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TK2 (thymidine kinase 2)

Identity

Alias (NCBI)MTDPS2
MTTK
PEOB3
SCA31
HGNC (Hugo) TK2
HGNC Alias symbSCA31
HGNC Alias namemitochondrial thymidine kinase
HGNC Previous namethymidine kinase 2, mitochondrial
LocusID (NCBI) 7084
Atlas_Id 42577
Location 16q21  [Link to chromosome band 16q21]
Location_base_pair Starts at 66508003 and ends at 66550122 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TK2 (16q21) / EXOC3L1 (16q22.1)TK2 16q21 / EXOC3L1 16q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(4;22)(q12;q11) BCR/PDGFRA


External links

 

Nomenclature
HGNC (Hugo)TK2   11831
Cards
Entrez_Gene (NCBI)TK2    thymidine kinase 2
AliasesMTDPS2; MTTK; PEOB3; SCA31
GeneCards (Weizmann)TK2
Ensembl hg19 (Hinxton)ENSG00000166548 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166548 [Gene_View]  ENSG00000166548 [Sequence]  chr16:66508003-66550122 [Contig_View]  TK2 [Vega]
ICGC DataPortalENSG00000166548
TCGA cBioPortalTK2
AceView (NCBI)TK2
Genatlas (Paris)TK2
SOURCE (Princeton)TK2
Genetics Home Reference (NIH)TK2
Genomic and cartography
GoldenPath hg38 (UCSC)TK2  -     chr16:66508003-66550122 -  16q21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TK2  -     16q21   [Description]    (hg19-Feb_2009)
GoldenPathTK2 - 16q21 [CytoView hg19]  TK2 - 16q21 [CytoView hg38]
ImmunoBaseENSG00000166548
Genome Data Viewer NCBITK2 [Mapview hg19]  
OMIM188250   609560   617069   
Gene and transcription
Genbank (Entrez)AF521891 AK026021 AK026041 AK294627 AK295808
RefSeq transcript (Entrez)NM_001172643 NM_001172644 NM_001172645 NM_001271934 NM_001271935 NM_001272050 NM_004614
Consensus coding sequences : CCDS (NCBI)TK2
Gene ExpressionTK2 [ NCBI-GEO ]   TK2 [ EBI - ARRAY_EXPRESS ]   TK2 [ SEEK ]   TK2 [ MEM ]
Gene Expression Viewer (FireBrowse)TK2 [ Firebrowse - Broad ]
GenevisibleExpression of TK2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7084
GTEX Portal (Tissue expression)TK2
Human Protein AtlasENSG00000166548-TK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00142   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00142  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00142
Catalytic activity : Enzyme2.7.1.21 [ Enzyme-Expasy ]   2.7.1.212.7.1.21 [ IntEnz-EBI ]   2.7.1.21 [ BRENDA ]   2.7.1.21 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusO00142
Domains : Interpro (EBI)DCK/DGK    DNK_dom    P-loop_NTPase   
Domain families : Pfam (Sanger)dNK (PF01712)   
Domain families : Pfam (NCBI)pfam01712   
Conserved Domain (NCBI)TK2
SuperfamilyO00142
AlphaFold pdb e-kbO00142   
Human Protein Atlas [tissue]ENSG00000166548-TK2 [tissue]
HPRD01770
Protein Interaction databases
DIP (DOE-UCLA)O00142
IntAct (EBI)O00142
BioGRIDTK2
STRING (EMBL)TK2
ZODIACTK2
Ontologies - Pathways
QuickGOO00142
Ontology : AmiGOdeoxycytidine kinase activity  thymidine kinase activity  ATP binding  cytoplasm  mitochondrial matrix  nucleobase-containing compound metabolic process  deoxyribonucleoside monophosphate biosynthetic process  phosphorylation  deoxynucleoside kinase activity  pyrimidine nucleoside salvage  deoxycytidine metabolic process  thymidine metabolic process  DNA biosynthetic process  
Ontology : EGO-EBIdeoxycytidine kinase activity  thymidine kinase activity  ATP binding  cytoplasm  mitochondrial matrix  nucleobase-containing compound metabolic process  deoxyribonucleoside monophosphate biosynthetic process  phosphorylation  deoxynucleoside kinase activity  pyrimidine nucleoside salvage  deoxycytidine metabolic process  thymidine metabolic process  DNA biosynthetic process  
Pathways : KEGGPyrimidine metabolism    Drug metabolism - other enzymes   
NDEx NetworkTK2
Atlas of Cancer Signalling NetworkTK2
Wikipedia pathwaysTK2
Orthology - Evolution
OrthoDB7084
GeneTree (enSembl)ENSG00000166548
Phylogenetic Trees/Animal Genes : TreeFamTK2
Homologs : HomoloGeneTK2
Homology/Alignments : Family Browser (UCSC)TK2
Gene fusions - Rearrangements
Fusion : MitelmanTK2/EXOC3L1 [16q21/16q22.1]  
Fusion : QuiverTK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TK2
dbVarTK2
ClinVarTK2
MonarchTK2
1000_GenomesTK2 
Exome Variant ServerTK2
GNOMAD BrowserENSG00000166548
Varsome BrowserTK2
ACMGTK2 variants
VarityO00142
Genomic Variants (DGV)TK2 [DGVbeta]
DECIPHERTK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTK2 
Mutations
ICGC Data PortalTK2 
TCGA Data PortalTK2 
Broad Tumor PortalTK2
OASIS PortalTK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTK2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTK2
Mutations and Diseases : HGMDTK2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTK2
DgiDB (Drug Gene Interaction Database)TK2
DoCM (Curated mutations)TK2
CIViC (Clinical Interpretations of Variants in Cancer)TK2
Cancer3DTK2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM188250    609560    617069   
Orphanet19795    19793   
DisGeNETTK2
MedgenTK2
Genetic Testing Registry TK2
NextProtO00142 [Medical]
GENETestsTK2
Target ValidationTK2
Huge Navigator TK2 [HugePedia]
ClinGenTK2
Clinical trials, drugs, therapy
MyCancerGenomeTK2
Protein Interactions : CTDTK2
Pharm GKB GenePA36535
PharosO00142
Clinical trialTK2
Miscellaneous
canSAR (ICR)TK2
HarmonizomeTK2
DataMed IndexTK2
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:35:11 CEST 2021

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