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TKT (transketolase)

Identity

Alias (NCBI)HEL-S-48
HEL107
SDDHD
TK
TKT1
HGNC (Hugo) TKT
HGNC Alias nameWernicke-Korsakoff syndrome
LocusID (NCBI) 7086
Atlas_Id 53265
Location 3p21.1  [Link to chromosome band 3p21]
Location_base_pair Starts at 53225636 and ends at 53256114 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AD_1 () / TKT (3p21.1)CDC37 (19p13.2) / TKT (3p21.1)PBRM1 (3p21.1) / TKT (3p21.1)
RPL11 (1p36.11) / TKT (3p21.1)TKT (3p21.1) / C3orf67 (3p14.2)TKT (3p21.1) / CPXM2 (10q26.13)
TKT (3p21.1) / TKT (3p21.1)TKT (3p21.1) / YLPM1 (14q24.3)UBE2J2 (1p36.33) / TKT (3p21.1)
PBRM1 3p21.1 / TKT 3p21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TKT   11834
Cards
Entrez_Gene (NCBI)TKT    transketolase
AliasesHEL-S-48; HEL107; SDDHD; TK; 
TKT1
GeneCards (Weizmann)TKT
Ensembl hg19 (Hinxton)ENSG00000163931 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163931 [Gene_View]  ENSG00000163931 [Sequence]  chr3:53225636-53256114 [Contig_View]  TKT [Vega]
ICGC DataPortalENSG00000163931
TCGA cBioPortalTKT
AceView (NCBI)TKT
Genatlas (Paris)TKT
SOURCE (Princeton)TKT
Genetics Home Reference (NIH)TKT
Genomic and cartography
GoldenPath hg38 (UCSC)TKT  -     chr3:53225636-53256114 -  3p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TKT  -     3p21.1   [Description]    (hg19-Feb_2009)
GoldenPathTKT - 3p21.1 [CytoView hg19]  TKT - 3p21.1 [CytoView hg38]
ImmunoBaseENSG00000163931
Genome Data Viewer NCBITKT [Mapview hg19]  
OMIM606781   617044   
Gene and transcription
Genbank (Entrez)AK057092 AK092084 AK093667 AK223614 AK289454
RefSeq transcript (Entrez)NM_001064 NM_001135055 NM_001135056 NM_001258028
Consensus coding sequences : CCDS (NCBI)TKT
Gene ExpressionTKT [ NCBI-GEO ]   TKT [ EBI - ARRAY_EXPRESS ]   TKT [ SEEK ]   TKT [ MEM ]
Gene Expression Viewer (FireBrowse)TKT [ Firebrowse - Broad ]
GenevisibleExpression of TKT in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7086
GTEX Portal (Tissue expression)TKT
Human Protein AtlasENSG00000163931-TKT [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP29401   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP29401  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP29401
PhosPhoSitePlusP29401
Domaine pattern : Prosite (Expaxy)TRANSKETOLASE_1 (PS00801)    TRANSKETOLASE_2 (PS00802)   
Domains : Interpro (EBI)THDP-binding    Transketo_C/PFOR_II    Transketolase-like_Pyr-bd    Transketolase_BS    Transketolase_C    Transketolase_N   
Domain families : Pfam (Sanger)Transket_pyr (PF02779)    Transketolase_C (PF02780)    Transketolase_N (PF00456)   
Domain families : Pfam (NCBI)pfam02779    pfam02780    pfam00456   
Domain families : Smart (EMBL)Transket_pyr (SM00861)  
Conserved Domain (NCBI)TKT
PDB (RSDB)3MOS    3OOY    4KXU    4KXV    4KXW    4KXX    4KXY    6HA3    6HAD    6RJB   
PDB Europe3MOS    3OOY    4KXU    4KXV    4KXW    4KXX    4KXY    6HA3    6HAD    6RJB   
PDB (PDBSum)3MOS    3OOY    4KXU    4KXV    4KXW    4KXX    4KXY    6HA3    6HAD    6RJB   
PDB (IMB)3MOS    3OOY    4KXU    4KXV    4KXW    4KXX    4KXY    6HA3    6HAD    6RJB   
Structural Biology KnowledgeBase3MOS    3OOY    4KXU    4KXV    4KXW    4KXX    4KXY    6HA3    6HAD    6RJB   
SCOP (Structural Classification of Proteins)3MOS    3OOY    4KXU    4KXV    4KXW    4KXX    4KXY    6HA3    6HAD    6RJB   
