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TIRAP (TIR domain containing adaptor protein)

Identity

Alias (NCBI)BACTS1
Mal
MyD88-2
wyatt
HGNC (Hugo) TIRAP
HGNC Alias symbMal
wyatt
HGNC Alias nameMyD88 adapter-like
HGNC Previous nameToll-interleukin 1 receptor (TIR) domain-containing adaptor protein
LocusID (NCBI) 114609
Atlas_Id 42972
Location 11q24.2  [Link to chromosome band 11q24]
Location_base_pair Starts at 126283087 and ends at 126293176 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KMT2A (11q23.3) / TIRAP (11q24.2)RBM15 (1p13.3) / TIRAP (11q24.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  del(11)(q24) KMT2A/TIRAP
t(11;11)(q24;q23) TIRAP/KMT2A

External links

Nomenclature
HGNC (Hugo)TIRAP   17192
Cards
Entrez_Gene (NCBI)TIRAP    TIR domain containing adaptor protein
AliasesBACTS1; Mal; MyD88-2; wyatt
GeneCards (Weizmann)TIRAP
Ensembl hg19 (Hinxton)ENSG00000150455 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000150455 [Gene_View]  ENSG00000150455 [Sequence]  chr11:126283087-126293176 [Contig_View]  TIRAP [Vega]
ICGC DataPortalENSG00000150455
TCGA cBioPortalTIRAP
AceView (NCBI)TIRAP
Genatlas (Paris)TIRAP
SOURCE (Princeton)TIRAP
Genetics Home Reference (NIH)TIRAP
Genomic and cartography
GoldenPath hg38 (UCSC)TIRAP  -     chr11:126283087-126293176 +  11q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TIRAP  -     11q24.2   [Description]    (hg19-Feb_2009)
GoldenPathTIRAP - 11q24.2 [CytoView hg19]  TIRAP - 11q24.2 [CytoView hg38]
ImmunoBaseENSG00000150455
genome Data Viewer NCBITIRAP [Mapview hg19]  
OMIM606252   607948   611162   614382   
Gene and transcription
Genbank (Entrez)AB446477 AF378129 AF406652 AF410783 AK124298
RefSeq transcript (Entrez)NM_001039661 NM_001318776 NM_001318777 NM_052887 NM_148910
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TIRAP
Alternative Splicing GalleryENSG00000150455
Gene ExpressionTIRAP [ NCBI-GEO ]   TIRAP [ EBI - ARRAY_EXPRESS ]   TIRAP [ SEEK ]   TIRAP [ MEM ]
Gene Expression Viewer (FireBrowse)TIRAP [ Firebrowse - Broad ]
GenevisibleExpression of TIRAP in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)114609
GTEX Portal (Tissue expression)TIRAP
Human Protein AtlasENSG00000150455-TIRAP [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP58753   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP58753  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP58753
Splice isoforms : SwissVarP58753
PhosPhoSitePlusP58753
Domaine pattern : Prosite (Expaxy)TIR (PS50104)   
Domains : Interpro (EBI)TIR_dom    Tol-interleuk_rcpt_adapt_Tirap    Toll_tir_struct_dom_sf   
Domain families : Pfam (Sanger)TIR_2 (PF13676)   
Domain families : Pfam (NCBI)pfam13676   
Conserved Domain (NCBI)TIRAP
Blocks (Seattle)TIRAP
PDB (RSDB)2NDH    2Y92    3UB2    3UB3    3UB4    4FZ5    4LQD    5T7Q    5UZB   
PDB Europe2NDH    2Y92    3UB2    3UB3    3UB4    4FZ5    4LQD    5T7Q    5UZB   
PDB (PDBSum)2NDH    2Y92    3UB2    3UB3    3UB4    4FZ5    4LQD    5T7Q    5UZB   
PDB (IMB)2NDH    2Y92    3UB2    3UB3    3UB4    4FZ5    4LQD    5T7Q    5UZB   
Structural Biology KnowledgeBase2NDH    2Y92    3UB2    3UB3    3UB4    4FZ5    4LQD    5T7Q    5UZB   
SCOP (Structural Classification of Proteins)2NDH    2Y92    3UB2    3UB3    3UB4    4FZ5    4LQD    5T7Q    5UZB   
CATH (Classification of proteins structures)2NDH    2Y92    3UB2    3UB3    3UB4    4FZ5    4LQD    5T7Q    5UZB   
SuperfamilyP58753
Human Protein Atlas [tissue]ENSG00000150455-TIRAP [tissue]
Peptide AtlasP58753
IPIIPI00718966   IPI00104143   IPI00171090   IPI01010981   
Protein Interaction databases
DIP (DOE-UCLA)P58753
IntAct (EBI)P58753
BioGRIDTIRAP
STRING (EMBL)TIRAP
ZODIACTIRAP
Ontologies - Pathways
QuickGOP58753
Ontology : AmiGOMyD88-dependent toll-like receptor signaling pathway  protein kinase C binding  protein binding  phosphatidylinositol-4,5-bisphosphate binding  cytoplasm  cytosol  plasma membrane  plasma membrane  inflammatory response  cell surface receptor signaling pathway  activation of NF-kappaB-inducing kinase activity  myeloid cell differentiation  endocytic vesicle  protein binding, bridging  positive regulation of B cell proliferation  positive regulation of protein complex assembly  response to lipopolysaccharide  ruffle membrane  regulation of interferon-beta production  positive regulation of interleukin-12 production  positive regulation of interleukin-15 production  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  positive regulation of toll-like receptor 2 signaling pathway  positive regulation of toll-like receptor 3 signaling pathway  positive regulation of toll-like