THPO (thrombopoietin)

2003-02-01  

Identity

HGNC
LOCATION
3q27.1
LOCUSID
ALIAS
MGDF,MKCSF,ML,MPLLG,THCYT1,TPO
FUSION GENES

Other Information

Locus ID:

NCBI: 7066
MIM: 600044
HGNC: 11795
Ensembl: ENSG00000090534

Variants:

dbSNP: 7066
ClinVar: 7066
TCGA: ENSG00000090534
COSMIC: THPO

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090534ENST00000421442F8W6L1
ENSG00000090534ENST00000445696P40225
ENSG00000090534ENST00000477594A0A2R8Y734
ENSG00000090534ENST00000645603A0A3B3ITS0
ENSG00000090534ENST00000647395P40225
ENSG00000090534ENST00000649095A0A3B3ITS0
ENSG00000090534ENST00000650229Q5FBX8

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Hematopoietic cell lineageKEGGko04640
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Hematopoietic cell lineageKEGGhsa04640
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Platelet Aggregation (Plug Formation)REACTOMER-HSA-76009

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
212628272011Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo.62
254859122015The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling.57
206738682010A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).36
146709162004Thrombopoietin cooperates with FLT3-ligand in the generation of plasmacytoid dendritic cell precursors from human hematopoietic progenitors.33
261406052015TPO-Induced Metabolic Reprogramming Drives Liver Metastasis of Colorectal Cancer CD110+ Tumor-Initiating Cells.30
117564172002Thrombopoietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways.28
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
204524822010Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.26
157057852005Thrombopoietin enhances expression of vascular endothelial growth factor (VEGF) in primitive hematopoietic cells through induction of HIF-1alpha.25

Citation

Dessen P

THPO (thrombopoietin)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42552/thpo