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TLE4 (transducin like enhancer of split 4)

Identity

Other aliasBCE-1
BCE1
E(spI)
ESG
ESG4
GRG4
Grg-4
HGNC (Hugo) TLE4
LocusID (NCBI) 7091
Atlas_Id 56639
Location 9q21.31  [Link to chromosome band 9q21]
Location_base_pair Starts at 79571773 and ends at 79726881 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TLE4 (9q21.31) / UBC (12q24.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TLE4   11840
Cards
Entrez_Gene (NCBI)TLE4  7091  transducin like enhancer of split 4
AliasesBCE-1; BCE1; E(spI); ESG; 
ESG4; GRG4; Grg-4
GeneCards (Weizmann)TLE4
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr9:79571773-79726881 [Contig_View]  TLE4 [Vega]
TCGA cBioPortalTLE4
AceView (NCBI)TLE4
Genatlas (Paris)TLE4
WikiGenes7091
SOURCE (Princeton)TLE4
Genetics Home Reference (NIH)TLE4
Genomic and cartography
GoldenPath hg38 (UCSC)TLE4  -     chr9:79571773-79726881 +  9q21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TLE4  -     9q21.31   [Description]    (hg19-Feb_2009)
EnsemblTLE4 - 9q21.31 [CytoView hg19]  TLE4 - 9q21.31 [CytoView hg38]
Mapping of homologs : NCBITLE4 [Mapview hg19]  TLE4 [Mapview hg38]
OMIM605132   
Gene and transcription
Genbank (Entrez)AB033087 AF068197 AI279314 AI620368 AK057236
RefSeq transcript (Entrez)NM_001282748 NM_001282749 NM_001282753 NM_001282760 NM_007005
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TLE4
Cluster EST : UnigeneHs.444213 [ NCBI ]
CGAP (NCI)Hs.444213
Gene ExpressionTLE4 [ NCBI-GEO ]   TLE4 [ EBI - ARRAY_EXPRESS ]   TLE4 [ SEEK ]   TLE4 [ MEM ]
Gene Expression Viewer (FireBrowse)TLE4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7091
GTEX Portal (Tissue expression)TLE4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ04727   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ04727  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ04727
Splice isoforms : SwissVarQ04727
PhosPhoSitePlusQ04727
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)Groucho/TLE_N    Groucho_enhance    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)TLE_N (PF03920)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam03920    pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)TLE4
DMDM Disease mutations7091
Blocks (Seattle)TLE4
SuperfamilyQ04727
Peptide AtlasQ04727
IPIIPI00749371   IPI00877770   IPI00446767   IPI01022512   IPI00952807   IPI00514390   IPI00915943   IPI00515073   IPI00374034   IPI00645562   IPI00981743   IPI01011078   IPI00947122   IPI00947254   IPI00981152   IPI00945441   
Protein Interaction databases
DIP (DOE-UCLA)Q04727
IntAct (EBI)Q04727
BioGRIDTLE4
STRING (EMBL)TLE4
ZODIACTLE4
Ontologies - Pathways
QuickGOQ04727
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  molecular_function  chromatin binding  transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding  transcription corepressor activity  protein binding  nucleus  nucleus  nucleoplasm  transcription, DNA-templated  biological_process  Wnt signaling pathway  repressing transcription factor binding  beta-catenin-TCF complex assembly  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  molecular_function  chromatin binding  transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding  transcription corepressor activity  protein binding  nucleus  nucleus  nucleoplasm  transcription, DNA-templated  biological_process  Wnt signaling pathway  repressing transcription factor binding  beta-catenin-TCF complex assembly  
NDEx NetworkTLE4
Atlas of Cancer Signalling NetworkTLE4
Wikipedia pathwaysTLE4
Orthology - Evolution
OrthoDB7091
Phylogenetic Trees/Animal Genes : TreeFamTLE4
HOVERGENQ04727
HOGENOMQ04727
Homologs : HomoloGeneTLE4
Homology/Alignments : Family Browser (UCSC)TLE4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTLE4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLE4
dbVarTLE4
ClinVarTLE4
1000_GenomesTLE4 
Exome Variant ServerTLE4
ExAC (Exome Aggregation Consortium)TLE4 (select the gene name)
Genetic variants : HAPMAP7091
Genomic Variants (DGV)TLE4 [DGVbeta]
DECIPHERTLE4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTLE4 
Mutations
ICGC Data PortalTLE4 
TCGA Data PortalTLE4 
Broad Tumor PortalTLE4
OASIS PortalTLE4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTLE4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTLE4
BioMutasearch TLE4
DgiDB (Drug Gene Interaction Database)TLE4
DoCM (Curated mutations)TLE4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TLE4 (select a term)
intoGenTLE4
Cancer3DTLE4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605132   
Orphanet
MedgenTLE4
Genetic Testing Registry TLE4
NextProtQ04727 [Medical]
TSGene7091
GENETestsTLE4
Huge Navigator TLE4 [HugePedia]
snp3D : Map Gene to Disease7091
BioCentury BCIQTLE4
ClinGenTLE4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7091
Chemical/Pharm GKB GenePA36542
Clinical trialTLE4
Miscellaneous
canSAR (ICR)TLE4 (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTLE4
EVEXTLE4
GoPubMedTLE4
iHOPTLE4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:41:06 CEST 2017

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