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TK1 (thymidine kinase 1)

Identity

Alias_namesthymidine kinase 1
Other aliasTK2
HGNC (Hugo) TK1
LocusID (NCBI) 7083
Atlas_Id 42576
Location 17q25.3  [Link to chromosome band 17q25]
Location_base_pair Starts at 78174079 and ends at 78187204 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CALCOCO1 (12q13.13) / TK1 (17q25.3)TK1 (17q25.3) / CAMTA1 (1p36.31)TK1 (17q25.3) / DNAH17 (17q25.3)
TMC6 (17q25.3) / TK1 (17q25.3)UBTF (17q21.31) / TK1 (17q25.3)TK1 17q25.3 / DNAH17 17q25.3
TMC6 17q25.3 / TK1 17q25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(4;22)(q12;q11) BCR/PDGFRA

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(17;17)(q25;q25) TK1/DNAH17
t(17;17)(q25;q25) TMC6/TK1

External links

Nomenclature
HGNC (Hugo)TK1   11830
Cards
Entrez_Gene (NCBI)TK1  7083  thymidine kinase 1
AliasesTK2
GeneCards (Weizmann)TK1
Ensembl hg19 (Hinxton)ENSG00000167900 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167900 [Gene_View]  ENSG00000167900 [Sequence]  chr17:78174079-78187204 [Contig_View]  TK1 [Vega]
ICGC DataPortalENSG00000167900
TCGA cBioPortalTK1
AceView (NCBI)TK1
Genatlas (Paris)TK1
WikiGenes7083
SOURCE (Princeton)TK1
Genetics Home Reference (NIH)TK1
Genomic and cartography
GoldenPath hg38 (UCSC)TK1  -     chr17:78174079-78187204 -  17q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TK1  -     17q25.3   [Description]    (hg19-Feb_2009)
EnsemblTK1 - 17q25.3 [CytoView hg19]  TK1 - 17q25.3 [CytoView hg38]
Mapping of homologs : NCBITK1 [Mapview hg19]  TK1 [Mapview hg38]
OMIM188300   
Gene and transcription
Genbank (Entrez)AA633286 AB451268 AB451395 AK314950 AW183491
RefSeq transcript (Entrez)NM_001346663 NM_003258
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TK1
Cluster EST : UnigeneHs.515122 [ NCBI ]
CGAP (NCI)Hs.515122
Alternative Splicing GalleryENSG00000167900
Gene ExpressionTK1 [ NCBI-GEO ]   TK1 [ EBI - ARRAY_EXPRESS ]   TK1 [ SEEK ]   TK1 [ MEM ]
Gene Expression Viewer (FireBrowse)TK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7083
GTEX Portal (Tissue expression)TK1
Human Protein AtlasENSG00000167900-TK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04183   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP04183  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP04183
Splice isoforms : SwissVarP04183
PhosPhoSitePlusP04183
Domaine pattern : Prosite (Expaxy)TK_CELLULAR_TYPE (PS00603)   
Domains : Interpro (EBI)P-loop_NTPase    Thymidine_kinase    Thymidine_kinase_CS   
Domain families : Pfam (Sanger)TK (PF00265)   
Domain families : Pfam (NCBI)pfam00265   
Conserved Domain (NCBI)TK1
DMDM Disease mutations7083
Blocks (Seattle)TK1
PDB (SRS)1W4R    1XBT    2ORV    2WVJ   
PDB (PDBSum)1W4R    1XBT    2ORV    2WVJ   
PDB (IMB)1W4R    1XBT    2ORV    2WVJ   
PDB (RSDB)1W4R    1XBT    2ORV    2WVJ   
Structural Biology KnowledgeBase1W4R    1XBT    2ORV    2WVJ   
SCOP (Structural Classification of Proteins)1W4R    1XBT    2ORV    2WVJ   
CATH (Classification of proteins structures)1W4R    1XBT    2ORV    2WVJ   
SuperfamilyP04183
Human Protein Atlas [tissue]ENSG00000167900-TK1 [tissue]
Peptide AtlasP04183
HPRD01771
IPIIPI00299214   
Protein Interaction databases
DIP (DOE-UCLA)P04183
IntAct (EBI)P04183
FunCoupENSG00000167900
BioGRIDTK1
STRING (EMBL)TK1
ZODIACTK1
Ontologies - Pathways
QuickGOP04183
Ontology : AmiGOthymidine kinase activity  protein binding  ATP binding  cytosol  nucleobase-containing compound metabolic process  DNA metabolic process  zinc ion binding  deoxyribonucleoside monophosphate biosynthetic process  nucleotide biosynthetic process  phosphorylation  nucleoside kinase activity  identical protein binding  pyrimidine nucleoside salvage  thymidine metabolic process  protein homotetramerization  DNA biosynthetic process  
Ontology : EGO-EBIthymidine kinase activity  protein binding  ATP binding  cytosol  nucleobase-containing compound metabolic process  DNA metabolic process  zinc ion binding  deoxyribonucleoside monophosphate biosynthetic process  nucleotide biosynthetic process  phosphorylation  nucleoside kinase activity  identical protein binding  pyrimidine nucleoside salvage  thymidine metabolic process  protein homotetramerization  DNA biosynthetic process  
Pathways : KEGGPyrimidine metabolism   
NDEx NetworkTK1
Atlas of Cancer Signalling NetworkTK1
Wikipedia pathwaysTK1
Orthology - Evolution
OrthoDB7083
GeneTree (enSembl)ENSG00000167900
Phylogenetic Trees/Animal Genes : TreeFamTK1
HOVERGENP04183
HOGENOMP04183
Homologs : HomoloGeneTK1
Homology/Alignments : Family Browser (UCSC)TK1
Gene fusions - Rearrangements
Fusion : MitelmanTK1/DNAH17 [17q25.3/17q25.3]  
Fusion : MitelmanTMC6/TK1 [17q25.3/17q25.3]  [t(17;17)(q25;q25)]  
Fusion PortalTK1 17q25.3 DNAH17 17q25.3 BLCA
Fusion PortalTMC6 17q25.3 TK1 17q25.3 OV
Fusion : QuiverTK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TK1
dbVarTK1
ClinVarTK1
1000_GenomesTK1 
Exome Variant ServerTK1
ExAC (Exome Aggregation Consortium)ENSG00000167900
GNOMAD BrowserENSG00000167900
Genetic variants : HAPMAP7083
Genomic Variants (DGV)TK1 [DGVbeta]
DECIPHERTK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTK1 
Mutations
ICGC Data PortalTK1 
TCGA Data PortalTK1 
Broad Tumor PortalTK1
OASIS PortalTK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TK1
DgiDB (Drug Gene Interaction Database)TK1
DoCM (Curated mutations)TK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TK1 (select a term)
intoGenTK1
Cancer3DTK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM188300   
Orphanet
DisGeNETTK1
MedgenTK1
Genetic Testing Registry TK1
NextProtP04183 [Medical]
TSGene7083
GENETestsTK1
Target ValidationTK1
Huge Navigator TK1 [HugePedia]
snp3D : Map Gene to Disease7083
BioCentury BCIQTK1
ClinGenTK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7083
Chemical/Pharm GKB GenePA352
Clinical trialTK1
Miscellaneous
canSAR (ICR)TK1 (select the gene name)
Probes
Litterature
PubMed93 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTK1
EVEXTK1
GoPubMedTK1
iHOPTK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:54:03 CEST 2018
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