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THOP1 (thimet oligopeptidase 1)

Identity

Alias (NCBI)EP24.15
MEPD_HUMAN
MP78
TOP
HGNC (Hugo) THOP1
LocusID (NCBI) 7064
Atlas_Id 55021
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 2785503 and ends at 2815807 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
THOP1 (19p13.3) / THOP1 (19p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)THOP1   11793
Cards
Entrez_Gene (NCBI)THOP1    thimet oligopeptidase 1
AliasesEP24.15; MEPD_HUMAN; MP78; TOP
GeneCards (Weizmann)THOP1
Ensembl hg19 (Hinxton)ENSG00000172009 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172009 [Gene_View]  ENSG00000172009 [Sequence]  chr19:2785503-2815807 [Contig_View]  THOP1 [Vega]
ICGC DataPortalENSG00000172009
TCGA cBioPortalTHOP1
AceView (NCBI)THOP1
Genatlas (Paris)THOP1
SOURCE (Princeton)THOP1
Genetics Home Reference (NIH)THOP1
Genomic and cartography
GoldenPath hg38 (UCSC)THOP1  -     chr19:2785503-2815807 +  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)THOP1  -     19p13.3   [Description]    (hg19-Feb_2009)
GoldenPathTHOP1 - 19p13.3 [CytoView hg19]  THOP1 - 19p13.3 [CytoView hg38]
ImmunoBaseENSG00000172009
Genome Data Viewer NCBITHOP1 [Mapview hg19]  
OMIM601117   
Gene and transcription
Genbank (Entrez)AK093392 AK300552 BC000135 BC000583 BC002391
RefSeq transcript (Entrez)NM_003249
Consensus coding sequences : CCDS (NCBI)THOP1
Gene ExpressionTHOP1 [ NCBI-GEO ]   THOP1 [ EBI - ARRAY_EXPRESS ]   THOP1 [ SEEK ]   THOP1 [ MEM ]
Gene Expression Viewer (FireBrowse)THOP1 [ Firebrowse - Broad ]
GenevisibleExpression of THOP1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7064
GTEX Portal (Tissue expression)THOP1
Human Protein AtlasENSG00000172009-THOP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52888   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52888  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52888
Catalytic activity : Enzyme3.4.24.15 [ Enzyme-Expasy ]   3.4.24.153.4.24.15 [ IntEnz-EBI ]   3.4.24.15 [ BRENDA ]   3.4.24.15 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP52888
Domaine pattern : Prosite (Expaxy)ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)MetalloPept_cat_dom_sf    Neurolysin/TOP_dom2    Neurolysin/TOP_N    Pept_M3A_M3B   
Domain families : Pfam (Sanger)Peptidase_M3 (PF01432)   
Domain families : Pfam (NCBI)pfam01432   
Conserved Domain (NCBI)THOP1
PDB (RSDB)1S4B    2O36   
PDB Europe1S4B    2O36   
PDB (PDBSum)1S4B    2O36   
PDB (IMB)1S4B    2O36   
Structural Biology KnowledgeBase1S4B    2O36   
SCOP (Structural Classification of Proteins)1S4B    2O36   
CATH (Classification of proteins structures)1S4B    2O36   
SuperfamilyP52888
AlphaFold pdb e-kbP52888   
Human Protein Atlas [tissue]ENSG00000172009-THOP1 [tissue]
HPRD03072
Protein Interaction databases
DIP (DOE-UCLA)P52888
IntAct (EBI)P52888
BioGRIDTHOP1
STRING (EMBL)THOP1
ZODIACTHOP1
Ontologies - Pathways
QuickGOP52888
Ontology : AmiGOprotein polyubiquitination  metalloendopeptidase activity  protein binding  mitochondrial intermembrane space  cytosol  proteolysis  peptide metabolic process  peptide binding  metal ion binding  
Ontology : EGO-EBIprotein polyubiquitination  metalloendopeptidase activity  protein binding  mitochondrial intermembrane space  cytosol  proteolysis  peptide metabolic process  peptide binding  metal ion binding  
Pathways : KEGGRenin-angiotensin system    African trypanosomiasis   
NDEx NetworkTHOP1
Atlas of Cancer Signalling NetworkTHOP1
Wikipedia pathwaysTHOP1
Orthology - Evolution
OrthoDB7064
GeneTree (enSembl)ENSG00000172009
Phylogenetic Trees/Animal Genes : TreeFamTHOP1
Homologs : HomoloGeneTHOP1
Homology/Alignments : Family Browser (UCSC)THOP1
Gene fusions - Rearrangements
Fusion : QuiverTHOP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTHOP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)THOP1
dbVarTHOP1
ClinVarTHOP1
MonarchTHOP1
1000_GenomesTHOP1 
Exome Variant ServerTHOP1
GNOMAD BrowserENSG00000172009
Varsome BrowserTHOP1
ACMGTHOP1 variants
VarityP52888
Genomic Variants (DGV)THOP1 [DGVbeta]
DECIPHERTHOP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTHOP1 
Mutations
ICGC Data PortalTHOP1 
TCGA Data PortalTHOP1 
Broad Tumor PortalTHOP1
OASIS PortalTHOP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTHOP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTHOP1
Mutations and Diseases : HGMDTHOP1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTHOP1
DgiDB (Drug Gene Interaction Database)THOP1
DoCM (Curated mutations)THOP1
CIViC (Clinical Interpretations of Variants in Cancer)THOP1
Cancer3DTHOP1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601117   
Orphanet
DisGeNETTHOP1
MedgenTHOP1
Genetic Testing Registry THOP1
NextProtP52888 [Medical]
GENETestsTHOP1
Target ValidationTHOP1
Huge Navigator THOP1 [HugePedia]
ClinGenTHOP1
Clinical trials, drugs, therapy
MyCancerGenomeTHOP1
Protein Interactions : CTDTHOP1
Pharm GKB GenePA36505
PharosP52888
Clinical trialTHOP1
Miscellaneous
canSAR (ICR)THOP1
HarmonizomeTHOP1
DataMed IndexTHOP1
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTHOP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:02 CEST 2021

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