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TIRAP (toll-interleukin 1 receptor (TIR) domain containing adaptor protein)

Identity

Alias_namesToll-interleukin 1 receptor (TIR) domain-containing adaptor protein
Alias_symbol (synonym)Mal
wyatt
Other aliasBACTS1
MyD88-2
HGNC (Hugo) TIRAP
LocusID (NCBI) 114609
Atlas_Id 42972
Location 11q24.2  [Link to chromosome band 11q24]
Location_base_pair Starts at 126152982 and ends at 126164828 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
KMT2A (11q23.3) / TIRAP (11q24.2)RBM15 (1p13.3) / TIRAP (11q24.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TIRAP   17192
Cards
Entrez_Gene (NCBI)TIRAP  114609  toll-interleukin 1 receptor (TIR) domain containing adaptor protein
AliasesBACTS1; Mal; MyD88-2; wyatt
GeneCards (Weizmann)TIRAP
Ensembl hg19 (Hinxton)ENSG00000150455 [Gene_View]  chr11:126152982-126164828 [Contig_View]  TIRAP [Vega]
Ensembl hg38 (Hinxton)ENSG00000150455 [Gene_View]  chr11:126152982-126164828 [Contig_View]  TIRAP [Vega]
ICGC DataPortalENSG00000150455
TCGA cBioPortalTIRAP
AceView (NCBI)TIRAP
Genatlas (Paris)TIRAP
WikiGenes114609
SOURCE (Princeton)TIRAP
Genetics Home Reference (NIH)TIRAP
Genomic and cartography
GoldenPath hg19 (UCSC)TIRAP  -     chr11:126152982-126164828 +  11q24.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TIRAP  -     11q24.2   [Description]    (hg38-Dec_2013)
EnsemblTIRAP - 11q24.2 [CytoView hg19]  TIRAP - 11q24.2 [CytoView hg38]
Mapping of homologs : NCBITIRAP [Mapview hg19]  TIRAP [Mapview hg38]
OMIM606252   607948   610799   611162   614382   
Gene and transcription
Genbank (Entrez)AB446477 AF378129 AF406652 AF410783 AK124298
RefSeq transcript (Entrez)NM_001039661 NM_001318776 NM_001318777 NM_052887 NM_148910
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_011523 NT_033899 NW_004929381
Consensus coding sequences : CCDS (NCBI)TIRAP
Cluster EST : UnigeneHs.537126 [ NCBI ]
CGAP (NCI)Hs.537126
Alternative Splicing GalleryENSG00000150455
Gene ExpressionTIRAP [ NCBI-GEO ]   TIRAP [ EBI - ARRAY_EXPRESS ]   TIRAP [ SEEK ]   TIRAP [ MEM ]
Gene Expression Viewer (FireBrowse)TIRAP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)114609
GTEX Portal (Tissue expression)TIRAP
Protein : pattern, domain, 3D structure
UniProt/SwissProtP58753   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP58753  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP58753
Splice isoforms : SwissVarP58753
PhosPhoSitePlusP58753
Domaine pattern : Prosite (Expaxy)TIR (PS50104)   
Domains : Interpro (EBI)TIR_dom    Tol-interleuk_rcpt_adapt_Tirap   
Domain families : Pfam (Sanger)TIR_2 (PF13676)   
Domain families : Pfam (NCBI)pfam13676   
Conserved Domain (NCBI)TIRAP
DMDM Disease mutations114609
Blocks (Seattle)TIRAP
PDB (SRS)2Y92    3UB2    3UB3    3UB4    4FZ5    4LQD   
PDB (PDBSum)2Y92    3UB2    3UB3    3UB4    4FZ5    4LQD   
PDB (IMB)2Y92    3UB2    3UB3    3UB4    4FZ5    4LQD   
PDB (RSDB)2Y92    3UB2    3UB3    3UB4    4FZ5    4LQD   
Structural Biology KnowledgeBase2Y92    3UB2    3UB3    3UB4    4FZ5    4LQD   
SCOP (Structural Classification of Proteins)2Y92    3UB2    3UB3    3UB4    4FZ5    4LQD   
CATH (Classification of proteins structures)2Y92    3UB2    3UB3    3UB4    4FZ5    4LQD   
SuperfamilyP58753
Human Protein AtlasENSG00000150455
Peptide AtlasP58753
IPIIPI00718966   IPI00104143   IPI00171090   IPI01010981   
Protein Interaction databases
DIP (DOE-UCLA)P58753
IntAct (EBI)P58753
FunCoupENSG00000150455
BioGRIDTIRAP
STRING (EMBL)TIRAP
ZODIACTIRAP
Ontologies - Pathways
QuickGOP58753
Ontology : AmiGOMyD88-dependent toll-like receptor signaling pathway  protein kinase C binding  protein binding  phosphatidylinositol-4,5-bisphosphate binding  nucleoplasm  cytoplasm  cytosol  plasma membrane  plasma membrane  inflammatory response  cell surface receptor signaling pathway  myeloid cell differentiation  endocytic vesicle  protein binding, bridging  positive regulation of B cell proliferation  response to lipopolysaccharide  ruffle membrane  regulation of interferon-beta production  positive regulation of interleukin-12 production  positive regulation of interleukin-15 production  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  positive regulation of toll-like receptor 2 signaling pathway  positive regulation of toll-like receptor 3 signaling pathway  toll-like receptor 4 signaling pathway  positive regulation of toll-like receptor 4 signaling pathway  Toll-like receptor 4 binding  Toll-like receptor 2 binding  TIRAP-dependent toll-like receptor 4 signaling pathway  protein homodimerization activity  positive regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of