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TICAM2 (toll like receptor adaptor molecule 2)

Identity

Alias_namestoll-like receptor adaptor molecule 2
Alias_symbol (synonym)TRAM
TICAM-2
TIRP
Other aliasMyD88-4
TIRAP3
HGNC (Hugo) TICAM2
LocusID (NCBI) 353376
Atlas_Id 74694
Location 5q22.3  [Link to chromosome band 5q22]
Location_base_pair Starts at 115578496 and ends at 115602479 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TICAM2   21354
Cards
Entrez_Gene (NCBI)TICAM2  353376  toll like receptor adaptor molecule 2
AliasesMyD88-4; TICAM-2; TIRAP3; TIRP; 
TRAM
GeneCards (Weizmann)TICAM2
Ensembl hg19 (Hinxton)ENSG00000243414 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000243414 [Gene_View]  chr5:115578496-115602479 [Contig_View]  TICAM2 [Vega]
ICGC DataPortalENSG00000243414
TCGA cBioPortalTICAM2
AceView (NCBI)TICAM2
Genatlas (Paris)TICAM2
WikiGenes353376
SOURCE (Princeton)TICAM2
Genetics Home Reference (NIH)TICAM2
Genomic and cartography
GoldenPath hg38 (UCSC)TICAM2  -     chr5:115578496-115602479 -  5q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TICAM2  -     5q22.3   [Description]    (hg19-Feb_2009)
EnsemblTICAM2 - 5q22.3 [CytoView hg19]  TICAM2 - 5q22.3 [CytoView hg38]
Mapping of homologs : NCBITICAM2 [Mapview hg19]  TICAM2 [Mapview hg38]
OMIM608321   
Gene and transcription
Genbank (Entrez)AB002444 AB091054 AB097022 AB109098 AB446491
RefSeq transcript (Entrez)NM_021649
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TICAM2
Cluster EST : UnigeneHs.718838 [ NCBI ]
CGAP (NCI)Hs.718838
Alternative Splicing GalleryENSG00000243414
Gene ExpressionTICAM2 [ NCBI-GEO ]   TICAM2 [ EBI - ARRAY_EXPRESS ]   TICAM2 [ SEEK ]   TICAM2 [ MEM ]
Gene Expression Viewer (FireBrowse)TICAM2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)353376
GTEX Portal (Tissue expression)TICAM2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86XR7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86XR7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86XR7
Splice isoforms : SwissVarQ86XR7
PhosPhoSitePlusQ86XR7
Domaine pattern : Prosite (Expaxy)TIR (PS50104)   
Domains : Interpro (EBI)TIR_dom    TMP21-related   
Domain families : Pfam (Sanger)TIR_2 (PF13676)   
Domain families : Pfam (NCBI)pfam13676   
Conserved Domain (NCBI)TICAM2
DMDM Disease mutations353376
Blocks (Seattle)TICAM2
PDB (SRS)2M1W   
PDB (PDBSum)2M1W   
PDB (IMB)2M1W   
PDB (RSDB)2M1W   
Structural Biology KnowledgeBase2M1W   
SCOP (Structural Classification of Proteins)2M1W   
CATH (Classification of proteins structures)2M1W   
SuperfamilyQ86XR7
Human Protein AtlasENSG00000243414
Peptide AtlasQ86XR7
HPRD16313
IPIIPI00428967   
Protein Interaction databases
DIP (DOE-UCLA)Q86XR7
IntAct (EBI)Q86XR7
FunCoupENSG00000243414
BioGRIDTICAM2
STRING (EMBL)TICAM2
ZODIACTICAM2
Ontologies - Pathways
QuickGOQ86XR7
Ontology : AmiGOMyD88-independent toll-like receptor signaling pathway  signal transducer activity  protein binding  phospholipid binding  endoplasmic reticulum  Golgi apparatus  plasma membrane  inflammatory response  I-kappaB kinase/NF-kappaB signaling  endosome membrane  secretory granule membrane  early endosome membrane  late endosome membrane  positive regulation of interferon-gamma production  positive regulation of interleukin-6 production  negative regulation of MyD88-independent toll-like receptor signaling pathway  toll-like receptor 4 signaling pathway  positive regulation of toll-like receptor 4 signaling pathway  TRIF-dependent toll-like receptor signaling pathway  TRAM-dependent toll-like receptor 4 signaling pathway  positive regulation of I-kappaB kinase/NF-kappaB signaling  neutrophil degranulation  innate immune response  defense response to virus  necroptotic process  response to interleukin-12  cellular response to lipopolysaccharide  positive regulation of chemokine (C-C motif) ligand 5 production  apoptotic signaling pathway  positive regulation of interleukin-18-mediated signaling pathway  