receptor 4 signaling pathway  Toll-like receptor 4 binding  Toll-like receptor 2 binding  TIRAP-dependent toll-like receptor 4 signaling pathway  identical protein binding  identical protein binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  innate immune response  regulation of innate immune response  positive regulation of interleukin-6 biosynthetic process  positive regulation of JNK cascade  defense response to Gram-positive bacterium  positive regulation of NF-kappaB transcription factor activity  positive regulation of ERK1 and ERK2 cascade  3'-UTR-mediated mRNA stabilization  cellular response to bacterial lipopeptide  cellular response to lipoteichoic acid  positive regulation of neutrophil chemotaxis  positive regulation of chemokine (C-X-C motif) ligand 1 production  positive regulation of chemokine (C-X-C motif) ligand 2 production  
Ontology : EGO-EBIMyD88-dependent toll-like receptor signaling pathway  protein kinase C binding  protein binding  phosphatidylinositol-4,5-bisphosphate binding  cytoplasm  cytosol  plasma membrane  plasma membrane  inflammatory response  cell surface receptor signaling pathway  activation of NF-kappaB-inducing kinase activity  myeloid cell differentiation  endocytic vesicle  protein binding, bridging  positive regulation of B cell proliferation  positive regulation of protein complex assembly  response to lipopolysaccharide  ruffle membrane  regulation of interferon-beta production  positive regulation of interleukin-12 production  positive regulation of interleukin-15 production  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  positive regulation of toll-like receptor 2 signaling pathway  positive regulation of toll-like receptor 3 signaling pathway  positive regulation of toll-like receptor 4 signaling pathway  Toll-like receptor 4 binding  Toll-like receptor 2 binding  TIRAP-dependent toll-like receptor 4 signaling pathway  identical protein binding  identical protein binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  innate immune response  regulation of innate immune response  positive regulation of interleukin-6 biosynthetic process  positive regulation of JNK cascade  defense response to Gram-positive bacterium  positive regulation of NF-kappaB transcription factor activity  positive regulation of ERK1 and ERK2 cascade  3'-UTR-mediated mRNA stabilization  cellular response to bacterial lipopeptide  cellular response to lipoteichoic acid  positive regulation of neutrophil chemotaxis  positive regulation of chemokine (C-X-C motif) ligand 1 production  positive regulation of chemokine (C-X-C motif) ligand 2 production  
Pathways : KEGGNF-kappa B signaling pathway    Toll-like receptor signaling pathway    Pertussis    Tuberculosis    Hepatitis B   
NDEx NetworkTIRAP
Atlas of Cancer Signalling NetworkTIRAP
Wikipedia pathwaysTIRAP
Orthology - Evolution
OrthoDB114609
GeneTree (enSembl)ENSG00000150455
Phylogenetic Trees/Animal Genes : TreeFamTIRAP
HOGENOMP58753
Homologs : HomoloGeneTIRAP
Homology/Alignments : Family Browser (UCSC)TIRAP
Gene fusions - Rearrangements
Fusion : QuiverTIRAP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTIRAP [hg38]
dbVarTIRAP
ClinVarTIRAP
MonarchTIRAP
1000_GenomesTIRAP 
Exome Variant ServerTIRAP
GNOMAD BrowserENSG00000150455
Varsome BrowserTIRAP
Genomic Variants (DGV)TIRAP [DGVbeta]
DECIPHERTIRAP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTIRAP 
Mutations
ICGC Data PortalTIRAP 
TCGA Data PortalTIRAP 
Broad Tumor PortalTIRAP
OASIS PortalTIRAP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTIRAP  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTIRAP
Mutations and Diseases : HGMDTIRAP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMutasearch TIRAP
DgiDB (Drug Gene Interaction Database)TIRAP
DoCM (Curated mutations)TIRAP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TIRAP (select a term)
intoGenTIRAP
Cancer3DTIRAP(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606252    607948    611162    614382   
Orphanet
DisGeNETTIRAP
MedgenTIRAP
Genetic Testing Registry TIRAP
NextProtP58753 [Medical]
GENETestsTIRAP
Target ValidationTIRAP
Huge Navigator TIRAP [HugePedia]
ClinGenTIRAP
Clinical trials, drugs, therapy
MyCancerGenomeTIRAP
Protein Interactions : CTD
Pharm GKB GenePA134972842
PharosP58753
Clinical trialTIRAP
Miscellaneous
canSAR (ICR)TIRAP (select the gene name)
HarmonizomeTIRAP
DataMed IndexTIRAP
Probes
Litterature
PubMed140 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTIRAP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:41:15 CET 2021
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