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TKFC (triokinase and FMN cyclase)

Identity

Alias (NCBI)DAK
NET45
HGNC (Hugo) TKFC
HGNC Alias symbDKFZP586B1621
NET45
HGNC Alias nameFAD-AMP lyase (cyclizing)
HGNC Previous nameDAK
HGNC Previous namedihydroxyacetone kinase 2 homolog (yeast)
 dihydroxyacetone kinase 2 homolog (S. cerevisiae)
 triokinase/FMN cyclase
LocusID (NCBI) 26007
Atlas_Id 77106
Location 11q12.2  [Link to chromosome band 11q12]
Location_base_pair Starts at 61333182 and ends at 61348759 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TKFC (11q12.2) / FTX (Xq13.2)TKFC (11q12.2) / TMEM109 (11q12.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  TKFC/TMEM109 (11q12)

External links

Nomenclature
HGNC (Hugo)TKFC   24552
Cards
Entrez_Gene (NCBI)TKFC    triokinase and FMN cyclase
AliasesDAK; NET45
GeneCards (Weizmann)TKFC
Ensembl hg19 (Hinxton)ENSG00000149476 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149476 [Gene_View]  ENSG00000149476 [Sequence]  chr11:61333182-61348759 [Contig_View]  TKFC [Vega]
ICGC DataPortalENSG00000149476
TCGA cBioPortalTKFC
AceView (NCBI)TKFC
Genatlas (Paris)TKFC
SOURCE (Princeton)TKFC
Genetics Home Reference (NIH)TKFC
Genomic and cartography
GoldenPath hg38 (UCSC)TKFC  -     chr11:61333182-61348759 +  11q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TKFC  -     11q12.2   [Description]    (hg19-Feb_2009)
GoldenPathTKFC - 11q12.2 [CytoView hg19]  TKFC - 11q12.2 [CytoView hg38]
ImmunoBaseENSG00000149476
genome Data Viewer NCBITKFC [Mapview hg19]  
OMIM615844   
Gene and transcription
Genbank (Entrez)AK023915 AK094516 AK223580 AK308553 AL110260
RefSeq transcript (Entrez)NM_001351976 NM_001351977 NM_001351978 NM_001351979 NM_001351980 NM_015533
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TKFC
Alternative Splicing GalleryENSG00000149476
Gene ExpressionTKFC [ NCBI-GEO ]   TKFC [ EBI - ARRAY_EXPRESS ]   TKFC [ SEEK ]   TKFC [ MEM ]
Gene Expression Viewer (FireBrowse)TKFC [ Firebrowse - Broad ]
GenevisibleExpression of TKFC in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26007
GTEX Portal (Tissue expression)TKFC
Human Protein AtlasENSG00000149476-TKFC [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ3LXA3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ3LXA3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ3LXA3
Splice isoforms : SwissVarQ3LXA3
Catalytic activity : Enzyme2.7.1.28 [ Enzyme-Expasy ]   2.7.1.282.7.1.28 [ IntEnz-EBI ]   2.7.1.28 [ BRENDA ]   2.7.1.28 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ3LXA3
Domaine pattern : Prosite (Expaxy)DHAK (PS51481)    DHAL (PS51480)   
Domains : Interpro (EBI)DhaK_ATP    DhaK_dom    DhaL_dom    DhaL_dom_sf   
Domain families : Pfam (Sanger)Dak1 (PF02733)    Dak2 (PF02734)   
Domain families : Pfam (NCBI)pfam02733    pfam02734   
Domain families : Smart (EMBL)Dak2 (SM01120)  
Conserved Domain (NCBI)TKFC
Blocks (Seattle)TKFC
SuperfamilyQ3LXA3
Human Protein Atlas [tissue]ENSG00000149476-TKFC [tissue]
Peptide AtlasQ3LXA3
HPRD13180
IPIIPI00551024   IPI00985053   IPI00419032   IPI00982539   IPI00978708   IPI00981415   
Protein Interaction databases
DIP (DOE-UCLA)Q3LXA3
IntAct (EBI)Q3LXA3
BioGRIDTKFC
STRING (EMBL)TKFC
ZODIACTKFC
Ontologies - Pathways
QuickGOQ3LXA3
Ontology : AmiGOglycerone kinase activity  glycerone kinase activity  protein binding  ATP binding  nucleus  cytosol  cytosol  glycerol catabolic process  FAD-AMP lyase (cyclizing) activity  negative regulation of MDA-5 signaling pathway  cellular carbohydrate metabolic process  innate immune response  regulation of innate immune response  carbohydrate phosphorylation  metal ion binding  triokinase activity  fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate  extracellular exosome  
Ontology : EGO-EBIglycerone kinase activity  glycerone kinase activity  protein binding  ATP binding  nucleus  cytosol  cytosol  glycerol catabolic process  FAD-AMP lyase (cyclizing) activity  negative regulation of MDA-5 signaling pathway  cellular carbohydrate metabolic process  innate immune response  regulation of innate immune response  carbohydrate phosphorylation  metal ion binding  triokinase activity  fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate  extracellular exosome  
NDEx NetworkTKFC
Atlas of Cancer Signalling NetworkTKFC
Wikipedia pathwaysTKFC
Orthology - Evolution
OrthoDB26007
GeneTree (enSembl)ENSG00000149476
Phylogenetic Trees/Animal Genes : TreeFamTKFC
HOGENOMQ3LXA3
Homologs : HomoloGeneTKFC
Homology/Alignments : Family Browser (UCSC)TKFC
Gene fusions - Rearrangements
Fusion : QuiverTKFC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTKFC [hg38]
dbVarTKFC
ClinVarTKFC
MonarchTKFC
1000_GenomesTKFC 
Exome Variant ServerTKFC
GNOMAD BrowserENSG00000149476
Varsome BrowserTKFC
Genomic Variants (DGV)TKFC [DGVbeta]
DECIPHERTKFC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTKFC 
Mutations
ICGC Data PortalTKFC 
TCGA Data PortalTKFC 
Broad Tumor PortalTKFC
OASIS PortalTKFC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTKFC  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTKFC
Mutations and Diseases : HGMDTKFC
BioMutasearch TKFC
DgiDB (Drug Gene Interaction Database)TKFC
DoCM (Curated mutations)TKFC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TKFC (select a term)
intoGenTKFC
Cancer3DTKFC(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615844   
Orphanet
DisGeNETTKFC
MedgenTKFC
Genetic Testing Registry TKFC
NextProtQ3LXA3 [Medical]
GENETestsTKFC
Target ValidationTKFC
Huge Navigator TKFC [HugePedia]
ClinGenTKFC
Clinical trials, drugs, therapy
MyCancerGenomeTKFC
Protein Interactions : CTD
Pharm GKB GenePA142672014
Clinical trialTKFC
Miscellaneous
canSAR (ICR)TKFC (select the gene name)
HarmonizomeTKFC
DataMed IndexTKFC
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTKFC
EVEXTKFC
GoPubMedTKFC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Dec 5 17:31:47 CET 2020
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