Atlas of Genetics and Cytogenetics in Oncology and Haematology


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THOC5 (THO complex 5)

Identity

Alias_namesC22orf19
chromosome 22 open reading frame 19
Alias_symbol (synonym)PK1.3
KIAA0983
Fmip
fSAP79
Other alias
HGNC (Hugo) THOC5
LocusID (NCBI) 8563
Atlas_Id 884
Location 22q12.2  [Link to chromosome band 22q12]
Location_base_pair Starts at 29508167 and ends at 29553747 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
THOC5 (22q12.2) / NIPSNAP1 (22q12.2)THOC5 (22q12.2) / PATZ1 (22q12.2)THOC5 22q12.2 / NIPSNAP1 22q12.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)THOC5   19074
Cards
Entrez_Gene (NCBI)THOC5  8563  THO complex 5
AliasesC22orf19; Fmip; PK1.3; fSAP79
GeneCards (Weizmann)THOC5
Ensembl hg19 (Hinxton)ENSG00000100296 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100296 [Gene_View]  chr22:29508167-29553747 [Contig_View]  THOC5 [Vega]
ICGC DataPortalENSG00000100296
TCGA cBioPortalTHOC5
AceView (NCBI)THOC5
Genatlas (Paris)THOC5
WikiGenes8563
SOURCE (Princeton)THOC5
Genetics Home Reference (NIH)THOC5
Genomic and cartography
GoldenPath hg38 (UCSC)THOC5  -     chr22:29508167-29553747 -  22q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)THOC5  -     22q12.2   [Description]    (hg19-Feb_2009)
EnsemblTHOC5 - 22q12.2 [CytoView hg19]  THOC5 - 22q12.2 [CytoView hg38]
Mapping of homologs : NCBITHOC5 [Mapview hg19]  THOC5 [Mapview hg38]
OMIM612733   
Gene and transcription
Genbank (Entrez)AB023200 AJ006069 AK025385 AK098709 AK122673
RefSeq transcript (Entrez)NM_001002877 NM_001002878 NM_001002879 NM_003678
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)THOC5
Cluster EST : UnigeneHs.75361 [ NCBI ]
CGAP (NCI)Hs.75361
Alternative Splicing GalleryENSG00000100296
Gene ExpressionTHOC5 [ NCBI-GEO ]   THOC5 [ EBI - ARRAY_EXPRESS ]   THOC5 [ SEEK ]   THOC5 [ MEM ]
Gene Expression Viewer (FireBrowse)THOC5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8563
GTEX Portal (Tissue expression)THOC5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13769   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13769  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13769
Splice isoforms : SwissVarQ13769
PhosPhoSitePlusQ13769
Domains : Interpro (EBI)THO_Thoc5   
Domain families : Pfam (Sanger)FimP (PF09766)   
Domain families : Pfam (NCBI)pfam09766   
Conserved Domain (NCBI)THOC5
DMDM Disease mutations8563
Blocks (Seattle)THOC5
SuperfamilyQ13769
Human Protein AtlasENSG00000100296
Peptide AtlasQ13769
HPRD16650
IPIIPI00299417   IPI00893079   IPI00892995   IPI00892999   IPI00892608   IPI00894470   IPI00894067   IPI00894183   IPI01009664   
Protein Interaction databases
DIP (DOE-UCLA)Q13769
IntAct (EBI)Q13769
FunCoupENSG00000100296
BioGRIDTHOC5
STRING (EMBL)THOC5
ZODIACTHOC5
Ontologies - Pathways
QuickGOQ13769
Ontology : AmiGOtranscription export complex  THO complex  THO complex part of transcription export complex  nuclear chromosome, telomeric region  mRNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  termination of RNA polymerase II transcription  RNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  RNA splicing  monocyte differentiation  mRNA 3'-end processing  positive regulation of DNA-templated transcription, elongation  viral mRNA export from host cell nucleus  primitive hemopoiesis  negative regulation of DNA damage checkpoint  
Ontology : EGO-EBItranscription export complex  THO complex  THO complex part of transcription export complex  nuclear chromosome, telomeric region  mRNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  termination of RNA polymerase II transcription  RNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  RNA splicing  monocyte differentiation  mRNA 3'-end processing  positive regulation of DNA-templated transcription, elongation  viral mRNA export from host cell nucleus  primitive hemopoiesis  negative regulation of DNA damage checkpoint  
Pathways : KEGGRNA transport   
NDEx NetworkTHOC5
Atlas of Cancer Signalling NetworkTHOC5
Wikipedia pathwaysTHOC5
Orthology - Evolution
OrthoDB8563
GeneTree (enSembl)ENSG00000100296
Phylogenetic Trees/Animal Genes : TreeFamTHOC5
HOVERGENQ13769
HOGENOMQ13769
Homologs : HomoloGeneTHOC5
Homology/Alignments : Family Browser (UCSC)THOC5
Gene fusions - Rearrangements
Fusion : MitelmanTHOC5/NIPSNAP1 [22q12.2/22q12.2]  
Fusion: TCGATHOC5 22q12.2 NIPSNAP1 22q12.2 OV
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTHOC5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)THOC5
dbVarTHOC5
ClinVarTHOC5
1000_GenomesTHOC5 
Exome Variant ServerTHOC5
ExAC (Exome Aggregation Consortium)THOC5 (select the gene name)
Genetic variants : HAPMAP8563
Genomic Variants (DGV)THOC5 [DGVbeta]
DECIPHERTHOC5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTHOC5 
Mutations
ICGC Data PortalTHOC5 
TCGA Data PortalTHOC5 
Broad Tumor PortalTHOC5
OASIS PortalTHOC5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTHOC5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTHOC5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch THOC5
DgiDB (Drug Gene Interaction Database)THOC5
DoCM (Curated mutations)THOC5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)THOC5 (select a term)
intoGenTHOC5
Cancer3DTHOC5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612733   
Orphanet
MedgenTHOC5
Genetic Testing Registry THOC5
NextProtQ13769 [Medical]
TSGene8563
GENETestsTHOC5
Target ValidationTHOC5
Huge Navigator THOC5 [HugePedia]
snp3D : Map Gene to Disease8563
BioCentury BCIQTHOC5
ClinGenTHOC5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8563
Chemical/Pharm GKB GenePA38188
Clinical trialTHOC5
Miscellaneous
canSAR (ICR)THOC5 (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTHOC5
EVEXTHOC5
GoPubMedTHOC5
iHOPTHOC5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:34:58 CEST 2017

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