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TICAM2 (toll like receptor adaptor molecule 2)

Identity

Alias (NCBI)MyD88-4
TICAM-2
TIRAP3
TIRP
TRAM
HGNC (Hugo) TICAM2
HGNC Alias symbTRAM
TICAM-2
TIRP
HGNC Previous nametoll-like receptor adaptor molecule 2
LocusID (NCBI) 353376
Atlas_Id 74694
Location 5q22.3  [Link to chromosome band 5q22]
Location_base_pair Starts at 115578496 and ends at 115602479 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TICAM2   21354
Cards
Entrez_Gene (NCBI)TICAM2    toll like receptor adaptor molecule 2
AliasesMyD88-4; TICAM-2; TIRAP3; TIRP; 
TRAM
GeneCards (Weizmann)TICAM2
Ensembl hg19 (Hinxton)ENSG00000243414 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000243414 [Gene_View]  ENSG00000243414 [Sequence]  chr5:115578496-115602479 [Contig_View]  TICAM2 [Vega]
ICGC DataPortalENSG00000243414
TCGA cBioPortalTICAM2
AceView (NCBI)TICAM2
Genatlas (Paris)TICAM2
SOURCE (Princeton)TICAM2
Genetics Home Reference (NIH)TICAM2
Genomic and cartography
GoldenPath hg38 (UCSC)TICAM2  -     chr5:115578496-115602479 -  5q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TICAM2  -     5q22.3   [Description]    (hg19-Feb_2009)
GoldenPathTICAM2 - 5q22.3 [CytoView hg19]  TICAM2 - 5q22.3 [CytoView hg38]
ImmunoBaseENSG00000243414
Genome Data Viewer NCBITICAM2 [Mapview hg19]  
OMIM608321   
Gene and transcription
Genbank (Entrez)AB002444 AB091054 AB097022 AB109098 AB446491
RefSeq transcript (Entrez)NM_021649
Consensus coding sequences : CCDS (NCBI)TICAM2
Gene ExpressionTICAM2 [ NCBI-GEO ]   TICAM2 [ EBI - ARRAY_EXPRESS ]   TICAM2 [ SEEK ]   TICAM2 [ MEM ]
Gene Expression Viewer (FireBrowse)TICAM2 [ Firebrowse - Broad ]
GenevisibleExpression of TICAM2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)353376
GTEX Portal (Tissue expression)TICAM2
Human Protein AtlasENSG00000243414-TICAM2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86XR7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86XR7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86XR7
PhosPhoSitePlusQ86XR7
Domaine pattern : Prosite (Expaxy)TIR (PS50104)   
Domains : Interpro (EBI)Emp24-like    TIR_dom    Toll_tir_struct_dom_sf   
Domain families : Pfam (Sanger)TIR_2 (PF13676)   
Domain families : Pfam (NCBI)pfam13676   
Conserved Domain (NCBI)TICAM2
PDB (RSDB)2M1W   
PDB Europe2M1W   
PDB (PDBSum)2M1W   
PDB (IMB)2M1W   
Structural Biology KnowledgeBase2M1W   
SCOP (Structural Classification of Proteins)2M1W   
CATH (Classification of proteins structures)2M1W   
SuperfamilyQ86XR7
AlphaFold pdb e-kbQ86XR7   
Human Protein Atlas [tissue]ENSG00000243414-TICAM2 [tissue]
HPRD16313
Protein Interaction databases
DIP (DOE-UCLA)Q86XR7
IntAct (EBI)Q86XR7
BioGRIDTICAM2
STRING (EMBL)TICAM2
ZODIACTICAM2
Ontologies - Pathways
QuickGOQ86XR7
Ontology : AmiGOphagocytic cup  MyD88-independent toll-like receptor signaling pathway  protein binding  endoplasmic reticulum  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  plasma membrane  intracellular protein transport  endoplasmic reticulum to Golgi vesicle-mediated transport  phagocytosis  inflammatory response  Golgi organization  I-kappaB kinase/NF-kappaB signaling  endosome membrane  COPII-coated ER to Golgi transport vesicle  secretory granule membrane  early endosome membrane  late endosome membrane  negative regulation of MyD88-independent toll-like receptor signaling pathway  toll-like receptor 4 signaling pathway  positive regulation of toll-like receptor 4 signaling pathway  TRIF-dependent toll-like receptor signaling pathway  TRAM-dependent toll-like receptor 4 signaling pathway  cell projection  positive regulation of I-kappaB kinase/NF-kappaB signaling  neutrophil degranulation  innate immune response  necroptotic process  cellular response to lipopolysaccharide  apoptotic signaling pathway  positive regulation of interleukin-18-mediated signaling pathway  
