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TLE3 (TLE family member 3, transcriptional corepressor)

Identity

Alias_namestransducin-like enhancer of split 3 (E(sp1) homolog
Alias_symbol (synonym)ESG
ESG3
KIAA1547
HsT18976
GRG3
Other alias
HGNC (Hugo) TLE3
LocusID (NCBI) 7090
Atlas_Id 50058
Location 15q23  [Link to chromosome band 15q23]
Location_base_pair Starts at 70047791 and ends at 70097917 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PPP1R12C (19q13.42) / TLE3 (15q23)TLE3 (15q23) / HGS (17q25.3)TLE3 (15q23) / MLKL (16q23.1)
TLE3 (15q23) / PLEKHG2 (19q13.2)TLE3 (15q23) / THAP10 (15q23)TMEM18 (2p25.3) / TLE3 (15q23)
TLE3 15q23 / THAP10 15q23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TLE3   11839
Cards
Entrez_Gene (NCBI)TLE3  7090  TLE family member 3, transcriptional corepressor
AliasesESG; ESG3; GRG3; HsT18976
GeneCards (Weizmann)TLE3
Ensembl hg19 (Hinxton)ENSG00000140332 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140332 [Gene_View]  ENSG00000140332 [Sequence]  chr15:70047791-70097917 [Contig_View]  TLE3 [Vega]
ICGC DataPortalENSG00000140332
TCGA cBioPortalTLE3
AceView (NCBI)TLE3
Genatlas (Paris)TLE3
WikiGenes7090
SOURCE (Princeton)TLE3
Genetics Home Reference (NIH)TLE3
Genomic and cartography
GoldenPath hg38 (UCSC)TLE3  -     chr15:70047791-70097917 -  15q23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TLE3  -     15q23   [Description]    (hg19-Feb_2009)
EnsemblTLE3 - 15q23 [CytoView hg19]  TLE3 - 15q23 [CytoView hg38]
Mapping of homologs : NCBITLE3 [Mapview hg19]  TLE3 [Mapview hg38]
OMIM600190   
Gene and transcription
Genbank (Entrez)AB046767 AB209672 AK000083 AK001258 AK096779
RefSeq transcript (Entrez)NM_001105192 NM_001282979 NM_001282980 NM_001282981 NM_001282982 NM_005078 NM_020908
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TLE3
Cluster EST : UnigeneHs.287362 [ NCBI ]
CGAP (NCI)Hs.287362
Alternative Splicing GalleryENSG00000140332
Gene ExpressionTLE3 [ NCBI-GEO ]   TLE3 [ EBI - ARRAY_EXPRESS ]   TLE3 [ SEEK ]   TLE3 [ MEM ]
Gene Expression Viewer (FireBrowse)TLE3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7090
GTEX Portal (Tissue expression)TLE3
Human Protein AtlasENSG00000140332-TLE3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ04726   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ04726  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ04726
Splice isoforms : SwissVarQ04726
PhosPhoSitePlusQ04726
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)Groucho/TLE_N    Groucho_enhance    WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom    WD40_repeat_dom_sf   
Domain families : Pfam (Sanger)TLE_N (PF03920)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam03920    pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)TLE3
DMDM Disease mutations7090
Blocks (Seattle)TLE3
SuperfamilyQ04726
Human Protein Atlas [tissue]ENSG00000140332-TLE3 [tissue]
Peptide AtlasQ04726
HPRD02558
IPIIPI00219368   IPI00177938   IPI00182478   IPI00221206   IPI01018263   IPI01026229   IPI00556433   IPI01011727   IPI00867718   
Protein Interaction databases
DIP (DOE-UCLA)Q04726
IntAct (EBI)Q04726
FunCoupENSG00000140332
BioGRIDTLE3
STRING (EMBL)TLE3
ZODIACTLE3
Ontologies - Pathways
QuickGOQ04726
Ontology : AmiGOtranscription corepressor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  regulation of transcription, DNA-templated  signal transduction  animal organ morphogenesis  Wnt signaling pathway  repressing transcription factor binding  negative regulation of canonical Wnt signaling pathway  negative regulation of cold-induced thermogenesis  negative regulation of nucleic acid-templated transcription  beta-catenin-TCF complex assembly  beta-catenin-TCF complex  
Ontology : EGO-EBItranscription corepressor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  regulation of transcription, DNA-templated  signal transduction  animal organ morphogenesis  Wnt signaling pathway  repressing transcription factor binding  negative regulation of canonical Wnt signaling pathway  negative regulation of cold-induced thermogenesis  negative regulation of nucleic acid-templated transcription  beta-catenin-TCF complex assembly  beta-catenin-TCF complex  
NDEx NetworkTLE3
Atlas of Cancer Signalling NetworkTLE3
Wikipedia pathwaysTLE3
Orthology - Evolution
OrthoDB7090
GeneTree (enSembl)ENSG00000140332
Phylogenetic Trees/Animal Genes : TreeFamTLE3
HOGENOMQ04726
Homologs : HomoloGeneTLE3
Homology/Alignments : Family Browser (UCSC)TLE3
Gene fusions - Rearrangements
Fusion PortalTLE3 15q23 THAP10 15q23 HNSC
Fusion : QuiverTLE3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTLE3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLE3
dbVarTLE3
ClinVarTLE3
1000_GenomesTLE3 
Exome Variant ServerTLE3
ExAC (Exome Aggregation Consortium)ENSG00000140332
GNOMAD BrowserENSG00000140332
Varsome BrowserTLE3
Genetic variants : HAPMAP7090
Genomic Variants (DGV)TLE3 [DGVbeta]
DECIPHERTLE3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTLE3 
Mutations
ICGC Data PortalTLE3 
TCGA Data PortalTLE3 
Broad Tumor PortalTLE3
OASIS PortalTLE3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTLE3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTLE3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TLE3
DgiDB (Drug Gene Interaction Database)TLE3
DoCM (Curated mutations)TLE3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TLE3 (select a term)
intoGenTLE3
Cancer3DTLE3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600190   
Orphanet
DisGeNETTLE3
MedgenTLE3
Genetic Testing Registry TLE3
NextProtQ04726 [Medical]
TSGene7090
GENETestsTLE3
Target ValidationTLE3
Huge Navigator TLE3 [HugePedia]
snp3D : Map Gene to Disease7090
BioCentury BCIQTLE3
ClinGenTLE3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7090
Chemical/Pharm GKB GenePA36541
Clinical trialTLE3
Miscellaneous
canSAR (ICR)TLE3 (select the gene name)
DataMed IndexTLE3
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTLE3
EVEXTLE3
GoPubMedTLE3
iHOPTLE3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 17 18:42:30 CET 2019
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