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THPO (thrombopoietin)

Identity

Other namesMGDF
MKCSF
ML
MPLLG
THCYT1
TPO
HGNC (Hugo) THPO
LocusID (NCBI) 7066
Atlas_Id 42552
Location 3q27.1
Location_base_pair Starts at 184089723 and ends at 184095996 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
THPO (3q27.1) / THPO (3q27.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)THPO   11795
Cards
Entrez_Gene (NCBI)THPO  7066  thrombopoietin
AliasesMGDF; MKCSF; ML; MPLLG; 
THCYT1; TPO
GeneCards (Weizmann)THPO
Ensembl hg19 (Hinxton)ENSG00000090534 [Gene_View]  chr3:184089723-184095996 [Contig_View]  THPO [Vega]
Ensembl hg38 (Hinxton)ENSG00000090534 [Gene_View]  chr3:184089723-184095996 [Contig_View]  THPO [Vega]
ICGC DataPortalENSG00000090534
TCGA cBioPortalTHPO
AceView (NCBI)THPO
Genatlas (Paris)THPO
WikiGenes7066
SOURCE (Princeton)THPO
Genomic and cartography
GoldenPath hg19 (UCSC)THPO  -     chr3:184089723-184095996 -  3q27.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)THPO  -     3q27.1   [Description]    (hg38-Dec_2013)
EnsemblTHPO - 3q27.1 [CytoView hg19]  THPO - 3q27.1 [CytoView hg38]
Mapping of homologs : NCBITHPO [Mapview hg19]  THPO [Mapview hg38]
OMIM187950   600044   
Gene and transcription
Genbank (Entrez)AA479058 AA480029 AB014681 AB014682 AB014683
RefSeq transcript (Entrez)NM_000460 NM_001177597 NM_001177598 NM_001289997 NM_001289998 NM_001290003 NM_001290022 NM_001290026 NM_001290027 NM_001290028 NM_199228 NM_199356
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_012136 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)THPO
Cluster EST : UnigeneHs.734657 [ NCBI ]
CGAP (NCI)Hs.734657
Alternative Splicing GalleryENSG00000090534
Gene ExpressionTHPO [ NCBI-GEO ]   THPO [ EBI - ARRAY_EXPRESS ]   THPO [ SEEK ]   THPO [ MEM ]
Gene Expression Viewer (FireBrowse)THPO [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7066
GTEX Portal (Tissue expression)THPO
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40225 (Uniprot)
NextProtP40225  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP40225
Splice isoforms : SwissVarP40225 (Swissvar)
PhosPhoSitePlusP40225
Domaine pattern : Prosite (Expaxy)EPO_TPO (PS00817)   
Domains : Interpro (EBI)4_helix_cytokine-like_core    4_helix_cytokine_core    EPO/TPO_CS    EPO_TPO    Thrombopoeitin   
Domain families : Pfam (Sanger)EPO_TPO (PF00758)   
Domain families : Pfam (NCBI)pfam00758   
DMDM Disease mutations7066
Blocks (Seattle)THPO
PDB (SRS)1V7M    1V7N   
PDB (PDBSum)1V7M    1V7N   
PDB (IMB)1V7M    1V7N   
PDB (RSDB)1V7M    1V7N   
Structural Biology KnowledgeBase1V7M    1V7N   
SCOP (Structural Classification of Proteins)1V7M    1V7N   
CATH (Classification of proteins structures)1V7M    1V7N   
SuperfamilyP40225
Human Protein AtlasENSG00000090534
Peptide AtlasP40225
HPRD02500
IPIIPI00218254   IPI00219943   IPI00411545   IPI00554602   
Protein Interaction databases
DIP (DOE-UCLA)P40225
IntAct (EBI)P40225
FunCoupENSG00000090534
BioGRIDTHPO
STRING (EMBL)THPO
ZODIACTHPO
Ontologies - Pathways
QuickGOP40225
Ontology : AmiGOpositive regulation of protein phosphorylation  cytokine activity  hormone activity  extracellular space  multicellular organism development  growth factor activity  cell proliferation  myeloid cell differentiation  thrombopoietin-mediated signaling pathway  positive regulation of megakaryocyte differentiation  positive regulation of protein kinase B signaling  positive regulation of ERK1 and ERK2 cascade  positive regulation of hematopoietic stem cell proliferation  
Ontology : EGO-EBIpositive regulation of protein phosphorylation  cytokine activity  hormone activity  extracellular space  multicellular organism development  growth factor activity  cell proliferation  myeloid cell differentiation  thrombopoietin-mediated signaling pathway  positive regulation of megakaryocyte differentiation  positive regulation of protein kinase B signaling  positive regulation of ERK1 and ERK2 cascade  positive regulation of hematopoietic stem cell proliferation  
Pathways : BIOCARTATPO Signaling Pathway [Genes]   
Pathways : KEGGHematopoietic cell lineage   
NDEx Network
Atlas of Cancer Signalling NetworkTHPO
Wikipedia pathwaysTHPO
Orthology - Evolution
OrthoDB7066
GeneTree (enSembl)ENSG00000090534
Phylogenetic Trees/Animal Genes : TreeFamTHPO
Homologs : HomoloGeneTHPO
Homology/Alignments : Family Browser (UCSC)THPO
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerTHPO [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)THPO
dbVarTHPO
ClinVarTHPO
1000_GenomesTHPO 
Exome Variant ServerTHPO
ExAC (Exome Aggregation Consortium)THPO (select the gene name)
Genetic variants : HAPMAP7066
Genomic Variants (DGV)THPO [DGVbeta]
Mutations
ICGC Data PortalTHPO 
TCGA Data PortalTHPO 
Broad Tumor PortalTHPO
OASIS PortalTHPO [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTHPO 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch THPO
DgiDB (Drug Gene Interaction Database)THPO
DoCM (Curated mutations)THPO (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)THPO (select a term)
intoGenTHPO
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)3:184089723-184095996  ENSG00000090534
CONAN: Copy Number AnalysisTHPO 
Mutations and Diseases : HGMDTHPO
OMIM187950    600044   
MedgenTHPO
Genetic Testing Registry THPO
NextProtP40225 [Medical]
TSGene7066
GENETestsTHPO
Huge Navigator THPO [HugePedia]
snp3D : Map Gene to Disease7066
BioCentury BCIQTHPO
ClinGenTHPO
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7066
Chemical/Pharm GKB GenePA36506
Clinical trialTHPO
Miscellaneous
canSAR (ICR)THPO (select the gene name)
Probes
Litterature
PubMed114 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTHPO
EVEXTHPO
GoPubMedTHPO
iHOPTHPO
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 11:24:22 CEST 2016

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