TIPIN (TIMELESS interacting protein)

2015-10-01  

Identity

HGNC
LOCATION
15q22.31
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 54962
MIM: 610716
HGNC: 30750
Ensembl: ENSG00000075131

Variants:

dbSNP: 54962
ClinVar: 54962
TCGA: ENSG00000075131
COSMIC: TIPIN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000075131ENST00000261881Q9BVW5
ENSG00000075131ENST00000562124H3BU04
ENSG00000075131ENST00000566524H3BQ83
ENSG00000075131ENST00000568216H3BTH1
ENSG00000075131ENST00000570251H3BVG9

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
172967252007The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement.124
171168852006Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function.82
171418022007Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors.71
171021372007Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint.68
201244172010Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesion.58
202337252010Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress.54
201746232010Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance.27
233596762013Human Tim-Tipin complex affects the biochemical properties of the replicative DNA helicase and DNA polymerases.27
214901032011The replisome pausing factor Timeless is required for episomal maintenance of latent Epstein-Barr virus.13
260040862015TIPIN depletion leads to apoptosis in breast cancer cells.10

Citation

Dessen P

TIPIN (TIMELESS interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2015-10-01

Online version: http://atlasgeneticsoncology.org/gene/55466/tipin