THRA (thyroid hormone receptor alpha)

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THRA (thyroid hormone receptor alpha)

Identity

Alias_names	THRA1
	THRA2
	ERBA1
	thyroid hormone receptor, alpha (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog)
	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
Alias_symbol (synonym)	EAR-7.1/EAR-7.2
	THRA3
	AR7
	ERBA
	NR1A1
Other alias	CHNG6
	EAR7
	ERB-T-1
	c-ERBA-1
HGNC (Hugo)	THRA
LocusID (NCBI)	7067
Atlas_Id	42553
Location	17q21.1 [Link to chromosome band 17q21]
Location_base_pair	Starts at 40062815 and ends at 40090037 bp from pter ( according to hg38-Dec_2013)

Fusion genes
(updated 2017)

Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

AEBP1 (7p13) / THRA (17q21.1)	FCHSD2 (11q13.4) / THRA (17q21.1)	FDPS (1q22) / THRA (17q21.1)
NME1 (17q21.33) / THRA (17q21.1)	THRA (17q21.1) / B4GALNT2 (17q21.32)	THRA (17q21.1) / FDPS (1q22)
THRA (17q21.1) / GSDMA (17q21.1)	THRA (17q21.1) / PSMD3 (17q21.1)	THRA (17q21.1) / TADA2A (17q12)
THRA (17q21.1) / THRA (17q21.1)	THRA (17q21.1) / USP5 (12p13.31)	THRA 17q21.1 / B4GALNT2 17q21.32
THRA 17q21.1 / GSDMA 17q21.1	THRA 17q21.1 / PSMD3 17q21.1	THRA 17q21.1 / TADA2A 17q12

Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]

t(7;17)(p13;q21) AEBP1/THRA
t(11;17)(q13;q21) FCHSD2/THRA
t(17;17)(q12;q21) THRA/TADA2A
THRA/B4GALNT2 (17q21)
THRA/GSDMA (17q21)
THRA/PSMD3 (17q21)

