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TIA1 (TIA1 cytotoxic granule associated RNA binding protein)

Identity

Alias (NCBI)ALS26
TIA-1
WDM
HGNC (Hugo) TIA1
HGNC Alias symbTIA-1
HGNC Alias nameT-cell-restricted intracellular antigen-1
 nucleolysin TIA-1 isoform p40
HGNC Previous nameTIA1 cytotoxic granule-associated RNA-binding protein
LocusID (NCBI) 7072
Atlas_Id 46551
Location 2p13.3  [Link to chromosome band 2p13]
Location_base_pair Starts at 70209444 and ends at 70248628 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TIA1 (2p13.3) / ACTR2 (2p14)TIA1 (2p13.3) / BCL11A (2p16.1)TIA1 (2p13.3) / DIRC2 (3q21.1)
TIA1 (2p13.3) / HSPA13 (21q11.2)TIA1 (2p13.3) / TGFA (2p13.3)TIA1 (2p13.3) / ZFYVE26 (14q24.1)
TIA1 2p13.3 / ACTR2 2p14TIA1 2p13.3 / BCL11A 2p16.1TIA1 2p13.3 / TGFA 2p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;14)(p25.3;q11.2) TRA/IRF4


External links

 

Nomenclature
HGNC (Hugo)TIA1   11802
Cards
Entrez_Gene (NCBI)TIA1    TIA1 cytotoxic granule associated RNA binding protein
AliasesALS26; TIA-1; WDM
GeneCards (Weizmann)TIA1
Ensembl hg19 (Hinxton)ENSG00000116001 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116001 [Gene_View]  ENSG00000116001 [Sequence]  chr2:70209444-70248628 [Contig_View]  TIA1 [Vega]
ICGC DataPortalENSG00000116001
TCGA cBioPortalTIA1
AceView (NCBI)TIA1
Genatlas (Paris)TIA1
SOURCE (Princeton)TIA1
Genetics Home Reference (NIH)TIA1
Genomic and cartography
GoldenPath hg38 (UCSC)TIA1  -     chr2:70209444-70248628 -  2p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TIA1  -     2p13.3   [Description]    (hg19-Feb_2009)
GoldenPathTIA1 - 2p13.3 [CytoView hg19]  TIA1 - 2p13.3 [CytoView hg38]
ImmunoBaseENSG00000116001
Genome Data Viewer NCBITIA1 [Mapview hg19]  
OMIM603518   604454   619133   
Gene and transcription
Genbank (Entrez)AB209211 AK093744 AK303345 BC015944 BM146739
RefSeq transcript (Entrez)NM_001351508 NM_001351509 NM_001351510 NM_001351511 NM_001351512 NM_001351513 NM_001351514 NM_001351515 NM_001351516 NM_001351517 NM_001351518 NM_001351519 NM_001351520 NM_001351521 NM_001351522 NM_001351523 NM_001351524 NM_001351525 NM_022037 NM_022173
Consensus coding sequences : CCDS (NCBI)TIA1
Gene ExpressionTIA1 [ NCBI-GEO ]   TIA1 [ EBI - ARRAY_EXPRESS ]   TIA1 [ SEEK ]   TIA1 [ MEM ]
Gene Expression Viewer (FireBrowse)TIA1 [ Firebrowse - Broad ]
GenevisibleExpression of TIA1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7072
GTEX Portal (Tissue expression)TIA1
Human Protein AtlasENSG00000116001-TIA1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP31483   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP31483  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP31483
PhosPhoSitePlusP31483
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait_sf    RBD_domain_sf    RRM_dom    RRM_dom_euk    TIA1_RRM2    TIA1_RRM3   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  RRM_1 (SM00361)  
Conserved Domain (NCBI)TIA1
PDB (RSDB)2MJN    3BS9    5ITH    5O2V    5O3J    6ELD   
PDB Europe2MJN    3BS9    5ITH    5O2V    5O3J    6ELD   
PDB (PDBSum)2MJN    3BS9    5ITH    5O2V    5O3J    6ELD   
PDB (IMB)2MJN    3BS9    5ITH    5O2V    5O3J    6ELD   
Structural Biology KnowledgeBase2MJN    3BS9    5ITH    5O2V    5O3J    6ELD   
SCOP (Structural Classification of Proteins)2MJN    3BS9    5ITH    5O2V    5O3J    6ELD   
CATH (Classification of proteins structures)2MJN    3BS9    5ITH    5O2V    5O3J    6ELD   
