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THOP1 (thimet oligopeptidase 1)

Identity

Other aliasEP24.15
MEPD_HUMAN
MP78
TOP
HGNC (Hugo) THOP1
LocusID (NCBI) 7064
Atlas_Id 55021
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 2785460 and ends at 2813604 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
THOP1 (19p13.3) / THOP1 (19p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)THOP1   11793
Cards
Entrez_Gene (NCBI)THOP1  7064  thimet oligopeptidase 1
AliasesEP24.15; MEPD_HUMAN; MP78; TOP
GeneCards (Weizmann)THOP1
Ensembl hg19 (Hinxton)ENSG00000172009 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172009 [Gene_View]  chr19:2785460-2813604 [Contig_View]  THOP1 [Vega]
ICGC DataPortalENSG00000172009
TCGA cBioPortalTHOP1
AceView (NCBI)THOP1
Genatlas (Paris)THOP1
WikiGenes7064
SOURCE (Princeton)THOP1
Genetics Home Reference (NIH)THOP1
Genomic and cartography
GoldenPath hg38 (UCSC)THOP1  -     chr19:2785460-2813604 +  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)THOP1  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblTHOP1 - 19p13.3 [CytoView hg19]  THOP1 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBITHOP1 [Mapview hg19]  THOP1 [Mapview hg38]
OMIM601117   
Gene and transcription
Genbank (Entrez)AK093392 AK300552 BC000135 BC000583 BC002391
RefSeq transcript (Entrez)NM_003249
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)THOP1
Cluster EST : UnigeneHs.78769 [ NCBI ]
CGAP (NCI)Hs.78769
Alternative Splicing GalleryENSG00000172009
Gene ExpressionTHOP1 [ NCBI-GEO ]   THOP1 [ EBI - ARRAY_EXPRESS ]   THOP1 [ SEEK ]   THOP1 [ MEM ]
Gene Expression Viewer (FireBrowse)THOP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7064
GTEX Portal (Tissue expression)THOP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52888   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52888  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52888
Splice isoforms : SwissVarP52888
Catalytic activity : Enzyme3.4.24.15 [ Enzyme-Expasy ]   3.4.24.153.4.24.15 [ IntEnz-EBI ]   3.4.24.15 [ BRENDA ]   3.4.24.15 [ KEGG ]   
PhosPhoSitePlusP52888
Domaine pattern : Prosite (Expaxy)ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)MetalloPept_cat_dom    Neurolysin/TOP_dom2    Neurolysin/TOP_N    Pept_M3A_M3B   
Domain families : Pfam (Sanger)Peptidase_M3 (PF01432)   
Domain families : Pfam (NCBI)pfam01432   
Conserved Domain (NCBI)THOP1
DMDM Disease mutations7064
Blocks (Seattle)THOP1
PDB (SRS)1S4B    2O36   
PDB (PDBSum)1S4B    2O36   
PDB (IMB)1S4B    2O36   
PDB (RSDB)1S4B    2O36   
Structural Biology KnowledgeBase1S4B    2O36   
SCOP (Structural Classification of Proteins)1S4B    2O36   
CATH (Classification of proteins structures)1S4B    2O36   
SuperfamilyP52888
Human Protein AtlasENSG00000172009
Peptide AtlasP52888
HPRD03072
IPIIPI00549189   IPI00903276   
Protein Interaction databases
DIP (DOE-UCLA)P52888
IntAct (EBI)P52888
FunCoupENSG00000172009
BioGRIDTHOP1
STRING (EMBL)THOP1
ZODIACTHOP1
Ontologies - Pathways
QuickGOP52888
Ontology : AmiGOmetalloendopeptidase activity  protein binding  mitochondrial intermembrane space  proteolysis  peptide metabolic process  peptide binding  metal ion binding  
Ontology : EGO-EBImetalloendopeptidase activity  protein binding  mitochondrial intermembrane space  proteolysis  peptide metabolic process  peptide binding  metal ion binding  
Pathways : KEGGRenin-angiotensin system    African trypanosomiasis   
NDEx NetworkTHOP1
Atlas of Cancer Signalling NetworkTHOP1
Wikipedia pathwaysTHOP1
Orthology - Evolution
OrthoDB7064
GeneTree (enSembl)ENSG00000172009
Phylogenetic Trees/Animal Genes : TreeFamTHOP1
HOVERGENP52888
HOGENOMP52888
Homologs : HomoloGeneTHOP1
Homology/Alignments : Family Browser (UCSC)THOP1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTHOP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)THOP1
dbVarTHOP1
ClinVarTHOP1
1000_GenomesTHOP1 
Exome Variant ServerTHOP1
ExAC (Exome Aggregation Consortium)THOP1 (select the gene name)
Genetic variants : HAPMAP7064
Genomic Variants (DGV)THOP1 [DGVbeta]
DECIPHERTHOP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTHOP1 
Mutations
ICGC Data PortalTHOP1 
TCGA Data PortalTHOP1 
Broad Tumor PortalTHOP1
OASIS PortalTHOP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTHOP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTHOP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch THOP1
DgiDB (Drug Gene Interaction Database)THOP1
DoCM (Curated mutations)THOP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)THOP1 (select a term)
intoGenTHOP1
Cancer3DTHOP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601117   
Orphanet
MedgenTHOP1
Genetic Testing Registry THOP1
NextProtP52888 [Medical]
TSGene7064
GENETestsTHOP1
Target ValidationTHOP1
Huge Navigator THOP1 [HugePedia]
snp3D : Map Gene to Disease7064
BioCentury BCIQTHOP1
ClinGenTHOP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7064
Chemical/Pharm GKB GenePA36505
Clinical trialTHOP1
Miscellaneous
canSAR (ICR)THOP1 (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTHOP1
EVEXTHOP1
GoPubMedTHOP1
iHOPTHOP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:34:58 CEST 2017

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