Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

THOC2 (THO complex 2)

Identity

Alias_namesCXorf3
MRX12
MRX35
chromosome X open reading frame 3
mental retardation, X-linked 12
mental retardation, X-linked 35
Alias_symbol (synonym)THO2
dJ506G2.1
Other aliashTREX120
HGNC (Hugo) THOC2
LocusID (NCBI) 57187
Atlas_Id 74679
Location Xq25  [Link to chromosome band Xq25]
Location_base_pair Starts at 123600561 and ends at 123733054 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DIP2A (21q22.3) / THOC2 (Xq25)THOC2 (Xq25) / MTSS1 (8q24.13)THOC2 (Xq25) / SEC62 (3q26.2)
ZNF500 (16p13.3) / THOC2 (Xq25)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)THOC2   19073
Cards
Entrez_Gene (NCBI)THOC2  57187  THO complex 2
AliasesCXorf3; MRX12; MRX35; THO2; 
dJ506G2.1; hTREX120
GeneCards (Weizmann)THOC2
Ensembl hg19 (Hinxton)ENSG00000125676 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125676 [Gene_View]  chrX:123600561-123733054 [Contig_View]  THOC2 [Vega]
ICGC DataPortalENSG00000125676
TCGA cBioPortalTHOC2
AceView (NCBI)THOC2
Genatlas (Paris)THOC2
WikiGenes57187
SOURCE (Princeton)THOC2
Genetics Home Reference (NIH)THOC2
Genomic and cartography
GoldenPath hg38 (UCSC)THOC2  -     chrX:123600561-123733054 -  Xq25   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)THOC2  -     Xq25   [Description]    (hg19-Feb_2009)
EnsemblTHOC2 - Xq25 [CytoView hg19]  THOC2 - Xq25 [CytoView hg38]
Mapping of homologs : NCBITHOC2 [Mapview hg19]  THOC2 [Mapview hg38]
OMIM300395   300957   
Gene and transcription
Genbank (Entrez)AF441770 AK001758 AK023659 AK296780 AW206982
RefSeq transcript (Entrez)NM_001081550 NM_020449
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)THOC2
Cluster EST : UnigeneHs.149991 [ NCBI ]
CGAP (NCI)Hs.149991
Alternative Splicing GalleryENSG00000125676
Gene ExpressionTHOC2 [ NCBI-GEO ]   THOC2 [ EBI - ARRAY_EXPRESS ]   THOC2 [ SEEK ]   THOC2 [ MEM ]
Gene Expression Viewer (FireBrowse)THOC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57187
GTEX Portal (Tissue expression)THOC2
Human Protein AtlasENSG00000125676-THOC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NI27   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NI27  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NI27
Splice isoforms : SwissVarQ8NI27
PhosPhoSitePlusQ8NI27
Domains : Interpro (EBI)THO_THOC2_C    THO_THOC2_N    THOC2_N   
Domain families : Pfam (Sanger)Tho2 (PF11262)    Thoc2 (PF11732)    THOC2_N (PF16134)   
Domain families : Pfam (NCBI)pfam11262    pfam11732    pfam16134   
Conserved Domain (NCBI)THOC2
DMDM Disease mutations57187
Blocks (Seattle)THOC2
SuperfamilyQ8NI27
Human Protein Atlas [tissue]ENSG00000125676-THOC2 [tissue]
Peptide AtlasQ8NI27
HPRD02317
IPIIPI00915022   IPI00853065   IPI00158615   IPI00552909   IPI00894279   IPI01013250   IPI00892853   IPI00892734   IPI00894153   IPI00917521   IPI01009435   
Protein Interaction databases
DIP (DOE-UCLA)Q8NI27
IntAct (EBI)Q8NI27
FunCoupENSG00000125676
BioGRIDTHOC2
STRING (EMBL)THOC2
ZODIACTHOC2
Ontologies - Pathways
QuickGOQ8NI27
Ontology : AmiGOtranscription export complex  THO complex  THO complex part of transcription export complex  nuclear chromosome, telomeric region  mRNA binding  protein binding  nucleoplasm  termination of RNA polymerase II transcription  RNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  RNA splicing  nuclear speck  poly(A)+ mRNA export from nucleus  mRNA 3'-end processing  viral mRNA export from host cell nucleus  neuron development  generation of neurons  
Ontology : EGO-EBItranscription export complex  THO complex  THO complex part of transcription export complex  nuclear chromosome, telomeric region  mRNA binding  protein binding  nucleoplasm  termination of RNA polymerase II transcription  RNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  RNA splicing  nuclear speck  poly(A)+ mRNA export from nucleus  mRNA 3'-end processing  viral mRNA export from host cell nucleus  neuron development  generation of neurons  
Pathways : KEGGRNA transport    Spliceosome   
NDEx NetworkTHOC2
Atlas of Cancer Signalling NetworkTHOC2
Wikipedia pathwaysTHOC2
Orthology - Evolution
OrthoDB57187
GeneTree (enSembl)ENSG00000125676
Phylogenetic Trees/Animal Genes : TreeFamTHOC2
HOVERGENQ8NI27
HOGENOMQ8NI27
Homologs : HomoloGeneTHOC2
Homology/Alignments : Family Browser (UCSC)THOC2
Gene fusions - Rearrangements
Tumor Fusion PortalTHOC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTHOC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)THOC2
dbVarTHOC2
ClinVarTHOC2
1000_GenomesTHOC2 
Exome Variant ServerTHOC2
ExAC (Exome Aggregation Consortium)ENSG00000125676
GNOMAD BrowserENSG00000125676
Genetic variants : HAPMAP57187
Genomic Variants (DGV)THOC2 [DGVbeta]
DECIPHERTHOC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTHOC2 
Mutations
ICGC Data PortalTHOC2 
TCGA Data PortalTHOC2 
Broad Tumor PortalTHOC2
OASIS PortalTHOC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTHOC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTHOC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch THOC2
DgiDB (Drug Gene Interaction Database)THOC2
DoCM (Curated mutations)THOC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)THOC2 (select a term)
intoGenTHOC2
Cancer3DTHOC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300395    300957   
Orphanet23714   
DisGeNETTHOC2
MedgenTHOC2
Genetic Testing Registry THOC2
NextProtQ8NI27 [Medical]
TSGene57187
GENETestsTHOC2
Target ValidationTHOC2
Huge Navigator THOC2 [HugePedia]
snp3D : Map Gene to Disease57187
BioCentury BCIQTHOC2
ClinGenTHOC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57187
Chemical/Pharm GKB GenePA128395788
Clinical trialTHOC2
Miscellaneous
canSAR (ICR)THOC2 (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTHOC2
EVEXTHOC2
GoPubMedTHOC2
iHOPTHOC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Nov 20 20:17:58 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.