Atlas of Genetics and Cytogenetics in Oncology and Haematology


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THOC5 (THO complex 5)

Identity

Alias (NCBI)C22orf19
Fmip
PK1.3
fSAP79
HGNC (Hugo) THOC5
HGNC Alias symbPK1.3
KIAA0983
Fmip
fSAP79
HGNC Alias namefunctional spliceosome-associated protein 79
HGNC Previous nameC22orf19
HGNC Previous namechromosome 22 open reading frame 19
LocusID (NCBI) 8563
Atlas_Id 884
Location 22q12.2  [Link to chromosome band 22q12]
Location_base_pair Starts at 29505879 and ends at 29553757 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
THOC5 (22q12.2) / NIPSNAP1 (22q12.2)THOC5 (22q12.2) / PATZ1 (22q12.2)THOC5 22q12.2 / NIPSNAP1 22q12.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)THOC5   19074
Cards
Entrez_Gene (NCBI)THOC5    THO complex 5
AliasesC22orf19; Fmip; PK1.3; fSAP79
GeneCards (Weizmann)THOC5
Ensembl hg19 (Hinxton)ENSG00000100296 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100296 [Gene_View]  ENSG00000100296 [Sequence]  chr22:29505879-29553757 [Contig_View]  THOC5 [Vega]
ICGC DataPortalENSG00000100296
TCGA cBioPortalTHOC5
AceView (NCBI)THOC5
Genatlas (Paris)THOC5
SOURCE (Princeton)THOC5
Genetics Home Reference (NIH)THOC5
Genomic and cartography
GoldenPath hg38 (UCSC)THOC5  -     chr22:29505879-29553757 -  22q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)THOC5  -     22q12.2   [Description]    (hg19-Feb_2009)
GoldenPathTHOC5 - 22q12.2 [CytoView hg19]  THOC5 - 22q12.2 [CytoView hg38]
ImmunoBaseENSG00000100296
Genome Data Viewer NCBITHOC5 [Mapview hg19]  
OMIM612733   
Gene and transcription
Genbank (Entrez)AB023200 AJ006069 AK025385 AK098709 AK122673
RefSeq transcript (Entrez)NM_001002877 NM_001002878 NM_001002879 NM_003678
Consensus coding sequences : CCDS (NCBI)THOC5
Gene ExpressionTHOC5 [ NCBI-GEO ]   THOC5 [ EBI - ARRAY_EXPRESS ]   THOC5 [ SEEK ]   THOC5 [ MEM ]
Gene Expression Viewer (FireBrowse)THOC5 [ Firebrowse - Broad ]
GenevisibleExpression of THOC5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8563
GTEX Portal (Tissue expression)THOC5
Human Protein AtlasENSG00000100296-THOC5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13769   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13769  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13769
PhosPhoSitePlusQ13769
Domains : Interpro (EBI)THO_Thoc5   
Domain families : Pfam (Sanger)FmiP_Thoc5 (PF09766)   
Domain families : Pfam (NCBI)pfam09766   
Conserved Domain (NCBI)THOC5
SuperfamilyQ13769
AlphaFold pdb e-kbQ13769   
Human Protein Atlas [tissue]ENSG00000100296-THOC5 [tissue]
HPRD16650
Protein Interaction databases
DIP (DOE-UCLA)Q13769
IntAct (EBI)Q13769
BioGRIDTHOC5
STRING (EMBL)THOC5
ZODIACTHOC5
Ontologies - Pathways
QuickGOQ13769
Ontology : AmiGOtranscription export complex  THO complex  THO complex part of transcription export complex  THO complex part of transcription export complex  chromosome, telomeric region  mRNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  RNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  RNA splicing  monocyte differentiation  mRNA 3'-end processing  positive regulation of DNA-templated transcription, elongation  positive regulation of DNA-templated transcription, elongation  viral mRNA export from host cell nucleus  primitive hemopoiesis  negative regulation of DNA damage checkpoint  
Ontology : EGO-EBItranscription export complex  THO complex  THO complex part of transcription export complex  THO complex part of transcription export complex  chromosome, telomeric region  mRNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  RNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  RNA splicing  monocyte differentiation  mRNA 3'-end processing  positive regulation of DNA-templated transcription, elongation  positive regulation of DNA-templated transcription, elongation  viral mRNA export from host cell nucleus  primitive hemopoiesis  negative regulation of DNA damage checkpoint  
Pathways : KEGGRNA transport   
NDEx NetworkTHOC5
Atlas of Cancer Signalling NetworkTHOC5
Wikipedia pathwaysTHOC5
Orthology - Evolution
OrthoDB8563
GeneTree (enSembl)ENSG00000100296
Phylogenetic Trees/Animal Genes : TreeFamTHOC5
Homologs : HomoloGeneTHOC5
Homology/Alignments : Family Browser (UCSC)THOC5
Gene fusions - Rearrangements
Fusion : MitelmanTHOC5/NIPSNAP1 [22q12.2/22q12.2]  
Fusion : QuiverTHOC5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTHOC5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)THOC5
dbVarTHOC5
ClinVarTHOC5
MonarchTHOC5
1000_GenomesTHOC5 
Exome Variant ServerTHOC5
GNOMAD BrowserENSG00000100296
Varsome BrowserTHOC5
ACMGTHOC5 variants
VarityQ13769
Genomic Variants (DGV)THOC5 [DGVbeta]
DECIPHERTHOC5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTHOC5 
Mutations
ICGC Data PortalTHOC5 
TCGA Data PortalTHOC5 
Broad Tumor PortalTHOC5
OASIS PortalTHOC5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTHOC5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTHOC5
Mutations and Diseases : HGMDTHOC5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTHOC5
DgiDB (Drug Gene Interaction Database)THOC5
DoCM (Curated mutations)THOC5
CIViC (Clinical Interpretations of Variants in Cancer)THOC5
Cancer3DTHOC5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612733   
Orphanet
DisGeNETTHOC5
MedgenTHOC5
Genetic Testing Registry THOC5
NextProtQ13769 [Medical]
GENETestsTHOC5
Target ValidationTHOC5
Huge Navigator THOC5 [HugePedia]
ClinGenTHOC5
Clinical trials, drugs, therapy
MyCancerGenomeTHOC5
Protein Interactions : CTDTHOC5
Pharm GKB GenePA38188
PharosQ13769
Clinical trialTHOC5
Miscellaneous
canSAR (ICR)THOC5
HarmonizomeTHOC5
DataMed IndexTHOC5
Probes
Litterature
PubMed65 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTHOC5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:02 CEST 2021

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