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TINF2 (TERF1 (TRF1)-interacting nuclear factor 2)

Identity

Alias_namesTERF1 (TRF1)-interacting nuclear factor 2
Alias_symbol (synonym)TIN2
HGNC (Hugo) TINF2
LocusID (NCBI) 26277
Atlas_Id 42575
Location 14q12  [Link to chromosome band 14q12]
Location_base_pair Starts at 24708851 and ends at 24711880 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Dyskeratosis congenita (DKC)


External links

Nomenclature
HGNC (Hugo)TINF2   11824
Cards
Entrez_Gene (NCBI)TINF2  26277  TERF1 (TRF1)-interacting nuclear factor 2
AliasesDKCA3; TIN2
GeneCards (Weizmann)TINF2
Ensembl hg19 (Hinxton)ENSG00000092330 [Gene_View]  chr14:24708851-24711880 [Contig_View]  TINF2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000092330 [Gene_View]  chr14:24708851-24711880 [Contig_View]  TINF2 [Vega]
ICGC DataPortalENSG00000092330
TCGA cBioPortalTINF2
AceView (NCBI)TINF2
Genatlas (Paris)TINF2
WikiGenes26277
SOURCE (Princeton)TINF2
Genetics Home Reference (NIH)TINF2
Genomic and cartography
GoldenPath hg19 (UCSC)TINF2  -     chr14:24708851-24711880 -  14q12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TINF2  -     14q12   [Description]    (hg38-Dec_2013)
EnsemblTINF2 - 14q12 [CytoView hg19]  TINF2 - 14q12 [CytoView hg38]
Mapping of homologs : NCBITINF2 [Mapview hg19]  TINF2 [Mapview hg38]
OMIM127550   268130   604319   613990   
Gene and transcription
Genbank (Entrez)AF195512 AK023166 AK225379 AK294119 AK315084
RefSeq transcript (Entrez)NM_001099274 NM_012461
RefSeq genomic (Entrez)NC_000014 NC_018925 NG_016650 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)TINF2
Cluster EST : UnigeneHs.496191 [ NCBI ]
CGAP (NCI)Hs.496191
Alternative Splicing GalleryENSG00000092330
Gene ExpressionTINF2 [ NCBI-GEO ]   TINF2 [ EBI - ARRAY_EXPRESS ]   TINF2 [ SEEK ]   TINF2 [ MEM ]
Gene Expression Viewer (FireBrowse)TINF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26277
GTEX Portal (Tissue expression)TINF2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BSI4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BSI4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BSI4
Splice isoforms : SwissVarQ9BSI4
PhosPhoSitePlusQ9BSI4
Domains : Interpro (EBI)TINF2_N   
Domain families : Pfam (Sanger)TINF2_N (PF14973)   
Domain families : Pfam (NCBI)pfam14973   
Conserved Domain (NCBI)TINF2
DMDM Disease mutations26277
Blocks (Seattle)TINF2
PDB (SRS)3BQO    3BU8   
PDB (PDBSum)3BQO    3BU8   
PDB (IMB)3BQO    3BU8   
PDB (RSDB)3BQO    3BU8   
Structural Biology KnowledgeBase3BQO    3BU8   
SCOP (Structural Classification of Proteins)3BQO    3BU8   
CATH (Classification of proteins structures)3BQO    3BU8   
SuperfamilyQ9BSI4
Human Protein AtlasENSG00000092330
Peptide AtlasQ9BSI4
HPRD16056
IPIIPI00074109   IPI00218680   IPI00218681   IPI01010915   IPI01011406   
Protein Interaction databases
DIP (DOE-UCLA)Q9BSI4
IntAct (EBI)Q9BSI4
FunCoupENSG00000092330
BioGRIDTINF2
STRING (EMBL)TINF2
ZODIACTINF2
Ontologies - Pathways
QuickGOQ9BSI4
Ontology : AmiGOchromosome, telomeric region  nuclear telomere cap complex  nuclear chromosome, telomeric region  DNA binding  protein binding  nucleus  nucleoplasm  perinucleolar chromocenter  telomerase inhibitor activity  telomere maintenance via telomere lengthening  negative regulation of protein ADP-ribosylation  negative regulation of protein ADP-ribosylation  telomere capping  nuclear matrix  telomere assembly  positive regulation of telomere maintenance  negative regulation of telomere maintenance via telomerase  negative regulation of telomere maintenance via telomerase  negative regulation of telomere maintenance via telomerase  protein localization to chromosome  telomeric DNA binding  negative regulation of epithelial cell proliferation  negative regulation of telomerase activity  telosome  telosome  protein localization to chromosome, telomeric region  
Ontology : EGO-EBIchromosome, telomeric region  nuclear telomere cap complex  nuclear chromosome, telomeric region  DNA binding  protein binding  nucleus  nucleoplasm  perinucleolar chromocenter  telomerase inhibitor activity  telomere maintenance via telomere lengthening  negative regulation of protein ADP-ribosylation  negative regulation of protein ADP-ribosylation  telomere capping  nuclear matrix  telomere assembly  positive regulation of telomere maintenance  negative regulation of telomere maintenance via telomerase  negative regulation of telomere maintenance via telomerase  negative regulation of telomere maintenance via telomerase  protein localization to chromosome  telomeric DNA binding  negative regulation of epithelial cell proliferation  negative regulation of telomerase activity  telosome  telosome  protein localization to chromosome, telomeric region  
NDEx NetworkTINF2
Atlas of Cancer Signalling NetworkTINF2
Wikipedia pathwaysTINF2
Orthology - Evolution
OrthoDB26277
GeneTree (enSembl)ENSG00000092330
Phylogenetic Trees/Animal Genes : TreeFamTINF2
HOVERGENQ9BSI4
HOGENOMQ9BSI4
Homologs : HomoloGeneTINF2
Homology/Alignments : Family Browser (UCSC)TINF2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTINF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TINF2
dbVarTINF2
ClinVarTINF2
1000_GenomesTINF2 
Exome Variant ServerTINF2
ExAC (Exome Aggregation Consortium)TINF2 (select the gene name)
Genetic variants : HAPMAP26277
Genomic Variants (DGV)TINF2 [DGVbeta]
DECIPHER (Syndromes)14:24708851-24711880  ENSG00000092330
CONAN: Copy Number AnalysisTINF2 
Mutations
ICGC Data PortalTINF2 
TCGA Data PortalTINF2 
Broad Tumor PortalTINF2
OASIS PortalTINF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTINF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTINF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch TINF2
DgiDB (Drug Gene Interaction Database)TINF2
DoCM (Curated mutations)TINF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TINF2 (select a term)
intoGenTINF2
Cancer3DTINF2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM127550    268130    604319    613990   
Orphanet477    2771    2949   
MedgenTINF2
Genetic Testing Registry TINF2
NextProtQ9BSI4 [Medical]
TSGene26277
GENETestsTINF2
Huge Navigator TINF2 [HugePedia]
snp3D : Map Gene to Disease26277
BioCentury BCIQTINF2
ClinGenTINF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26277
Chemical/Pharm GKB GenePA36530
Clinical trialTINF2
Miscellaneous
canSAR (ICR)TINF2 (select the gene name)
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTINF2
EVEXTINF2
GoPubMedTINF2
iHOPTINF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Nov 18 19:53:49 CET 2016

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