growth of symbiont in host  innate immune response  regulation of innate immune response  intercellular bridge  positive regulation of interleukin-6 biosynthetic process  positive regulation of JNK cascade  protein heterodimerization activity  defense response to Gram-positive bacterium  positive regulation of NF-kappaB transcription factor activity  positive regulation of ERK1 and ERK2 cascade  3'-UTR-mediated mRNA stabilization  cellular response to bacterial lipopeptide  cellular response to lipoteichoic acid  positive regulation of neutrophil chemotaxis  positive regulation of protein homodimerization activity  positive regulation of chemokine (C-X-C motif) ligand 1 production  positive regulation of chemokine (C-X-C motif) ligand 2 production  
Ontology : EGO-EBIMyD88-dependent toll-like receptor signaling pathway  protein kinase C binding  protein binding  phosphatidylinositol-4,5-bisphosphate binding  nucleoplasm  cytoplasm  cytosol  plasma membrane  plasma membrane  inflammatory response  cell surface receptor signaling pathway  myeloid cell differentiation  endocytic vesicle  protein binding, bridging  positive regulation of B cell proliferation  response to lipopolysaccharide  ruffle membrane  regulation of interferon-beta production  positive regulation of interleukin-12 production  positive regulation of interleukin-15 production  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  positive regulation of toll-like receptor 2 signaling pathway  positive regulation of toll-like receptor 3 signaling pathway  toll-like receptor 4 signaling pathway  positive regulation of toll-like receptor 4 signaling pathway  Toll-like receptor 4 binding  Toll-like receptor 2 binding  TIRAP-dependent toll-like receptor 4 signaling pathway  protein homodimerization activity  positive regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of growth of symbiont in host  innate immune response  regulation of innate immune response  intercellular bridge  positive regulation of interleukin-6 biosynthetic process  positive regulation of JNK cascade  protein heterodimerization activity  defense response to Gram-positive bacterium  positive regulation of NF-kappaB transcription factor activity  positive regulation of ERK1 and ERK2 cascade  3'-UTR-mediated mRNA stabilization  cellular response to bacterial lipopeptide  cellular response to lipoteichoic acid  positive regulation of neutrophil chemotaxis  positive regulation of protein homodimerization activity  positive regulation of chemokine (C-X-C motif) ligand 1 production  positive regulation of chemokine (C-X-C motif) ligand 2 production  
Pathways : KEGGNF-kappa B signaling pathway    Toll-like receptor signaling pathway    Pertussis    Tuberculosis    Hepatitis B   
NDEx NetworkTIRAP
Atlas of Cancer Signalling NetworkTIRAP
Wikipedia pathwaysTIRAP
Orthology - Evolution
OrthoDB114609
GeneTree (enSembl)ENSG00000150455
Phylogenetic Trees/Animal Genes : TreeFamTIRAP
HOVERGENP58753
HOGENOMP58753
Homologs : HomoloGeneTIRAP
Homology/Alignments : Family Browser (UCSC)TIRAP
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTIRAP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TIRAP
dbVarTIRAP
ClinVarTIRAP
1000_GenomesTIRAP 
Exome Variant ServerTIRAP
ExAC (Exome Aggregation Consortium)TIRAP (select the gene name)
Genetic variants : HAPMAP114609
Genomic Variants (DGV)TIRAP [DGVbeta]
DECIPHER (Syndromes)11:126152982-126164828  ENSG00000150455
CONAN: Copy Number AnalysisTIRAP 
Mutations
ICGC Data PortalTIRAP 
TCGA Data PortalTIRAP 
Broad Tumor PortalTIRAP
OASIS PortalTIRAP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTIRAP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTIRAP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMutasearch TIRAP
DgiDB (Drug Gene Interaction Database)TIRAP
DoCM (Curated mutations)TIRAP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TIRAP (select a term)
intoGenTIRAP
Cancer3DTIRAP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606252    607948    610799    611162    614382   
Orphanet
MedgenTIRAP
Genetic Testing Registry TIRAP
NextProtP58753 [Medical]
TSGene114609
GENETestsTIRAP
Huge Navigator TIRAP [HugePedia]
snp3D : Map Gene to Disease114609
BioCentury BCIQTIRAP
ClinGenTIRAP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD114609
Chemical/Pharm GKB GenePA134972842
Clinical trialTIRAP
Miscellaneous
canSAR (ICR)TIRAP (select the gene name)
Probes
Litterature
PubMed111 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTIRAP
EVEXTIRAP
GoPubMedTIRAP
iHOPTIRAP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:31:11 CET 2017

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