TLE3 (TLE family member 3, transcriptional corepressor)

2008-03-01  

Identity

HGNC
TLE3
LOCATION
15q23
LOCUSID
7090
ALIAS
ESG,ESG3,GRG3,HsT18976
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7090
MIM: 600190
HGNC: 11839
Ensembl: ENSG00000140332

Variants:

dbSNP: 7090
ClinVar: 7090
TCGA: ENSG00000140332
COSMIC: TLE3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140332ENST00000317509Q04726
ENSG00000140332ENST00000440567Q04726
ENSG00000140332ENST00000451782Q04726
ENSG00000140332ENST00000537387Q672R2
ENSG00000140332ENST00000557907Q04726
ENSG00000140332ENST00000557919H0YKH0
ENSG00000140332ENST00000557984H0YKH5
ENSG00000140332ENST00000557997Q04726
ENSG00000140332ENST00000558201H0YKN8
ENSG00000140332ENST00000558379Q04726
ENSG00000140332ENST00000558939Q04726
ENSG00000140332ENST00000559048Q04726
ENSG00000140332ENST00000559191H0YNI7
ENSG00000140332ENST00000559929H0YL70
ENSG00000140332ENST00000560525H0YLI3
ENSG00000140332ENST00000560589H0YNT2
ENSG00000140332ENST00000560939H0YKT5
ENSG00000140332ENST00000561453H0YLW9
ENSG00000140332ENST00000627388A0A0D9SES8

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
NOTCH1 Intracellular Domain Regulates TranscriptionREACTOMER-HSA-2122947
Signaling by WntREACTOMER-HSA-195721
Degradation of beta-catenin by the destruction complexREACTOMER-HSA-195253
Repression of WNT target genesREACTOMER-HSA-4641265
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Formation of the beta-catenin:TCF transactivating complexREACTOMER-HSA-201722
Deactivation of the beta-catenin transactivating complexREACTOMER-HSA-3769402

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
281071932017MicroRNA-744 promotes prostate cancer progression through aberrantly activating Wnt/β-catenin signaling.14
201817232010Corepressors TLE1 and TLE3 interact with HESX1 and PROP1.13
286896572017Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5.13
221945272012TLE3 expression is associated with sensitivity to taxane treatment in ovarian carcinoma.12
293740672018RNF6 Promotes Colorectal Cancer by Activating the Wnt/β-Catenin Pathway via Ubiquitination of TLE3.12
220500932011Angiosarcoma: a study of 98 cases with immunohistochemical evaluation of TLE3, a recently described marker of potential taxane responsiveness.11
244446082014Expression of TLE3 by bone marrow stromal cells is regulated by canonical Wnt signaling.11
182734432007Splice variants of TLE family genes and up-regulation of a TLE3 isoform in prostate tumors.10
288596152017Identification of predictive markers of the therapeutic effect of eribulin chemotherapy for locally advanced or metastatic breast cancer.5
252490072015Transducin-like enhancer of split 3 (TLE3) in adipose tissue is increased in situations characterized by decreased PPARγ gene expression.3

Citation

Dessen P

TLE3 (TLE family member 3, transcriptional corepressor)

Atlas Genet Cytogenet Oncol Haematol. 2008-03-01

Online version: http://atlasgeneticsoncology.org/gene/50058/tle3