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TIAL1 (TIA1 cytotoxic granule associated RNA binding protein like 1)

Identity

Alias_namesTIA1 cytotoxic granule-associated RNA-binding protein-like 1
Alias_symbol (synonym)TIAR
Other aliasTCBP
HGNC (Hugo) TIAL1
LocusID (NCBI) 7073
Atlas_Id 43936
Location 10q26.11  [Link to chromosome band 10q26]
Location_base_pair Starts at 119573466 and ends at 119597029 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PRDX3 (10q26.11) / TIAL1 (10q26.11)TIAL1 (10q26.11) / CUZD1 (10q26.13)TIAL1 (10q26.11) / DKK3 (11p15.3)
TIAL1 (10q26.11) / MCMBP (10q26.11)TIAL1 (10q26.11) / NCLN (19p13.3)TIAL1 (10q26.11) / PSAP (10q22.1)
TIAL1 10q26.11 / CUZD1 10q26.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TIAL1   11804
Cards
Entrez_Gene (NCBI)TIAL1  7073  TIA1 cytotoxic granule associated RNA binding protein like 1
AliasesTCBP; TIAR
GeneCards (Weizmann)TIAL1
Ensembl hg19 (Hinxton)ENSG00000151923 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000151923 [Gene_View]  chr10:119573466-119597029 [Contig_View]  TIAL1 [Vega]
ICGC DataPortalENSG00000151923
TCGA cBioPortalTIAL1
AceView (NCBI)TIAL1
Genatlas (Paris)TIAL1
WikiGenes7073
SOURCE (Princeton)TIAL1
Genetics Home Reference (NIH)TIAL1
Genomic and cartography
GoldenPath hg38 (UCSC)TIAL1  -     chr10:119573466-119597029 -  10q26.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TIAL1  -     10q26.11   [Description]    (hg19-Feb_2009)
EnsemblTIAL1 - 10q26.11 [CytoView hg19]  TIAL1 - 10q26.11 [CytoView hg38]
Mapping of homologs : NCBITIAL1 [Mapview hg19]  TIAL1 [Mapview hg38]
OMIM603413   
Gene and transcription
Genbank (Entrez)AA972022 AB209260 AK125264 AK290695 AK290984
RefSeq transcript (Entrez)NM_001033925 NM_001323964 NM_001323965 NM_001323967 NM_001323968 NM_001323969 NM_001323970 NM_003252
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TIAL1
Cluster EST : UnigeneHs.501203 [ NCBI ]
CGAP (NCI)Hs.501203
Alternative Splicing GalleryENSG00000151923
Gene ExpressionTIAL1 [ NCBI-GEO ]   TIAL1 [ EBI - ARRAY_EXPRESS ]   TIAL1 [ SEEK ]   TIAL1 [ MEM ]
Gene Expression Viewer (FireBrowse)TIAL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7073
GTEX Portal (Tissue expression)TIAL1
Human Protein AtlasENSG00000151923-TIAL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ01085   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ01085  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ01085
Splice isoforms : SwissVarQ01085
PhosPhoSitePlusQ01085
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait    RRM_dom    RRM_dom_euk   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  RRM_1 (SM00361)  
Conserved Domain (NCBI)TIAL1
DMDM Disease mutations7073
Blocks (Seattle)TIAL1
PDB (SRS)1X4G    2CQI    2DH7   
PDB (PDBSum)1X4G    2CQI    2DH7   
PDB (IMB)1X4G    2CQI    2DH7   
PDB (RSDB)1X4G    2CQI    2DH7   
Structural Biology KnowledgeBase1X4G    2CQI    2DH7   
SCOP (Structural Classification of Proteins)1X4G    2CQI    2DH7   
CATH (Classification of proteins structures)1X4G    2CQI    2DH7   
SuperfamilyQ01085
Human Protein Atlas [tissue]ENSG00000151923-TIAL1 [tissue]
Peptide AtlasQ01085
HPRD04563
IPIIPI00005615   IPI00647436   IPI01013673   IPI00644708   IPI00646522   IPI01012546   
Protein Interaction databases
DIP (DOE-UCLA)Q01085
IntAct (EBI)Q01085
FunCoupENSG00000151923
BioGRIDTIAL1
STRING (EMBL)TIAL1
ZODIACTIAL1
Ontologies - Pathways
QuickGOQ01085
Ontology : AmiGODNA binding  RNA binding  nucleus  nucleoplasm  cytoplasm  lysosome  regulation of transcription from RNA polymerase II promoter  apoptotic process  defense response  germ cell development  positive regulation of cell proliferation  fibroblast growth factor receptor signaling pathway  cytoplasmic stress granule  AU-rich element binding  stem cell division  extracellular exosome  
Ontology : EGO-EBIDNA binding  RNA binding  nucleus  nucleoplasm  cytoplasm  lysosome  regulation of transcription from RNA polymerase II promoter  apoptotic process  defense response  germ cell development  positive regulation of cell proliferation  fibroblast growth factor receptor signaling pathway  cytoplasmic stress granule  AU-rich element binding  stem cell division  extracellular exosome  
Pathways : BIOCARTAWest Nile Virus [Genes]   
NDEx NetworkTIAL1
Atlas of Cancer Signalling NetworkTIAL1
Wikipedia pathwaysTIAL1
Orthology - Evolution
OrthoDB7073
GeneTree (enSembl)ENSG00000151923
Phylogenetic Trees/Animal Genes : TreeFamTIAL1
HOVERGENQ01085
HOGENOMQ01085
Homologs : HomoloGeneTIAL1
Homology/Alignments : Family Browser (UCSC)TIAL1
Gene fusions - Rearrangements
Fusion : MitelmanTIAL1/CUZD1 [10q26.11/10q26.13]  
Fusion : MitelmanTIAL1/MCMBP [10q26.11/10q26.11]  [t(10;10)(q26;q26)]  
Fusion: TCGA_MDACCTIAL1 10q26.11 CUZD1 10q26.13 BRCA
Tumor Fusion PortalTIAL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTIAL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TIAL1
dbVarTIAL1
ClinVarTIAL1
1000_GenomesTIAL1 
Exome Variant ServerTIAL1
ExAC (Exome Aggregation Consortium)ENSG00000151923
GNOMAD BrowserENSG00000151923
Genetic variants : HAPMAP7073
Genomic Variants (DGV)TIAL1 [DGVbeta]
DECIPHERTIAL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTIAL1 
Mutations
ICGC Data PortalTIAL1 
TCGA Data PortalTIAL1 
Broad Tumor PortalTIAL1
OASIS PortalTIAL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTIAL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTIAL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TIAL1
DgiDB (Drug Gene Interaction Database)TIAL1
DoCM (Curated mutations)TIAL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TIAL1 (select a term)
intoGenTIAL1
Cancer3DTIAL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603413   
Orphanet
DisGeNETTIAL1
MedgenTIAL1
Genetic Testing Registry TIAL1
NextProtQ01085 [Medical]
TSGene7073
GENETestsTIAL1
Target ValidationTIAL1
Huge Navigator TIAL1 [HugePedia]
snp3D : Map Gene to Disease7073
BioCentury BCIQTIAL1
ClinGenTIAL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7073
Chemical/Pharm GKB GenePA36513
Clinical trialTIAL1
Miscellaneous
canSAR (ICR)TIAL1 (select the gene name)
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTIAL1
EVEXTIAL1
GoPubMedTIAL1
iHOPTIAL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:38:26 CET 2017

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