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TLE1 (transducin like enhancer of split 1)

Identity

Alias_namestransducin-like enhancer of split 1 (E(sp1) homolog
Alias_symbol (synonym)ESG1
GRG1
ESG
Other alias
HGNC (Hugo) TLE1
LocusID (NCBI) 7088
Atlas_Id 46607
Location 9q21.32  [Link to chromosome band 9q21]
Location_base_pair Starts at 81583683 and ends at 81689535 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)		CPM (12q15) / TLE1 (9q21.32)GMDS (6p25.3) / TLE1 (9q21.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TLE1   11837
Cards
Entrez_Gene (NCBI)TLE1  7088  transducin like enhancer of split 1
AliasesESG; ESG1; GRG1
GeneCards (Weizmann)TLE1
Ensembl hg19 (Hinxton)ENSG00000196781 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196781 [Gene_View]  chr9:81583683-81689535 [Contig_View]  TLE1 [Vega]
ICGC DataPortalENSG00000196781
TCGA cBioPortalTLE1
AceView (NCBI)TLE1
Genatlas (Paris)TLE1
WikiGenes7088
SOURCE (Princeton)TLE1
Genetics Home Reference (NIH)TLE1
Genomic and cartography
GoldenPath hg38 (UCSC)TLE1  -     chr9:81583683-81689535 -  9q21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TLE1  -     9q21.32   [Description]    (hg19-Feb_2009)
EnsemblTLE1 - 9q21.32 [CytoView hg19]  TLE1 - 9q21.32 [CytoView hg38]
Mapping of homologs : NCBITLE1 [Mapview hg19]  TLE1 [Mapview hg38]
OMIM600189   
Gene and transcription
Genbank (Entrez)AB209854 AK290860 AK293606 AK304565 AY129016
RefSeq transcript (Entrez)NM_001303103 NM_001303104 NM_005077
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TLE1
Cluster EST : UnigeneHs.689805 [ NCBI ]
CGAP (NCI)Hs.689805
Alternative Splicing GalleryENSG00000196781
Gene ExpressionTLE1 [ NCBI-GEO ]   TLE1 [ EBI - ARRAY_EXPRESS ]   TLE1 [ SEEK ]   TLE1 [ MEM ]
Gene Expression Viewer (FireBrowse)TLE1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7088
GTEX Portal (Tissue expression)TLE1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ04724   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ04724  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ04724
Splice isoforms : SwissVarQ04724
PhosPhoSitePlusQ04724
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)Groucho/TLE_N    Groucho_enhance    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)TLE_N (PF03920)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam03920    pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)TLE1
DMDM Disease mutations7088
Blocks (Seattle)TLE1
PDB (SRS)1GXR    2CE8    2CE9    4OM2    4OM3   
PDB (PDBSum)1GXR    2CE8    2CE9    4OM2    4OM3   
PDB (IMB)1GXR    2CE8    2CE9    4OM2    4OM3   
PDB (RSDB)1GXR    2CE8    2CE9    4OM2    4OM3   
Structural Biology KnowledgeBase1GXR    2CE8    2CE9    4OM2    4OM3   
SCOP (Structural Classification of Proteins)1GXR    2CE8    2CE9    4OM2    4OM3   
CATH (Classification of proteins structures)1GXR    2CE8    2CE9    4OM2    4OM3   
SuperfamilyQ04724
Human Protein AtlasENSG00000196781
Peptide AtlasQ04724
HPRD02557
IPIIPI00413270   IPI00909752   IPI00433458   IPI00643674   IPI00514959   IPI00844327   
Protein Interaction databases
DIP (DOE-UCLA)Q04724
IntAct (EBI)Q04724
FunCoupENSG00000196781
BioGRIDTLE1
STRING (EMBL)TLE1
ZODIACTLE1
Ontologies - Pathways
QuickGOQ04724
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II transcription corepressor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytosol  transcription, DNA-templated  signal transduction  multicellular organism development  transcription factor binding  transcription factor binding  animal organ morphogenesis  positive regulation of gene expression  Wnt signaling pathway  negative regulation of Wnt signaling pathway  identical protein binding  negative regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of transcription, DNA-templated  beta-catenin-TCF complex assembly  negative regulation of anoikis  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II transcription corepressor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytosol  transcription, DNA-templated  signal transduction  multicellular organism development  transcription factor binding  transcription factor binding  animal organ morphogenesis  positive regulation of gene expression  Wnt signaling pathway  negative regulation of Wnt signaling pathway  identical protein binding  negative regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of transcription, DNA-templated  beta-catenin-TCF complex assembly  negative regulation of anoikis  
Pathways : BIOCARTAWNT Signaling Pathway [Genes]   
NDEx NetworkTLE1
Atlas of Cancer Signalling NetworkTLE1
Wikipedia pathwaysTLE1
Orthology - Evolution
OrthoDB7088
GeneTree (enSembl)ENSG00000196781
Phylogenetic Trees/Animal Genes : TreeFamTLE1
HOVERGENQ04724
HOGENOMQ04724
Homologs : HomoloGeneTLE1
Homology/Alignments : Family Browser (UCSC)TLE1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTLE1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLE1
dbVarTLE1
ClinVarTLE1
1000_GenomesTLE1 
Exome Variant ServerTLE1
ExAC (Exome Aggregation Consortium)TLE1 (select the gene name)
Genetic variants : HAPMAP7088
Genomic Variants (DGV)TLE1 [DGVbeta]
DECIPHERTLE1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTLE1 
Mutations
ICGC Data PortalTLE1 
TCGA Data PortalTLE1 
Broad Tumor PortalTLE1
OASIS PortalTLE1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTLE1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTLE1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TLE1
DgiDB (Drug Gene Interaction Database)TLE1
DoCM (Curated mutations)TLE1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TLE1 (select a term)
intoGenTLE1
Cancer3DTLE1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600189   
Orphanet
MedgenTLE1
Genetic Testing Registry TLE1
NextProtQ04724 [Medical]
TSGene7088
GENETestsTLE1
Huge Navigator TLE1 [HugePedia]
snp3D : Map Gene to Disease7088
BioCentury BCIQTLE1
ClinGenTLE1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7088
Chemical/Pharm GKB GenePA36539
Clinical trialTLE1
Miscellaneous
canSAR (ICR)TLE1 (select the gene name)
Probes
Litterature
PubMed76 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTLE1
EVEXTLE1
GoPubMedTLE1
iHOPTLE1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:41:06 CEST 2017
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