External links

	Nomenclature
HGNC (Hugo)	THRA 11796
	Cards
Entrez_Gene (NCBI)	THRA 7067 thyroid hormone receptor alpha
Aliases	AR7; CHNG6; EAR7; ERB-T-1;
	ERBA; ERBA1; NR1A1; THRA1; THRA2; c-ERBA-1
GeneCards (Weizmann)	THRA
Ensembl hg19 (Hinxton)	ENSG00000126351 [Gene_View]
Ensembl hg38 (Hinxton)	ENSG00000126351 [Gene_View] ENSG00000126351 [Sequence] chr17:40062815-40090037 [Contig_View] THRA [Vega]
ICGC DataPortal	ENSG00000126351
TCGA cBioPortal	THRA
AceView (NCBI)	THRA
Genatlas (Paris)	THRA
WikiGenes	7067
SOURCE (Princeton)	THRA
Genetics Home Reference (NIH)	THRA
	Genomic and cartography
GoldenPath hg38 (UCSC)	THRA - chr17:40062815-40090037 + 17q21.1 [Description] (hg38-Dec_2013)
GoldenPath hg19 (UCSC)	THRA - 17q21.1 [Description] (hg19-Feb_2009)
Ensembl	THRA - 17q21.1 [CytoView hg19] THRA - 17q21.1 [CytoView hg38]
Mapping of homologs : NCBI	THRA [Mapview hg19] THRA [Mapview hg38]
OMIM	190120 614450
	Gene and transcription
Genbank (Entrez)	AB209346 AB307686 AF522368 AK290071 AK290530
RefSeq transcript (Entrez)	NM_001190918 NM_001190919 NM_003250 NM_199334
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)	THRA
Cluster EST : Unigene	Hs.724 [ NCBI ]
CGAP (NCI)	Hs.724
Alternative Splicing Gallery	ENSG00000126351
Gene Expression	THRA [ NCBI-GEO ] THRA [ EBI - ARRAY_EXPRESS ] THRA [ SEEK ] THRA [ MEM ]
Gene Expression Viewer (FireBrowse)	THRA [ Firebrowse - Broad ]
SOURCE (Princeton)	Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60]
Genevestigator	Expression in : [tissues] [cell-lines] [cancer] [perturbations]
BioGPS (Tissue expression)	7067
GTEX Portal (Tissue expression)	THRA
Human Protein Atlas	ENSG00000126351-THRA [pathology] [cell] [tissue]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P10827 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction]
NextProt	P10827 [Sequence] [Exons] [Medical] [Publications]
With graphics : InterPro	P10827
Splice isoforms : SwissVar	P10827
PhosPhoSitePlus	P10827
Domaine pattern : Prosite (Expaxy)	NR_LBD (PS51843) NUCLEAR_REC_DBD_1 (PS00031) NUCLEAR_REC_DBD_2 (PS51030)
Domains : Interpro (EBI)	NHR_like_dom_sf Nucl_hrmn_rcpt_lig-bd Nuclear_hrmn_rcpt ThyrH_rcpt Znf_hrmn_rcpt Znf_NHR/GATA
Domain families : Pfam (Sanger)	Hormone_recep (PF00104) zf-C4 (PF00105)
Domain families : Pfam (NCBI)	pfam00104 pfam00105
Domain families : Smart (EMBL)	HOLI (SM00430) ZnF_C4 (SM00399)
Conserved Domain (NCBI)	THRA
DMDM Disease mutations	7067
Blocks (Seattle)	THRA
PDB (SRS)	1NAV 2H77 2H79 3HZF 3ILZ 3JZB 4LNW 4LNX
PDB (PDBSum)	1NAV 2H77 2H79 3HZF 3ILZ 3JZB 4LNW 4LNX
PDB (IMB)	1NAV 2H77 2H79 3HZF 3ILZ 3JZB 4LNW 4LNX
PDB (RSDB)	1NAV 2H77 2H79 3HZF 3ILZ 3JZB 4LNW 4LNX
Structural Biology KnowledgeBase	1NAV 2H77 2H79 3HZF 3ILZ 3JZB 4LNW 4LNX
SCOP (Structural Classification of Proteins)	1NAV 2H77 2H79 3HZF 3ILZ 3JZB 4LNW 4LNX
CATH (Classification of proteins structures)	1NAV 2H77 2H79 3HZF 3ILZ 3JZB 4LNW 4LNX
Superfamily	P10827
Human Protein Atlas [tissue]	ENSG00000126351-THRA [tissue]
Peptide Atlas	P10827
HPRD	07185
IPI	IPI00022991 IPI00219099 IPI00219100 IPI00219101
	Protein Interaction databases
DIP (DOE-UCLA)	P10827
IntAct (EBI)	P10827
FunCoup	ENSG00000126351
BioGRID	THRA
STRING (EMBL)	THRA
ZODIAC	THRA
	Ontologies - Pathways
QuickGO	P10827
Ontology : AmiGO	negative regulation of transcription by RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II transcription factor binding cartilage condensation ossification steroid receptor RNA activator RNA binding thyroid hormone mediated signaling pathway regulation of thyroid hormone mediated signaling pathway DNA-binding transcription factor activity DNA-binding transcription factor activity steroid hormone receptor activity nuclear receptor activity thyroid hormone receptor activity thyroid hormone receptor activity protein binding nucleus nucleus nucleoplasm cytosol regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription initiation from RNA polymerase II promoter multicellular organism development brain development learning or memory regulation of heart contraction female courtship behavior transcription factor binding transcription factor binding zinc ion binding response to cold hormone-mediated signaling pathway hormone-mediated signaling pathway animal organ morphogenesis positive regulation of myotube differentiation TBP-class protein binding negative regulation of RNA polymerase II transcriptional preinitiation complex assembly protein domain specific binding cell differentiation erythrocyte differentiation nuclear receptor transcription coactivator activity intracellular receptor signaling pathway thyroid gland development thyroid gland development chromatin DNA binding regulation of myeloid cell apoptotic process response to lipid cytoplasmic sequestering of transcription factor steroid hormone mediated signaling pathway transcription regulatory region DNA binding protein-containing complex binding negative regulation of transcription, DNA-templated positive regulation of female receptivity positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of lipid catabolic process type I pneumocyte differentiation type I pneumocyte differentiation thyroid hormone binding thyroid hormone binding RNA polymerase II transcription factor complex transcription factor activity, direct ligand regulated sequence-specific DNA binding negative regulation of DNA-templated transcription, initiation
