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TJP1 (tight junction protein 1)

Identity

Alias (NCBI)ZO-1
HGNC (Hugo) TJP1
HGNC Alias symbZO-1
MGC133289
DKFZp686M05161
HGNC Alias namezona occludens 1
 tight junction protein ZO-1
LocusID (NCBI) 7082
Atlas_Id 45883
Location 15q13.1  [Link to chromosome band 15q13]
Location_base_pair Starts at 29699367 and ends at 29822468 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TJP1 (15q13.1) / FAM189A1 (15q13.1)TJP1 (15q13.1) / RNASE1 (14q11.2)TJP1 (15q13.1) / TJP1 (15q13.1)
TJP1 (15q13.1) / VTN (17q11.2)TJP1 (15q13.1) / YPEL5 (2p23.1)TYRO3 (15q15.1) / TJP1 (15q13.1)
UNKL (16p13.3) / TJP1 (15q13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TJP1   11827
Cards
Entrez_Gene (NCBI)TJP1    tight junction protein 1
AliasesZO-1
GeneCards (Weizmann)TJP1
Ensembl hg19 (Hinxton)ENSG00000104067 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104067 [Gene_View]  ENSG00000104067 [Sequence]  chr15:29699367-29822468 [Contig_View]  TJP1 [Vega]
ICGC DataPortalENSG00000104067
TCGA cBioPortalTJP1
AceView (NCBI)TJP1
Genatlas (Paris)TJP1
SOURCE (Princeton)TJP1
Genetics Home Reference (NIH)TJP1
Genomic and cartography
GoldenPath hg38 (UCSC)TJP1  -     chr15:29699367-29822468 -  15q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TJP1  -     15q13.1   [Description]    (hg19-Feb_2009)
GoldenPathTJP1 - 15q13.1 [CytoView hg19]  TJP1 - 15q13.1 [CytoView hg38]
ImmunoBaseENSG00000104067
Genome Data Viewer NCBITJP1 [Mapview hg19]  
OMIM601009   
Gene and transcription
Genbank (Entrez)AA101028 AB370197 AF035298 AK302971 AK304758
RefSeq transcript (Entrez)NM_001301025 NM_001301026 NM_001330239 NM_001355012 NM_001355013 NM_001355014 NM_001355015 NM_003257 NM_175610
Consensus coding sequences : CCDS (NCBI)TJP1
Gene ExpressionTJP1 [ NCBI-GEO ]   TJP1 [ EBI - ARRAY_EXPRESS ]   TJP1 [ SEEK ]   TJP1 [ MEM ]
Gene Expression Viewer (FireBrowse)TJP1 [ Firebrowse - Broad ]
GenevisibleExpression of TJP1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7082
GTEX Portal (Tissue expression)TJP1
Human Protein AtlasENSG00000104067-TJP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ07157   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ07157  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ07157
PhosPhoSitePlusQ07157
Domaine pattern : Prosite (Expaxy)GUANYLATE_KINASE_2 (PS50052)    PDZ (PS50106)    SH3 (PS50002)    ZU5 (PS51145)   
Domains : Interpro (EBI)GK/Ca_channel_bsu    Guanylate_kin-like_dom    P-loop_NTPase    PDZ    PDZ_sf    SH3-like_dom_sf    SH3_domain    ZO    ZO-1    ZO-1_SH3    ZU5_dom   
Domain families : Pfam (Sanger)Guanylate_kin (PF00625)    PDZ (PF00595)    SH3_2 (PF07653)    ZU5 (PF00791)   
Domain families : Pfam (NCBI)pfam00625    pfam00595    pfam07653    pfam00791   
Domain families : Smart (EMBL)GuKc (SM00072)  PDZ (SM00228)  ZU5 (SM00218)  
Conserved Domain (NCBI)TJP1
PDB (RSDB)2H2B    2H2C    2H3M    2JWE    2KXR    2KXS    2RCZ    3CYY    3LH5    3SHU    3SHW    3TSV    3TSW    3TSZ    4OEO    4OEP    4Q2Q    4YYX   
PDB Europe2H2B    2H2C    2H3M    2JWE    2KXR    2KXS    2RCZ    3CYY    3LH5    3SHU    3SHW    3TSV    3TSW    3TSZ    4OEO    4OEP    4Q2Q    4YYX   
PDB (PDBSum)2H2B    2H2C    2H3M    2JWE    2KXR    2KXS    2RCZ    3CYY    3LH5    3SHU    3SHW    3TSV    3TSW    3TSZ    4OEO    4OEP    4Q2Q    4YYX   
PDB (IMB)2H2B    2H2C    2H3M    2JWE    2KXR    2KXS    2RCZ    3CYY    3LH5    3SHU    3SHW    3TSV    3TSW    3TSZ    4OEO    4OEP    4Q2Q    4YYX   
Structural Biology KnowledgeBase2H2B    2H2C    2H3M    2JWE    2KXR    2KXS    2RCZ    3CYY    3LH5    3SHU    3SHW    3TSV    3TSW    3TSZ    4OEO    4OEP    4Q2Q    4YYX   
SCOP (Structural Classification of Proteins)2H2B    2H2C    2H3M    2JWE    2KXR    2KXS    2RCZ    3CYY    3LH5    3SHU    3SHW    3TSV    3TSW    3TSZ    4OEO    4OEP    4Q2Q    4YYX   
CATH (Classification of proteins structures)2H2B    2H2C    2H3M    2JWE    2KXR    2KXS    2RCZ    3CYY    3LH5    3SHU    3SHW    3TSV    3TSW    3TSZ    4OEO    4OEP    4Q2Q    4YYX   
SuperfamilyQ07157
AlphaFold pdb e-kbQ07157   
Human Protein Atlas [tissue]ENSG00000104067-TJP1 [tissue]
HPRD03002
Protein Interaction databases
DIP (DOE-UCLA)Q07157
IntAct (EBI)Q07157
BioGRIDTJP1
STRING (EMBL)TJP1
ZODIACTJP1
Ontologies - Pathways
QuickGOQ07157
