phylogenetic Trees/Animal Genes : TreeFamTHOC1
HOVERGENQ96FV9
HOGENOMQ96FV9
Homologs : HomoloGeneTHOC1
Homology/Alignments : Family Browser (UCSC)THOC1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTHOC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)THOC1
dbVarTHOC1
ClinVarTHOC1
1000_GenomesTHOC1 
Exome Variant ServerTHOC1
ExAC (Exome Aggregation Consortium)THOC1 (select the gene name)
Genetic variants : HAPMAP9984
Genomic Variants (DGV)THOC1 [DGVbeta]
DECIPHER (Syndromes)18:214520-268059  ENSG00000079134
CONAN: Copy Number AnalysisTHOC1 
Mutations
ICGC Data PortalTHOC1 
TCGA Data PortalTHOC1 
Broad Tumor PortalTHOC1
OASIS PortalTHOC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTHOC1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTHOC1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch THOC1
DgiDB (Drug Gene Interaction Database)THOC1
DoCM (Curated mutations)THOC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)THOC1 (select a term)
intoGenTHOC1
Cancer3DTHOC1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606930   
Orphanet
MedgenTHOC1
Genetic Testing Registry THOC1
NextProtQ96FV9 [Medical]
TSGene9984
GENETestsTHOC1
Huge Navigator THOC1 [HugePedia]
snp3D : Map Gene to Disease9984
BioCentury BCIQTHOC1
ClinGenTHOC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9984
Chemical/Pharm GKB GenePA134887435
Clinical trialTHOC1
Miscellaneous
canSAR (ICR)THOC1 (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTHOC1
EVEXTHOC1
GoPubMedTHOC1
iHOPTHOC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:31:03 CET 2017

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