Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TIMP1 (TIMP metallopeptidase inhibitor 1)

Identity

Alias (NCBI)CLGI
EPA
EPO
HCI
TIMP
TIMP-1
HGNC (Hugo) TIMP1
HGNC Alias symbEPO
HGNC Previous nameTIMP
 CLGI
HGNC Previous nametissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor)
LocusID (NCBI) 7076
Atlas_Id 42571
Location Xp11.3  [Link to chromosome band Xp11]
Location_base_pair Starts at 47582436 and ends at 47586789 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TIMP1   11820
Cards
Entrez_Gene (NCBI)TIMP1    TIMP metallopeptidase inhibitor 1
AliasesCLGI; EPA; EPO; HCI; 
TIMP; TIMP-1
GeneCards (Weizmann)TIMP1
Ensembl hg19 (Hinxton)ENSG00000102265 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000102265 [Gene_View]  ENSG00000102265 [Sequence]  chrX:47582436-47586789 [Contig_View]  TIMP1 [Vega]
ICGC DataPortalENSG00000102265
TCGA cBioPortalTIMP1
AceView (NCBI)TIMP1
Genatlas (Paris)TIMP1
SOURCE (Princeton)TIMP1
Genetics Home Reference (NIH)TIMP1
Genomic and cartography
GoldenPath hg38 (UCSC)TIMP1  -     chrX:47582436-47586789 +  Xp11.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TIMP1  -     Xp11.3   [Description]    (hg19-Feb_2009)
GoldenPathTIMP1 - Xp11.3 [CytoView hg19]  TIMP1 - Xp11.3 [CytoView hg38]
ImmunoBaseENSG00000102265
genome Data Viewer NCBITIMP1 [Mapview hg19]  
OMIM305370   
Gene and transcription
Genbank (Entrez)A10416 AK074854 AK296116 AK307222 AK310206
RefSeq transcript (Entrez)NM_003254
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TIMP1
Alternative Splicing GalleryENSG00000102265
Gene ExpressionTIMP1 [ NCBI-GEO ]   TIMP1 [ EBI - ARRAY_EXPRESS ]   TIMP1 [ SEEK ]   TIMP1 [ MEM ]
Gene Expression Viewer (FireBrowse)TIMP1 [ Firebrowse - Broad ]
GenevisibleExpression of TIMP1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7076
GTEX Portal (Tissue expression)TIMP1
Human Protein AtlasENSG00000102265-TIMP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01033   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01033  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01033
Splice isoforms : SwissVarP01033
PhosPhoSitePlusP01033
Domaine pattern : Prosite (Expaxy)NTR (PS50189)    TIMP (PS00288)   
Domains : Interpro (EBI)Netrin_domain    TIMP    TIMP-like_OB-fold    TIMP1    TIMP_C    TIMP_CS   
Domain families : Pfam (Sanger)TIMP (PF00965)   
Domain families : Pfam (NCBI)pfam00965   
Domain families : Smart (EMBL)NTR (SM00206)  
Conserved Domain (NCBI)TIMP1
Blocks (Seattle)TIMP1
PDB (RSDB)1D2B    1LQN    1OO9    1UEA    2J0T    3MA2    3V96    6MAV    6N9D   
PDB Europe1D2B    1LQN    1OO9    1UEA    2J0T    3MA2    3V96    6MAV    6N9D   
PDB (PDBSum)1D2B    1LQN    1OO9    1UEA    2J0T    3MA2    3V96    6MAV    6N9D   
PDB (IMB)1D2B    1LQN    1OO9    1UEA    2J0T    3MA2    3V96    6MAV    6N9D   
Structural Biology KnowledgeBase1D2B    1LQN    1OO9    1UEA    2J0T    3MA2    3V96    6MAV    6N9D   
SCOP (Structural Classification of Proteins)1D2B    1LQN    1OO9    1UEA    2J0T    3MA2    3V96    6MAV    6N9D   
CATH (Classification of proteins structures)1D2B    1LQN    1OO9    1UEA    2J0T    3MA2    3V96    6MAV    6N9D   
SuperfamilyP01033
Human Protein Atlas [tissue]ENSG00000102265-TIMP1 [tissue]
Peptide AtlasP01033
HPRD02371
IPIIPI00032292   IPI00910845   IPI00552089   IPI00642739   IPI00639839   
Protein Interaction databases
DIP (DOE-UCLA)P01033
IntAct (EBI)P01033
BioGRIDTIMP1
STRING (EMBL)TIMP1
ZODIACTIMP1
Ontologies - Pathways
QuickGOP01033
