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TIGIT (T-cell immunoreceptor with Ig and ITIM domains)

Identity

Alias_namesVSIG9
VSTM3
V-set and immunoglobulin domain containing 9
V-set and transmembrane domain containing 3
T cell immunoreceptor with Ig and ITIM domains
Alias_symbol (synonym)FLJ39873
DKFZp667A205
Other aliasWUCAM
HGNC (Hugo) TIGIT
LocusID (NCBI) 201633
Atlas_Id 51271
Location 3q13.31  [Link to chromosome band 3q13]
Location_base_pair Starts at 114012833 and ends at 114029135 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TIGIT   26838
Cards
Entrez_Gene (NCBI)TIGIT  201633  T-cell immunoreceptor with Ig and ITIM domains
AliasesVSIG9; VSTM3; WUCAM
GeneCards (Weizmann)TIGIT
Ensembl hg19 (Hinxton)ENSG00000181847 [Gene_View]  chr3:114012833-114029135 [Contig_View]  TIGIT [Vega]
Ensembl hg38 (Hinxton)ENSG00000181847 [Gene_View]  chr3:114012833-114029135 [Contig_View]  TIGIT [Vega]
ICGC DataPortalENSG00000181847
TCGA cBioPortalTIGIT
AceView (NCBI)TIGIT
Genatlas (Paris)TIGIT
WikiGenes201633
SOURCE (Princeton)TIGIT
Genetics Home Reference (NIH)TIGIT
Genomic and cartography
GoldenPath hg19 (UCSC)TIGIT  -     chr3:114012833-114029135 +  3q13.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TIGIT  -     3q13.31   [Description]    (hg38-Dec_2013)
EnsemblTIGIT - 3q13.31 [CytoView hg19]  TIGIT - 3q13.31 [CytoView hg38]
Mapping of homologs : NCBITIGIT [Mapview hg19]  TIGIT [Mapview hg38]
OMIM612859   
Gene and transcription
Genbank (Entrez)AK097192 AL833175 BC101288 BC101289 BC101290
RefSeq transcript (Entrez)NM_173799
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)TIGIT
Cluster EST : UnigeneHs.421750 [ NCBI ]
CGAP (NCI)Hs.421750
Alternative Splicing GalleryENSG00000181847
Gene ExpressionTIGIT [ NCBI-GEO ]   TIGIT [ EBI - ARRAY_EXPRESS ]   TIGIT [ SEEK ]   TIGIT [ MEM ]
Gene Expression Viewer (FireBrowse)TIGIT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)201633
GTEX Portal (Tissue expression)TIGIT
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ495A1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ495A1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ495A1
Splice isoforms : SwissVarQ495A1
PhosPhoSitePlusQ495A1
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_sub    Ig_V-set   
Domain families : Pfam (Sanger)V-set (PF07686)   
Domain families : Pfam (NCBI)pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  
Conserved Domain (NCBI)TIGIT
DMDM Disease mutations201633
Blocks (Seattle)TIGIT
PDB (SRS)3Q0H    3RQ3    3UCR    3UDW   
PDB (PDBSum)3Q0H    3RQ3    3UCR    3UDW   
PDB (IMB)3Q0H    3RQ3    3UCR    3UDW   
PDB (RSDB)3Q0H    3RQ3    3UCR    3UDW   
Structural Biology KnowledgeBase3Q0H    3RQ3    3UCR    3UDW   
SCOP (Structural Classification of Proteins)3Q0H    3RQ3    3UCR    3UDW   
CATH (Classification of proteins structures)3Q0H    3RQ3    3UCR    3UDW   
SuperfamilyQ495A1
Human Protein AtlasENSG00000181847
Peptide AtlasQ495A1
HPRD08804
IPIIPI00174439   IPI00789390   IPI00945834   IPI00945475   
Protein Interaction databases
DIP (DOE-UCLA)Q495A1
IntAct (EBI)Q495A1
FunCoupENSG00000181847
BioGRIDTIGIT
STRING (EMBL)TIGIT
ZODIACTIGIT
Ontologies - Pathways
QuickGOQ495A1
Ontology : AmiGOreceptor activity  receptor binding  protein binding  integral component of plasma membrane  cell-cell adherens junction  homophilic cell adhesion via plasma membrane adhesion molecules  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  cell recognition  cell surface  negative regulation of interleukin-12 production  positive regulation of interleukin-10 production  protein homodimerization activity  cell adhesion molecule binding  negative regulation of T cell activation  negative regulation of T cell activation  
Ontology : EGO-EBIreceptor activity  receptor binding  protein binding  integral component of plasma membrane  cell-cell adherens junction  homophilic cell adhesion via plasma membrane adhesion molecules  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  cell recognition  cell surface  negative regulation of interleukin-12 production  positive regulation of interleukin-10 production  protein homodimerization activity  cell adhesion molecule binding  negative regulation of T cell activation  negative regulation of T cell activation  
Pathways : KEGGCell adhesion molecules (CAMs)   
NDEx NetworkTIGIT
Atlas of Cancer Signalling NetworkTIGIT
Wikipedia pathwaysTIGIT
Orthology - Evolution
OrthoDB201633
GeneTree (enSembl)ENSG00000181847
Phylogenetic Trees/Animal Genes : TreeFamTIGIT
HOVERGENQ495A1
HOGENOMQ495A1
Homologs : HomoloGeneTIGIT
Homology/Alignments : Family Browser (UCSC)TIGIT
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTIGIT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TIGIT
dbVarTIGIT
ClinVarTIGIT
1000_GenomesTIGIT 
Exome Variant ServerTIGIT
ExAC (Exome Aggregation Consortium)TIGIT (select the gene name)
Genetic variants : HAPMAP201633
Genomic Variants (DGV)TIGIT [DGVbeta]
DECIPHER (Syndromes)3:114012833-114029135  ENSG00000181847
CONAN: Copy Number AnalysisTIGIT 
Mutations
ICGC Data PortalTIGIT 
TCGA Data PortalTIGIT 
Broad Tumor PortalTIGIT
OASIS PortalTIGIT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTIGIT  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTIGIT
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TIGIT
DgiDB (Drug Gene Interaction Database)TIGIT
DoCM (Curated mutations)TIGIT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TIGIT (select a term)
intoGenTIGIT
Cancer3DTIGIT(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612859   
Orphanet
MedgenTIGIT
Genetic Testing Registry TIGIT
NextProtQ495A1 [Medical]
TSGene201633
GENETestsTIGIT
Huge Navigator TIGIT [HugePedia]
snp3D : Map Gene to Disease201633
BioCentury BCIQTIGIT
ClinGenTIGIT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD201633
Chemical/Pharm GKB GenePA164726482
Clinical trialTIGIT
Miscellaneous
canSAR (ICR)TIGIT (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTIGIT
EVEXTIGIT
GoPubMedTIGIT
iHOPTIGIT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:31:06 CET 2017

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