Atlas of Genetics and Cytogenetics in Oncology and Haematology


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THOC3 (THO complex 3)

Identity

Alias_symbol (synonym)TEX1
MGC5469
Other aliasTHO3
hTREX45
HGNC (Hugo) THOC3
LocusID (NCBI) 84321
Atlas_Id 74680
Location 5q35.2  [Link to chromosome band 5q35]
Location_base_pair Starts at 175959531 and ends at 175968315 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
THOC3 (5q35.2) / EPHA4 (2q36.1)THOC3 (5q35.2) / RCBTB2 (13q14.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)THOC3   19072
Cards
Entrez_Gene (NCBI)THOC3  84321  THO complex 3
AliasesTHO3; hTREX45
GeneCards (Weizmann)THOC3
Ensembl hg19 (Hinxton)ENSG00000051596 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000051596 [Gene_View]  chr5:175959531-175968315 [Contig_View]  THOC3 [Vega]
ICGC DataPortalENSG00000051596
TCGA cBioPortalTHOC3
AceView (NCBI)THOC3
Genatlas (Paris)THOC3
WikiGenes84321
SOURCE (Princeton)THOC3
Genetics Home Reference (NIH)THOC3
Genomic and cartography
GoldenPath hg38 (UCSC)THOC3  -     chr5:175959531-175968315 -  5q35.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)THOC3  -     5q35.2   [Description]    (hg19-Feb_2009)
EnsemblTHOC3 - 5q35.2 [CytoView hg19]  THOC3 - 5q35.2 [CytoView hg38]
Mapping of homologs : NCBITHOC3 [Mapview hg19]  THOC3 [Mapview hg38]
OMIM606929   
Gene and transcription
Genbank (Entrez)AW511349 AW628745 BC006849 BC066325 BC068499
RefSeq transcript (Entrez)NM_032361
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)THOC3
Cluster EST : UnigeneHs.715943 [ NCBI ]
CGAP (NCI)Hs.715943
Alternative Splicing GalleryENSG00000051596
Gene ExpressionTHOC3 [ NCBI-GEO ]   THOC3 [ EBI - ARRAY_EXPRESS ]   THOC3 [ SEEK ]   THOC3 [ MEM ]
Gene Expression Viewer (FireBrowse)THOC3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84321
GTEX Portal (Tissue expression)THOC3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96J01   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96J01  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96J01
Splice isoforms : SwissVarQ96J01
PhosPhoSitePlusQ96J01
Domaine pattern : Prosite (Expaxy)WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)Apc4_WD40_dom    G-protein_beta_WD-40_rep    TIF_beta_prop-like    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_dom   
Domain families : Pfam (Sanger)ANAPC4_WD40 (PF12894)    eIF2A (PF08662)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam12894    pfam08662    pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)THOC3
DMDM Disease mutations84321
Blocks (Seattle)THOC3
SuperfamilyQ96J01
Human Protein AtlasENSG00000051596
Peptide AtlasQ96J01
HPRD09497
IPIIPI00063729   IPI00744510   IPI00967408   IPI00964379   IPI00433833   IPI00964087   IPI00964543   IPI00968127   IPI00967674   IPI00967326   
Protein Interaction databases
DIP (DOE-UCLA)Q96J01
IntAct (EBI)Q96J01
FunCoupENSG00000051596
BioGRIDTHOC3
STRING (EMBL)THOC3
ZODIACTHOC3
Ontologies - Pathways
QuickGOQ96J01
Ontology : AmiGOtranscription export complex  THO complex part of transcription export complex  nuclear chromosome, telomeric region  RNA binding  nucleoplasm  termination of RNA polymerase II transcription  RNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  RNA splicing  nuclear speck  mRNA 3'-end processing  viral mRNA export from host cell nucleus  
Ontology : EGO-EBItranscription export complex  THO complex part of transcription export complex  nuclear chromosome, telomeric region  RNA binding  nucleoplasm  termination of RNA polymerase II transcription  RNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  RNA splicing  nuclear speck  mRNA 3'-end processing  viral mRNA export from host cell nucleus  
Pathways : KEGGRNA transport    Spliceosome   
NDEx NetworkTHOC3
Atlas of Cancer Signalling NetworkTHOC3
Wikipedia pathwaysTHOC3
Orthology - Evolution
OrthoDB84321
GeneTree (enSembl)ENSG00000051596
Phylogenetic Trees/Animal Genes : TreeFamTHOC3
HOVERGENQ96J01
HOGENOMQ96J01
Homologs : HomoloGeneTHOC3
Homology/Alignments : Family Browser (UCSC)THOC3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTHOC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)THOC3
dbVarTHOC3
ClinVarTHOC3
1000_GenomesTHOC3 
Exome Variant ServerTHOC3
ExAC (Exome Aggregation Consortium)THOC3 (select the gene name)
Genetic variants : HAPMAP84321
Genomic Variants (DGV)THOC3 [DGVbeta]
DECIPHERTHOC3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTHOC3 
Mutations
ICGC Data PortalTHOC3 
TCGA Data PortalTHOC3 
Broad Tumor PortalTHOC3
OASIS PortalTHOC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTHOC3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTHOC3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch THOC3
DgiDB (Drug Gene Interaction Database)THOC3
DoCM (Curated mutations)THOC3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)THOC3 (select a term)
intoGenTHOC3
Cancer3DTHOC3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606929   
Orphanet
MedgenTHOC3
Genetic Testing Registry THOC3
NextProtQ96J01 [Medical]
TSGene84321
GENETestsTHOC3
Target ValidationTHOC3
Huge Navigator THOC3 [HugePedia]
snp3D : Map Gene to Disease84321
BioCentury BCIQTHOC3
ClinGenTHOC3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84321
Chemical/Pharm GKB GenePA134893535
Clinical trialTHOC3
Miscellaneous
canSAR (ICR)THOC3 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTHOC3
EVEXTHOC3
GoPubMedTHOC3
iHOPTHOC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:41:24 CEST 2017

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