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TICRR (TOPBP1 interacting checkpoint and replication regulator)

Identity

Alias (NCBI)C15orf42
SLD3
Treslin
HGNC (Hugo) TICRR
HGNC Alias symbMGC45866
FLJ41618
Treslin
SLD3
HGNC Alias nameTOPBP1-interacting replication-stimulating protein
 SLD3 homolog (S. cerevisiae)
HGNC Previous nameC15orf42
HGNC Previous namechromosome 15 open reading frame 42
LocusID (NCBI) 90381
Atlas_Id 51393
Location 15q26.1  [Link to chromosome band 15q26]
Location_base_pair Starts at 89575469 and ends at 89628022 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DPP8 (15q22.31) / TICRR (15q26.1)TICRR (15q26.1) / ATXN7L1 (7q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TICRR   28704
Cards
Entrez_Gene (NCBI)TICRR    TOPBP1 interacting checkpoint and replication regulator
AliasesC15orf42; SLD3; Treslin
GeneCards (Weizmann)TICRR
Ensembl hg19 (Hinxton)ENSG00000140534 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140534 [Gene_View]  ENSG00000140534 [Sequence]  chr15:89575469-89628022 [Contig_View]  TICRR [Vega]
ICGC DataPortalENSG00000140534
TCGA cBioPortalTICRR
AceView (NCBI)TICRR
Genatlas (Paris)TICRR
SOURCE (Princeton)TICRR
Genetics Home Reference (NIH)TICRR
Genomic and cartography
GoldenPath hg38 (UCSC)TICRR  -     chr15:89575469-89628022 +  15q26.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TICRR  -     15q26.1   [Description]    (hg19-Feb_2009)
GoldenPathTICRR - 15q26.1 [CytoView hg19]  TICRR - 15q26.1 [CytoView hg38]
ImmunoBaseENSG00000140534
Genome Data Viewer NCBITICRR [Mapview hg19]  
OMIM613298   
Gene and transcription
Genbank (Entrez)AK074727 AK123612 AK315750 AW627706 BC002881
RefSeq transcript (Entrez)NM_001308025 NM_152259
Consensus coding sequences : CCDS (NCBI)TICRR
Gene ExpressionTICRR [ NCBI-GEO ]   TICRR [ EBI - ARRAY_EXPRESS ]   TICRR [ SEEK ]   TICRR [ MEM ]
Gene Expression Viewer (FireBrowse)TICRR [ Firebrowse - Broad ]
GenevisibleExpression of TICRR in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)90381
GTEX Portal (Tissue expression)TICRR
Human Protein AtlasENSG00000140534-TICRR [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z2Z1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z2Z1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z2Z1
PhosPhoSitePlusQ7Z2Z1
Domains : Interpro (EBI)Treslin    Treslin_N   
Domain families : Pfam (Sanger)Treslin_N (PF15292)   
Domain families : Pfam (NCBI)pfam15292   
Conserved Domain (NCBI)TICRR
SuperfamilyQ7Z2Z1
AlphaFold pdb e-kbQ7Z2Z1   
Human Protein Atlas [tissue]ENSG00000140534-TICRR [tissue]
HPRD11357
Protein Interaction databases
DIP (DOE-UCLA)Q7Z2Z1
IntAct (EBI)Q7Z2Z1
BioGRIDTICRR
STRING (EMBL)TICRR
ZODIACTICRR
Ontologies - Pathways
QuickGOQ7Z2Z1
Ontology : AmiGOchromatin binding  chromatin binding  protein binding  nucleus  nucleus  nucleoplasm  cytosol  DNA replication  DNA replication  DNA repair  mitotic G2 DNA damage checkpoint signaling  mitotic G2 DNA damage checkpoint signaling  response to ionizing radiation  regulation of DNA-dependent DNA replication initiation  regulation of DNA-dependent DNA replication initiation  mitotic DNA replication checkpoint signaling  mitotic DNA replication checkpoint signaling  intracellular membrane-bounded organelle  
Ontology : EGO-EBIchromatin binding  chromatin binding  protein binding  nucleus  nucleus  nucleoplasm  cytosol  DNA replication  DNA replication  DNA repair  mitotic G2 DNA damage checkpoint signaling  mitotic G2 DNA damage checkpoint signaling  response to ionizing radiation  regulation of DNA-dependent DNA replication initiation  regulation of DNA-dependent DNA replication initiation  mitotic DNA replication checkpoint signaling  mitotic DNA replication checkpoint signaling  intracellular membrane-bounded organelle  
NDEx NetworkTICRR
Atlas of Cancer Signalling NetworkTICRR
Wikipedia pathwaysTICRR
Orthology - Evolution
OrthoDB90381
GeneTree (enSembl)ENSG00000140534
Phylogenetic Trees/Animal Genes : TreeFamTICRR
Homologs : HomoloGeneTICRR
Homology/Alignments : Family Browser (UCSC)TICRR
Gene fusions - Rearrangements
Fusion : MitelmanDPP8/TICRR [15q22.31/15q26.1]  
Fusion : MitelmanTICRR/ATXN7L1 [15q26.1/7q22.3]  
Fusion : QuiverTICRR
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTICRR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TICRR
dbVarTICRR
ClinVarTICRR
MonarchTICRR
1000_GenomesTICRR 
Exome Variant ServerTICRR
GNOMAD BrowserENSG00000140534
Varsome BrowserTICRR
ACMGTICRR variants
VarityQ7Z2Z1
Genomic Variants (DGV)TICRR [DGVbeta]
DECIPHERTICRR [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTICRR 
Mutations
ICGC Data PortalTICRR 
TCGA Data PortalTICRR 
Broad Tumor PortalTICRR
OASIS PortalTICRR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTICRR  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTICRR
Mutations and Diseases : HGMDTICRR
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTICRR
DgiDB (Drug Gene Interaction Database)TICRR
DoCM (Curated mutations)TICRR
CIViC (Clinical Interpretations of Variants in Cancer)TICRR
Cancer3DTICRR
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613298   
Orphanet
DisGeNETTICRR
MedgenTICRR
Genetic Testing Registry TICRR
NextProtQ7Z2Z1 [Medical]
GENETestsTICRR
Target ValidationTICRR
Huge Navigator TICRR [HugePedia]
ClinGenTICRR
Clinical trials, drugs, therapy
MyCancerGenomeTICRR
Protein Interactions : CTDTICRR
Pharm GKB GenePA142672278
PharosQ7Z2Z1
Clinical trialTICRR
Miscellaneous
canSAR (ICR)TICRR
HarmonizomeTICRR
DataMed IndexTICRR
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTICRR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:35:05 CEST 2021

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