THRB (thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian))

Identity

Other names	ERBA-BETA
	ERBA2
	GRTH
	MGC126109
	MGC126110
	NR1A2
	THR1
	THRB1
	THRB2
HGNC	THRB
Location	3p24.1-p22
Location_base_pair	Starts at 24133649 and ends at 24511317 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	THRB   11799
Entrez_Gene	THRB  7068  thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
	Cards
GeneCards	THRB
Ensembl	ENSG00000151090 [Gene_View]  THRB [Vega]
Genatlas	THRB
	Genomic and cartography
GoldenPath	THRB  -     chr3:24133649-24511317 -  3p24.2   [Description]    (hg18-March_2006)
Ensembl	THRB - 3p24.2 [CytoView]
NCBI	Mapview
OMIM	188570 Disease map [OMIM]
OMIM	190160 Disease map [OMIM]
OMIM	274300 Disease map [OMIM]
HomoloGene	THRB
	Gene and transcription
Genbank	AI003028 [ ENTREZ ]
Genbank	AK095776 [ ENTREZ ]
Genbank	AK096628 [ ENTREZ ]
Genbank	AK096885 [ ENTREZ ]
Genbank	AK098084 [ ENTREZ ]
RefSeq	NM_000461 [ SRS ]    NM_000461 [ ENTREZ ]
RefSeq	NM_001128176 [ SRS ]    NM_001128176 [ ENTREZ ]
RefSeq	NM_001128177 [ SRS ]    NM_001128177 [ ENTREZ ]
RefSeq	AC_000046 [ SRS ]    AC_000046 [ ENTREZ ]
RefSeq	AC_000135 [ SRS ]    AC_000135 [ ENTREZ ]
RefSeq	NC_000003 [ SRS ]    NC_000003 [ ENTREZ ]
RefSeq	NT_022517 [ SRS ]    NT_022517 [ ENTREZ ]
RefSeq	NW_001838877 [ SRS ]    NW_001838877 [ ENTREZ ]
RefSeq	NW_921651 [ SRS ]    NW_921651 [ ENTREZ ]
CCDS	THRB CCDS - NCBI
AceView	THRB AceView - NCBI
Unigene	Hs.610189 [ SRS ]    Hs.610189 [ NCBI ]
Fast-db	3057 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P10828 [ SRS]    P10828 [ EXPASY ]     P10828 [ INTERPRO ]     P10828 [ UNIPROT ] P10828 [ VarSplice FASTA ]
Prosite	PS00031 NUCLEAR_REC_DBD_1 [ SRS ]    PS00031 NUCLEAR_REC_DBD_1 [ Expasy ]
Prosite	PS51030 NUCLEAR_REC_DBD_2 [ SRS ]    PS51030 NUCLEAR_REC_DBD_2 [ Expasy ]
Interpro	IPR008946 Nucl_hormone_rcpt_ligand-bd [ SRS ]    IPR008946 Nucl_hormone_rcpt_ligand-bd [ EBI ]
Interpro	IPR000536 Nucl_hrmn_rcpt_lig-bd_core [ SRS ]    IPR000536 Nucl_hrmn_rcpt_lig-bd_core [ EBI ]
Interpro	IPR001723 Str_hrmn_rcpt [ SRS ]    IPR001723 Str_hrmn_rcpt [ EBI ]
Interpro	IPR001728 ThyrH_rcpt [ SRS ]    IPR001728 ThyrH_rcpt [ EBI ]
Interpro	IPR001628 Znf_hrmn_rcpt [ SRS ]    IPR001628 Znf_hrmn_rcpt [ EBI ]
Interpro	IPR013088 Znf_NHR/GATA [ SRS ]    IPR013088 Znf_NHR/GATA [ EBI ]
CluSTr	P10828
Pfam	PF00104 Hormone_recep [ SRS ]    PF00104 Hormone_recep [ Sanger ]    pfam00104 [ NCBI-CDD ]
Pfam	PF00105 zf-C4 [ SRS ]    PF00105 zf-C4 [ Sanger ]    pfam00105 [ NCBI-CDD ]
Smart	SM00430 HOLI [EMBL]
Smart	SM00399 ZnF_C4 [EMBL]
Prodom	PD000035 Znf_C4steroid[INRA-Toulouse]
Prodom	P10828 THB_HUMAN [ Domain structure ]   P10828 THB_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P10828
