Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

THOC2 (THO complex 2)

Identity

Alias (NCBI)CXorf3
MRX12
MRX35
THO2
dJ506G2.1
hTREX120
HGNC (Hugo) THOC2
HGNC Alias symbTHO2
dJ506G2.1
HGNC Previous nameCXorf3
 MRX12
 MRX35
HGNC Previous namechromosome X open reading frame 3
 mental retardation, X-linked 12
 mental retardation, X-linked 35
LocusID (NCBI) 57187
Atlas_Id 74679
Location Xq25  [Link to chromosome band Xq25]
Location_base_pair Starts at 123600570 and ends at 123733052 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DIP2A (21q22.3) / THOC2 (Xq25)THOC2 (Xq25) / MTSS1 (8q24.13)THOC2 (Xq25) / SEC62 (3q26.2)
ZNF500 (16p13.3) / THOC2 (Xq25)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)THOC2   19073
Cards
Entrez_Gene (NCBI)THOC2    THO complex 2
AliasesCXorf3; MRX12; MRX35; THO2; 
dJ506G2.1; hTREX120
GeneCards (Weizmann)THOC2
Ensembl hg19 (Hinxton)ENSG00000125676 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125676 [Gene_View]  ENSG00000125676 [Sequence]  chrX:123600570-123733052 [Contig_View]  THOC2 [Vega]
ICGC DataPortalENSG00000125676
TCGA cBioPortalTHOC2
AceView (NCBI)THOC2
Genatlas (Paris)THOC2
SOURCE (Princeton)THOC2
Genetics Home Reference (NIH)THOC2
Genomic and cartography
GoldenPath hg38 (UCSC)THOC2  -     chrX:123600570-123733052 -  Xq25   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)THOC2  -     Xq25   [Description]    (hg19-Feb_2009)
GoldenPathTHOC2 - Xq25 [CytoView hg19]  THOC2 - Xq25 [CytoView hg38]
ImmunoBaseENSG00000125676
Genome Data Viewer NCBITHOC2 [Mapview hg19]  
OMIM300395   300957   
Gene and transcription
Genbank (Entrez)AF441770 AK001758 AK023659 AK296780 AW206982
RefSeq transcript (Entrez)NM_001081550 NM_020449
Consensus coding sequences : CCDS (NCBI)THOC2
Gene ExpressionTHOC2 [ NCBI-GEO ]   THOC2 [ EBI - ARRAY_EXPRESS ]   THOC2 [ SEEK ]   THOC2 [ MEM ]
Gene Expression Viewer (FireBrowse)THOC2 [ Firebrowse - Broad ]
GenevisibleExpression of THOC2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57187
GTEX Portal (Tissue expression)THOC2
Human Protein AtlasENSG00000125676-THOC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NI27   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NI27  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NI27
PhosPhoSitePlusQ8NI27
Domains : Interpro (EBI)Tho2    THO_THOC2_C    THO_THOC2_N    THOC2_N   
Domain families : Pfam (Sanger)Tho2 (PF11262)    Thoc2 (PF11732)    THOC2_N (PF16134)   
Domain families : Pfam (NCBI)pfam11262    pfam11732    pfam16134   
Conserved Domain (NCBI)THOC2
SuperfamilyQ8NI27
AlphaFold pdb e-kbQ8NI27   
Human Protein Atlas [tissue]ENSG00000125676-THOC2 [tissue]
HPRD02317
Protein Interaction databases
DIP (DOE-UCLA)Q8NI27
IntAct (EBI)Q8NI27
BioGRIDTHOC2
STRING (EMBL)THOC2
ZODIACTHOC2
Ontologies - Pathways
QuickGOQ8NI27
Ontology : AmiGOtranscription export complex  THO complex  THO complex part of transcription export complex  THO complex part of transcription export complex  chromosome, telomeric region  mRNA binding  protein binding  nucleoplasm  RNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  RNA splicing  negative regulation of neuron projection development  nuclear speck  poly(A)+ mRNA export from nucleus  mRNA 3'-end processing  viral mRNA export from host cell nucleus  neuron development  generation of neurons  
Ontology : EGO-EBItranscription export complex  THO complex  THO complex part of transcription export complex  THO complex part of transcription export complex  chromosome, telomeric region  mRNA binding  protein binding  nucleoplasm  RNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  RNA splicing  negative regulation of neuron projection development  nuclear speck  poly(A)+ mRNA export from nucleus  mRNA 3'-end processing  viral mRNA export from host cell nucleus  neuron development  generation of neurons  
NDEx NetworkTHOC2
Atlas of Cancer Signalling NetworkTHOC2
Wikipedia pathwaysTHOC2
Orthology - Evolution
OrthoDB57187
GeneTree (enSembl)ENSG00000125676
Phylogenetic Trees/Animal Genes : TreeFamTHOC2
Homologs : HomoloGeneTHOC2
Homology/Alignments : Family Browser (UCSC)THOC2
Gene fusions - Rearrangements
Fusion : QuiverTHOC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTHOC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)THOC2
dbVarTHOC2
ClinVarTHOC2
MonarchTHOC2
1000_GenomesTHOC2 
Exome Variant ServerTHOC2
GNOMAD BrowserENSG00000125676
Varsome BrowserTHOC2
ACMGTHOC2 variants
VarityQ8NI27
Genomic Variants (DGV)THOC2 [DGVbeta]
DECIPHERTHOC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTHOC2 
Mutations
ICGC Data PortalTHOC2 
TCGA Data PortalTHOC2 
Broad Tumor PortalTHOC2
OASIS PortalTHOC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTHOC2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTHOC2
Mutations and Diseases : HGMDTHOC2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTHOC2
DgiDB (Drug Gene Interaction Database)THOC2
DoCM (Curated mutations)THOC2
CIViC (Clinical Interpretations of Variants in Cancer)THOC2
Cancer3DTHOC2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300395    300957   
Orphanet23714   
DisGeNETTHOC2
MedgenTHOC2
Genetic Testing Registry THOC2
NextProtQ8NI27 [Medical]
GENETestsTHOC2
Target ValidationTHOC2
Huge Navigator THOC2 [HugePedia]
ClinGenTHOC2
Clinical trials, drugs, therapy
MyCancerGenomeTHOC2
Protein Interactions : CTDTHOC2
Pharm GKB GenePA128395788
PharosQ8NI27
Clinical trialTHOC2
Miscellaneous
canSAR (ICR)THOC2
HarmonizomeTHOC2
DataMed IndexTHOC2
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTHOC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 16:25:28 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.