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THRA (thyroid hormone receptor alpha)

Identity

Alias_namesTHRA1
THRA2
ERBA1
thyroid hormone receptor, alpha (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog)
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
Alias_symbol (synonym)EAR-7.1/EAR-7.2
THRA3
AR7
ERBA
NR1A1
Other aliasCHNG6
EAR7
ERB-T-1
c-ERBA-1
HGNC (Hugo) THRA
LocusID (NCBI) 7067
Atlas_Id 42553
Location 17q21.1  [Link to chromosome band 17q21]
Location_base_pair Starts at 40062815 and ends at 40090037 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AEBP1 (7p13) / THRA (17q21.1)FCHSD2 (11q13.4) / THRA (17q21.1)FDPS (1q22) / THRA (17q21.1)
NME1 (17q21.33) / THRA (17q21.1)THRA (17q21.1) / B4GALNT2 (17q21.32)THRA (17q21.1) / FDPS (1q22)
THRA (17q21.1) / GSDMA (17q21.1)THRA (17q21.1) / PSMD3 (17q21.1)THRA (17q21.1) / TADA2A (17q12)
THRA (17q21.1) / THRA (17q21.1)THRA (17q21.1) / USP5 (12p13.31)THRA 17q21.1 / B4GALNT2 17q21.32
THRA 17q21.1 / GSDMA 17q21.1THRA 17q21.1 / PSMD3 17q21.1THRA 17q21.1 / TADA2A 17q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]
  t(7;17)(p13;q21) AEBP1/THRA
t(11;17)(q13;q21) FCHSD2/THRA
t(17;17)(q12;q21) THRA/TADA2A
t(17;17)(q21;q21) THRA/GSDMA
t(17;17)(q21;q21) THRA/B4GALNT2
t(17;17)(q21;q21) THRA/PSMD3

External links

Nomenclature
HGNC (Hugo)THRA   11796
Cards
Entrez_Gene (NCBI)THRA  7067  thyroid hormone receptor alpha
AliasesAR7; CHNG6; EAR7; ERB-T-1; 
ERBA; ERBA1; NR1A1; THRA1; THRA2; c-ERBA-1
GeneCards (Weizmann)THRA
Ensembl hg19 (Hinxton)ENSG00000126351 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126351 [Gene_View]ENSG00000126351 [Sequence]  chr17:40062815-40090037 [Contig_View]  THRA [Vega]
ICGC DataPortalENSG00000126351
TCGA cBioPortalTHRA
AceView (NCBI)THRA
Genatlas (Paris)THRA
WikiGenes7067
SOURCE (Princeton)THRA
Genetics Home Reference (NIH)THRA
Genomic and cartography
GoldenPath hg38 (UCSC)THRA  -     chr17:40062815-40090037 +  17q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)THRA  -     17q21.1   [Description]    (hg19-Feb_2009)
EnsemblTHRA - 17q21.1 [CytoView hg19]  THRA - 17q21.1 [CytoView hg38]
Mapping of homologs : NCBITHRA [Mapview hg19]  THRA [Mapview hg38]
OMIM190120   614450   
Gene and transcription
Genbank (Entrez)AB209346 AB307686 AF522368 AK290071 AK290530
RefSeq transcript (Entrez)NM_001190918 NM_001190919 NM_003250 NM_199334
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)THRA
Cluster EST : UnigeneHs.724 [ NCBI ]
CGAP (NCI)Hs.724
Alternative Splicing GalleryENSG00000126351
Gene ExpressionTHRA [ NCBI-GEO ]   THRA [ EBI - ARRAY_EXPRESS ]   THRA [ SEEK ]   THRA [ MEM ]
Gene Expression Viewer (FireBrowse)THRA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7067
GTEX Portal (Tissue expression)THRA
Human Protein AtlasENSG00000126351-THRA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10827   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10827  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10827
Splice isoforms : SwissVarP10827
PhosPhoSitePlusP10827
Domaine pattern : Prosite (Expaxy)NUCLEAR_REC_DBD_1 (PS00031)    NUCLEAR_REC_DBD_2 (PS51030)   
Domains : Interpro (EBI)Nucl_hrmn_rcpt_lig-bd    Nuclear_hrmn_rcpt    ThyrH_rcpt    Znf_hrmn_rcpt    Znf_NHR/GATA   
Domain families : Pfam (Sanger)Hormone_recep (PF00104)    zf-C4 (PF00105)   
Domain families : Pfam (NCBI)pfam00104    pfam00105   
Domain families : Smart (EMBL)HOLI (SM00430)  ZnF_C4 (SM00399)  
