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TIMP4 (TIMP metallopeptidase inhibitor 4)

Identity

Alias_namestissue inhibitor of metalloproteinase 4
Other alias-
HGNC (Hugo) TIMP4
LocusID (NCBI) 7079
Atlas_Id 42574
Location 3p25.2  [Link to chromosome band 3p25]
Location_base_pair Starts at 12153068 and ends at 12159351 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TIMP4   11823
Cards
Entrez_Gene (NCBI)TIMP4  7079  TIMP metallopeptidase inhibitor 4
Aliases
GeneCards (Weizmann)TIMP4
Ensembl hg19 (Hinxton)ENSG00000157150 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000157150 [Gene_View]  chr3:12153068-12159351 [Contig_View]  TIMP4 [Vega]
ICGC DataPortalENSG00000157150
TCGA cBioPortalTIMP4
AceView (NCBI)TIMP4
Genatlas (Paris)TIMP4
WikiGenes7079
SOURCE (Princeton)TIMP4
Genetics Home Reference (NIH)TIMP4
Genomic and cartography
GoldenPath hg38 (UCSC)TIMP4  -     chr3:12153068-12159351 -  3p25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TIMP4  -     3p25.2   [Description]    (hg19-Feb_2009)
EnsemblTIMP4 - 3p25.2 [CytoView hg19]  TIMP4 - 3p25.2 [CytoView hg38]
Mapping of homologs : NCBITIMP4 [Mapview hg19]  TIMP4 [Mapview hg38]
OMIM601915   
Gene and transcription
Genbank (Entrez)AK313018 BC010553 BT019627 DQ891795 DQ894978
RefSeq transcript (Entrez)NM_003256
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TIMP4
Cluster EST : UnigeneHs.591665 [ NCBI ]
CGAP (NCI)Hs.591665
Alternative Splicing GalleryENSG00000157150
Gene ExpressionTIMP4 [ NCBI-GEO ]   TIMP4 [ EBI - ARRAY_EXPRESS ]   TIMP4 [ SEEK ]   TIMP4 [ MEM ]
Gene Expression Viewer (FireBrowse)TIMP4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7079
GTEX Portal (Tissue expression)TIMP4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99727   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99727  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99727
Splice isoforms : SwissVarQ99727
PhosPhoSitePlusQ99727
Domaine pattern : Prosite (Expaxy)NTR (PS50189)    TIMP (PS00288)   
Domains : Interpro (EBI)Netrin_domain    TIMP    TIMP-like_OB-fold    TIMP_C    TIMP_CS   
Domain families : Pfam (Sanger)TIMP (PF00965)   
Domain families : Pfam (NCBI)pfam00965   
Domain families : Smart (EMBL)NTR (SM00206)  
Conserved Domain (NCBI)TIMP4
DMDM Disease mutations7079
Blocks (Seattle)TIMP4
SuperfamilyQ99727
Human Protein AtlasENSG00000157150
Peptide AtlasQ99727
HPRD03557
IPIIPI00017745   
Protein Interaction databases
DIP (DOE-UCLA)Q99727
IntAct (EBI)Q99727
FunCoupENSG00000157150
BioGRIDTIMP4
STRING (EMBL)TIMP4
ZODIACTIMP4
Ontologies - Pathways
QuickGOQ99727
Ontology : AmiGOprotease binding  proteinaceous extracellular matrix  extracellular space  Notch signaling pathway  central nervous system development  biological_process  metalloendopeptidase inhibitor activity  metalloendopeptidase inhibitor activity  response to hormone  negative regulation of endopeptidase activity  sarcomere  response to lipopolysaccharide  response to cytokine  response to drug  ovulation cycle  negative regulation of catalytic activity  response to peptide hormone  metal ion binding  negative regulation of membrane protein ectodomain proteolysis  
Ontology : EGO-EBIprotease binding  proteinaceous extracellular matrix  extracellular space  Notch signaling pathway  central nervous system development  biological_process  metalloendopeptidase inhibitor activity  metalloendopeptidase inhibitor activity  response to hormone  negative regulation of endopeptidase activity  sarcomere  response to lipopolysaccharide  response to cytokine  response to drug  ovulation cycle  negative regulation of catalytic activity  response to peptide hormone  metal ion binding  negative regulation of membrane protein ectodomain proteolysis  
Pathways : BIOCARTAInhibition of Matrix Metalloproteinases [Genes]   
NDEx NetworkTIMP4
Atlas of Cancer Signalling NetworkTIMP4
Wikipedia pathwaysTIMP4
Orthology - Evolution
OrthoDB7079
GeneTree (enSembl)ENSG00000157150
Phylogenetic Trees/Animal Genes : TreeFamTIMP4
HOVERGENQ99727
HOGENOMQ99727
Homologs : HomoloGeneTIMP4
Homology/Alignments : Family Browser (UCSC)TIMP4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTIMP4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TIMP4
dbVarTIMP4
ClinVarTIMP4
1000_GenomesTIMP4 
Exome Variant ServerTIMP4
ExAC (Exome Aggregation Consortium)TIMP4 (select the gene name)
Genetic variants : HAPMAP7079
Genomic Variants (DGV)TIMP4 [DGVbeta]
DECIPHERTIMP4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTIMP4 
Mutations
ICGC Data PortalTIMP4 
TCGA Data PortalTIMP4 
Broad Tumor PortalTIMP4
OASIS PortalTIMP4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTIMP4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTIMP4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TIMP4
DgiDB (Drug Gene Interaction Database)TIMP4
DoCM (Curated mutations)TIMP4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TIMP4 (select a term)
intoGenTIMP4
Cancer3DTIMP4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601915   
Orphanet
MedgenTIMP4
Genetic Testing Registry TIMP4
NextProtQ99727 [Medical]
TSGene7079
GENETestsTIMP4
Huge Navigator TIMP4 [HugePedia]
snp3D : Map Gene to Disease7079
BioCentury BCIQTIMP4
ClinGenTIMP4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7079
Chemical/Pharm GKB GenePA36529
Clinical trialTIMP4
Miscellaneous
canSAR (ICR)TIMP4 (select the gene name)
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTIMP4
EVEXTIMP4
GoPubMedTIMP4
iHOPTIMP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:41:03 CEST 2017

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