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TIGIT (T cell immunoreceptor with Ig and ITIM domains)

Identity

Alias (NCBI)VSIG9
VSTM3
WUCAM
HGNC (Hugo) TIGIT
HGNC Alias symbFLJ39873
DKFZp667A205
HGNC Previous nameVSIG9
 VSTM3
HGNC Previous nameVSIG9, VSTM3
LocusID (NCBI) 201633
Atlas_Id 51271
Location 3q13.31  [Link to chromosome band 3q13]
Location_base_pair Starts at 114294028 and ends at 114310288 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(14;19)(q11;q13) TRA/NECTIN2
t(14;19)(q32;q13) IGH/Various Partners


External links

 

Nomenclature
HGNC (Hugo)TIGIT   26838
Cards
Entrez_Gene (NCBI)TIGIT    T cell immunoreceptor with Ig and ITIM domains
AliasesVSIG9; VSTM3; WUCAM
GeneCards (Weizmann)TIGIT
Ensembl hg19 (Hinxton)ENSG00000181847 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000181847 [Gene_View]  ENSG00000181847 [Sequence]  chr3:114294028-114310288 [Contig_View]  TIGIT [Vega]
ICGC DataPortalENSG00000181847
TCGA cBioPortalTIGIT
AceView (NCBI)TIGIT
Genatlas (Paris)TIGIT
SOURCE (Princeton)TIGIT
Genetics Home Reference (NIH)TIGIT
Genomic and cartography
GoldenPath hg38 (UCSC)TIGIT  -     chr3:114294028-114310288 +  3q13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TIGIT  -     3q13.31   [Description]    (hg19-Feb_2009)
GoldenPathTIGIT - 3q13.31 [CytoView hg19]  TIGIT - 3q13.31 [CytoView hg38]
ImmunoBaseENSG00000181847
Genome Data Viewer NCBITIGIT [Mapview hg19]  
OMIM612859   
Gene and transcription
Genbank (Entrez)AK097192 AL833175 BC101288 BC101289 BC101290
RefSeq transcript (Entrez)NM_173799
Consensus coding sequences : CCDS (NCBI)TIGIT
Gene ExpressionTIGIT [ NCBI-GEO ]   TIGIT [ EBI - ARRAY_EXPRESS ]   TIGIT [ SEEK ]   TIGIT [ MEM ]
Gene Expression Viewer (FireBrowse)TIGIT [ Firebrowse - Broad ]
GenevisibleExpression of TIGIT in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)201633
GTEX Portal (Tissue expression)TIGIT
Human Protein AtlasENSG00000181847-TIGIT [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ495A1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ495A1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ495A1
PhosPhoSitePlusQ495A1
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_sub    Ig_V-set    TIGIT   
Domain families : Pfam (Sanger)V-set (PF07686)   
Domain families : Pfam (NCBI)pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  
Conserved Domain (NCBI)TIGIT
PDB (RSDB)3Q0H    3RQ3    3UCR    3UDW    5V52   
PDB Europe3Q0H    3RQ3    3UCR    3UDW    5V52   
PDB (PDBSum)3Q0H    3RQ3    3UCR    3UDW    5V52   
PDB (IMB)3Q0H    3RQ3    3UCR    3UDW    5V52   
Structural Biology KnowledgeBase3Q0H    3RQ3    3UCR    3UDW    5V52   
SCOP (Structural Classification of Proteins)3Q0H    3RQ3    3UCR    3UDW    5V52   
CATH (Classification of proteins structures)3Q0H    3RQ3    3UCR    3UDW    5V52   
SuperfamilyQ495A1
AlphaFold pdb e-kbQ495A1   
Human Protein Atlas [tissue]ENSG00000181847-TIGIT [tissue]
HPRD08804
Protein Interaction databases
DIP (DOE-UCLA)Q495A1
IntAct (EBI)Q495A1
BioGRIDTIGIT
STRING (EMBL)TIGIT
ZODIACTIGIT
Ontologies - Pathways
QuickGOQ495A1
Ontology : AmiGOsignaling receptor binding  signaling receptor binding  protein binding  plasma membrane  cell surface  cell surface  integral component of membrane  negative regulation of interleukin-12 production  negative regulation of interleukin-12 production  positive regulation of interleukin-10 production  positive regulation of interleukin-10 production  identical protein binding  negative regulation of T cell activation  negative regulation of T cell activation  negative regulation of T cell activation  
Ontology : EGO-EBIsignaling receptor binding  signaling receptor binding  protein binding  plasma membrane  cell surface  cell surface  integral component of membrane  negative regulation of interleukin-12 production  negative regulation of interleukin-12 production  positive regulation of interleukin-10 production  positive regulation of interleukin-10 production  identical protein binding  negative regulation of T cell activation  negative regulation of T cell activation  negative regulation of T cell activation  
Pathways : KEGGCell adhesion molecules (CAMs)   
NDEx NetworkTIGIT
Atlas of Cancer Signalling NetworkTIGIT
Wikipedia pathwaysTIGIT
Orthology - Evolution
OrthoDB201633
GeneTree (enSembl)ENSG00000181847
Phylogenetic Trees/Animal Genes : TreeFamTIGIT
Homologs : HomoloGeneTIGIT
Homology/Alignments : Family Browser (UCSC)TIGIT
Gene fusions - Rearrangements
Fusion : QuiverTIGIT
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTIGIT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TIGIT
dbVarTIGIT
ClinVarTIGIT
MonarchTIGIT
1000_GenomesTIGIT 
Exome Variant ServerTIGIT
GNOMAD BrowserENSG00000181847
Varsome BrowserTIGIT
ACMGTIGIT variants
VarityQ495A1
Genomic Variants (DGV)TIGIT [DGVbeta]
DECIPHERTIGIT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTIGIT 
Mutations
ICGC Data PortalTIGIT 
TCGA Data PortalTIGIT 
Broad Tumor PortalTIGIT
OASIS PortalTIGIT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTIGIT  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTIGIT
Mutations and Diseases : HGMDTIGIT
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTIGIT
DgiDB (Drug Gene Interaction Database)TIGIT
DoCM (Curated mutations)TIGIT
CIViC (Clinical Interpretations of Variants in Cancer)TIGIT
Cancer3DTIGIT
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612859   
Orphanet
DisGeNETTIGIT
MedgenTIGIT
Genetic Testing Registry TIGIT
NextProtQ495A1 [Medical]
GENETestsTIGIT
Target ValidationTIGIT
Huge Navigator TIGIT [HugePedia]
ClinGenTIGIT
Clinical trials, drugs, therapy
MyCancerGenomeTIGIT
Protein Interactions : CTDTIGIT
Pharm GKB GenePA164726482
PharosQ495A1
Clinical trialTIGIT
Miscellaneous
canSAR (ICR)TIGIT
HarmonizomeTIGIT
DataMed IndexTIGIT
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTIGIT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:05 CEST 2021

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