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TLE2 (transducin like enhancer of split 2)

Identity

Alias_namestransducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
Alias_symbol (synonym)ESG2
GRG2
ESG
FLJ41188
Other alias
HGNC (Hugo) TLE2
LocusID (NCBI) 7089
Atlas_Id 74721
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 2997638 and ends at 3047635 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BIN1 (2q14.3) / TLE2 (19p13.3)TICAM1 (19p13.3) / TLE2 (19p13.3)TLE2 (19p13.3) / TLE2 (19p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TLE2   11838
Cards
Entrez_Gene (NCBI)TLE2  7089  transducin like enhancer of split 2
AliasesESG; ESG2; GRG2
GeneCards (Weizmann)TLE2
Ensembl hg19 (Hinxton)ENSG00000065717 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000065717 [Gene_View]  chr19:2997638-3047635 [Contig_View]  TLE2 [Vega]
ICGC DataPortalENSG00000065717
TCGA cBioPortalTLE2
AceView (NCBI)TLE2
Genatlas (Paris)TLE2
WikiGenes7089
SOURCE (Princeton)TLE2
Genetics Home Reference (NIH)TLE2
Genomic and cartography
GoldenPath hg38 (UCSC)TLE2  -     chr19:2997638-3047635 -  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TLE2  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblTLE2 - 19p13.3 [CytoView hg19]  TLE2 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBITLE2 [Mapview hg19]  TLE2 [Mapview hg38]
OMIM601041   
Gene and transcription
Genbank (Entrez)AK123183 AK293407 AK293482 AK303102 AK308137
RefSeq transcript (Entrez)NM_001144761 NM_001144762 NM_001300846 NM_003260
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TLE2
Cluster EST : UnigeneHs.332173 [ NCBI ]
CGAP (NCI)Hs.332173
Alternative Splicing GalleryENSG00000065717
Gene ExpressionTLE2 [ NCBI-GEO ]   TLE2 [ EBI - ARRAY_EXPRESS ]   TLE2 [ SEEK ]   TLE2 [ MEM ]
Gene Expression Viewer (FireBrowse)TLE2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7089
GTEX Portal (Tissue expression)TLE2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ04725   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ04725  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ04725
Splice isoforms : SwissVarQ04725
PhosPhoSitePlusQ04725
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)Groucho/TLE_N    Groucho_enhance    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)TLE_N (PF03920)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam03920    pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)TLE2
DMDM Disease mutations7089
Blocks (Seattle)TLE2
SuperfamilyQ04725
Human Protein AtlasENSG00000065717
Peptide AtlasQ04725
HPRD03025
IPIIPI00297659   IPI00908501   IPI00910527   IPI00478062   IPI01014374   IPI00921163   IPI00910233   
Protein Interaction databases
DIP (DOE-UCLA)Q04725
IntAct (EBI)Q04725
FunCoupENSG00000065717
BioGRIDTLE2
STRING (EMBL)TLE2
ZODIACTLE2
Ontologies - Pathways
QuickGOQ04725
Ontology : AmiGOtranscription corepressor activity  protein binding  extracellular space  nucleus  nucleoplasm  focal adhesion  transcription, DNA-templated  signal transduction  animal organ morphogenesis  Wnt signaling pathway  nuclear body  negative regulation of transcription, DNA-templated  negative regulation of canonical Wnt signaling pathway  beta-catenin-TCF complex assembly  
Ontology : EGO-EBItranscription corepressor activity  protein binding  extracellular space  nucleus  nucleoplasm  focal adhesion  transcription, DNA-templated  signal transduction  animal organ morphogenesis  Wnt signaling pathway  nuclear body  negative regulation of transcription, DNA-templated  negative regulation of canonical Wnt signaling pathway  beta-catenin-TCF complex assembly  
NDEx NetworkTLE2
Atlas of Cancer Signalling NetworkTLE2
Wikipedia pathwaysTLE2
Orthology - Evolution
OrthoDB7089
GeneTree (enSembl)ENSG00000065717
Phylogenetic Trees/Animal Genes : TreeFamTLE2
HOVERGENQ04725
HOGENOMQ04725
Homologs : HomoloGeneTLE2
Homology/Alignments : Family Browser (UCSC)TLE2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTLE2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLE2
dbVarTLE2
ClinVarTLE2
1000_GenomesTLE2 
Exome Variant ServerTLE2
ExAC (Exome Aggregation Consortium)TLE2 (select the gene name)
Genetic variants : HAPMAP7089
Genomic Variants (DGV)TLE2 [DGVbeta]
DECIPHERTLE2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTLE2 
Mutations
ICGC Data PortalTLE2 
TCGA Data PortalTLE2 
Broad Tumor PortalTLE2
OASIS PortalTLE2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTLE2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTLE2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TLE2
DgiDB (Drug Gene Interaction Database)TLE2
DoCM (Curated mutations)TLE2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TLE2 (select a term)
intoGenTLE2
Cancer3DTLE2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601041   
Orphanet
MedgenTLE2
Genetic Testing Registry TLE2
NextProtQ04725 [Medical]
TSGene7089
GENETestsTLE2
Target ValidationTLE2
Huge Navigator TLE2 [HugePedia]
snp3D : Map Gene to Disease7089
BioCentury BCIQTLE2
ClinGenTLE2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7089
Chemical/Pharm GKB GenePA36540
Clinical trialTLE2
Miscellaneous
canSAR (ICR)TLE2 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTLE2
EVEXTLE2
GoPubMedTLE2
iHOPTLE2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:41:30 CEST 2017

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