Ontology : EGO-EBIphagocytic cup  MyD88-independent toll-like receptor signaling pathway  protein binding  endoplasmic reticulum  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  plasma membrane  intracellular protein transport  endoplasmic reticulum to Golgi vesicle-mediated transport  phagocytosis  inflammatory response  Golgi organization  I-kappaB kinase/NF-kappaB signaling  endosome membrane  COPII-coated ER to Golgi transport vesicle  secretory granule membrane  early endosome membrane  late endosome membrane  negative regulation of MyD88-independent toll-like receptor signaling pathway  toll-like receptor 4 signaling pathway  positive regulation of toll-like receptor 4 signaling pathway  TRIF-dependent toll-like receptor signaling pathway  TRAM-dependent toll-like receptor 4 signaling pathway  cell projection  positive regulation of I-kappaB kinase/NF-kappaB signaling  neutrophil degranulation  innate immune response  necroptotic process  cellular response to lipopolysaccharide  apoptotic signaling pathway  positive regulation of interleukin-18-mediated signaling pathway  
Pathways : KEGGToll-like receptor signaling pathway   
NDEx NetworkTICAM2
Atlas of Cancer Signalling NetworkTICAM2
Wikipedia pathwaysTICAM2
Orthology - Evolution
OrthoDB353376
GeneTree (enSembl)ENSG00000243414
Phylogenetic Trees/Animal Genes : TreeFamTICAM2
Homologs : HomoloGeneTICAM2
Homology/Alignments : Family Browser (UCSC)TICAM2
Gene fusions - Rearrangements
Fusion : QuiverTICAM2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTICAM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TICAM2
dbVarTICAM2
ClinVarTICAM2
MonarchTICAM2
1000_GenomesTICAM2 
Exome Variant ServerTICAM2
GNOMAD BrowserENSG00000243414
Varsome BrowserTICAM2
ACMGTICAM2 variants
VarityQ86XR7
Genomic Variants (DGV)TICAM2 [DGVbeta]
DECIPHERTICAM2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTICAM2 
Mutations
ICGC Data PortalTICAM2 
TCGA Data PortalTICAM2 
Broad Tumor PortalTICAM2
OASIS PortalTICAM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTICAM2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTICAM2
Mutations and Diseases : HGMDTICAM2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTICAM2
DgiDB (Drug Gene Interaction Database)TICAM2
DoCM (Curated mutations)TICAM2
CIViC (Clinical Interpretations of Variants in Cancer)TICAM2
Cancer3DTICAM2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608321   
Orphanet
DisGeNETTICAM2
MedgenTICAM2
Genetic Testing Registry TICAM2
NextProtQ86XR7 [Medical]
GENETestsTICAM2
Target ValidationTICAM2
Huge Navigator TICAM2 [HugePedia]
ClinGenTICAM2
Clinical trials, drugs, therapy
MyCancerGenomeTICAM2
Protein Interactions : CTDTICAM2
Pharm GKB GenePA134881157
PharosQ86XR7
Clinical trialTICAM2
Miscellaneous
canSAR (ICR)TICAM2
HarmonizomeTICAM2
DataMed IndexTICAM2
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTICAM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 16:25:31 CEST 2021

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