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TJP3 (tight junction protein 3)

Identity

Alias (NCBI)ZO-3
ZO3
HGNC (Hugo) TJP3
HGNC Alias symbZO-3
HGNC Alias namezona occludens 3
LocusID (NCBI) 27134
Atlas_Id 56287
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 3721737 and ends at 3750813 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SHC2 (19p13.3) / TJP3 (19p13.3)TJP3 (19p13.3) / LRRC8E (19p13.2)TJP3 (19p13.3) / ZNF554 (19p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TJP3   11829
Cards
Entrez_Gene (NCBI)TJP3    tight junction protein 3
AliasesZO-3; ZO3
GeneCards (Weizmann)TJP3
Ensembl hg19 (Hinxton)ENSG00000105289 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105289 [Gene_View]  ENSG00000105289 [Sequence]  chr19:3721737-3750813 [Contig_View]  TJP3 [Vega]
ICGC DataPortalENSG00000105289
TCGA cBioPortalTJP3
AceView (NCBI)TJP3
Genatlas (Paris)TJP3
SOURCE (Princeton)TJP3
Genetics Home Reference (NIH)TJP3
Genomic and cartography
GoldenPath hg38 (UCSC)TJP3  -     chr19:3721737-3750813 +  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TJP3  -     19p13.3   [Description]    (hg19-Feb_2009)
GoldenPathTJP3 - 19p13.3 [CytoView hg19]  TJP3 - 19p13.3 [CytoView hg38]
ImmunoBaseENSG00000105289
Genome Data Viewer NCBITJP3 [Mapview hg19]  
OMIM612689   
Gene and transcription
Genbank (Entrez)AK027292 AK091118 AK128237 AK304462 AL555606
RefSeq transcript (Entrez)NM_001267560 NM_001267561 NM_014428
Consensus coding sequences : CCDS (NCBI)TJP3
Gene ExpressionTJP3 [ NCBI-GEO ]   TJP3 [ EBI - ARRAY_EXPRESS ]   TJP3 [ SEEK ]   TJP3 [ MEM ]
Gene Expression Viewer (FireBrowse)TJP3 [ Firebrowse - Broad ]
GenevisibleExpression of TJP3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27134
GTEX Portal (Tissue expression)TJP3
Human Protein AtlasENSG00000105289-TJP3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95049   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95049  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95049
PhosPhoSitePlusO95049
Domaine pattern : Prosite (Expaxy)GUANYLATE_KINASE_2 (PS50052)    PDZ (PS50106)    SH3 (PS50002)   
Domains : Interpro (EBI)GK/Ca_channel_bsu    Guanylate_kin-like_dom    P-loop_NTPase    PDZ    PDZ_sf    SH3-like_dom_sf    SH3_domain    ZO    ZO-3   
Domain families : Pfam (Sanger)Guanylate_kin (PF00625)    PDZ (PF00595)    SH3_2 (PF07653)   
Domain families : Pfam (NCBI)pfam00625    pfam00595    pfam07653   
Domain families : Smart (EMBL)GuKc (SM00072)  PDZ (SM00228)  SH3 (SM00326)  
Conserved Domain (NCBI)TJP3
PDB (RSDB)3KFV   
PDB Europe3KFV   
PDB (PDBSum)3KFV   
PDB (IMB)3KFV   
Structural Biology KnowledgeBase3KFV   
SCOP (Structural Classification of Proteins)3KFV   
CATH (Classification of proteins structures)3KFV   
SuperfamilyO95049
AlphaFold pdb e-kbO95049   
Human Protein Atlas [tissue]ENSG00000105289-TJP3 [tissue]
HPRD18194
Protein Interaction databases
DIP (DOE-UCLA)O95049
IntAct (EBI)O95049
BioGRIDTJP3
STRING (EMBL)TJP3
ZODIACTJP3
Ontologies - Pathways
QuickGOO95049
Ontology : AmiGOprotein binding  nucleus  nucleoplasm  plasma membrane  plasma membrane  bicellular tight junction  bicellular tight junction  cell junction  maintenance of blood-brain barrier  cell-cell junction organization  cell adhesion molecule binding  establishment of endothelial intestinal barrier  cell-cell adhesion  protein localization to cell-cell junction  positive regulation of blood-brain barrier permeability  
Ontology : EGO-EBIprotein binding  nucleus  nucleoplasm  plasma membrane  plasma membrane  bicellular tight junction  bicellular tight junction  cell junction  maintenance of blood-brain barrier  cell-cell junction organization  cell adhesion molecule binding  establishment of endothelial intestinal barrier  cell-cell adhesion  protein localization to cell-cell junction  positive regulation of blood-brain barrier permeability  
Pathways : KEGGTight junction   
NDEx NetworkTJP3
Atlas of Cancer Signalling NetworkTJP3
Wikipedia pathwaysTJP3
Orthology - Evolution
OrthoDB27134
GeneTree (enSembl)ENSG00000105289
Phylogenetic Trees/Animal Genes : TreeFamTJP3
Homologs : HomoloGeneTJP3
Homology/Alignments : Family Browser (UCSC)TJP3
Gene fusions - Rearrangements
Fusion : QuiverTJP3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTJP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TJP3
dbVarTJP3
ClinVarTJP3
MonarchTJP3
1000_GenomesTJP3 
Exome Variant ServerTJP3
GNOMAD BrowserENSG00000105289
Varsome BrowserTJP3
ACMGTJP3 variants
VarityO95049
Genomic Variants (DGV)TJP3 [DGVbeta]
DECIPHERTJP3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTJP3 
Mutations
ICGC Data PortalTJP3 
TCGA Data PortalTJP3 
Broad Tumor PortalTJP3
OASIS PortalTJP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTJP3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTJP3
Mutations and Diseases : HGMDTJP3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTJP3
DgiDB (Drug Gene Interaction Database)TJP3
DoCM (Curated mutations)TJP3
CIViC (Clinical Interpretations of Variants in Cancer)TJP3
Cancer3DTJP3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612689   
Orphanet
DisGeNETTJP3
MedgenTJP3
Genetic Testing Registry TJP3
NextProtO95049 [Medical]
GENETestsTJP3
Target ValidationTJP3
Huge Navigator TJP3 [HugePedia]
ClinGenTJP3
Clinical trials, drugs, therapy
MyCancerGenomeTJP3
Protein Interactions : CTDTJP3
Pharm GKB GenePA36534
PharosO95049
Clinical trialTJP3
Miscellaneous
canSAR (ICR)TJP3
HarmonizomeTJP3
DataMed IndexTJP3
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTJP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:10 CEST 2021

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