Ontology : AmiGOcell activation  protease binding  connective tissue replacement involved in inflammatory response wound healing  platelet degranulation  cytokine activity  protein binding  extracellular region  extracellular region  basement membrane  extracellular space  extracellular space  endoplasmic reticulum lumen  aging  growth factor activity  metalloendopeptidase inhibitor activity  metalloendopeptidase inhibitor activity  zinc ion binding  positive regulation of cell proliferation  response to hormone  response to organic substance  negative regulation of endopeptidase activity  negative regulation of endopeptidase activity  cytokine-mediated signaling pathway  extracellular matrix disassembly  peptidase inhibitor activity  extracellular matrix  platelet alpha granule lumen  response to cytokine  negative regulation of apoptotic process  negative regulation of catalytic activity  response to peptide hormone  post-translational protein modification  cellular protein metabolic process  negative regulation of membrane protein ectodomain proteolysis  negative regulation of membrane protein ectodomain proteolysis  cartilage development  extracellular exosome  negative regulation of trophoblast cell migration  negative regulation of metallopeptidase activity  regulation of integrin-mediated signaling pathway  
Ontology : EGO-EBIcell activation  protease binding  connective tissue replacement involved in inflammatory response wound healing  platelet degranulation  cytokine activity  protein binding  extracellular region  extracellular region  basement membrane  extracellular space  extracellular space  endoplasmic reticulum lumen  aging  growth factor activity  metalloendopeptidase inhibitor activity  metalloendopeptidase inhibitor activity  zinc ion binding  positive regulation of cell proliferation  response to hormone  response to organic substance  negative regulation of endopeptidase activity  negative regulation of endopeptidase activity  cytokine-mediated signaling pathway  extracellular matrix disassembly  peptidase inhibitor activity  extracellular matrix  platelet alpha granule lumen  response to cytokine  negative regulation of apoptotic process  negative regulation of catalytic activity  response to peptide hormone  post-translational protein modification  cellular protein metabolic process  negative regulation of membrane protein ectodomain proteolysis  negative regulation of membrane protein ectodomain proteolysis  cartilage development  extracellular exosome  negative regulation of trophoblast cell migration  negative regulation of metallopeptidase activity  regulation of integrin-mediated signaling pathway  
Pathways : KEGGHIF-1 signaling pathway   
NDEx NetworkTIMP1
Atlas of Cancer Signalling NetworkTIMP1
Wikipedia pathwaysTIMP1
Orthology - Evolution
OrthoDB7076
GeneTree (enSembl)ENSG00000102265
Phylogenetic Trees/Animal Genes : TreeFamTIMP1
HOGENOMP01033
Homologs : HomoloGeneTIMP1
Homology/Alignments : Family Browser (UCSC)TIMP1
Gene fusions - Rearrangements
Fusion : QuiverTIMP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTIMP1 [hg38]
dbVarTIMP1
ClinVarTIMP1
MonarchTIMP1
1000_GenomesTIMP1 
Exome Variant ServerTIMP1
GNOMAD BrowserENSG00000102265
Varsome BrowserTIMP1
Genomic Variants (DGV)TIMP1 [DGVbeta]
DECIPHERTIMP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTIMP1 
Mutations
ICGC Data PortalTIMP1 
TCGA Data PortalTIMP1 
Broad Tumor PortalTIMP1
OASIS PortalTIMP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTIMP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTIMP1
Mutations and Diseases : HGMDTIMP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch TIMP1
DgiDB (Drug Gene Interaction Database)TIMP1
DoCM (Curated mutations)TIMP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TIMP1 (select a term)
intoGenTIMP1
Cancer3DTIMP1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM305370   
Orphanet
DisGeNETTIMP1
MedgenTIMP1
Genetic Testing Registry TIMP1
NextProtP01033 [Medical]
GENETestsTIMP1
Target ValidationTIMP1
Huge Navigator TIMP1 [HugePedia]
ClinGenTIMP1
Clinical trials, drugs, therapy
MyCancerGenomeTIMP1
Protein Interactions : CTD
Pharm GKB GenePA36526
PharosP01033
Clinical trialTIMP1
Miscellaneous
canSAR (ICR)TIMP1 (select the gene name)
HarmonizomeTIMP1
DataMed IndexTIMP1
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTIMP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:41:13 CET 2021
Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.