CATH (Classification of proteins structures)3MOS    3OOY    4KXU    4KXV    4KXW    4KXX    4KXY    6HA3    6HAD    6RJB   
SuperfamilyP29401
AlphaFold pdb e-kbP29401   
Human Protein Atlas [tissue]ENSG00000163931-TKT [tissue]
HPRD06001
Protein Interaction databases
DIP (DOE-UCLA)P29401
IntAct (EBI)P29401
BioGRIDTKT
STRING (EMBL)TKT
ZODIACTKT
Ontologies - Pathways
QuickGOP29401
Ontology : AmiGOmagnesium ion binding  transketolase activity  transketolase activity  calcium ion binding  protein binding  nucleoplasm  peroxisome  endoplasmic reticulum membrane  cytosol  xylulose biosynthetic process  pentose-phosphate shunt  pentose-phosphate shunt  pentose-phosphate shunt, non-oxidative branch  pentose-phosphate shunt, non-oxidative branch  nuclear body  thiamine pyrophosphate binding  vesicle  regulation of growth  protein homodimerization activity  glyceraldehyde-3-phosphate biosynthetic process  ribose phosphate biosynthetic process  extracellular exosome  
Ontology : EGO-EBImagnesium ion binding  transketolase activity  transketolase activity  calcium ion binding  protein binding  nucleoplasm  peroxisome  endoplasmic reticulum membrane  cytosol  xylulose biosynthetic process  pentose-phosphate shunt  pentose-phosphate shunt  pentose-phosphate shunt, non-oxidative branch  pentose-phosphate shunt, non-oxidative branch  nuclear body  thiamine pyrophosphate binding  vesicle  regulation of growth  protein homodimerization activity  glyceraldehyde-3-phosphate biosynthetic process  ribose phosphate biosynthetic process  extracellular exosome  
Pathways : KEGGPentose phosphate pathway   
NDEx NetworkTKT
Atlas of Cancer Signalling NetworkTKT
Wikipedia pathwaysTKT
Orthology - Evolution
OrthoDB7086
GeneTree (enSembl)ENSG00000163931
Phylogenetic Trees/Animal Genes : TreeFamTKT
Homologs : HomoloGeneTKT
Homology/Alignments : Family Browser (UCSC)TKT
Gene fusions - Rearrangements
Fusion : MitelmanPBRM1/TKT [3p21.1/3p21.1]  
Fusion Cancer (Beijing)AD_1 [TKT]  -  3p21.1 [FUSC000402]
Fusion : QuiverTKT
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTKT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TKT
dbVarTKT
ClinVarTKT
MonarchTKT
1000_GenomesTKT 
Exome Variant ServerTKT
GNOMAD BrowserENSG00000163931
Varsome BrowserTKT
ACMGTKT variants
VarityP29401
Genomic Variants (DGV)TKT [DGVbeta]
DECIPHERTKT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTKT 
Mutations
ICGC Data PortalTKT 
TCGA Data PortalTKT 
Broad Tumor PortalTKT
OASIS PortalTKT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTKT  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTKT
Mutations and Diseases : HGMDTKT
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTKT
DgiDB (Drug Gene Interaction Database)TKT
DoCM (Curated mutations)TKT
CIViC (Clinical Interpretations of Variants in Cancer)TKT
Cancer3DTKT
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606781    617044   
Orphanet
DisGeNETTKT
MedgenTKT
Genetic Testing Registry TKT
NextProtP29401 [Medical]
GENETestsTKT
Target ValidationTKT
Huge Navigator TKT [HugePedia]
ClinGenTKT
Clinical trials, drugs, therapy
MyCancerGenomeTKT
Protein Interactions : CTDTKT
Pharm GKB GenePA36537
PharosP29401
Clinical trialTKT
Miscellaneous
canSAR (ICR)TKT
HarmonizomeTKT
DataMed IndexTKT
Probes
Litterature
PubMed131 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTKT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:11 CEST 2021

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