Atlas of Genetics and Cytogenetics in Oncology and Haematology


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THPO (thrombopoietin)

Identity

Other namesMGDF
MKCSF
ML
MPLLG
THCYT1
TPO
HGNC (Hugo) THPO
LocusID (NCBI) 7066
Location 3q27.1
Location_base_pair Starts at 184089723 and ends at 184095996 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)THPO   11795
Cards
Entrez_Gene (NCBI)THPO  7066  thrombopoietin
GeneCards (Weizmann)THPO
Ensembl (Hinxton)ENSG00000090534 [Gene_View]  chr3:184089723-184095996 [Contig_View]  THPO [Vega]
ICGC DataPortalENSG00000090534
cBioPortalTHPO
AceView (NCBI)THPO
Genatlas (Paris)THPO
WikiGenes7066
SOURCE (Princeton)NM_000460 NM_001177597 NM_001177598 NM_001289997 NM_001289998 NM_001290003 NM_001290022 NM_001290026 NM_001290027 NM_001290028 NM_199228 NM_199356
Genomic and cartography
GoldenPath (UCSC)THPO  -  3q27.1   chr3:184089723-184095996 -  3q27.1   [Description]    (hg19-Feb_2009)
EnsemblTHPO - 3q27.1 [CytoView]
Mapping of homologs : NCBITHPO [Mapview]
OMIM187950   600044   
Gene and transcription
Genbank (Entrez)AA479058 AA480029 AB014681 AB014682 AB014683
RefSeq transcript (Entrez)NM_000460 NM_001177597 NM_001177598 NM_001289997 NM_001289998 NM_001290003 NM_001290022 NM_001290026 NM_001290027 NM_001290028 NM_199228 NM_199356
RefSeq genomic (Entrez)AC_000135 NC_000003 NC_018914 NG_012136 NT_005612 NW_001838884 NW_004929311
Consensus coding sequences : CCDS (NCBI)THPO
Cluster EST : UnigeneHs.734657 [ NCBI ]
CGAP (NCI)Hs.734657
Alternative Splicing : Fast-db (Paris)GSHG0022282
Alternative Splicing GalleryENSG00000090534
Gene ExpressionTHPO [ NCBI-GEO ]     THPO [ SEEK ]   THPO [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40225 (Uniprot)
NextProtP40225  [Medical]
With graphics : InterProP40225
Splice isoforms : SwissVarP40225 (Swissvar)
Domaine pattern : Prosite (Expaxy)EPO_TPO (PS00817)   
Domains : Interpro (EBI)4_helix_cytokine-like_core [organisation]   4_helix_cytokine_core [organisation]   EPO/TPO_CS [organisation]   EPO_TPO [organisation]   Thrombopoeitin [organisation]  
Related proteins : CluSTrP40225
Domain families : Pfam (Sanger)EPO_TPO (PF00758)   
Domain families : Pfam (NCBI)pfam00758   
DMDM Disease mutations7066
Blocks (Seattle)P40225
PDB (SRS)1V7M    1V7N   
PDB (PDBSum)1V7M    1V7N   
PDB (IMB)1V7M    1V7N   
PDB (RSDB)1V7M    1V7N   
Human Protein AtlasENSG00000090534 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP40225
HPRD02500
IPIIPI00218254   IPI00219943   IPI00411545   IPI00554602   
Protein Interaction databases
DIP (DOE-UCLA)P40225
IntAct (EBI)P40225
FunCoupENSG00000090534
BioGRIDTHPO
InParanoidP40225
Interologous Interaction database P40225
IntegromeDBTHPO
STRING (EMBL)THPO
Ontologies - Pathways
Ontology : AmiGOpositive regulation of protein phosphorylation  cytokine activity  hormone activity  extracellular space  multicellular organismal development  blood coagulation  growth factor activity  cell proliferation  myeloid cell differentiation  platelet activation  thrombopoietin-mediated signaling pathway  positive regulation of megakaryocyte differentiation  positive regulation of protein kinase B signaling  positive regulation of ERK1 and ERK2 cascade  
Ontology : EGO-EBIpositive regulation of protein phosphorylation  cytokine activity  hormone activity  extracellular space  multicellular organismal development  blood coagulation  growth factor activity  cell proliferation  myeloid cell differentiation  platelet activation  thrombopoietin-mediated signaling pathway  positive regulation of megakaryocyte differentiation  positive regulation of protein kinase B signaling  positive regulation of ERK1 and ERK2 cascade  
Pathways : BIOCARTATPO Signaling Pathway [Genes]   
Pathways : KEGGHematopoietic cell lineage   
Protein Interaction DatabaseTHPO
Wikipedia pathwaysTHPO
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)THPO
snp3D : Map Gene to Disease7066
SNP (GeneSNP Utah)THPO
SNP : HGBaseTHPO
Genetic variants : HAPMAPTHPO
Exome VariantTHPO
1000_GenomesTHPO 
ICGC programENSG00000090534 
Somatic Mutations in Cancer : COSMICTHPO 
CONAN: Copy Number AnalysisTHPO 
Mutations and Diseases : HGMDTHPO
Mutations and Diseases : intOGenTHPO
Genomic VariantsTHPO  THPO [DGVbeta]
dbVarTHPO
ClinVarTHPO
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM187950    600044   
MedgenTHPO
GENETestsTHPO
Disease Genetic AssociationTHPO
Huge Navigator THPO [HugePedia]  THPO [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneTHPO
Homology/Alignments : Family Browser (UCSC)THPO
Phylogenetic Trees/Animal Genes : TreeFamTHPO
Chemical/Protein Interactions : CTD7066
Chemical/Pharm GKB GenePA36506
Clinical trialTHPO
Cancer Resource (Charite)ENSG00000090534
Other databases
Probes
Litterature
PubMed106 Pubmed reference(s) in Entrez
CoreMineTHPO
iHOPTHPO
OncoSearchTHPO
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 17:07:36 CEST 2014

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