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TIA1 (TIA1 cytotoxic granule-associated RNA binding protein)

Identity

Alias_namesTIA1 cytotoxic granule-associated RNA-binding protein
Other aliasTIA-1
WDM
HGNC (Hugo) TIA1
LocusID (NCBI) 7072
Atlas_Id 46551
Location 2p13.3  [Link to chromosome band 2p13]
Location_base_pair Starts at 70436576 and ends at 70475779 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
TIA1 (2p13.3) / ACTR2 (2p14)TIA1 (2p13.3) / BCL11A (2p16.1)TIA1 (2p13.3) / DIRC2 (3q21.1)
TIA1 (2p13.3) / HSPA13 (21q11.2)TIA1 (2p13.3) / TGFA (2p13.3)TIA1 (2p13.3) / ZFYVE26 (14q24.1)
TIA1 2p13.3 / ACTR2 2p14TIA1 2p13.3 / BCL11A 2p16.1TIA1 2p13.3 / TGFA 2p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;14)(p25.3;q11.2) TRA/IRF4


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Prostate tumors: an overview


External links

Nomenclature
HGNC (Hugo)TIA1   11802
Cards
Entrez_Gene (NCBI)TIA1  7072  TIA1 cytotoxic granule-associated RNA binding protein
AliasesTIA-1; WDM
GeneCards (Weizmann)TIA1
Ensembl hg19 (Hinxton)ENSG00000116001 [Gene_View]  chr2:70436576-70475779 [Contig_View]  TIA1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000116001 [Gene_View]  chr2:70436576-70475779 [Contig_View]  TIA1 [Vega]
ICGC DataPortalENSG00000116001
TCGA cBioPortalTIA1
AceView (NCBI)TIA1
Genatlas (Paris)TIA1
WikiGenes7072
SOURCE (Princeton)TIA1
Genetics Home Reference (NIH)TIA1
Genomic and cartography
GoldenPath hg19 (UCSC)TIA1  -     chr2:70436576-70475779 -  2p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TIA1  -     2p13.3   [Description]    (hg38-Dec_2013)
EnsemblTIA1 - 2p13.3 [CytoView hg19]  TIA1 - 2p13.3 [CytoView hg38]
Mapping of homologs : NCBITIA1 [Mapview hg19]  TIA1 [Mapview hg38]
OMIM603518   604454   
Gene and transcription
Genbank (Entrez)AB209211 AK093744 AK303345 BC015944 BM146739
RefSeq transcript (Entrez)NM_022037 NM_022173
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_029967 NT_022184 NW_004929300
Consensus coding sequences : CCDS (NCBI)TIA1
Cluster EST : UnigeneHs.413123 [ NCBI ]
CGAP (NCI)Hs.413123
Alternative Splicing GalleryENSG00000116001
Gene ExpressionTIA1 [ NCBI-GEO ]   TIA1 [ EBI - ARRAY_EXPRESS ]   TIA1 [ SEEK ]   TIA1 [ MEM ]
Gene Expression Viewer (FireBrowse)TIA1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7072
GTEX Portal (Tissue expression)TIA1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP31483   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP31483  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP31483
Splice isoforms : SwissVarP31483
PhosPhoSitePlusP31483
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait    RRM_dom   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  
Conserved Domain (NCBI)TIA1
DMDM Disease mutations7072
Blocks (Seattle)TIA1
PDB (SRS)2MJN    3BS9   
PDB (PDBSum)2MJN    3BS9   
PDB (IMB)2MJN    3BS9   
PDB (RSDB)2MJN    3BS9   
Structural Biology KnowledgeBase2MJN    3BS9   
SCOP (Structural Classification of Proteins)2MJN    3BS9   
CATH (Classification of proteins structures)2MJN    3BS9   
SuperfamilyP31483
Human Protein AtlasENSG00000116001
Peptide AtlasP31483
HPRD04626
IPIIPI00291398   IPI00333996   IPI00927286   IPI00743479   IPI00926358   IPI00926546   IPI00972993   IPI00974428   IPI00974016   
Protein Interaction databases
DIP (DOE-UCLA)P31483
IntAct (EBI)P31483
FunCoupENSG00000116001
