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THSD4 (thrombospondin type 1 domain containing 4)

Identity

Alias (NCBI)ADAMTSL-6
ADAMTSL6
FVSY9334
PRO34005
HGNC (Hugo) THSD4
HGNC Alias symbFVSY9334
PRO34005
FLJ13710
ADAMTSL6
LocusID (NCBI) 79875
Atlas_Id 54700
Location 15q23  [Link to chromosome band 15q23]
Location_base_pair Starts at 71141449 and ends at 71783383 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RNF128 (Xq22.3) / THSD4 (15q23)THSD4 (15q23) / ALDH1A2 (15q21.3)THSD4 (15q23) / LRRC49 (15q23)
THSD4 (15q23) / PTMA (2q37.1)THSD4 (15q23) / SERHL2 (22q13.2)THSD4 (15q23) / THSD4 (15q23)
TMED10 (14q24.3) / THSD4 (15q23)THSD4 15q23 / ALDH1A2 15q21.3THSD4 15q23 / LRRC49 15q23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)THSD4   25835
Cards
Entrez_Gene (NCBI)THSD4    thrombospondin type 1 domain containing 4
AliasesADAMTSL-6; ADAMTSL6; FVSY9334; PRO34005
GeneCards (Weizmann)THSD4
Ensembl hg19 (Hinxton)ENSG00000187720 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000187720 [Gene_View]  ENSG00000187720 [Sequence]  chr15:71141449-71783383 [Contig_View]  THSD4 [Vega]
ICGC DataPortalENSG00000187720
TCGA cBioPortalTHSD4
AceView (NCBI)THSD4
Genatlas (Paris)THSD4
SOURCE (Princeton)THSD4
Genetics Home Reference (NIH)THSD4
Genomic and cartography
GoldenPath hg38 (UCSC)THSD4  -     chr15:71141449-71783383 +  15q23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)THSD4  -     15q23   [Description]    (hg19-Feb_2009)
GoldenPathTHSD4 - 15q23 [CytoView hg19]  THSD4 - 15q23 [CytoView hg38]
ImmunoBaseENSG00000187720
Genome Data Viewer NCBITHSD4 [Mapview hg19]  
OMIM614476   
Gene and transcription
Genbank (Entrez)AK000582 AK023772 AK130734 AK131551 AK299056
RefSeq transcript (Entrez)NM_001286429 NM_001394532 NM_024817
Consensus coding sequences : CCDS (NCBI)THSD4
Gene ExpressionTHSD4 [ NCBI-GEO ]   THSD4 [ EBI - ARRAY_EXPRESS ]   THSD4 [ SEEK ]   THSD4 [ MEM ]
Gene Expression Viewer (FireBrowse)THSD4 [ Firebrowse - Broad ]
GenevisibleExpression of THSD4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79875
GTEX Portal (Tissue expression)THSD4
Human Protein AtlasENSG00000187720-THSD4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZMP0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZMP0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZMP0
PhosPhoSitePlusQ6ZMP0
Domaine pattern : Prosite (Expaxy)PLAC (PS50900)    TSP1 (PS50092)   
Domains : Interpro (EBI)ADAM_spacer1    PLAC    TSP1_rpt    TSP1_rpt_sf   
Domain families : Pfam (Sanger)ADAM_spacer1 (PF05986)    PLAC (PF08686)    TSP_1 (PF00090)   
Domain families : Pfam (NCBI)pfam05986    pfam08686    pfam00090   
Domain families : Smart (EMBL)TSP1 (SM00209)  
Conserved Domain (NCBI)THSD4
SuperfamilyQ6ZMP0
AlphaFold pdb e-kbQ6ZMP0   
Human Protein Atlas [tissue]ENSG00000187720-THSD4 [tissue]
HPRD07835
Protein Interaction databases
DIP (DOE-UCLA)Q6ZMP0
IntAct (EBI)Q6ZMP0
BioGRIDTHSD4
STRING (EMBL)THSD4
ZODIACTHSD4
Ontologies - Pathways
QuickGOQ6ZMP0
Ontology : AmiGOmicrofibril  metalloendopeptidase activity  extracellular matrix structural constituent  proteolysis  extracellular matrix organization  extracellular matrix  elastic fiber assembly  collagen-containing extracellular matrix  extracellular exosome  
Ontology : EGO-EBImicrofibril  metalloendopeptidase activity  extracellular matrix structural constituent  proteolysis  extracellular matrix organization  extracellular matrix  elastic fiber assembly  collagen-containing extracellular matrix  extracellular exosome  
NDEx NetworkTHSD4
Atlas of Cancer Signalling NetworkTHSD4
Wikipedia pathwaysTHSD4
Orthology - Evolution
OrthoDB79875
GeneTree (enSembl)ENSG00000187720
Phylogenetic Trees/Animal Genes : TreeFamTHSD4
Homologs : HomoloGeneTHSD4
Homology/Alignments : Family Browser (UCSC)THSD4
Gene fusions - Rearrangements
Fusion : MitelmanTHSD4/ALDH1A2 [15q23/15q21.3]  
Fusion : QuiverTHSD4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTHSD4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)THSD4
dbVarTHSD4
ClinVarTHSD4
MonarchTHSD4
1000_GenomesTHSD4 
Exome Variant ServerTHSD4
GNOMAD BrowserENSG00000187720
Varsome BrowserTHSD4
ACMGTHSD4 variants
VarityQ6ZMP0
Genomic Variants (DGV)THSD4 [DGVbeta]
DECIPHERTHSD4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTHSD4 
Mutations
ICGC Data PortalTHSD4 
TCGA Data PortalTHSD4 
Broad Tumor PortalTHSD4
OASIS PortalTHSD4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTHSD4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTHSD4
Mutations and Diseases : HGMDTHSD4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTHSD4
DgiDB (Drug Gene Interaction Database)THSD4
DoCM (Curated mutations)THSD4
CIViC (Clinical Interpretations of Variants in Cancer)THSD4
Cancer3DTHSD4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614476   
Orphanet
DisGeNETTHSD4
MedgenTHSD4
Genetic Testing Registry THSD4
NextProtQ6ZMP0 [Medical]
GENETestsTHSD4
Target ValidationTHSD4
Huge Navigator THSD4 [HugePedia]
ClinGenTHSD4
Clinical trials, drugs, therapy
MyCancerGenomeTHSD4
Protein Interactions : CTDTHSD4
Pharm GKB GenePA143485631
PharosQ6ZMP0
Clinical trialTHSD4
Miscellaneous
canSAR (ICR)THSD4
HarmonizomeTHSD4
DataMed IndexTHSD4
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTHSD4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:03 CEST 2021

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