THOC5 (THO complex 5)

2003-06-01  

Identity

HGNC
LOCATION
22q12.2
LOCUSID
ALIAS
C22orf19,Fmip,PK1.3,fSAP79
FUSION GENES

Other Information

Locus ID:

NCBI: 8563
MIM: 612733
HGNC: 19074
Ensembl: ENSG00000100296

Variants:

dbSNP: 8563
ClinVar: 8563
TCGA: ENSG00000100296
COSMIC: THOC5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100296ENST00000358079F5GZF3
ENSG00000100296ENST00000397871Q13769
ENSG00000100296ENST00000397871A0A024R1D6
ENSG00000100296ENST00000397872Q13769
ENSG00000100296ENST00000397872A0A024R1D6
ENSG00000100296ENST00000397873Q13769
ENSG00000100296ENST00000397873A0A024R1D6
ENSG00000100296ENST00000414902F8WES8
ENSG00000100296ENST00000418021C9JXU6
ENSG00000100296ENST00000428374C9JCL9
ENSG00000100296ENST00000440771C9JXG5
ENSG00000100296ENST00000442555F8WCP5
ENSG00000100296ENST00000443089H7C072
ENSG00000100296ENST00000455450H7C441
ENSG00000100296ENST00000490103Q13769
ENSG00000100296ENST00000490103A0A024R1D6

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
THC complexKEGGhsa_M00405
TREX complexKEGGhsa_M00406
THC complexKEGGM00405
TREX complexKEGGM00406
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA 3'-end processingREACTOMER-HSA-72187
Transport of Mature Transcript to CytoplasmREACTOMER-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing TranscriptREACTOMER-HSA-159236

References

Pubmed IDYearTitleCitations
191651462009Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA.66
236854342013Human TREX component Thoc5 affects alternative polyadenylation site choice by recruiting mammalian cleavage factor I.26
230327222013A pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5.11
190150242009THOC5 couples M-CSF receptor signaling to transcription factor expression.9
219377062011An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5.9
190592472009Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP).8
240232612013THOC5: a novel gene involved in HDL-cholesterol metabolism.4
265490212016Depletion of three combined THOC5 mRNA export protein target genes synergistically induces human hepatocellular carcinoma cell death.4
307215632019Human THO coordinates transcription termination and subsequent transcript release from the HSP70 locus.0

Citation

Dessen P

THOC5 (THO complex 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/884/thoc5