Conserved Domain (NCBI)THRA
DMDM Disease mutations7067
Blocks (Seattle)THRA
PDB (SRS)1NAV    2H77    2H79    3HZF    3ILZ    3JZB    4LNW    4LNX   
PDB (PDBSum)1NAV    2H77    2H79    3HZF    3ILZ    3JZB    4LNW    4LNX   
PDB (IMB)1NAV    2H77    2H79    3HZF    3ILZ    3JZB    4LNW    4LNX   
PDB (RSDB)1NAV    2H77    2H79    3HZF    3ILZ    3JZB    4LNW    4LNX   
Structural Biology KnowledgeBase1NAV    2H77    2H79    3HZF    3ILZ    3JZB    4LNW    4LNX   
SCOP (Structural Classification of Proteins)1NAV    2H77    2H79    3HZF    3ILZ    3JZB    4LNW    4LNX   
CATH (Classification of proteins structures)1NAV    2H77    2H79    3HZF    3ILZ    3JZB    4LNW    4LNX   
SuperfamilyP10827
Human Protein Atlas [tissue]ENSG00000126351-THRA [tissue]
Peptide AtlasP10827
HPRD07185
IPIIPI00022991   IPI00219099   IPI00219100   IPI00219101   
Protein Interaction databases
DIP (DOE-UCLA)P10827
IntAct (EBI)P10827
FunCoupENSG00000126351
BioGRIDTHRA
STRING (EMBL)THRA
ZODIACTHRA
Ontologies - Pathways
QuickGOP10827
Ontology : AmiGOtranscription regulatory region sequence-specific DNA binding  cartilage condensation  ossification  steroid receptor RNA activator RNA binding  regulation of thyroid hormone mediated signaling pathway  DNA binding transcription factor activity  steroid hormone receptor activity  thyroid hormone receptor activity  protein binding  nucleus  nucleoplasm  cytosol  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  transcription initiation from RNA polymerase II promoter  learning or memory  regulation of heart contraction  female courtship behavior  transcription factor binding  zinc ion binding  response to cold  hormone-mediated signaling pathway  positive regulation of myotube differentiation  TBP-class protein binding  negative regulation of RNA polymerase II transcriptional preinitiation complex assembly  protein domain specific binding  erythrocyte differentiation  intracellular receptor signaling pathway  thyroid gland development  chromatin DNA binding  protein complex binding  regulation of myeloid cell apoptotic process  cytoplasmic sequestering of transcription factor  steroid hormone mediated signaling pathway  transcription regulatory region DNA binding  negative regulation of transcription, DNA-templated  positive regulation of female receptivity  positive regulation of transcription by RNA polymerase II  regulation of lipid catabolic process  Type I pneumocyte differentiation  thyroid hormone binding  thyroid hormone binding  negative regulation of DNA-templated transcription, initiation  
Ontology : EGO-EBItranscription regulatory region sequence-specific DNA binding  cartilage condensation  ossification  steroid receptor RNA activator RNA binding  regulation of thyroid hormone mediated signaling pathway  DNA binding transcription factor activity  steroid hormone receptor activity  thyroid hormone receptor activity  protein binding  nucleus  nucleoplasm  cytosol  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  transcription initiation from RNA polymerase II promoter  learning or memory  regulation of heart contraction  female courtship behavior  transcription factor binding  zinc ion binding  response to cold  hormone-mediated signaling pathway  positive regulation of myotube differentiation  TBP-class protein binding  negative regulation of RNA polymerase II transcriptional