BioGRIDTIA1
STRING (EMBL)TIA1
ZODIACTIA1
Ontologies - Pathways
QuickGOP31483
Ontology : AmiGOnucleotide binding  protein binding  nucleoplasm  nucleoplasm  cytoplasm  apoptotic process  poly(A) binding  fibroblast growth factor receptor signaling pathway  cytoplasmic stress granule  AU-rich element binding  negative regulation of translation  negative regulation of cytokine biosynthetic process  poly(A) RNA binding  regulation of mRNA splicing, via spliceosome  nuclear stress granule  protein localization to cytoplasmic stress granule  positive regulation of epithelial cell apoptotic process  
Ontology : EGO-EBInucleotide binding  protein binding  nucleoplasm  nucleoplasm  cytoplasm  apoptotic process  poly(A) binding  fibroblast growth factor receptor signaling pathway  cytoplasmic stress granule  AU-rich element binding  negative regulation of translation  negative regulation of cytokine biosynthetic process  poly(A) RNA binding  regulation of mRNA splicing, via spliceosome  nuclear stress granule  protein localization to cytoplasmic stress granule  positive regulation of epithelial cell apoptotic process  
Pathways : BIOCARTAWest Nile Virus [Genes]   
NDEx NetworkTIA1
Atlas of Cancer Signalling NetworkTIA1
Wikipedia pathwaysTIA1
Orthology - Evolution
OrthoDB7072
GeneTree (enSembl)ENSG00000116001
Phylogenetic Trees/Animal Genes : TreeFamTIA1
HOVERGENP31483
HOGENOMP31483
Homologs : HomoloGeneTIA1
Homology/Alignments : Family Browser (UCSC)TIA1
Gene fusions - Rearrangements
Fusion : MitelmanTIA1/ACTR2 [2p13.3/2p14]  
Fusion : MitelmanTIA1/BCL11A [2p13.3/2p16.1]  [t(2;2)(p13;p16)]  
Fusion : MitelmanTIA1/DIRC2 [2p13.3/3q21.1]  [t(2;3)(p13;q21)]  
Fusion : MitelmanTIA1/TGFA [2p13.3/2p13.3]  [t(2;2)(p13;p13)]  
Fusion: TCGATIA1 2p13.3 ACTR2 2p14 PRAD
Fusion: TCGATIA1 2p13.3 BCL11A 2p16.1 LUAD
Fusion: TCGATIA1 2p13.3 TGFA 2p13.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTIA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TIA1
dbVarTIA1
ClinVarTIA1
1000_GenomesTIA1 
Exome Variant ServerTIA1
ExAC (Exome Aggregation Consortium)TIA1 (select the gene name)
Genetic variants : HAPMAP7072
Genomic Variants (DGV)TIA1 [DGVbeta]
DECIPHER (Syndromes)2:70436576-70475779  ENSG00000116001
CONAN: Copy Number AnalysisTIA1 
Mutations
ICGC Data PortalTIA1 
TCGA Data PortalTIA1 
Broad Tumor PortalTIA1
OASIS PortalTIA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTIA1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTIA1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TIA1
DgiDB (Drug Gene Interaction Database)TIA1
DoCM (Curated mutations)TIA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TIA1 (select a term)
intoGenTIA1
Cancer3DTIA1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603518    604454   
Orphanet8727   
MedgenTIA1
Genetic Testing Registry TIA1
NextProtP31483 [Medical]
TSGene7072
GENETestsTIA1
Huge Navigator TIA1 [HugePedia]
snp3D : Map Gene to Disease7072
BioCentury BCIQTIA1
ClinGenTIA1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7072
Chemical/Pharm GKB GenePA36511
Clinical trialTIA1
Miscellaneous
canSAR (ICR)TIA1 (select the gene name)
Probes
Litterature
PubMed79 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTIA1
EVEXTIA1
GoPubMedTIA1
iHOPTIA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:31:05 CET 2017

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