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TIMP1 (TIMP metallopeptidase inhibitor 1)

Identity

Alias_namesTIMP
CLGI
tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity
Alias_symbol (synonym)EPO
Other aliasEPA
HCI
TIMP-1
HGNC (Hugo) TIMP1
LocusID (NCBI) 7076
Atlas_Id 42571
Location Xp11.23  [Link to chromosome band Xp11]
Location_base_pair Starts at 47441690 and ends at 47446190 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TIMP1   11820
Cards
Entrez_Gene (NCBI)TIMP1  7076  TIMP metallopeptidase inhibitor 1
AliasesCLGI; EPA; EPO; HCI; 
TIMP; TIMP-1
GeneCards (Weizmann)TIMP1
Ensembl hg19 (Hinxton)ENSG00000102265 [Gene_View]  chrX:47441690-47446190 [Contig_View]  TIMP1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000102265 [Gene_View]  chrX:47441690-47446190 [Contig_View]  TIMP1 [Vega]
ICGC DataPortalENSG00000102265
TCGA cBioPortalTIMP1
AceView (NCBI)TIMP1
Genatlas (Paris)TIMP1
WikiGenes7076
SOURCE (Princeton)TIMP1
Genetics Home Reference (NIH)TIMP1
Genomic and cartography
GoldenPath hg19 (UCSC)TIMP1  -     chrX:47441690-47446190 +  Xp11.23   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TIMP1  -     Xp11.23   [Description]    (hg38-Dec_2013)
EnsemblTIMP1 - Xp11.23 [CytoView hg19]  TIMP1 - Xp11.23 [CytoView hg38]
Mapping of homologs : NCBITIMP1 [Mapview hg19]  TIMP1 [Mapview hg38]
OMIM305370   
Gene and transcription
Genbank (Entrez)A10416 AK074854 AK296116 AK307222 AK310206
RefSeq transcript (Entrez)NM_003254
RefSeq genomic (Entrez)NC_000023 NC_018934 NG_008437 NG_012533 NT_079573 NW_004929439
Consensus coding sequences : CCDS (NCBI)TIMP1
Cluster EST : UnigeneHs.522632 [ NCBI ]
CGAP (NCI)Hs.522632
Alternative Splicing GalleryENSG00000102265
Gene ExpressionTIMP1 [ NCBI-GEO ]   TIMP1 [ EBI - ARRAY_EXPRESS ]   TIMP1 [ SEEK ]   TIMP1 [ MEM ]
Gene Expression Viewer (FireBrowse)TIMP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7076
GTEX Portal (Tissue expression)TIMP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01033   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01033  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01033
Splice isoforms : SwissVarP01033
PhosPhoSitePlusP01033
Domaine pattern : Prosite (Expaxy)NTR (PS50189)    TIMP (PS00288)   
Domains : Interpro (EBI)Netrin_domain    TIMP    TIMP-like_OB-fold    TIMP1    TIMP_C    TIMP_CS   
Domain families : Pfam (Sanger)TIMP (PF00965)   
Domain families : Pfam (NCBI)pfam00965   
Domain families : Smart (EMBL)NTR (SM00206)  
Conserved Domain (NCBI)TIMP1
DMDM Disease mutations7076
Blocks (Seattle)TIMP1
PDB (SRS)1D2B    1LQN    1OO9    1UEA    2J0T    3MA2    3V96   
PDB (PDBSum)1D2B    1LQN    1OO9    1UEA    2J0T    3MA2    3V96   
PDB (IMB)1D2B    1LQN    1OO9    1UEA    2J0T    3MA2    3V96   
PDB (RSDB)1D2B    1LQN    1OO9    1UEA    2J0T    3MA2    3V96   
Structural Biology KnowledgeBase1D2B    1LQN    1OO9    1UEA    2J0T    3MA2    3V96   
SCOP (Structural Classification of Proteins)1D2B    1LQN    1OO9    1UEA    2J0T    3MA2    3V96   
CATH (Classification of proteins structures)1D2B    1LQN    1OO9    1UEA    2J0T    3MA2    3V96   
SuperfamilyP01033
Human Protein AtlasENSG00000102265
Peptide AtlasP01033
HPRD02371
IPIIPI00032292   IPI00910845   IPI00552089   IPI00642739   IPI00639839   
Protein Interaction databases
DIP (DOE-UCLA)P01033
IntAct (EBI)P01033
FunCoupENSG00000102265
BioGRIDTIMP1
STRING (EMBL)TIMP1
ZODIACTIMP1
Ontologies - Pathways
QuickGOP01033
