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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome

Donate (in Euros)

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TKTL1 (transketolase-like 1)

Identity

Other namesTKR
TKT2
HGNC (Hugo) TKTL1
LocusID (NCBI) 8277
Location Xq28
Location_base_pair Starts at 153524027 and ends at 153558713 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TKTL1   11835
Cards
Entrez_Gene (NCBI)TKTL1  8277  transketolase-like 1
GeneCards (Weizmann)TKTL1
Ensembl hg19 (Hinxton)ENSG00000007350 [Gene_View]  chrX:153524027-153558713 [Contig_View]  TKTL1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000007350 [Gene_View]  chrX:153524027-153558713 [Contig_View]  TKTL1 [Vega]
ICGC DataPortalENSG00000007350
cBioPortalTKTL1
AceView (NCBI)TKTL1
Genatlas (Paris)TKTL1
WikiGenes8277
SOURCE (Princeton)TKTL1
Genomic and cartography
GoldenPath hg19 (UCSC)TKTL1  -     chrX:153524027-153558713 +  Xq28   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TKTL1  -     Xq28   [Description]    (hg38-Dec_2013)
EnsemblTKTL1 - Xq28 [CytoView hg19]  TKTL1 - Xq28 [CytoView hg38]
Mapping of homologs : NCBITKTL1 [Mapview hg19]  TKTL1 [Mapview hg38]
OMIM300044   
Gene and transcription
Genbank (Entrez)AK292224 AK292261 AK301724 AK302044 AK302261
RefSeq transcript (Entrez)NM_001145933 NM_001145934 NM_012253
RefSeq genomic (Entrez)AC_000155 NC_000023 NC_018934 NG_028264 NT_011681 NW_001842419 NW_004929448
Consensus coding sequences : CCDS (NCBI)TKTL1
Cluster EST : UnigeneHs.102866 [ NCBI ]
CGAP (NCI)Hs.102866
Alternative Splicing : Fast-db (Paris)GSHG0031918
Alternative Splicing GalleryENSG00000007350
Gene ExpressionTKTL1 [ NCBI-GEO ]     TKTL1 [ SEEK ]   TKTL1 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51854 (Uniprot)
NextProtP51854  [Medical]
With graphics : InterProP51854
Splice isoforms : SwissVarP51854 (Swissvar)
Catalytic activity : Enzyme2.2.1.1 [ Enzyme-Expasy ]   2.2.1.12.2.1.1 [ IntEnz-EBI ]   2.2.1.1 [ BRENDA ]   2.2.1.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)TRANSKETOLASE_2 (PS00802)   
Domains : Interpro (EBI)THDP-binding    Transketo_C/Pyr-ferredox_oxred    Transketolase-like_Pyr-bd    Transketolase_BS    Transketolase_C    Transketolase_N   
Related proteins : CluSTrP51854
Domain families : Pfam (Sanger)Transket_pyr (PF02779)    Transketolase_C (PF02780)    Transketolase_N (PF00456)   
Domain families : Pfam (NCBI)pfam02779    pfam02780    pfam00456   
Domain families : Smart (EMBL)Transket_pyr (SM00861)  
DMDM Disease mutations8277
Blocks (Seattle)P51854
Human Protein AtlasENSG00000007350
Peptide AtlasP51854
HPRD02080
IPIIPI00747585   IPI00644689   IPI00922309   IPI00926092   IPI00844184   IPI00827651   IPI00827648   IPI00893346   
Protein Interaction databases
DIP (DOE-UCLA)P51854
IntAct (EBI)P51854
FunCoupENSG00000007350
BioGRIDTKTL1
IntegromeDBTKTL1
STRING (EMBL)TKTL1
Ontologies - Pathways
QuickGOP51854
Ontology : AmiGOtransketolase activity  nucleus  cytoplasm  glucose catabolic process  thiamine metabolic process  metal ion binding  
Ontology : EGO-EBItransketolase activity  nucleus  cytoplasm  glucose catabolic process  thiamine metabolic process  metal ion binding  
Pathways : KEGGPentose phosphate pathway   
Protein Interaction DatabaseTKTL1
DoCM (Curated mutations)TKTL1
Wikipedia pathwaysTKTL1
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerTKTL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TKTL1
dbVarTKTL1
ClinVarTKTL1
1000_GenomesTKTL1 
Exome Variant ServerTKTL1
SNP (GeneSNP Utah)TKTL1
SNP : HGBaseTKTL1
Genetic variants : HAPMAPTKTL1
Genomic Variants (DGV)TKTL1 [DGVbeta]
Mutations
ICGC Data PortalENSG00000007350 
Somatic Mutations in Cancer : COSMICTKTL1 
CONAN: Copy Number AnalysisTKTL1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)X:153524027-153558713
Mutations and Diseases : HGMDTKTL1
OMIM300044   
MedgenTKTL1
NextProtP51854 [Medical]
GENETestsTKTL1
Disease Genetic AssociationTKTL1
Huge Navigator TKTL1 [HugePedia]  TKTL1 [HugeCancerGEM]
snp3D : Map Gene to Disease8277
DGIdb (Drug Gene Interaction db)TKTL1
General knowledge
Homologs : HomoloGeneTKTL1
Homology/Alignments : Family Browser (UCSC)TKTL1
Phylogenetic Trees/Animal Genes : TreeFamTKTL1
Chemical/Protein Interactions : CTD8277
Chemical/Pharm GKB GenePA36538
Clinical trialTKTL1
Cancer Resource (Charite)ENSG00000007350
Other databases
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
CoreMineTKTL1
GoPubMedTKTL1
iHOPTKTL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 14 19:01:49 CET 2015

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