TIAM2 (TIAM Rac1 associated GEF 2)

2003-06-01  

Identity

HGNC
LOCATION
6q25.2
LOCUSID
ALIAS
STEF,TIAM-2
FUSION GENES

Other Information

Locus ID:

NCBI: 26230
MIM: 604709
HGNC: 11806
Ensembl: ENSG00000146426

Variants:

dbSNP: 26230
ClinVar: 26230
TCGA: ENSG00000146426
COSMIC: TIAM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146426ENST00000275246Q8IVF5
ENSG00000146426ENST00000360366Q8IVF5
ENSG00000146426ENST00000456877Q8IVF5
ENSG00000146426ENST00000461783Q8IVF5
ENSG00000146426ENST00000462408H7C5V6
ENSG00000146426ENST00000528391E9PKT1
ENSG00000146426ENST00000528535E9PMZ8
ENSG00000146426ENST00000529824Q8IVF5
ENSG00000146426ENST00000535231F5H1M3
ENSG00000146426ENST00000535583F5H6W6
ENSG00000146426ENST00000538270F5H6R0
ENSG00000146426ENST00000543712H0YGV1
ENSG00000146426ENST00000545347F5H1M3

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
103642281999Identification of the stef gene that encodes a novel guanine nucleotide exchange factor specific for Rac1.39
214691462012Expression of T-cell lymphoma invasion and metastasis 2 (TIAM2) promotes proliferation and invasion of liver cancer.18
267634862016Sp1-mediated ectopic expression of T-cell lymphoma invasion and metastasis 2 in hepatocellular carcinoma.15
275977582016Tiam-Rac signaling mediates trans-endocytosis of ephrin receptor EphB2 and is important for cell repulsion.12
119009752002Expression of stef, an activator of Rac1, correlates with the stages of neuronal morphological development in the mouse brain.10
243775222013TIAM2 enhances non-small cell lung cancer cell invasion and motility.8
298443642018STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap.7

Citation

Dessen P

TIAM2 (TIAM Rac1 associated GEF 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42558/tiam2