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TIAL1 (TIA1 cytotoxic granule associated RNA binding protein like 1)

Identity

Alias (NCBI)TCBP
TIAR
HGNC (Hugo) TIAL1
HGNC Alias symbTIAR
HGNC Alias nameTIA1 related
HGNC Previous nameTIA1 cytotoxic granule-associated RNA-binding protein-like 1
LocusID (NCBI) 7073
Atlas_Id 43936
Location 10q26.11  [Link to chromosome band 10q26]
Location_base_pair Starts at 119573466 and ends at 119597029 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PRDX3 (10q26.11) / TIAL1 (10q26.11)TIAL1 (10q26.11) / CUZD1 (10q26.13)TIAL1 (10q26.11) / DKK3 (11p15.3)
TIAL1 (10q26.11) / MCMBP (10q26.11)TIAL1 (10q26.11) / NCLN (19p13.3)TIAL1 (10q26.11) / PSAP (10q22.1)
TIAL1 10q26.11 / CUZD1 10q26.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TIAL1   11804
Cards
Entrez_Gene (NCBI)TIAL1    TIA1 cytotoxic granule associated RNA binding protein like 1
AliasesTCBP; TIAR
GeneCards (Weizmann)TIAL1
Ensembl hg19 (Hinxton)ENSG00000151923 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000151923 [Gene_View]  ENSG00000151923 [Sequence]  chr10:119573466-119597029 [Contig_View]  TIAL1 [Vega]
ICGC DataPortalENSG00000151923
TCGA cBioPortalTIAL1
AceView (NCBI)TIAL1
Genatlas (Paris)TIAL1
SOURCE (Princeton)TIAL1
Genetics Home Reference (NIH)TIAL1
Genomic and cartography
GoldenPath hg38 (UCSC)TIAL1  -     chr10:119573466-119597029 -  10q26.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TIAL1  -     10q26.11   [Description]    (hg19-Feb_2009)
GoldenPathTIAL1 - 10q26.11 [CytoView hg19]  TIAL1 - 10q26.11 [CytoView hg38]
ImmunoBaseENSG00000151923
Genome Data Viewer NCBITIAL1 [Mapview hg19]  
OMIM603413   
Gene and transcription
Genbank (Entrez)AA972022 AB209260 AK125264 AK290695 AK290984
RefSeq transcript (Entrez)NM_001033925 NM_001323964 NM_001323965 NM_001323967 NM_001323968 NM_001323969 NM_001323970 NM_003252
Consensus coding sequences : CCDS (NCBI)TIAL1
Gene ExpressionTIAL1 [ NCBI-GEO ]   TIAL1 [ EBI - ARRAY_EXPRESS ]   TIAL1 [ SEEK ]   TIAL1 [ MEM ]
Gene Expression Viewer (FireBrowse)TIAL1 [ Firebrowse - Broad ]
GenevisibleExpression of TIAL1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7073
GTEX Portal (Tissue expression)TIAL1
Human Protein AtlasENSG00000151923-TIAL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ01085   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ01085  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ01085
PhosPhoSitePlusQ01085
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait_sf    RBD_domain_sf    RRM_dom    RRM_dom_euk    TIAR_RRM1    TIAR_RRM2    TIAR_RRM3   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  RRM_1 (SM00361)  
Conserved Domain (NCBI)TIAL1
PDB (RSDB)1X4G    2CQI    2DH7   
PDB Europe1X4G    2CQI    2DH7   
PDB (PDBSum)1X4G    2CQI    2DH7   
PDB (IMB)1X4G    2CQI    2DH7   
Structural Biology KnowledgeBase1X4G    2CQI    2DH7   
SCOP (Structural Classification of Proteins)1X4G    2CQI    2DH7   
CATH (Classification of proteins structures)1X4G    2CQI    2DH7   
SuperfamilyQ01085
AlphaFold pdb e-kbQ01085   
Human Protein Atlas [tissue]ENSG00000151923-TIAL1 [tissue]
HPRD04563
Protein Interaction databases
DIP (DOE-UCLA)Q01085
IntAct (EBI)Q01085
BioGRIDTIAL1
STRING (EMBL)TIAL1
ZODIACTIAL1
Ontologies - Pathways
QuickGOQ01085
Ontology : AmiGODNA binding  RNA binding  nucleus  nucleoplasm  cytoplasm  lysosome  regulation of transcription by RNA polymerase II  apoptotic process  defense response  germ cell development  positive regulation of cell population proliferation  fibroblast growth factor receptor signaling pathway  cytoplasmic stress granule  stem cell division  mRNA 3'-UTR AU-rich region binding  ribonucleoprotein complex  
Ontology : EGO-EBIDNA binding  RNA binding  nucleus  nucleoplasm  cytoplasm  lysosome  regulation of transcription by RNA polymerase II  apoptotic process  defense response  germ cell development  positive regulation of cell population proliferation  fibroblast growth factor receptor signaling pathway  cytoplasmic stress granule  stem cell division  mRNA 3'-UTR AU-rich region binding  ribonucleoprotein complex  
Pathways : BIOCARTAWest Nile Virus [Genes]   
NDEx NetworkTIAL1
Atlas of Cancer Signalling NetworkTIAL1
Wikipedia pathwaysTIAL1
Orthology - Evolution
OrthoDB7073
GeneTree (enSembl)ENSG00000151923
Phylogenetic Trees/Animal Genes : TreeFamTIAL1
Homologs : HomoloGeneTIAL1
Homology/Alignments : Family Browser (UCSC)TIAL1
Gene fusions - Rearrangements
Fusion : MitelmanTIAL1/CUZD1 [10q26.11/10q26.13]  
Fusion : MitelmanTIAL1/MCMBP [10q26.11/10q26.11]  
Fusion : QuiverTIAL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTIAL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TIAL1
dbVarTIAL1
ClinVarTIAL1
MonarchTIAL1
1000_GenomesTIAL1 
Exome Variant ServerTIAL1
GNOMAD BrowserENSG00000151923
Varsome BrowserTIAL1
ACMGTIAL1 variants
VarityQ01085
Genomic Variants (DGV)TIAL1 [DGVbeta]
DECIPHERTIAL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTIAL1 
Mutations
ICGC Data PortalTIAL1 
TCGA Data PortalTIAL1 
Broad Tumor PortalTIAL1
OASIS PortalTIAL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTIAL1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTIAL1
Mutations and Diseases : HGMDTIAL1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTIAL1
DgiDB (Drug Gene Interaction Database)TIAL1
DoCM (Curated mutations)TIAL1
CIViC (Clinical Interpretations of Variants in Cancer)TIAL1
Cancer3DTIAL1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603413   
Orphanet
DisGeNETTIAL1
MedgenTIAL1
Genetic Testing Registry TIAL1
NextProtQ01085 [Medical]
GENETestsTIAL1
Target ValidationTIAL1
Huge Navigator TIAL1 [HugePedia]
ClinGenTIAL1
Clinical trials, drugs, therapy
MyCancerGenomeTIAL1
Protein Interactions : CTDTIAL1
Pharm GKB GenePA36513
PharosQ01085
Clinical trialTIAL1
Miscellaneous
canSAR (ICR)TIAL1
HarmonizomeTIAL1
DataMed IndexTIAL1
Probes
Litterature
PubMed87 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTIAL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:04 CEST 2021

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