preinitiation complex assembly  protein domain specific binding  erythrocyte differentiation  intracellular receptor signaling pathway  thyroid gland development  chromatin DNA binding  protein complex binding  regulation of myeloid cell apoptotic process  cytoplasmic sequestering of transcription factor  steroid hormone mediated signaling pathway  transcription regulatory region DNA binding  negative regulation of transcription, DNA-templated  positive regulation of female receptivity  positive regulation of transcription by RNA polymerase II  regulation of lipid catabolic process  Type I pneumocyte differentiation  thyroid hormone binding  thyroid hormone binding  negative regulation of DNA-templated transcription, initiation  
Pathways : BIOCARTAMap Kinase Inactivation of SMRT Corepressor [Genes]   
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkTHRA
Atlas of Cancer Signalling NetworkTHRA
Wikipedia pathwaysTHRA
Orthology - Evolution
OrthoDB7067
GeneTree (enSembl)ENSG00000126351
Phylogenetic Trees/Animal Genes : TreeFamTHRA
HOVERGENP10827
HOGENOMP10827
Homologs : HomoloGeneTHRA
Homology/Alignments : Family Browser (UCSC)THRA
Gene fusions - Rearrangements
Fusion : MitelmanAEBP1/THRA [7p13/17q21.1]  [t(7;17)(p13;q21)]  
Fusion : MitelmanFCHSD2/THRA [11q13.4/17q21.1]  [t(11;17)(q13;q21)]  
Fusion : MitelmanTHRA/- [17q21.1/t(17;17)(q21;q21)]  
Fusion : MitelmanTHRA/B4GALNT2 [17q21.1/17q21.32]  [t(17;17)(q21;q21)]  
Fusion : MitelmanTHRA/GSDMA [17q21.1/17q21.1]  [t(17;17)(q21;q21)]  
Fusion : MitelmanTHRA/PSMD3 [17q21.1/17q21.1]  [t(17;17)(q21;q21)]  
Fusion : MitelmanTHRA/TADA2A [17q21.1/17q12]  [t(17;17)(q12;q21)]  
Fusion PortalTHRA 17q21.1 B4GALNT2 17q21.32 BRCA
Fusion PortalTHRA 17q21.1 GSDMA 17q21.1 GBM
Fusion PortalTHRA 17q21.1 PSMD3 17q21.1 LUAD
Fusion PortalTHRA 17q21.1 TADA2A 17q12 BRCA
Fusion : QuiverTHRA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTHRA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)THRA
dbVarTHRA
ClinVarTHRA
1000_GenomesTHRA 
Exome Variant ServerTHRA
ExAC (Exome Aggregation Consortium)ENSG00000126351
GNOMAD BrowserENSG00000126351
Genetic variants : HAPMAP7067
Genomic Variants (DGV)THRA [DGVbeta]
DECIPHERTHRA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTHRA 
Mutations
ICGC Data PortalTHRA 
TCGA Data PortalTHRA 
Broad Tumor PortalTHRA
OASIS PortalTHRA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTHRA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTHRA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch THRA
DgiDB (Drug Gene Interaction Database)THRA
DoCM (Curated mutations)THRA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)THRA (select a term)
intoGenTHRA
Cancer3DTHRA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM190120    614450   
Orphanet12947   
DisGeNETTHRA
MedgenTHRA
Genetic Testing Registry THRA
NextProtP10827 [Medical]
TSGene7067
GENETestsTHRA
Target ValidationTHRA
Huge Navigator THRA [HugePedia]
snp3D : Map Gene to Disease7067
BioCentury BCIQTHRA
ClinGenTHRA (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7067
Chemical/Pharm GKB GenePA36507
Clinical trialTHRA
Miscellaneous
canSAR (ICR)THRA (select the gene name)
Probes
Litterature
PubMed181 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTHRA
EVEXTHRA
GoPubMedTHRA
iHOPTHRA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jun 21 17:19:09 CEST 2018
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