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TJP3 (tight junction protein 3)

Identity

Alias_symbol (synonym)ZO-3
Other aliasZO3
HGNC (Hugo) TJP3
LocusID (NCBI) 27134
Atlas_Id 56287
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 3708337 and ends at 3750813 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SHC2 (19p13.3) / TJP3 (19p13.3)TJP3 (19p13.3) / LRRC8E (19p13.2)TJP3 (19p13.3) / ZNF554 (19p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TJP3   11829
Cards
Entrez_Gene (NCBI)TJP3  27134  tight junction protein 3
AliasesZO-3; ZO3
GeneCards (Weizmann)TJP3
Ensembl hg19 (Hinxton)ENSG00000105289 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105289 [Gene_View]  chr19:3708337-3750813 [Contig_View]  TJP3 [Vega]
ICGC DataPortalENSG00000105289
TCGA cBioPortalTJP3
AceView (NCBI)TJP3
Genatlas (Paris)TJP3
WikiGenes27134
SOURCE (Princeton)TJP3
Genetics Home Reference (NIH)TJP3
Genomic and cartography
GoldenPath hg38 (UCSC)TJP3  -     chr19:3708337-3750813 +  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TJP3  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblTJP3 - 19p13.3 [CytoView hg19]  TJP3 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBITJP3 [Mapview hg19]  TJP3 [Mapview hg38]
OMIM612689   
Gene and transcription
Genbank (Entrez)AK027292 AK091118 AK128237 AK304462 AL555606
RefSeq transcript (Entrez)NM_001267560 NM_001267561 NM_014428
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TJP3
Cluster EST : UnigeneHs.25527 [ NCBI ]
CGAP (NCI)Hs.25527
Alternative Splicing GalleryENSG00000105289
Gene ExpressionTJP3 [ NCBI-GEO ]   TJP3 [ EBI - ARRAY_EXPRESS ]   TJP3 [ SEEK ]   TJP3 [ MEM ]
Gene Expression Viewer (FireBrowse)TJP3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27134
GTEX Portal (Tissue expression)TJP3
Human Protein AtlasENSG00000105289-TJP3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95049   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95049  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95049
Splice isoforms : SwissVarO95049
PhosPhoSitePlusO95049
Domaine pattern : Prosite (Expaxy)GUANYLATE_KINASE_2 (PS50052)    PDZ (PS50106)    SH3 (PS50002)   
Domains : Interpro (EBI)GK/Ca_channel_bsu    Guanylate_kin-like_dom    P-loop_NTPase    PDZ    SH3_2    SH3_domain    ZO    ZO-3   
Domain families : Pfam (Sanger)Guanylate_kin (PF00625)    PDZ (PF00595)    SH3_2 (PF07653)   
Domain families : Pfam (NCBI)pfam00625    pfam00595    pfam07653   
Domain families : Smart (EMBL)GuKc (SM00072)  PDZ (SM00228)  SH3 (SM00326)  
Conserved Domain (NCBI)TJP3
DMDM Disease mutations27134
Blocks (Seattle)TJP3
PDB (SRS)3KFV   
PDB (PDBSum)3KFV   
PDB (IMB)3KFV   
PDB (RSDB)3KFV   
Structural Biology KnowledgeBase3KFV   
SCOP (Structural Classification of Proteins)3KFV   
CATH (Classification of proteins structures)3KFV   
SuperfamilyO95049
Human Protein Atlas [tissue]ENSG00000105289-TJP3 [tissue]
Peptide AtlasO95049
HPRD18194
IPIIPI00792295   IPI00744036   IPI00973106   IPI01012603   IPI01011942   
Protein Interaction databases
DIP (DOE-UCLA)O95049
IntAct (EBI)O95049
FunCoupENSG00000105289
BioGRIDTJP3
STRING (EMBL)TJP3
ZODIACTJP3
Ontologies - Pathways
QuickGOO95049
Ontology : AmiGOprotein binding  nucleus  plasma membrane  bicellular tight junction  
Ontology : EGO-EBIprotein binding  nucleus  plasma membrane  bicellular tight junction  
Pathways : KEGGTight junction   
NDEx NetworkTJP3
Atlas of Cancer Signalling NetworkTJP3
Wikipedia pathwaysTJP3
Orthology - Evolution
OrthoDB27134
GeneTree (enSembl)ENSG00000105289
Phylogenetic Trees/Animal Genes : TreeFamTJP3
HOVERGENO95049
HOGENOMO95049
Homologs : HomoloGeneTJP3
Homology/Alignments : Family Browser (UCSC)TJP3
Gene fusions - Rearrangements
Tumor Fusion PortalTJP3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTJP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TJP3
dbVarTJP3
ClinVarTJP3
1000_GenomesTJP3 
Exome Variant ServerTJP3
ExAC (Exome Aggregation Consortium)ENSG00000105289
GNOMAD BrowserENSG00000105289
Genetic variants : HAPMAP27134
Genomic Variants (DGV)TJP3 [DGVbeta]
DECIPHERTJP3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTJP3 
Mutations
ICGC Data PortalTJP3 
TCGA Data PortalTJP3 
Broad Tumor PortalTJP3
OASIS PortalTJP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTJP3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTJP3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TJP3
DgiDB (Drug Gene Interaction Database)TJP3
DoCM (Curated mutations)TJP3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TJP3 (select a term)
intoGenTJP3
Cancer3DTJP3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612689   
Orphanet
DisGeNETTJP3
MedgenTJP3
Genetic Testing Registry TJP3
NextProtO95049 [Medical]
TSGene27134
GENETestsTJP3
Target ValidationTJP3
Huge Navigator TJP3 [HugePedia]
snp3D : Map Gene to Disease27134
BioCentury BCIQTJP3
ClinGenTJP3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD27134
Chemical/Pharm GKB GenePA36534
Clinical trialTJP3
Miscellaneous
canSAR (ICR)TJP3 (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTJP3
EVEXTJP3
GoPubMedTJP3
iHOPTJP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:38:31 CET 2017

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