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TIAM2 (TIAM Rac1 associated GEF 2)

Identity

Alias (NCBI)STEF
TIAM-2
HGNC (Hugo) TIAM2
HGNC Alias symbSTEF
HGNC Alias nameSif and Tiam1-like exchange factor
HGNC Previous nameT-cell lymphoma invasion and metastasis 2
LocusID (NCBI) 26230
Atlas_Id 42558
Location 6q25.2  [Link to chromosome band 6q25]
Location_base_pair Starts at 155090289 and ends at 155257723 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANKHD1 (5q31.3) / TIAM2 (6q25.3)ARID1B (6q25.3) / TIAM2 (6q25.3)GORASP2 (2q31.1) / TIAM2 (6q25.3)
TIAM2 (6q25.3) / MKLN1 (7q32.3)TIAM2 (6q25.3) / NTN4 (12q22)TIAM2 (6q25.3) / PAPD4 (5q14.1)
TIAM2 (6q25.3) / RAD1 (5p13.2)TIAM2 (6q25.3) / TFB1M (6q25.3)TIAM2 (6q25.3) / TMEM57 (1p36.11)
ANKHD1 5q31.3 / TIAM2 6q25.3ARID1B 6q25.3 / TIAM2 6q25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TIAM2   11806
Cards
Entrez_Gene (NCBI)TIAM2    TIAM Rac1 associated GEF 2
AliasesSTEF; TIAM-2
GeneCards (Weizmann)TIAM2
Ensembl hg19 (Hinxton)ENSG00000146426 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146426 [Gene_View]  ENSG00000146426 [Sequence]  chr6:155090289-155257723 [Contig_View]  TIAM2 [Vega]
ICGC DataPortalENSG00000146426
TCGA cBioPortalTIAM2
AceView (NCBI)TIAM2
Genatlas (Paris)TIAM2
SOURCE (Princeton)TIAM2
Genetics Home Reference (NIH)TIAM2
Genomic and cartography
GoldenPath hg38 (UCSC)TIAM2  -     chr6:155090289-155257723 +  6q25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TIAM2  -     6q25.2   [Description]    (hg19-Feb_2009)
GoldenPathTIAM2 - 6q25.2 [CytoView hg19]  TIAM2 - 6q25.2 [CytoView hg38]
ImmunoBaseENSG00000146426
Genome Data Viewer NCBITIAM2 [Mapview hg19]  
OMIM604709   
Gene and transcription
Genbank (Entrez)AF120323 AF120324 AF195656 AK123859 AK125459
RefSeq transcript (Entrez)NM_001010927 NM_001384546 NM_001384547 NM_012454
Consensus coding sequences : CCDS (NCBI)TIAM2
Gene ExpressionTIAM2 [ NCBI-GEO ]   TIAM2 [ EBI - ARRAY_EXPRESS ]   TIAM2 [ SEEK ]   TIAM2 [ MEM ]
Gene Expression Viewer (FireBrowse)TIAM2 [ Firebrowse - Broad ]
GenevisibleExpression of TIAM2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26230
GTEX Portal (Tissue expression)TIAM2
Human Protein AtlasENSG00000146426-TIAM2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IVF5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IVF5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IVF5
PhosPhoSitePlusQ8IVF5
Domaine pattern : Prosite (Expaxy)DH_1 (PS00741)    DH_2 (PS50010)    PDZ (PS50106)    PH_DOMAIN (PS50003)    RBD (PS50898)   
Domains : Interpro (EBI)DBL_dom_sf    DH-domain    GDS_CDC24_CS    PDZ    PDZ_sf    PH-like_dom_sf    PH_domain    RBD_dom    Tiam1/Tiam2/Sif    TIAM1_CC-Ex   
Domain families : Pfam (Sanger)PDZ (PF00595)    PH (PF00169)    RhoGEF (PF00621)    Tiam_CC_Ex (PF18385)   
Domain families : Pfam (NCBI)pfam00595    pfam00169    pfam00621    pfam18385   
Domain families : Smart (EMBL)PDZ (SM00228)  PH (SM00233)  RBD (SM00455)  RhoGEF (SM00325)  
Conserved Domain (NCBI)TIAM2
SuperfamilyQ8IVF5
