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TLE5 (TLE family member 5, transcriptional modulator)

Identity

Alias (NCBI)AES
AES-1
AES-2
ESP1
GRG
GRG5
Grg-5
HGNC (Hugo) TLE5
HGNC Alias symbGRG5
HGNC Previous nameAES
HGNC Previous nameamino-terminal enhancer of split
LocusID (NCBI) 166
Atlas_Id 53080
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 3052910 and ends at 3062495 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AES 19p13.3 / ELK3 12q23.1FGFR3 4p16.3 / AES 19p13.3VPS41 7p14.1 / AES 19p13.3
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



External links

 

Nomenclature
HGNC (Hugo)TLE5   307
Cards
Entrez_Gene (NCBI)TLE5    TLE family member 5, transcriptional modulator
AliasesAES; AES-1; AES-2; ESP1; 
GRG; GRG5; Grg-5
GeneCards (Weizmann)TLE5
Ensembl hg19 (Hinxton)ENSG00000104964 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104964 [Gene_View]  ENSG00000104964 [Sequence]  chr19:3052910-3062495 [Contig_View]  TLE5 [Vega]
ICGC DataPortalENSG00000104964
TCGA cBioPortalTLE5
AceView (NCBI)TLE5
Genatlas (Paris)TLE5
SOURCE (Princeton)TLE5
Genetics Home Reference (NIH)TLE5
Genomic and cartography
GoldenPath hg38 (UCSC)TLE5  -     chr19:3052910-3062495 -  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TLE5  -     19p13.3   [Description]    (hg19-Feb_2009)
GoldenPathTLE5 - 19p13.3 [CytoView hg19]  TLE5 - 19p13.3 [CytoView hg38]
ImmunoBaseENSG00000104964
Genome Data Viewer NCBITLE5 [Mapview hg19]  
OMIM600188   
Gene and transcription
Genbank (Entrez)AF072902 AF269289 AK094591 AK095154 AK314713
RefSeq transcript (Entrez)NM_001130 NM_198969 NM_198970
Consensus coding sequences : CCDS (NCBI)TLE5
Gene ExpressionTLE5 [ NCBI-GEO ]   TLE5 [ EBI - ARRAY_EXPRESS ]   TLE5 [ SEEK ]   TLE5 [ MEM ]
Gene Expression Viewer (FireBrowse)TLE5 [ Firebrowse - Broad ]
GenevisibleExpression of TLE5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)166
GTEX Portal (Tissue expression)TLE5
Human Protein AtlasENSG00000104964-TLE5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ08117   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ08117  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ08117
PhosPhoSitePlusQ08117
Domains : Interpro (EBI)Groucho/TLE_N    Groucho_enhance   
Domain families : Pfam (Sanger)TLE_N (PF03920)   
Domain families : Pfam (NCBI)pfam03920   
Conserved Domain (NCBI)TLE5
SuperfamilyQ08117
AlphaFold pdb e-kbQ08117   
Human Protein Atlas [tissue]ENSG00000104964-TLE5 [tissue]
HPRD02556
Protein Interaction databases
DIP (DOE-UCLA)Q08117
IntAct (EBI)Q08117
BioGRIDTLE5
STRING (EMBL)TLE5
ZODIACTLE5
Ontologies - Pathways
QuickGOQ08117
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  skeletal system development  transcription corepressor activity  transcription corepressor activity  transcription corepressor activity  protein binding  nucleus  nucleus  transcription regulator complex  multicellular organism development  animal organ morphogenesis  negative regulation of gene expression  Wnt signaling pathway  cellular response to extracellular stimulus  negative regulation of protein binding  regulation of growth  negative regulation of transcription, DNA-templated  negative regulation of response to cytokine stimulus  response to interleukin-1  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  DNA-binding transcription factor binding  positive regulation of anoikis  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  skeletal system development  transcription corepressor activity  transcription corepressor activity  transcription corepressor activity  protein binding  nucleus  nucleus  transcription regulator complex  multicellular organism development  animal organ morphogenesis  negative regulation of gene expression  Wnt signaling pathway  cellular response to extracellular stimulus  negative regulation of protein binding  regulation of growth  negative regulation of transcription, DNA-templated  negative regulation of response to cytokine stimulus  response to interleukin-1  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  DNA-binding transcription factor binding  positive regulation of anoikis  
NDEx NetworkTLE5
Atlas of Cancer Signalling NetworkTLE5
Wikipedia pathwaysTLE5
Orthology - Evolution
OrthoDB166
GeneTree (enSembl)ENSG00000104964
Phylogenetic Trees/Animal Genes : TreeFamTLE5
Homologs : HomoloGeneTLE5
Homology/Alignments : Family Browser (UCSC)TLE5
Gene fusions - Rearrangements
Fusion : MitelmanAES/ELK3 [19p13.3/12q23.1]  
Fusion : MitelmanFGFR3/AES [4p16.3/19p13.3]  
Fusion : MitelmanVPS41/AES [7p14.1/19p13.3]  
Fusion Cancer (Beijing)AES [19p13.3]  -  HLA-C [6p21.33]  [FUSC002476]
Fusion : QuiverTLE5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTLE5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLE5
dbVarTLE5
ClinVarTLE5
MonarchTLE5
1000_GenomesTLE5 
Exome Variant ServerTLE5
GNOMAD BrowserENSG00000104964
Varsome BrowserTLE5
ACMGTLE5 variants
VarityQ08117
Genomic Variants (DGV)TLE5 [DGVbeta]
DECIPHERTLE5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTLE5 
Mutations
ICGC Data PortalTLE5 
TCGA Data PortalTLE5 
Broad Tumor PortalTLE5
OASIS PortalTLE5 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDTLE5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTLE5
DgiDB (Drug Gene Interaction Database)TLE5
DoCM (Curated mutations)TLE5
CIViC (Clinical Interpretations of Variants in Cancer)TLE5
Cancer3DTLE5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600188   
Orphanet
DisGeNETTLE5
MedgenTLE5
Genetic Testing Registry TLE5
NextProtQ08117 [Medical]
GENETestsTLE5
Target ValidationTLE5
Huge Navigator TLE5 [HugePedia]
ClinGenTLE5
Clinical trials, drugs, therapy
MyCancerGenomeTLE5
Protein Interactions : CTDTLE5
Pharm GKB GenePA24606
PharosQ08117
Clinical trialTLE5
Miscellaneous
canSAR (ICR)TLE5
HarmonizomeTLE5
DataMed IndexTLE5
Probes
Litterature
PubMed68 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTLE5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:12 CEST 2021

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