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TK2 (thymidine kinase 2, mitochondrial)

Identity

Other namesMTDPS2
MTTK
HGNC (Hugo) TK2
LocusID (NCBI) 7084
Location 16q21
Location_base_pair Starts at 66541906 and ends at 66584194 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias 11q23ChildAMLID1615

External links

Nomenclature
HGNC (Hugo)TK2   11831
Cards
Entrez_Gene (NCBI)TK2  7084  thymidine kinase 2, mitochondrial
GeneCards (Weizmann)TK2
Ensembl (Hinxton)ENSG00000166548 [Gene_View]  chr16:66541906-66584194 [Contig_View]  TK2 [Vega]
ICGC DataPortalENSG00000166548
cBioPortalTK2
AceView (NCBI)TK2
Genatlas (Paris)TK2
WikiGenes7084
SOURCE (Princeton)NM_001172643 NM_001172644 NM_001172645 NM_001271934 NM_001271935 NM_001272050 NM_004614
Genomic and cartography
GoldenPath (UCSC)TK2  -  16q21   chr16:66541906-66584194 -  16q21   [Description]    (hg19-Feb_2009)
EnsemblTK2 - 16q21 [CytoView]
Mapping of homologs : NCBITK2 [Mapview]
OMIM188250   609560   
Gene and transcription
Genbank (Entrez)AF521891 AK026021 AK026041 AK294627 AK295808
RefSeq transcript (Entrez)NM_001172643 NM_001172644 NM_001172645 NM_001271934 NM_001271935 NM_001272050 NM_004614
RefSeq genomic (Entrez)AC_000148 NC_000016 NC_018927 NG_016862 NT_010498 NW_001838290 NW_004929402
Consensus coding sequences : CCDS (NCBI)TK2
Cluster EST : UnigeneHs.512619 [ NCBI ]
CGAP (NCI)Hs.512619
Alternative Splicing : Fast-db (Paris)GSHG0011893
Alternative Splicing GalleryENSG00000166548
Gene ExpressionTK2 [ NCBI-GEO ]     TK2 [ SEEK ]   TK2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00142 (Uniprot)
NextProtO00142  [Medical]
With graphics : InterProO00142
Splice isoforms : SwissVarO00142 (Swissvar)
Catalytic activity : Enzyme2.7.1.21 [ Enzyme-Expasy ]   2.7.1.212.7.1.21 [ IntEnz-EBI ]   2.7.1.21 [ BRENDA ]   2.7.1.21 [ KEGG ]   
Domains : Interpro (EBI)Deoxynucleoside_kinase [organisation]   P-loop_NTPase [organisation]  
Related proteins : CluSTrO00142
Domain families : Pfam (Sanger)dNK (PF01712)   
Domain families : Pfam (NCBI)pfam01712   
DMDM Disease mutations7084
Blocks (Seattle)O00142
Human Protein AtlasENSG00000166548 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasO00142
HPRD01770
IPIIPI00215650   IPI00337439   IPI00955983   IPI00939299   IPI00983297   
Protein Interaction databases
DIP (DOE-UCLA)O00142
IntAct (EBI)O00142
FunCoupENSG00000166548
BioGRIDTK2
InParanoidO00142
Interologous Interaction database O00142
IntegromeDBTK2
STRING (EMBL)TK2
Ontologies - Pathways
Ontology : AmiGOdeoxycytidine kinase activity  thymidine kinase activity  ATP binding  mitochondrial inner membrane  mitochondrial matrix  nucleobase-containing compound metabolic process  pyrimidine nucleobase metabolic process  mitochondrial DNA replication  deoxyribonucleoside monophosphate biosynthetic process  deoxyribonucleoside monophosphate biosynthetic process  deoxyribonucleotide metabolic process  phosphorylation  phosphotransferase activity, alcohol group as acceptor  pyrimidine nucleoside salvage  small molecule metabolic process  deoxycytidine metabolic process  thymidine metabolic process  nucleobase-containing small molecule metabolic process  
Ontology : EGO-EBIdeoxycytidine kinase activity  thymidine kinase activity  ATP binding  mitochondrial inner membrane  mitochondrial matrix  nucleobase-containing compound metabolic process  pyrimidine nucleobase metabolic process  mitochondrial DNA replication  deoxyribonucleoside monophosphate biosynthetic process  deoxyribonucleoside monophosphate biosynthetic process  deoxyribonucleotide metabolic process  phosphorylation  phosphotransferase activity, alcohol group as acceptor  pyrimidine nucleoside salvage  small molecule metabolic process  deoxycytidine metabolic process  thymidine metabolic process  nucleobase-containing small molecule metabolic process  
Pathways : KEGGPyrimidine metabolism    Drug metabolism - other enzymes   
Protein Interaction DatabaseTK2
Wikipedia pathwaysTK2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)TK2
snp3D : Map Gene to Disease7084
SNP (GeneSNP Utah)TK2
SNP : HGBaseTK2
Genetic variants : HAPMAPTK2
Exome VariantTK2
1000_GenomesTK2 
ICGC programENSG00000166548 
Somatic Mutations in Cancer : COSMICTK2 
CONAN: Copy Number AnalysisTK2 
Mutations and Diseases : HGMDTK2
Mutations and Diseases : intOGenTK2
Genomic VariantsTK2  TK2 [DGVbeta]
dbVarTK2
ClinVarTK2
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM188250    609560   
MedgenTK2
GENETestsTK2
Disease Genetic AssociationTK2
Huge Navigator TK2 [HugePedia]  TK2 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneTK2
Homology/Alignments : Family Browser (UCSC)TK2
Phylogenetic Trees/Animal Genes : TreeFamTK2
Chemical/Protein Interactions : CTD7084
Chemical/Pharm GKB GenePA36535
Clinical trialTK2
Cancer Resource (Charite)ENSG00000166548
Other databases
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
CoreMineTK2
iHOPTK2
OncoSearchTK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 17:07:44 CEST 2014

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