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TIAM2 (T cell lymphoma invasion and metastasis 2)

Identity

Alias_symbol (synonym)STEF
Other aliasTIAM-2
HGNC (Hugo) TIAM2
LocusID (NCBI) 26230
Atlas_Id 42558
Location 6q25.2  [Link to chromosome band 6q25]
Location_base_pair Starts at 155090289 and ends at 155257723 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANKHD1 (5q31.3) / TIAM2 (6q25.3)ARID1B (6q25.3) / TIAM2 (6q25.3)GORASP2 (2q31.1) / TIAM2 (6q25.3)
TIAM2 (6q25.3) / MKLN1 (7q32.3)TIAM2 (6q25.3) / NTN4 (12q22)TIAM2 (6q25.3) / PAPD4 (5q14.1)
TIAM2 (6q25.3) / RAD1 (5p13.2)TIAM2 (6q25.3) / TFB1M (6q25.3)TIAM2 (6q25.3) / TMEM57 (1p36.11)
ANKHD1 5q31.3 / TIAM2 6q25.3ARID1B 6q25.3 / TIAM2 6q25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(5;6)(q31;q25) ANKHD1/TIAM2
ARID1B/TIAM2 (6q25)


External links

Nomenclature
HGNC (Hugo)TIAM2   11806
Cards
Entrez_Gene (NCBI)TIAM2  26230  T cell lymphoma invasion and metastasis 2
AliasesSTEF; TIAM-2
GeneCards (Weizmann)TIAM2
Ensembl hg19 (Hinxton)ENSG00000146426 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146426 [Gene_View]  ENSG00000146426 [Sequence]  chr6:155090289-155257723 [Contig_View]  TIAM2 [Vega]
ICGC DataPortalENSG00000146426
TCGA cBioPortalTIAM2
AceView (NCBI)TIAM2
Genatlas (Paris)TIAM2
WikiGenes26230
SOURCE (Princeton)TIAM2
Genetics Home Reference (NIH)TIAM2
Genomic and cartography
GoldenPath hg38 (UCSC)TIAM2  -     chr6:155090289-155257723 +  6q25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TIAM2  -     6q25.2   [Description]    (hg19-Feb_2009)
EnsemblTIAM2 - 6q25.2 [CytoView hg19]  TIAM2 - 6q25.2 [CytoView hg38]
Mapping of homologs : NCBITIAM2 [Mapview hg19]  TIAM2 [Mapview hg38]
OMIM604709   
Gene and transcription
Genbank (Entrez)AF120323 AF120324 AF195656 AK123859 AK125459
RefSeq transcript (Entrez)NM_001010927 NM_012454
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TIAM2
Cluster EST : UnigeneHs.586279 [ NCBI ]
CGAP (NCI)Hs.586279
Alternative Splicing GalleryENSG00000146426
Gene ExpressionTIAM2 [ NCBI-GEO ]   TIAM2 [ EBI - ARRAY_EXPRESS ]   TIAM2 [ SEEK ]   TIAM2 [ MEM ]
Gene Expression Viewer (FireBrowse)TIAM2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26230
GTEX Portal (Tissue expression)TIAM2
Human Protein AtlasENSG00000146426-TIAM2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IVF5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IVF5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IVF5
Splice isoforms : SwissVarQ8IVF5
PhosPhoSitePlusQ8IVF5
Domaine pattern : Prosite (Expaxy)DH_1 (PS00741)    DH_2 (PS50010)    PDZ (PS50106)    PH_DOMAIN (PS50003)    RBD (PS50898)   
Domains : Interpro (EBI)DBL_dom_sf    DH-domain    GDS_CDC24_CS    PDZ    PDZ_sf    PH-like_dom_sf    PH_domain    RBD_dom   
Domain families : Pfam (Sanger)PDZ (PF00595)    PH (PF00169)    RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam00595    pfam00169    pfam00621   
Domain families : Smart (EMBL)PDZ (SM00228)  PH (SM00233)  RBD (SM00455)  RhoGEF (SM00325)  
Conserved Domain (NCBI)TIAM2
DMDM Disease mutations26230
Blocks (Seattle)TIAM2
SuperfamilyQ8IVF5
Human Protein Atlas [tissue]ENSG00000146426-TIAM2 [tissue]
Peptide AtlasQ8IVF5
HPRD05273
