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TIMP4 (TIMP metallopeptidase inhibitor 4)

Identity

Alias (NCBI)TIMP-4
HGNC (Hugo) TIMP4
HGNC Previous nametissue inhibitor of metalloproteinase 4
LocusID (NCBI) 7079
Atlas_Id 42574
Location 3p25.2  [Link to chromosome band 3p25]
Location_base_pair Starts at 12153068 and ends at 12158912 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TIMP4   11823
Cards
Entrez_Gene (NCBI)TIMP4    TIMP metallopeptidase inhibitor 4
AliasesTIMP-4
GeneCards (Weizmann)TIMP4
Ensembl hg19 (Hinxton)ENSG00000157150 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000157150 [Gene_View]  ENSG00000157150 [Sequence]  chr3:12153068-12158912 [Contig_View]  TIMP4 [Vega]
ICGC DataPortalENSG00000157150
TCGA cBioPortalTIMP4
AceView (NCBI)TIMP4
Genatlas (Paris)TIMP4
SOURCE (Princeton)TIMP4
Genetics Home Reference (NIH)TIMP4
Genomic and cartography
GoldenPath hg38 (UCSC)TIMP4  -     chr3:12153068-12158912 -  3p25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TIMP4  -     3p25.2   [Description]    (hg19-Feb_2009)
GoldenPathTIMP4 - 3p25.2 [CytoView hg19]  TIMP4 - 3p25.2 [CytoView hg38]
ImmunoBaseENSG00000157150
Genome Data Viewer NCBITIMP4 [Mapview hg19]  
OMIM601915   
Gene and transcription
Genbank (Entrez)AK313018 BC010553 BT019627 U76456
RefSeq transcript (Entrez)NM_003256
Consensus coding sequences : CCDS (NCBI)TIMP4
Gene ExpressionTIMP4 [ NCBI-GEO ]   TIMP4 [ EBI - ARRAY_EXPRESS ]   TIMP4 [ SEEK ]   TIMP4 [ MEM ]
Gene Expression Viewer (FireBrowse)TIMP4 [ Firebrowse - Broad ]
GenevisibleExpression of TIMP4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7079
GTEX Portal (Tissue expression)TIMP4
Human Protein AtlasENSG00000157150-TIMP4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99727   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99727  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99727
PhosPhoSitePlusQ99727
Domaine pattern : Prosite (Expaxy)NTR (PS50189)    TIMP (PS00288)   
Domains : Interpro (EBI)Netrin_domain    TIMP    TIMP-like_OB-fold    TIMP4    TIMP_C    TIMP_CS   
Domain families : Pfam (Sanger)TIMP (PF00965)   
Domain families : Pfam (NCBI)pfam00965   
Domain families : Smart (EMBL)NTR (SM00206)  
Conserved Domain (NCBI)TIMP4
SuperfamilyQ99727
AlphaFold pdb e-kbQ99727   
Human Protein Atlas [tissue]ENSG00000157150-TIMP4 [tissue]
HPRD03557
Protein Interaction databases
DIP (DOE-UCLA)Q99727
IntAct (EBI)Q99727
BioGRIDTIMP4
STRING (EMBL)TIMP4
ZODIACTIMP4
Ontologies - Pathways
QuickGOQ99727
Ontology : AmiGOprotease binding  extracellular space  Notch signaling pathway  central nervous system development  biological_process  metalloendopeptidase inhibitor activity  metalloendopeptidase inhibitor activity  response to hormone  response to organic substance  negative regulation of endopeptidase activity  sarcomere  extracellular matrix  response to lipopolysaccharide  response to cytokine  response to drug  ovulation cycle  response to peptide hormone  metal ion binding  negative regulation of membrane protein ectodomain proteolysis  
Ontology : EGO-EBIprotease binding  extracellular space  Notch signaling pathway  central nervous system development  biological_process  metalloendopeptidase inhibitor activity  metalloendopeptidase inhibitor activity  response to hormone  response to organic substance  negative regulation of endopeptidase activity  sarcomere  extracellular matrix  response to lipopolysaccharide  response to cytokine  response to drug  ovulation cycle  response to peptide hormone  metal ion binding  negative regulation of membrane protein ectodomain proteolysis  
Pathways : BIOCARTAInhibition of Matrix Metalloproteinases [Genes]   
NDEx NetworkTIMP4
Atlas of Cancer Signalling NetworkTIMP4
Wikipedia pathwaysTIMP4
Orthology - Evolution
OrthoDB7079
GeneTree (enSembl)ENSG00000157150
Phylogenetic Trees/Animal Genes : TreeFamTIMP4
Homologs : HomoloGeneTIMP4
Homology/Alignments : Family Browser (UCSC)TIMP4
Gene fusions - Rearrangements
Fusion : QuiverTIMP4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTIMP4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TIMP4
dbVarTIMP4
ClinVarTIMP4
MonarchTIMP4
1000_GenomesTIMP4 
Exome Variant ServerTIMP4
GNOMAD BrowserENSG00000157150
Varsome BrowserTIMP4
ACMGTIMP4 variants
VarityQ99727
Genomic Variants (DGV)TIMP4 [DGVbeta]
DECIPHERTIMP4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTIMP4 
Mutations
ICGC Data PortalTIMP4 
TCGA Data PortalTIMP4 
Broad Tumor PortalTIMP4
OASIS PortalTIMP4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTIMP4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTIMP4
Mutations and Diseases : HGMDTIMP4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTIMP4
DgiDB (Drug Gene Interaction Database)TIMP4
DoCM (Curated mutations)TIMP4
CIViC (Clinical Interpretations of Variants in Cancer)TIMP4
Cancer3DTIMP4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601915   
Orphanet
DisGeNETTIMP4
MedgenTIMP4
Genetic Testing Registry TIMP4
NextProtQ99727 [Medical]
GENETestsTIMP4
Target ValidationTIMP4
Huge Navigator TIMP4 [HugePedia]
ClinGenTIMP4
Clinical trials, drugs, therapy
MyCancerGenomeTIMP4
Protein Interactions : CTDTIMP4
Pharm GKB GenePA36529
PharosQ99727
Clinical trialTIMP4
Miscellaneous
canSAR (ICR)TIMP4
HarmonizomeTIMP4
DataMed IndexTIMP4
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTIMP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:35:09 CEST 2021

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