Ontology : EGO-EBI	negative regulation of transcription by RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II transcription factor binding cartilage condensation ossification steroid receptor RNA activator RNA binding thyroid hormone mediated signaling pathway regulation of thyroid hormone mediated signaling pathway DNA-binding transcription factor activity DNA-binding transcription factor activity steroid hormone receptor activity nuclear receptor activity thyroid hormone receptor activity thyroid hormone receptor activity protein binding nucleus nucleus nucleoplasm cytosol regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription initiation from RNA polymerase II promoter multicellular organism development brain development learning or memory regulation of heart contraction female courtship behavior transcription factor binding transcription factor binding zinc ion binding response to cold hormone-mediated signaling pathway hormone-mediated signaling pathway animal organ morphogenesis positive regulation of myotube differentiation TBP-class protein binding negative regulation of RNA polymerase II transcriptional preinitiation complex assembly protein domain specific binding cell differentiation erythrocyte differentiation nuclear receptor transcription coactivator activity intracellular receptor signaling pathway thyroid gland development thyroid gland development chromatin DNA binding regulation of myeloid cell apoptotic process response to lipid cytoplasmic sequestering of transcription factor steroid hormone mediated signaling pathway transcription regulatory region DNA binding protein-containing complex binding negative regulation of transcription, DNA-templated positive regulation of female receptivity positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of lipid catabolic process type I pneumocyte differentiation type I pneumocyte differentiation thyroid hormone binding thyroid hormone binding RNA polymerase II transcription factor complex transcription factor activity, direct ligand regulated sequence-specific DNA binding negative regulation of DNA-templated transcription, initiation
Pathways : KEGG	Neuroactive ligand-receptor interaction Thyroid hormone signaling pathway
NDEx Network	THRA
Atlas of Cancer Signalling Network	THRA
Wikipedia pathways	THRA
	Orthology - Evolution
OrthoDB	7067
GeneTree (enSembl)	ENSG00000126351
Phylogenetic Trees/Animal Genes : TreeFam	THRA
HOVERGEN	P10827
HOGENOM	P10827
Homologs : HomoloGene	THRA
Homology/Alignments : Family Browser (UCSC)	THRA
	Gene fusions - Rearrangements
Fusion : Mitelman	AEBP1/THRA [7p13/17q21.1] [t(7;17)(p13;q21)]
Fusion : Mitelman	FCHSD2/THRA [11q13.4/17q21.1] [t(11;17)(q13;q21)]
Fusion : Mitelman	THRA/- [17q21.1/t(17;17)(q21;q21)]
Fusion : Mitelman	THRA/B4GALNT2 [17q21.1/17q21.32] [t(17;17)(q21;q21)]
Fusion : Mitelman	THRA/GSDMA [17q21.1/17q21.1] [t(17;17)(q21;q21)]
Fusion : Mitelman	THRA/PSMD3 [17q21.1/17q21.1] [t(17;17)(q21;q21)]
Fusion : Mitelman	THRA/TADA2A [17q21.1/17q12] [t(17;17)(q12;q21)]
Fusion Portal	THRA 17q21.1 B4GALNT2 17q21.32 BRCA
Fusion Portal	THRA 17q21.1 GSDMA 17q21.1 GBM
Fusion Portal	THRA 17q21.1 PSMD3 17q21.1 LUAD
Fusion Portal	THRA 17q21.1 TADA2A 17q12 BRCA
Fusion : Quiver	THRA
	Polymorphisms : SNP and Copy number variants
NCBI Variation Viewer	THRA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	THRA
dbVar	THRA
ClinVar	THRA
1000_Genomes	THRA
Exome Variant Server	THRA
ExAC (Exome Aggregation Consortium)	ENSG00000126351
GNOMAD Browser	ENSG00000126351
Varsome Browser	THRA
Genetic variants : HAPMAP	7067
Genomic Variants (DGV)	THRA [DGVbeta]
DECIPHER	THRA [patients] [syndromes] [variants] [genes]
CONAN: Copy Number Analysis	THRA
	Mutations
ICGC Data Portal	THRA
TCGA Data Portal	THRA
Broad Tumor Portal	THRA
OASIS Portal	THRA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMIC	THRA [overview] [genome browser] [tissue] [distribution]
Mutations and Diseases : HGMD	THRA
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
BioMuta	search THRA
DgiDB (Drug Gene Interaction Database)	THRA
DoCM (Curated mutations)	THRA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)	THRA (select a term)
intoGen	THRA
Cancer3D	THRA(select the gene name)
Impact of mutations	[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
	Diseases
OMIM	190120 614450
Orphanet	12947
DisGeNET	THRA
Medgen	THRA
Genetic Testing Registry	THRA
NextProt	P10827 [Medical]
TSGene	7067
GENETests	THRA
Target Validation	THRA
Huge Navigator	THRA [HugePedia]
snp3D : Map Gene to Disease	7067
BioCentury BCIQ	THRA
ClinGen	THRA (curated)
	Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD	7067
Chemical/Pharm GKB Gene	PA36507
Clinical trial	THRA
	Miscellaneous
canSAR (ICR)	THRA (select the gene name)
	Probes
	Litterature
PubMed	185 Pubmed reference(s) in Entrez
GeneRIFs	Gene References Into Functions (Entrez)
CoreMine	THRA
EVEX	THRA
GoPubMed	THRA
iHOP	THRA

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

indexed on : Mon Aug 27 11:57:25 CEST 2018

Home Genes Leukemias Solid Tumors Cancer-Prone Deep Insight Case Reports Journals Portal Teaching

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.

Atlas of Genetics and Cytogenetics in Oncology and Haematology

THRA (thyroid hormone receptor alpha)

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to How to contribute