Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TJP1 (tight junction protein 1)

Identity

Alias_symbol (synonym)ZO-1
MGC133289
DKFZp686M05161
Other alias
HGNC (Hugo) TJP1
LocusID (NCBI) 7082
Atlas_Id 45883
Location 15q13.1  [Link to chromosome band 15q13]
Location_base_pair Starts at 29699367 and ends at 29968799 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TJP1 (15q13.1) / FAM189A1 (15q13.1)TJP1 (15q13.1) / RNASE1 (14q11.2)TJP1 (15q13.1) / TJP1 (15q13.1)
TJP1 (15q13.1) / VTN (17q11.2)TJP1 (15q13.1) / YPEL5 (2p23.1)TYRO3 (15q15.1) / TJP1 (15q13.1)
UNKL (16p13.3) / TJP1 (15q13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TJP1   11827
Cards
Entrez_Gene (NCBI)TJP1  7082  tight junction protein 1
AliasesZO-1
GeneCards (Weizmann)TJP1
Ensembl hg19 (Hinxton)ENSG00000104067 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104067 [Gene_View]  chr15:29699367-29968799 [Contig_View]  TJP1 [Vega]
ICGC DataPortalENSG00000104067
TCGA cBioPortalTJP1
AceView (NCBI)TJP1
Genatlas (Paris)TJP1
WikiGenes7082
SOURCE (Princeton)TJP1
Genetics Home Reference (NIH)TJP1
Genomic and cartography
GoldenPath hg38 (UCSC)TJP1  -     chr15:29699367-29968799 -  15q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TJP1  -     15q13.1   [Description]    (hg19-Feb_2009)
EnsemblTJP1 - 15q13.1 [CytoView hg19]  TJP1 - 15q13.1 [CytoView hg38]
Mapping of homologs : NCBITJP1 [Mapview hg19]  TJP1 [Mapview hg38]
OMIM601009   
Gene and transcription
Genbank (Entrez)AB370197 AF035298 AK302971 AK304758 AK308113
RefSeq transcript (Entrez)NM_001301025 NM_001301026 NM_001330239 NM_003257 NM_175610
RefSeq genomic (Entrez)NC_000015 NC_018926 NT_187660 NW_011332701
Consensus coding sequences : CCDS (NCBI)TJP1
Cluster EST : UnigeneHs.743990 [ NCBI ]
CGAP (NCI)Hs.743990
Alternative Splicing GalleryENSG00000104067
Gene ExpressionTJP1 [ NCBI-GEO ]   TJP1 [ EBI - ARRAY_EXPRESS ]   TJP1 [ SEEK ]   TJP1 [ MEM ]
Gene Expression Viewer (FireBrowse)TJP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7082
GTEX Portal (Tissue expression)TJP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ07157   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ07157  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ07157
Splice isoforms : SwissVarQ07157
PhosPhoSitePlusQ07157
Domaine pattern : Prosite (Expaxy)GUANYLATE_KINASE_2 (PS50052)    PDZ (PS50106)    SH3 (PS50002)    ZU5 (PS51145)   
Domains : Interpro (EBI)GK/Ca_channel_bsu    Guanylate_kin-like_dom    P-loop_NTPase    PDZ    SH3_2    SH3_domain    ZO    ZO-1    ZU5_dom   
Domain families : Pfam (Sanger)Guanylate_kin (PF00625)    PDZ (PF00595)    SH3_2 (PF07653)    ZU5 (PF00791)   
Domain families : Pfam (NCBI)pfam00625    pfam00595    pfam07653    pfam00791   
Domain families : Smart (EMBL)GuKc (SM00072)  PDZ (SM00228)  ZU5 (SM00218)  
Conserved Domain (NCBI)TJP1
DMDM Disease mutations7082
Blocks (Seattle)TJP1
PDB (SRS)2H2B    2H2C    2H3M    2JWE    2KXR    2KXS    2RCZ    3CYY    3LH5    3SHU    3SHW    3TSV    3TSW    3TSZ    4OEO    4OEP    4Q2Q    4YYX   
PDB (PDBSum)2H2B    2H2C    2H3M    2JWE    2KXR    2KXS    2RCZ    3CYY    3LH5    3SHU    3SHW    3TSV    3TSW    3TSZ    4OEO    4OEP    4Q2Q    4YYX   
PDB (IMB)2H2B    2H2C    2H3M    2JWE    2KXR    2KXS    2RCZ    3CYY    3LH5    3SHU    3SHW    3TSV    3TSW    3TSZ    4OEO    4OEP    4Q2Q    4YYX   
PDB (RSDB)2H2B    2H2C    2H3M    2JWE    2KXR    2KXS    2RCZ    3CYY    3LH5    3SHU    3SHW    3TSV    3TSW    3TSZ    4OEO    4OEP    4Q2Q    4YYX   
Structural Biology KnowledgeBase2H2B    2H2C    2H3M    2JWE    2KXR    2KXS    2RCZ    3CYY    3LH5    3SHU    3SHW    3TSV    3TSW    3TSZ    4OEO    4OEP    4Q2Q    4YYX   