PDB	1BSX [ SRS ]    1BSX [ PdbSum ],   1BSX [ IMB ]   1BSX [ RSDB ]
PDB	1N46 [ SRS ]    1N46 [ PdbSum ],   1N46 [ IMB ]   1N46 [ RSDB ]
PDB	1NAX [ SRS ]    1NAX [ PdbSum ],   1NAX [ IMB ]   1NAX [ RSDB ]
PDB	1NQ0 [ SRS ]    1NQ0 [ PdbSum ],   1NQ0 [ IMB ]   1NQ0 [ RSDB ]
PDB	1NQ1 [ SRS ]    1NQ1 [ PdbSum ],   1NQ1 [ IMB ]   1NQ1 [ RSDB ]
PDB	1NQ2 [ SRS ]    1NQ2 [ PdbSum ],   1NQ2 [ IMB ]   1NQ2 [ RSDB ]
PDB	1NUO [ SRS ]    1NUO [ PdbSum ],   1NUO [ IMB ]   1NUO [ RSDB ]
PDB	1Q4X [ SRS ]    1Q4X [ PdbSum ],   1Q4X [ IMB ]   1Q4X [ RSDB ]
PDB	1R6G [ SRS ]    1R6G [ PdbSum ],   1R6G [ IMB ]   1R6G [ RSDB ]
PDB	1XZX [ SRS ]    1XZX [ PdbSum ],   1XZX [ IMB ]   1XZX [ RSDB ]
PDB	1Y0X [ SRS ]    1Y0X [ PdbSum ],   1Y0X [ IMB ]   1Y0X [ RSDB ]
PDB	2H6W [ SRS ]    2H6W [ PdbSum ],   2H6W [ IMB ]   2H6W [ RSDB ]
PDB	2J4A [ SRS ]    2J4A [ PdbSum ],   2J4A [ IMB ]   2J4A [ RSDB ]
PDB	2NLL [ SRS ]    2NLL [ PdbSum ],   2NLL [ IMB ]   2NLL [ RSDB ]
PDB	2PIN [ SRS ]    2PIN [ PdbSum ],   2PIN [ IMB ]   2PIN [ RSDB ]
HPRD	07521
	Protein Interaction databases
DIP	P10828
IntAct	P10828
	Polymorphism : SNP, mutations, diseases
OMIM	188570    [ map ]
OMIM	190160    [ map ]
OMIM	274300    [ map ]
GENETests	188570
GENETests	190160
GENETests	274300
SNP	THRB [dbSNP-NCBI]
SNP	NM_000461 [SNP-NCI]
SNP	NM_001128176 [SNP-NCI]
SNP	NM_001128177 [SNP-NCI]
SNP	THRB [GeneSNPs - Utah]  THRB] [HGBASE - SRS]
HAPMAP	THRB [HAPMAP]
COSMIC	THRB [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	THRB
Genetic Association	THRB
CDC HuGE	THRB
	General knowledge
Family Browser	THRB [UCSC Family Browser]
SOURCE	NM_000461
SOURCE	NM_001128176
SOURCE	NM_001128177
SMD	Hs.610189
SAGE	Hs.610189
GO	transcription factor activity [Amigo]  transcription factor activity
GO	steroid hormone receptor activity [Amigo]  steroid hormone receptor activity
GO	transcription corepressor activity [Amigo]  transcription corepressor activity
GO	thyroid hormone receptor activity [Amigo]  thyroid hormone receptor activity
GO	protein binding [Amigo]  protein binding
GO	nucleus [Amigo]  nucleus
GO	regulation of transcription, DNA-dependent [Amigo]  regulation of transcription, DNA-dependent
GO	sensory perception of sound [Amigo]  sensory perception of sound
GO	zinc ion binding [Amigo]  zinc ion binding
GO	sequence-specific DNA binding [Amigo]  sequence-specific DNA binding
GO	metal ion binding [Amigo]  metal ion binding
KEGG	Neuroactive ligand-receptor interaction
PubGene	THRB
TreeFam	THRB
CTD	7068 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	THRB Related clones (RZPD - Berlin)
	PubMed
PubMed	113 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu Nov 27 14:15:37 2008