Ontology : AmiGOpodosome  protein binding  calmodulin binding  cytoplasm  cytosol  cytosol  plasma membrane  plasma membrane  plasma membrane  plasma membrane  adherens junction  gap junction  bicellular tight junction  bicellular tight junction  cell-cell junction assembly  positive regulation of cell population proliferation  basolateral plasma membrane  cell junction  cell junction  positive regulation of cell migration  actomyosin structure organization  protein-containing complex  adherens junction maintenance  hippo signaling  maintenance of blood-brain barrier  cell projection  negative regulation of apoptotic process  apical junction complex  apical part of cell  cell-cell junction organization  cell-cell junction organization  cadherin binding  cell adhesion molecule binding  regulation of cytoskeleton organization  negative regulation of stress fiber assembly  tight junction  tight junction  protein localization to adherens junction  establishment of endothelial intestinal barrier  establishment of endothelial intestinal barrier  cell-cell adhesion  protein localization to cell-cell junction  protein localization to cell-cell junction  regulation of cell junction assembly  protein localization to bicellular tight junction  positive regulation of sprouting angiogenesis  positive regulation of blood-brain barrier permeability  positive regulation of blood-brain barrier permeability  positive regulation of cell-cell adhesion mediated by cadherin  negative regulation of actin cytoskeleton reorganization  regulation of bicellular tight junction assembly  regulation of bicellular tight junction assembly  
Ontology : EGO-EBIpodosome  protein binding  calmodulin binding  cytoplasm  cytosol  cytosol  plasma membrane  plasma membrane  plasma membrane  plasma membrane  adherens junction  gap junction  bicellular tight junction  bicellular tight junction  cell-cell junction assembly  positive regulation of cell population proliferation  basolateral plasma membrane  cell junction  cell junction  positive regulation of cell migration  actomyosin structure organization  protein-containing complex  adherens junction maintenance  hippo signaling  maintenance of blood-brain barrier  cell projection  negative regulation of apoptotic process  apical junction complex  apical part of cell  cell-cell junction organization  cell-cell junction organization  cadherin binding  cell adhesion molecule binding  regulation of cytoskeleton organization  negative regulation of stress fiber assembly  tight junction  tight junction  protein localization to adherens junction  establishment of endothelial intestinal barrier  establishment of endothelial intestinal barrier  cell-cell adhesion  protein localization to cell-cell junction  protein localization to cell-cell junction  regulation of cell junction assembly  protein localization to bicellular tight junction  positive regulation of sprouting angiogenesis  positive regulation of blood-brain barrier permeability  positive regulation of blood-brain barrier permeability  positive regulation of cell-cell adhesion mediated by cadherin  negative regulation of actin cytoskeleton reorganization  regulation of bicellular tight junction assembly  regulation of bicellular tight junction assembly  
Pathways : KEGGAdherens junction    Tight junction    Gap junction    Vibrio cholerae infection    Epithelial cell signaling in Helicobacter pylori infection    Salmonella infection   
NDEx NetworkTJP1
Atlas of Cancer Signalling NetworkTJP1
Wikipedia pathwaysTJP1
Orthology - Evolution
OrthoDB7082
GeneTree (enSembl)ENSG00000104067
Phylogenetic Trees/Animal Genes : TreeFamTJP1
Homologs : HomoloGeneTJP1
Homology/Alignments : Family Browser (UCSC)TJP1
Gene fusions - Rearrangements
Fusion Cancer (Beijing)TJP1 [15q13.1]  -  VTN [17q11.2]  [FUSC002289]
Fusion : QuiverTJP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTJP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TJP1
dbVarTJP1
ClinVarTJP1
MonarchTJP1
1000_GenomesTJP1 
Exome Variant ServerTJP1
GNOMAD BrowserENSG00000104067
Varsome BrowserTJP1
ACMGTJP1 variants
VarityQ07157
Genomic Variants (DGV)TJP1 [DGVbeta]
DECIPHERTJP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTJP1 
Mutations
ICGC Data PortalTJP1 
TCGA Data PortalTJP1 
Broad Tumor PortalTJP1
OASIS PortalTJP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTJP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTJP1
Mutations and Diseases : HGMDTJP1
intOGen PortalTJP1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTJP1
DgiDB (Drug Gene Interaction Database)TJP1
DoCM (Curated mutations)TJP1
CIViC (Clinical Interpretations of Variants in Cancer)TJP1
Cancer3DTJP1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601009   
Orphanet
DisGeNETTJP1
MedgenTJP1
Genetic Testing Registry TJP1
NextProtQ07157 [Medical]
GENETestsTJP1
Target ValidationTJP1
Huge Navigator TJP1 [HugePedia]
ClinGenTJP1
Clinical trials, drugs, therapy
MyCancerGenomeTJP1
Protein Interactions : CTDTJP1
Pharm GKB GenePA36532
PharosQ07157
Clinical trialTJP1
Miscellaneous
canSAR (ICR)TJP1
HarmonizomeTJP1
DataMed IndexTJP1
Probes
Litterature
PubMed324 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTJP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:10 CEST 2021

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