AlphaFold pdb e-kbQ8IVF5   
Human Protein Atlas [tissue]ENSG00000146426-TIAM2 [tissue]
HPRD05273
Protein Interaction databases
DIP (DOE-UCLA)Q8IVF5
IntAct (EBI)Q8IVF5
BioGRIDTIAM2
STRING (EMBL)TIAM2
ZODIACTIAM2
Ontologies - Pathways
QuickGOQ8IVF5
Ontology : AmiGOguanyl-nucleotide exchange factor activity  cytosol  G protein-coupled receptor signaling pathway  small GTPase mediated signal transduction  membrane  regulation of metabolic process  lamellipodium  filopodium  growth cone  positive regulation of apoptotic process  perikaryon  synapse  positive regulation of axonogenesis  regulation of small GTPase mediated signal transduction  extracellular exosome  activation of GTPase activity  
Ontology : EGO-EBIguanyl-nucleotide exchange factor activity  cytosol  G protein-coupled receptor signaling pathway  small GTPase mediated signal transduction  membrane  regulation of metabolic process  lamellipodium  filopodium  growth cone  positive regulation of apoptotic process  perikaryon  synapse  positive regulation of axonogenesis  regulation of small GTPase mediated signal transduction  extracellular exosome  activation of GTPase activity  
NDEx NetworkTIAM2
Atlas of Cancer Signalling NetworkTIAM2
Wikipedia pathwaysTIAM2
Orthology - Evolution
OrthoDB26230
GeneTree (enSembl)ENSG00000146426
Phylogenetic Trees/Animal Genes : TreeFamTIAM2
Homologs : HomoloGeneTIAM2
Homology/Alignments : Family Browser (UCSC)TIAM2
Gene fusions - Rearrangements
Fusion : MitelmanANKHD1/TIAM2 [5q31.3/6q25.3]  
Fusion : MitelmanARID1B/TIAM2 [6q25.3/6q25.3]  
Fusion : QuiverTIAM2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTIAM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TIAM2
dbVarTIAM2
ClinVarTIAM2
MonarchTIAM2
1000_GenomesTIAM2 
Exome Variant ServerTIAM2
GNOMAD BrowserENSG00000146426
Varsome BrowserTIAM2
ACMGTIAM2 variants
VarityQ8IVF5
Genomic Variants (DGV)TIAM2 [DGVbeta]
DECIPHERTIAM2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTIAM2 
Mutations
ICGC Data PortalTIAM2 
TCGA Data PortalTIAM2 
Broad Tumor PortalTIAM2
OASIS PortalTIAM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTIAM2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTIAM2
Mutations and Diseases : HGMDTIAM2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTIAM2
DgiDB (Drug Gene Interaction Database)TIAM2
DoCM (Curated mutations)TIAM2
CIViC (Clinical Interpretations of Variants in Cancer)TIAM2
Cancer3DTIAM2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604709   
Orphanet
DisGeNETTIAM2
MedgenTIAM2
Genetic Testing Registry TIAM2
NextProtQ8IVF5 [Medical]
GENETestsTIAM2
Target ValidationTIAM2
Huge Navigator TIAM2 [HugePedia]
ClinGenTIAM2
Clinical trials, drugs, therapy
MyCancerGenomeTIAM2
Protein Interactions : CTDTIAM2
Pharm GKB GenePA36515
PharosQ8IVF5
Clinical trialTIAM2
Miscellaneous
canSAR (ICR)TIAM2
HarmonizomeTIAM2
DataMed IndexTIAM2
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTIAM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:05 CEST 2021

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