IPIIPI00827882   IPI00018363   IPI00816630   IPI00885152   IPI01013367   IPI00885170   IPI00980005   IPI00976969   IPI01016058   IPI01015617   IPI01009950   IPI01009547   IPI01014121   IPI01013662   
Protein Interaction databases
DIP (DOE-UCLA)Q8IVF5
IntAct (EBI)Q8IVF5
FunCoupENSG00000146426
BioGRIDTIAM2
STRING (EMBL)TIAM2
ZODIACTIAM2
Ontologies - Pathways
QuickGOQ8IVF5
Ontology : AmiGOguanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  GTPase activator activity  cytosol  G protein-coupled receptor signaling pathway  membrane  regulation of lipid metabolic process  lamellipodium  filopodium  growth cone  regulation of Rho protein signal transduction  intracellular signal transduction  positive regulation of apoptotic process  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  extracellular exosome  
Ontology : EGO-EBIguanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  GTPase activator activity  cytosol  G protein-coupled receptor signaling pathway  membrane  regulation of lipid metabolic process  lamellipodium  filopodium  growth cone  regulation of Rho protein signal transduction  intracellular signal transduction  positive regulation of apoptotic process  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  extracellular exosome  
NDEx NetworkTIAM2
Atlas of Cancer Signalling NetworkTIAM2
Wikipedia pathwaysTIAM2
Orthology - Evolution
OrthoDB26230
GeneTree (enSembl)ENSG00000146426
Phylogenetic Trees/Animal Genes : TreeFamTIAM2
HOVERGENQ8IVF5
HOGENOMQ8IVF5
Homologs : HomoloGeneTIAM2
Homology/Alignments : Family Browser (UCSC)TIAM2
Gene fusions - Rearrangements
Fusion : MitelmanANKHD1/TIAM2 [5q31.3/6q25.3]  [t(5;6)(q31;q25)]  
Fusion : MitelmanARID1B/TIAM2 [6q25.3/6q25.3]  [t(6;6)(q25;q25)]  
Fusion PortalANKHD1 5q31.3 TIAM2 6q25.3 BRCA
Fusion PortalARID1B 6q25.3 TIAM2 6q25.3 GBM
Fusion : QuiverTIAM2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTIAM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TIAM2
dbVarTIAM2
ClinVarTIAM2
1000_GenomesTIAM2 
Exome Variant ServerTIAM2
ExAC (Exome Aggregation Consortium)ENSG00000146426
GNOMAD BrowserENSG00000146426
Varsome BrowserTIAM2
Genetic variants : HAPMAP26230
Genomic Variants (DGV)TIAM2 [DGVbeta]
DECIPHERTIAM2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTIAM2 
Mutations
ICGC Data PortalTIAM2 
TCGA Data PortalTIAM2 
Broad Tumor PortalTIAM2
OASIS PortalTIAM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTIAM2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTIAM2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TIAM2
DgiDB (Drug Gene Interaction Database)TIAM2
DoCM (Curated mutations)TIAM2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TIAM2 (select a term)
intoGenTIAM2
Cancer3DTIAM2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604709   
Orphanet
DisGeNETTIAM2
MedgenTIAM2
Genetic Testing Registry TIAM2
NextProtQ8IVF5 [Medical]
TSGene26230
GENETestsTIAM2
Target ValidationTIAM2
Huge Navigator TIAM2 [HugePedia]
snp3D : Map Gene to Disease26230
BioCentury BCIQTIAM2
ClinGenTIAM2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26230
Chemical/Pharm GKB GenePA36515
Clinical trialTIAM2
Miscellaneous
canSAR (ICR)TIAM2 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTIAM2
EVEXTIAM2
GoPubMedTIAM2
iHOPTIAM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:44:59 CET 2018

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