Atlas of Genetics and Cytogenetics in Oncology and Haematology


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THPO (thrombopoietin)

Identity

Other namesMGDF
MKCSF
ML
MPLLG
THCYT1
TPO
HGNC (Hugo) THPO
LocusID (NCBI) 7066
Location 3q27.1
Location_base_pair Starts at 184089773 and ends at 184095932 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)THPO   11795
Cards
Entrez_Gene (NCBI)THPO  7066  thrombopoietin
GeneCards (Weizmann)THPO
Ensembl (Hinxton)ENSG00000090534 [Gene_View]  chr3:184089773-184095932 [Contig_View]  THPO [Vega]
AceView (NCBI)THPO
Genatlas (Paris)THPO
WikiGenes7066
SOURCE (Princeton)NM_000460 NM_001177597 NM_001177598 NM_199228 NM_199356
Genomic and cartography
GoldenPath (UCSC)THPO  -  3q27.1   chr3:184089773-184095932 -  3q27.1   [Description]    (hg19-Feb_2009)
EnsemblTHPO - 3q27.1 [CytoView]
Mapping of homologs : NCBITHPO [Mapview]
OMIM187950   600044   
Gene and transcription
Genbank (Entrez)AB014681 AB014682 AB014683 AB102890 AB102892
RefSeq transcript (Entrez)NM_000460 NM_001177597 NM_001177598 NM_199228 NM_199356
RefSeq genomic (Entrez)AC_000135 NC_000003 NC_018914 NG_012136 NT_005612 NW_001838884 NW_004929311
Consensus coding sequences : CCDS (NCBI)THPO
Cluster EST : UnigeneHs.734657 [ NCBI ]
CGAP (NCI)Hs.734657
Alternative Splicing : Fast-db (Paris)GSHG0022282
Alternative Splicing GalleryENSG00000090534
Gene ExpressionTHPO [ NCBI-GEO ]     THPO [ SEEK ]   THPO [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40225 (Uniprot)
NextProtP40225  [Medical]
With graphics : InterProP40225
Splice isoforms : SwissVarP40225 (Swissvar)
Domaine pattern : Prosite (Expaxy)EPO_TPO (PS00817)   
Domains : Interpro (EBI)4_helix_cytokine-like_core    4_helix_cytokine_core    EPO/TPO_CS    EPO_TPO    Thrombopoeitin   
Related proteins : CluSTrP40225
Domain families : Pfam (Sanger)EPO_TPO (PF00758)   
Domain families : Pfam (NCBI)pfam00758   
DMDM Disease mutations7066
Blocks (Seattle)P40225
PDB (SRS)1V7M    1V7N   
PDB (PDBSum)1V7M    1V7N   
PDB (IMB)1V7M    1V7N   
PDB (RSDB)1V7M    1V7N   
Human Protein AtlasENSG00000090534
Peptide AtlasP40225
HPRD02500
IPIIPI00218254   IPI00219943   IPI00411545   IPI00554602   
Protein Interaction databases
DIP (DOE-UCLA)P40225
IntAct (EBI)P40225
FunCoupENSG00000090534
BioGRIDTHPO
InParanoidP40225
Interologous Interaction database P40225
IntegromeDBTHPO
STRING (EMBL)THPO
Ontologies - Pathways
Ontology : AmiGOcytokine activity  hormone activity  extracellular space  multicellular organismal development  blood coagulation  growth factor activity  cell proliferation  myeloid cell differentiation  platelet activation  
Ontology : EGO-EBIcytokine activity  hormone activity  extracellular space  multicellular organismal development  blood coagulation  growth factor activity  cell proliferation  myeloid cell differentiation  platelet activation  
Pathways : BIOCARTATPO Signaling Pathway [Genes]   
Pathways : KEGGHematopoietic cell lineage   
REACTOMETHPO
Protein Interaction DatabaseTHPO
Wikipedia pathwaysTHPO
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)THPO
SNP (GeneSNP Utah)THPO
SNP : HGBaseTHPO
Genetic variants : HAPMAPTHPO
1000_GenomesTHPO 
ICGC programENSG00000090534 
Somatic Mutations in Cancer : COSMICTHPO 
CONAN: Copy Number AnalysisTHPO 
Mutations and Diseases : HGMDTHPO
OMIM187950    600044   
GENETestsTHPO
Disease Genetic AssociationTHPO
Huge Navigator THPO [HugePedia]  THPO [HugeCancerGEM]
Genomic VariantsTHPO  THPO [DGVbeta]
Exome VariantTHPO
dbVarTHPO
ClinVarTHPO
snp3D : Map Gene to Disease7066
General knowledge
Homologs : HomoloGeneTHPO
Homology/Alignments : Family Browser (UCSC)THPO
Phylogenetic Trees/Animal Genes : TreeFamTHPO
Chemical/Protein Interactions : CTD7066
Chemical/Pharm GKB GenePA36506
Clinical trialTHPO
Cancer Resource (Charite)ENSG00000090534
Other databases
Probes
Litterature
PubMed100 Pubmed reference(s) in Entrez
CoreMineTHPO
iHOPTHPO
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 17:01:33 CEST 2014

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