TICAM2 (toll like receptor adaptor molecule 2)

2014-11-01  

Identity

HGNC
LOCATION
5q22.3
LOCUSID
ALIAS
MyD88-4,TICAM-2,TIRAP3,TIRP,TRAM

Other Information

Locus ID:

NCBI: 353376
MIM: 608321
HGNC: 21354
Ensembl: ENSG00000243414

Variants:

dbSNP: 353376
ClinVar: 353376
TCGA: ENSG00000243414
COSMIC: TICAM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000243414ENST00000427199Q86XR7

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Toll-like receptor signaling pathwayKEGGko04620
Toll-like receptor signaling pathwayKEGGhsa04620
PertussisKEGGko05133
PertussisKEGGhsa05133
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Hepatitis BKEGGhsa05161
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 3 (TLR3) CascadeREACTOMER-HSA-168164
MyD88-independent TLR3/TLR4 cascadeREACTOMER-HSA-166166
TRIF-mediated TLR3/TLR4 signalingREACTOMER-HSA-937061
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilonREACTOMER-HSA-936964
IKK complex recruitment mediated by RIP1REACTOMER-HSA-937041
TRIF-mediated programmed cell deathREACTOMER-HSA-2562578
TRAF6 mediated induction of TAK1 complexREACTOMER-HSA-937072
Toll Like Receptor 7/8 (TLR7/8) CascadeREACTOMER-HSA-168181
MyD88 dependent cascade initiated on endosomeREACTOMER-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationREACTOMER-HSA-975138
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulationREACTOMER-HSA-975163
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Caspase activation via extrinsic apoptotic signalling pathwayREACTOMER-HSA-5357769
Ligand-dependent caspase activationREACTOMER-HSA-140534
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
182970732008TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta.458
145197652003TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta.86
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
166036312006The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.61
195434012009Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women.59
208021452010Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule.46
194121842009TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway.41
229702352012Human cytomegalovirus induces TLR4 signaling components in monocytes altering TIRAP, TRAM and downstream interferon-beta and TNF-alpha expression.22
255212282015Polymorphisms in TICAM2 and IL1B are associated with TB.20
226855672012TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88.13

Citation

Dessen P

TICAM2 (toll like receptor adaptor molecule 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74694/ticam2