TIMP1 (TIMP metallopeptidase inhibitor 1)

2003-02-01  

Identity

HGNC
LOCATION
Xp11.3
LOCUSID
ALIAS
CLGI,EPA,EPO,HCI,TIMP,TIMP-1

Other Information

Locus ID:

NCBI: 7076
MIM: 305370
HGNC: 11820
Ensembl: ENSG00000102265

Variants:

dbSNP: 7076
ClinVar: 7076
TCGA: ENSG00000102265
COSMIC: TIMP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102265ENST00000218388P01033
ENSG00000102265ENST00000218388Q6FGX5
ENSG00000102265ENST00000377017Q5H9A7
ENSG00000102265ENST00000441738Q5H9B4
ENSG00000102265ENST00000445623H0Y789
ENSG00000102265ENST00000456754Q5H9B5

Expression (GTEx)

0
500
1000
1500
2000

Pathways

PathwaySourceExternal ID
HIF-1 signaling pathwayKEGGhsa04066
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
Interleukin-10 signalingREACTOMER-HSA-6783783

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
117967252002Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: implications for reversibility of liver fibrosis.117
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
161032402005Increased cardiac expression of tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart.68
241746282013Angiogenic capacity of M1- and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9.63
225321312012The role of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in the development of esophageal cancer.60
163729072005MMP-9, TIMP-1 and inflammatory cells in sputum from COPD patients during exacerbation.53
181590692008Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1.53
146485842003Tissue inhibitor of metalloproteinase (TIMP)-1: the TIMPed balance of matrix metalloproteinases in the central nervous system.51
129043052003Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells against intrinsic apoptotic cell death via the focal adhesion kinase/phosphatidylinositol 3-kinase and MAPK signaling pathway.48
218600872011Cerebrospinal fluid matrix metalloproteinases and tissue inhibitor of metalloproteinases in combination with subcortical and cortical biomarkers in vascular dementia and Alzheimer's disease.48

Citation

Dessen P

TIMP1 (TIMP metallopeptidase inhibitor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42571/timp1