TJP1 (tight junction protein 1)

2007-02-01  

Identity

HGNC
LOCATION
15q13.1
LOCUSID
ALIAS
ZO-1
FUSION GENES

Other Information

Locus ID:

NCBI: 7082
MIM: 601009
HGNC: 11827
Ensembl: ENSG00000104067

Variants:

dbSNP: 7082
ClinVar: 7082
TCGA: ENSG00000104067
COSMIC: TJP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104067ENST00000346128Q07157
ENSG00000104067ENST00000356107G3V1L9
ENSG00000104067ENST00000400007H0Y3R8
ENSG00000104067ENST00000400011G5E9E7
ENSG00000104067ENST00000495972H0YKB1
ENSG00000104067ENST00000545208Q07157
ENSG00000104067ENST00000558447H0YLT6
ENSG00000104067ENST00000614355A0A087X0K9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Adherens junctionKEGGko04520
Tight junctionKEGGko04530
Gap junctionKEGGko04540
Vibrio cholerae infectionKEGGko05110
Epithelial cell signaling in Helicobacter pylori infectionKEGGko05120
Adherens junctionKEGGhsa04520
Tight junctionKEGGhsa04530
Gap junctionKEGGhsa04540
Vibrio cholerae infectionKEGGhsa05110
Epithelial cell signaling in Helicobacter pylori infectionKEGGhsa05120
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Signal TransductionREACTOMER-HSA-162582
Signaling by HippoREACTOMER-HSA-2028269
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Gap junction trafficking and regulationREACTOMER-HSA-157858
Regulation of gap junction activityREACTOMER-HSA-191650
c-src mediated regulation of Cx43 function and closure of gap junctionsREACTOMER-HSA-191647
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptotic cleavage of cellular proteinsREACTOMER-HSA-111465
Apoptotic cleavage of cell adhesion proteinsREACTOMER-HSA-351906

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD
PA451257risperidoneChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
184746222008The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state.137
214116282011Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1.122
121690982002Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stress.118
181620652008Effect of alcohol on miR-212 expression in intestinal epithelial cells and its potential role in alcoholic liver disease.113
257530392015ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation.95
215367522011Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function.89
190176512009Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions.70
218578982011Matrix metalloproteinase-2 and -9 secreted by leukemic cells increase the permeability of blood-brain barrier by disrupting tight junction proteins.63
168916612006Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity.60
169091282006Characterization of epithelial cell shedding from human small intestine.60

Citation

Dessen P

TJP1 (tight junction protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45883/tjp1