TK1 (thymidine kinase 1)

2003-05-01 Affiliation

Identity

HGNC

TK1

LOCATION

17q25.3

LOCUSID

7083

ALIAS

TK2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7083
MIM: 188300
HGNC: 11830
Ensembl: ENSG00000167900

Variants:

dbSNP: 7083
ClinVar: 7083
TCGA: ENSG00000167900
COSMIC: TK1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000167900	ENST00000301634	P04183
ENSG00000167900	ENST00000301634	A0A384MDV9
ENSG00000167900	ENST00000586613	K7ERJ1
ENSG00000167900	ENST00000588734	K7ERV3
ENSG00000167900	ENST00000590430	K7ENW5
ENSG00000167900	ENST00000590862	K7ES52

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Pyrimidine metabolism	KEGG	ko00240
Drug metabolism - other enzymes	KEGG	ko00983
Pyrimidine metabolism	KEGG	hsa00240
Drug metabolism - other enzymes	KEGG	hsa00983
Metabolic pathways	KEGG	hsa01100
Metabolism	REACTOME	R-HSA-1430728
Metabolism of nucleotides	REACTOME	R-HSA-15869
Pyrimidine metabolism	REACTOME	R-HSA-73848
Pyrimidine salvage reactions	REACTOME	R-HSA-73614

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA128406956	fluorouracil	Chemical	VariantAnnotation	not associated	PD
PA445058	Neoplasm Metastasis	Disease	VariantAnnotation	not associated	PD
PA448771	capecitabine	Chemical	VariantAnnotation	not associated	PD
PA451954	zidovudine	Chemical	Pathway	associated		22960662

References

Pubmed ID	Year	Title	Citations
37673047	2024	Clinical Significance of the TK1-Specific Activity in the Early Detection of Ovarian Cancer.	0
37673047	2024	Clinical Significance of the TK1-Specific Activity in the Early Detection of Ovarian Cancer.	0
36982234	2023	Prediction of Overall Survival by Thymidine Kinase 1 Combined with Prostate-Specific Antigen in Men with Prostate Cancer.	2
37715794	2023	Transcription factor Dp-1 knockdown downregulates thymidine kinase 1 expression to protect against proliferation and epithelial-mesenchymal transition in cervical cancer.	0
38033034	2023	TK1 expression influences pathogenicity by cell cycle progression, cellular migration, and cellular survival in HCC 1806 breast cancer cells.	0
36982234	2023	Prediction of Overall Survival by Thymidine Kinase 1 Combined with Prostate-Specific Antigen in Men with Prostate Cancer.	2
37715794	2023	Transcription factor Dp-1 knockdown downregulates thymidine kinase 1 expression to protect against proliferation and epithelial-mesenchymal transition in cervical cancer.	0
38033034	2023	TK1 expression influences pathogenicity by cell cycle progression, cellular migration, and cellular survival in HCC 1806 breast cancer cells.	0
35220246	2022	Serum Concentration of Thymidine Kinase 1 (TK1) as a Tumor Marker in Soft Tissue Sarcomas.	0
35220246	2022	Serum Concentration of Thymidine Kinase 1 (TK1) as a Tumor Marker in Soft Tissue Sarcomas.	0
33517301	2021	Elevated Free Triiodothyronine Is Associated With Increased Proliferative Activity in Triple-negative Breast Cancer.	2
33517319	2021	Clinical Applicability of the Proliferation Marker Thymidine Kinase 1 in Head and Neck Cancer Patients.	1
34521624	2021	Evaluating Serum Thymidine Kinase 1 in Patients with Hormone Receptor-Positive Metastatic Breast Cancer Receiving First-line Endocrine Therapy in the SWOG S0226 Trial.	5
33517301	2021	Elevated Free Triiodothyronine Is Associated With Increased Proliferative Activity in Triple-negative Breast Cancer.	2
33517319	2021	Clinical Applicability of the Proliferation Marker Thymidine Kinase 1 in Head and Neck Cancer Patients.	1

Citation

Dessen P

TK1 (thymidine kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42576/tk1