SuperfamilyP31483
AlphaFold pdb e-kbP31483   
Human Protein Atlas [tissue]ENSG00000116001-TIA1 [tissue]
HPRD04626
Protein Interaction databases
DIP (DOE-UCLA)P31483
IntAct (EBI)P31483
BioGRIDTIA1
STRING (EMBL)TIA1
ZODIACTIA1
Ontologies - Pathways
QuickGOP31483
Ontology : AmiGOnegative regulation of cytokine production  RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  apoptotic process  poly(A) binding  fibroblast growth factor receptor signaling pathway  cytoplasmic stress granule  cytoplasmic stress granule  negative regulation of translation  mRNA 3'-UTR AU-rich region binding  regulation of mRNA splicing, via spliceosome  nuclear stress granule  protein localization to cytoplasmic stress granule  positive regulation of epithelial cell apoptotic process  ribonucleoprotein complex  
Ontology : EGO-EBInegative regulation of cytokine production  RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  apoptotic process  poly(A) binding  fibroblast growth factor receptor signaling pathway  cytoplasmic stress granule  cytoplasmic stress granule  negative regulation of translation  mRNA 3'-UTR AU-rich region binding  regulation of mRNA splicing, via spliceosome  nuclear stress granule  protein localization to cytoplasmic stress granule  positive regulation of epithelial cell apoptotic process  ribonucleoprotein complex  
Pathways : BIOCARTAWest Nile Virus [Genes]   
NDEx NetworkTIA1
Atlas of Cancer Signalling NetworkTIA1
Wikipedia pathwaysTIA1
Orthology - Evolution
OrthoDB7072
GeneTree (enSembl)ENSG00000116001
Phylogenetic Trees/Animal Genes : TreeFamTIA1
Homologs : HomoloGeneTIA1
Homology/Alignments : Family Browser (UCSC)TIA1
Gene fusions - Rearrangements
Fusion : MitelmanTIA1/ACTR2 [2p13.3/2p14]  
Fusion : MitelmanTIA1/BCL11A [2p13.3/2p16.1]  
Fusion : MitelmanTIA1/DIRC2 [2p13.3/3q21.1]  
Fusion : MitelmanTIA1/TGFA [2p13.3/2p13.3]  
Fusion : QuiverTIA1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTIA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TIA1
dbVarTIA1
ClinVarTIA1
MonarchTIA1
1000_GenomesTIA1 
Exome Variant ServerTIA1
GNOMAD BrowserENSG00000116001
Varsome BrowserTIA1
ACMGTIA1 variants
VarityP31483
Genomic Variants (DGV)TIA1 [DGVbeta]
DECIPHERTIA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTIA1 
Mutations
ICGC Data PortalTIA1 
TCGA Data PortalTIA1 
Broad Tumor PortalTIA1
OASIS PortalTIA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTIA1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTIA1
Mutations and Diseases : HGMDTIA1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTIA1
DgiDB (Drug Gene Interaction Database)TIA1
DoCM (Curated mutations)TIA1
CIViC (Clinical Interpretations of Variants in Cancer)TIA1
Cancer3DTIA1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603518    604454    619133   
Orphanet8727   
DisGeNETTIA1
MedgenTIA1
Genetic Testing Registry TIA1
NextProtP31483 [Medical]
GENETestsTIA1
Target ValidationTIA1
Huge Navigator TIA1 [HugePedia]
ClinGenTIA1
Clinical trials, drugs, therapy
MyCancerGenomeTIA1
Protein Interactions : CTDTIA1
Pharm GKB GenePA36511
PharosP31483
Clinical trialTIA1
Miscellaneous
canSAR (ICR)TIA1
HarmonizomeTIA1
DataMed IndexTIA1
Probes
Litterature
PubMed126 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTIA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:35:04 CEST 2021

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