Ontology : AmiGOcell activation  protease binding  platelet degranulation  cytokine activity  protein binding  extracellular region  extracellular region  proteinaceous extracellular matrix  basement membrane  extracellular space  aging  growth factor activity  metalloendopeptidase inhibitor activity  positive regulation of cell proliferation  response to hormone  negative regulation of endopeptidase activity  extracellular matrix disassembly  platelet alpha granule lumen  response to cytokine  wound healing  negative regulation of apoptotic process  response to peptide hormone  metal ion binding  negative regulation of membrane protein ectodomain proteolysis  cartilage development  extracellular exosome  negative regulation of trophoblast cell migration  regulation of integrin-mediated signaling pathway  
Ontology : EGO-EBIcell activation  protease binding  platelet degranulation  cytokine activity  protein binding  extracellular region  extracellular region  proteinaceous extracellular matrix  basement membrane  extracellular space  aging  growth factor activity  metalloendopeptidase inhibitor activity  positive regulation of cell proliferation  response to hormone  negative regulation of endopeptidase activity  extracellular matrix disassembly  platelet alpha granule lumen  response to cytokine  wound healing  negative regulation of apoptotic process  response to peptide hormone  metal ion binding  negative regulation of membrane protein ectodomain proteolysis  cartilage development  extracellular exosome  negative regulation of trophoblast cell migration  regulation of integrin-mediated signaling pathway  
Pathways : BIOCARTAInhibition of Matrix Metalloproteinases [Genes]   
Pathways : KEGGHIF-1 signaling pathway   
NDEx NetworkTIMP1
Atlas of Cancer Signalling NetworkTIMP1
Wikipedia pathwaysTIMP1
Orthology - Evolution
OrthoDB7076
GeneTree (enSembl)ENSG00000102265
Phylogenetic Trees/Animal Genes : TreeFamTIMP1
HOVERGENP01033
HOGENOMP01033
Homologs : HomoloGeneTIMP1
Homology/Alignments : Family Browser (UCSC)TIMP1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTIMP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TIMP1
dbVarTIMP1
ClinVarTIMP1
1000_GenomesTIMP1 
Exome Variant ServerTIMP1
ExAC (Exome Aggregation Consortium)TIMP1 (select the gene name)
Genetic variants : HAPMAP7076
Genomic Variants (DGV)TIMP1 [DGVbeta]
DECIPHER (Syndromes)X:47441690-47446190  ENSG00000102265
CONAN: Copy Number AnalysisTIMP1 
Mutations
ICGC Data PortalTIMP1 
TCGA Data PortalTIMP1 
Broad Tumor PortalTIMP1
OASIS PortalTIMP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTIMP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTIMP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch TIMP1
DgiDB (Drug Gene Interaction Database)TIMP1
DoCM (Curated mutations)TIMP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TIMP1 (select a term)
intoGenTIMP1
Cancer3DTIMP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM305370   
Orphanet
MedgenTIMP1
Genetic Testing Registry TIMP1
NextProtP01033 [Medical]
TSGene7076
GENETestsTIMP1
Huge Navigator TIMP1 [HugePedia]
snp3D : Map Gene to Disease7076
BioCentury BCIQTIMP1
ClinGenTIMP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7076
Chemical/Pharm GKB GenePA36526
Clinical trialTIMP1
Miscellaneous
canSAR (ICR)TIMP1 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTIMP1
EVEXTIMP1
GoPubMedTIMP1
iHOPTIMP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:31:09 CET 2017

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