TKFC (triokinase and FMN cyclase)

2015-06-01  

Identity

HGNC
LOCATION
11q12.2
LOCUSID
ALIAS
DAK,NET45,TKFCD
FUSION GENES

Other Information

Locus ID:

NCBI: 26007
MIM: 615844
HGNC: 24552
Ensembl: ENSG00000149476

Variants:

dbSNP: 26007
ClinVar: 26007
TCGA: ENSG00000149476
COSMIC: TKFC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149476ENST00000394900Q3LXA3
ENSG00000149476ENST00000394900A0A140VJH7
ENSG00000149476ENST00000524968E9PQR1
ENSG00000149476ENST00000529479H0YCY6
ENSG00000149476ENST00000532173E9PJG8
ENSG00000149476ENST00000534084I3L252

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Fructose and mannose metabolismKEGGko00051
Glycerolipid metabolismKEGGko00561
Fructose and mannose metabolismKEGGhsa00051
Glycerolipid metabolismKEGGhsa00561
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
Metabolic pathwaysKEGGhsa01100
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Fructose metabolismREACTOMER-HSA-5652084
Fructose catabolismREACTOMER-HSA-70350

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
176000902007Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase.52
162890322005Identification of human and rat FAD-AMP lyase (cyclic FMN forming) as ATP-dependent dihydroxyacetone kinases.11
245699952014Bifunctional homodimeric triokinase/FMN cyclase: contribution of protein domains to the activities of the human enzyme and molecular dynamics simulation of domain movements.2
242891552013Serum dihydroxyacetone kinase peptide m/z 520.3 as predictor of disease severity in patients with compensated chronic hepatitis B.0
320044462020Bi-allelic Variants in TKFC Encoding Triokinase/FMN Cyclase Are Associated with Cataracts and Multisystem Disease.0

Citation

Dessen P

TKFC (triokinase and FMN cyclase)

Atlas Genet Cytogenet Oncol Haematol. 2015-06-01

Online version: http://atlasgeneticsoncology.org/gene/77106/tkfc