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THSD4 (thrombospondin type 1 domain containing 4)

Identity

Alias_symbol (synonym)FVSY9334
PRO34005
FLJ13710
ADAMTSL6
Other aliasADAMTSL-6
HGNC (Hugo) THSD4
LocusID (NCBI) 79875
Atlas_Id 54700
Location 15q23  [Link to chromosome band 15q23]
Location_base_pair Starts at 71839541 and ends at 72075722 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RNF128 (Xq22.3) / THSD4 (15q23)THSD4 (15q23) / ALDH1A2 (15q21.3)THSD4 (15q23) / LRRC49 (15q23)
THSD4 (15q23) / PTMA (2q37.1)THSD4 (15q23) / SERHL2 (22q13.2)THSD4 (15q23) / THSD4 (15q23)
TMED10 (14q24.3) / THSD4 (15q23)THSD4 15q23 / ALDH1A2 15q21.3THSD4 15q23 / LRRC49 15q23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)THSD4   25835
Cards
Entrez_Gene (NCBI)THSD4  79875  thrombospondin type 1 domain containing 4
AliasesADAMTSL-6; ADAMTSL6; FVSY9334; PRO34005
GeneCards (Weizmann)THSD4
Ensembl hg19 (Hinxton)ENSG00000187720 [Gene_View]  chr15:71839541-72075722 [Contig_View]  THSD4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000187720 [Gene_View]  chr15:71839541-72075722 [Contig_View]  THSD4 [Vega]
ICGC DataPortalENSG00000187720
TCGA cBioPortalTHSD4
AceView (NCBI)THSD4
Genatlas (Paris)THSD4
WikiGenes79875
SOURCE (Princeton)THSD4
Genetics Home Reference (NIH)THSD4
Genomic and cartography
GoldenPath hg19 (UCSC)THSD4  -     chr15:71839541-72075722 +  15q23   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)THSD4  -     15q23   [Description]    (hg38-Dec_2013)
EnsemblTHSD4 - 15q23 [CytoView hg19]  THSD4 - 15q23 [CytoView hg38]
Mapping of homologs : NCBITHSD4 [Mapview hg19]  THSD4 [Mapview hg38]
OMIM614476   
Gene and transcription
Genbank (Entrez)AK000582 AK023772 AK130734 AK131551 AK299056
RefSeq transcript (Entrez)NM_001286429 NM_024817
RefSeq genomic (Entrez)NC_000015 NC_018926 NT_010194 NW_004929398
Consensus coding sequences : CCDS (NCBI)THSD4
Cluster EST : UnigeneHs.387057 [ NCBI ]
CGAP (NCI)Hs.387057
Alternative Splicing GalleryENSG00000187720
Gene ExpressionTHSD4 [ NCBI-GEO ]   THSD4 [ EBI - ARRAY_EXPRESS ]   THSD4 [ SEEK ]   THSD4 [ MEM ]
Gene Expression Viewer (FireBrowse)THSD4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79875
GTEX Portal (Tissue expression)THSD4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZMP0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZMP0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZMP0
Splice isoforms : SwissVarQ6ZMP0
PhosPhoSitePlusQ6ZMP0
Domaine pattern : Prosite (Expaxy)PLAC (PS50900)    TSP1 (PS50092)   
Domains : Interpro (EBI)ADAM_spacer1    PLAC    TSP1_rpt   
Domain families : Pfam (Sanger)ADAM_spacer1 (PF05986)    PLAC (PF08686)    TSP_1 (PF00090)   
Domain families : Pfam (NCBI)pfam05986    pfam08686    pfam00090   
Domain families : Smart (EMBL)TSP1 (SM00209)  
Conserved Domain (NCBI)THSD4
DMDM Disease mutations79875
Blocks (Seattle)THSD4
SuperfamilyQ6ZMP0
Human Protein AtlasENSG00000187720
Peptide AtlasQ6ZMP0
HPRD07835
IPIIPI00794391   IPI00879198   IPI00419784   IPI00908987   IPI00792759   
Protein Interaction databases
DIP (DOE-UCLA)Q6ZMP0
IntAct (EBI)Q6ZMP0
FunCoupENSG00000187720
BioGRIDTHSD4
STRING (EMBL)THSD4
ZODIACTHSD4
Ontologies - Pathways
QuickGOQ6ZMP0
Ontology : AmiGOmicrofibril  metalloendopeptidase activity  proteolysis  elastic fiber assembly  extracellular exosome  
Ontology : EGO-EBImicrofibril  metalloendopeptidase activity  proteolysis  elastic fiber assembly  extracellular exosome  
NDEx NetworkTHSD4
Atlas of Cancer Signalling NetworkTHSD4
Wikipedia pathwaysTHSD4
Orthology - Evolution
OrthoDB79875
GeneTree (enSembl)ENSG00000187720
Phylogenetic Trees/Animal Genes : TreeFamTHSD4
HOVERGENQ6ZMP0
HOGENOMQ6ZMP0
Homologs : HomoloGeneTHSD4
Homology/Alignments : Family Browser (UCSC)THSD4
Gene fusions - Rearrangements
Fusion : MitelmanTHSD4/ALDH1A2 [15q23/15q21.3]  
Fusion: TCGATHSD4 15q23 ALDH1A2 15q21.3 BRCA
Fusion: TCGATHSD4 15q23 LRRC49 15q23 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTHSD4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)THSD4
dbVarTHSD4
ClinVarTHSD4
1000_GenomesTHSD4 
Exome Variant ServerTHSD4
ExAC (Exome Aggregation Consortium)THSD4 (select the gene name)
Genetic variants : HAPMAP79875
Genomic Variants (DGV)THSD4 [DGVbeta]
DECIPHER (Syndromes)15:71839541-72075722  ENSG00000187720
CONAN: Copy Number AnalysisTHSD4 
Mutations
ICGC Data PortalTHSD4 
TCGA Data PortalTHSD4 
Broad Tumor PortalTHSD4
OASIS PortalTHSD4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTHSD4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTHSD4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch THSD4
DgiDB (Drug Gene Interaction Database)THSD4
DoCM (Curated mutations)THSD4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)THSD4 (select a term)
intoGenTHSD4
Cancer3DTHSD4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614476   
Orphanet
MedgenTHSD4
Genetic Testing Registry THSD4
NextProtQ6ZMP0 [Medical]
TSGene79875
GENETestsTHSD4
Huge Navigator THSD4 [HugePedia]
snp3D : Map Gene to Disease79875
BioCentury BCIQTHSD4
ClinGenTHSD4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79875
Chemical/Pharm GKB GenePA143485631
Clinical trialTHSD4
Miscellaneous
canSAR (ICR)THSD4 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTHSD4
EVEXTHSD4
GoPubMedTHSD4
iHOPTHSD4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:22:25 CEST 2017

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