Ontology : EGO-EBIMyD88-independent toll-like receptor signaling pathway  signal transducer activity  protein binding  phospholipid binding  endoplasmic reticulum  Golgi apparatus  plasma membrane  inflammatory response  I-kappaB kinase/NF-kappaB signaling  endosome membrane  secretory granule membrane  early endosome membrane  late endosome membrane  positive regulation of interferon-gamma production  positive regulation of interleukin-6 production  negative regulation of MyD88-independent toll-like receptor signaling pathway  toll-like receptor 4 signaling pathway  positive regulation of toll-like receptor 4 signaling pathway  TRIF-dependent toll-like receptor signaling pathway  TRAM-dependent toll-like receptor 4 signaling pathway  positive regulation of I-kappaB kinase/NF-kappaB signaling  neutrophil degranulation  innate immune response  defense response to virus  necroptotic process  response to interleukin-12  cellular response to lipopolysaccharide  positive regulation of chemokine (C-C motif) ligand 5 production  apoptotic signaling pathway  positive regulation of interleukin-18-mediated signaling pathway  
Pathways : KEGGNF-kappa B signaling pathway    Toll-like receptor signaling pathway    Pertussis    Hepatitis B   
NDEx NetworkTICAM2
Atlas of Cancer Signalling NetworkTICAM2
Wikipedia pathwaysTICAM2
Orthology - Evolution
OrthoDB353376
GeneTree (enSembl)ENSG00000243414
Phylogenetic Trees/Animal Genes : TreeFamTICAM2
HOVERGENQ86XR7
HOGENOMQ86XR7
Homologs : HomoloGeneTICAM2
Homology/Alignments : Family Browser (UCSC)TICAM2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTICAM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TICAM2
dbVarTICAM2
ClinVarTICAM2
1000_GenomesTICAM2 
Exome Variant ServerTICAM2
ExAC (Exome Aggregation Consortium)TICAM2 (select the gene name)
Genetic variants : HAPMAP353376
Genomic Variants (DGV)TICAM2 [DGVbeta]
DECIPHERTICAM2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTICAM2 
Mutations
ICGC Data PortalTICAM2 
TCGA Data PortalTICAM2 
Broad Tumor PortalTICAM2
OASIS PortalTICAM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTICAM2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTICAM2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TICAM2
DgiDB (Drug Gene Interaction Database)TICAM2
DoCM (Curated mutations)TICAM2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TICAM2 (select a term)
intoGenTICAM2
Cancer3DTICAM2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608321   
Orphanet
MedgenTICAM2
Genetic Testing Registry TICAM2
NextProtQ86XR7 [Medical]
TSGene353376
GENETestsTICAM2
Target ValidationTICAM2
Huge Navigator TICAM2 [HugePedia]
snp3D : Map Gene to Disease353376
BioCentury BCIQTICAM2
ClinGenTICAM2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD353376
Chemical/Pharm GKB GenePA134881157
Clinical trialTICAM2
Miscellaneous
canSAR (ICR)TICAM2 (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTICAM2
EVEXTICAM2
GoPubMedTICAM2
iHOPTICAM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:41:26 CEST 2017

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