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TKFC (triokinase and FMN cyclase)

Identity

Alias_namesDAK
dihydroxyacetone kinase 2 homolog (yeast)
dihydroxyacetone kinase 2 homolog (S. cerevisiae)
triokinase/FMN cyclase
Alias_symbol (synonym)DKFZP586B1621
NET45
Other alias
HGNC (Hugo) TKFC
LocusID (NCBI) 26007
Atlas_Id 77106
Location 11q12.2  [Link to chromosome band 11q12]
Location_base_pair Starts at 61333182 and ends at 61348759 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)		TKFC (11q12.2) / FTX (Xq13.2)TKFC (11q12.2) / TMEM109 (11q12.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TKFC   24552
Cards
Entrez_Gene (NCBI)TKFC  26007  triokinase and FMN cyclase
AliasesDAK; NET45
GeneCards (Weizmann)TKFC
Ensembl hg19 (Hinxton)ENSG00000149476 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149476 [Gene_View]  chr11:61333182-61348759 [Contig_View]  TKFC [Vega]
ICGC DataPortalENSG00000149476
TCGA cBioPortalTKFC
AceView (NCBI)TKFC
Genatlas (Paris)TKFC
WikiGenes26007
SOURCE (Princeton)TKFC
Genetics Home Reference (NIH)TKFC
Genomic and cartography
GoldenPath hg38 (UCSC)TKFC  -     chr11:61333182-61348759 +  11q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TKFC  -     11q12.2   [Description]    (hg19-Feb_2009)
EnsemblTKFC - 11q12.2 [CytoView hg19]  TKFC - 11q12.2 [CytoView hg38]
Mapping of homologs : NCBITKFC [Mapview hg19]  TKFC [Mapview hg38]
OMIM615844   
Gene and transcription
Genbank (Entrez)AK023915 AK094516 AK223580 AK308553 AL110260
RefSeq transcript (Entrez)NM_015533
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TKFC
Cluster EST : UnigeneHs.6278 [ NCBI ]
CGAP (NCI)Hs.6278
Alternative Splicing GalleryENSG00000149476
Gene ExpressionTKFC [ NCBI-GEO ]   TKFC [ EBI - ARRAY_EXPRESS ]   TKFC [ SEEK ]   TKFC [ MEM ]
Gene Expression Viewer (FireBrowse)TKFC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26007
GTEX Portal (Tissue expression)TKFC
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ3LXA3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ3LXA3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ3LXA3
Splice isoforms : SwissVarQ3LXA3
Catalytic activity : Enzyme2.7.1.28 [ Enzyme-Expasy ]   2.7.1.282.7.1.28 [ IntEnz-EBI ]   2.7.1.28 [ BRENDA ]   2.7.1.28 [ KEGG ]   
PhosPhoSitePlusQ3LXA3
Domaine pattern : Prosite (Expaxy)DHAK (PS51481)    DHAL (PS51480)   
Domains : Interpro (EBI)DhaK_ATP    DhaK_dom    DhaL_dom   
Domain families : Pfam (Sanger)Dak1 (PF02733)    Dak2 (PF02734)   
Domain families : Pfam (NCBI)pfam02733    pfam02734   
Domain families : Smart (EMBL)Dak2 (SM01120)  
Conserved Domain (NCBI)TKFC
DMDM Disease mutations26007
Blocks (Seattle)TKFC
SuperfamilyQ3LXA3
Human Protein AtlasENSG00000149476
Peptide AtlasQ3LXA3
HPRD13180
IPIIPI00551024   IPI00985053   IPI00419032   IPI00982539   IPI00978708   IPI00981415   
Protein Interaction databases
DIP (DOE-UCLA)Q3LXA3
IntAct (EBI)Q3LXA3
FunCoupENSG00000149476
BioGRIDTKFC
STRING (EMBL)TKFC
ZODIACTKFC
Ontologies - Pathways
QuickGOQ3LXA3
Ontology : AmiGOglycerone kinase activity  protein binding  ATP binding  nucleus  cytosol  glycerol metabolic process  FAD-AMP lyase (cyclizing) activity  negative regulation of MDA-5 signaling pathway  cellular carbohydrate metabolic process  innate immune response  regulation of innate immune response  carbohydrate phosphorylation  metal ion binding  triokinase activity  triokinase activity  fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate  extracellular exosome  
Ontology : EGO-EBIglycerone kinase activity  protein binding  ATP binding  nucleus  cytosol  glycerol metabolic process  FAD-AMP lyase (cyclizing) activity  negative regulation of MDA-5 signaling pathway  cellular carbohydrate metabolic process  innate immune response  regulation of innate immune response  carbohydrate phosphorylation  metal ion binding  triokinase activity  triokinase activity  fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate  extracellular exosome  
NDEx NetworkTKFC
Atlas of Cancer Signalling NetworkTKFC
Wikipedia pathwaysTKFC
Orthology - Evolution
OrthoDB26007
GeneTree (enSembl)ENSG00000149476
Phylogenetic Trees/Animal Genes : TreeFamTKFC
HOVERGENQ3LXA3
HOGENOMQ3LXA3
Homologs : HomoloGeneTKFC
Homology/Alignments : Family Browser (UCSC)TKFC
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTKFC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TKFC
dbVarTKFC
ClinVarTKFC
1000_GenomesTKFC 
Exome Variant ServerTKFC
ExAC (Exome Aggregation Consortium)TKFC (select the gene name)
Genetic variants : HAPMAP26007
Genomic Variants (DGV)TKFC [DGVbeta]
DECIPHERTKFC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTKFC 
Mutations
ICGC Data PortalTKFC 
TCGA Data PortalTKFC 
Broad Tumor PortalTKFC
OASIS PortalTKFC [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDTKFC
BioMutasearch TKFC
DgiDB (Drug Gene Interaction Database)TKFC
DoCM (Curated mutations)TKFC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TKFC (select a term)
intoGenTKFC
Cancer3DTKFC(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615844   
Orphanet
MedgenTKFC
Genetic Testing Registry TKFC
NextProtQ3LXA3 [Medical]
TSGene26007
GENETestsTKFC
Target ValidationTKFC
Huge Navigator TKFC [HugePedia]
snp3D : Map Gene to Disease26007
BioCentury BCIQTKFC
ClinGenTKFC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26007
Chemical/Pharm GKB GenePA142672014
Clinical trialTKFC
Miscellaneous
canSAR (ICR)TKFC (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTKFC
EVEXTKFC
GoPubMedTKFC
iHOPTKFC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:41:29 CEST 2017
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