SCOP (Structural Classification of Proteins)2H2B    2H2C    2H3M    2JWE    2KXR    2KXS    2RCZ    3CYY    3LH5    3SHU    3SHW    3TSV    3TSW    3TSZ    4OEO    4OEP    4Q2Q    4YYX   
CATH (Classification of proteins structures)2H2B    2H2C    2H3M    2JWE    2KXR    2KXS    2RCZ    3CYY    3LH5    3SHU    3SHW    3TSV    3TSW    3TSZ    4OEO    4OEP    4Q2Q    4YYX   
SuperfamilyQ07157
Human Protein AtlasENSG00000104067
Peptide AtlasQ07157
HPRD03002
IPIIPI00216219   IPI00335824   IPI00941530   IPI01013569   IPI00795990   
Protein Interaction databases
DIP (DOE-UCLA)Q07157
IntAct (EBI)Q07157
FunCoupENSG00000104067
BioGRIDTJP1
STRING (EMBL)TJP1
ZODIACTJP1
Ontologies - Pathways
QuickGOQ07157
Ontology : AmiGOprotein binding  calmodulin binding  cytoplasm  cytosol  cytosol  plasma membrane  plasma membrane  cell-cell adherens junction  gap junction  bicellular tight junction  cell-cell junction assembly  basolateral plasma membrane  cell junction  hippo signaling  apical junction complex  apical part of cell  cadherin binding  establishment of endothelial intestinal barrier  cell-cell signaling involved in cell-cell junction organization  
Ontology : EGO-EBIprotein binding  calmodulin binding  cytoplasm  cytosol  cytosol  plasma membrane  plasma membrane  cell-cell adherens junction  gap junction  bicellular tight junction  cell-cell junction assembly  basolateral plasma membrane  cell junction  hippo signaling  apical junction complex  apical part of cell  cadherin binding  establishment of endothelial intestinal barrier  cell-cell signaling involved in cell-cell junction organization  
Pathways : KEGGAdherens junction    Tight junction    Gap junction    Vibrio cholerae infection    Epithelial cell signaling in Helicobacter pylori infection    Salmonella infection   
NDEx NetworkTJP1
Atlas of Cancer Signalling NetworkTJP1
Wikipedia pathwaysTJP1
Orthology - Evolution
OrthoDB7082
GeneTree (enSembl)ENSG00000104067
Phylogenetic Trees/Animal Genes : TreeFamTJP1
HOVERGENQ07157
HOGENOMQ07157
Homologs : HomoloGeneTJP1
Homology/Alignments : Family Browser (UCSC)TJP1
Gene fusions - Rearrangements
Fusion Cancer (Beijing)TJP1 [15q13.1]  -  VTN [17q11.2]  [FUSC002289]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTJP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TJP1
dbVarTJP1
ClinVarTJP1
1000_GenomesTJP1 
Exome Variant ServerTJP1
ExAC (Exome Aggregation Consortium)TJP1 (select the gene name)
Genetic variants : HAPMAP7082
Genomic Variants (DGV)TJP1 [DGVbeta]
DECIPHERTJP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTJP1 
Mutations
ICGC Data PortalTJP1 
TCGA Data PortalTJP1 
Broad Tumor PortalTJP1
OASIS PortalTJP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTJP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTJP1
intOGen PortalTJP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TJP1
DgiDB (Drug Gene Interaction Database)TJP1
DoCM (Curated mutations)TJP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TJP1 (select a term)
intoGenTJP1
Cancer3DTJP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601009   
Orphanet
MedgenTJP1
Genetic Testing Registry TJP1
NextProtQ07157 [Medical]
TSGene7082
GENETestsTJP1
Target ValidationTJP1
Huge Navigator TJP1 [HugePedia]
snp3D : Map Gene to Disease7082
BioCentury BCIQTJP1
ClinGenTJP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7082
Chemical/Pharm GKB GenePA36532
Clinical trialTJP1
Miscellaneous
canSAR (ICR)TJP1 (select the gene name)
Probes
Litterature
PubMed232 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTJP1
EVEXTJP1
GoPubMedTJP1
iHOPTJP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:59:27 CEST 2017

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