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TLE6 (TLE family member 6, subcortical maternal complex member)

Identity

Alias_namestransducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)
transducin like enhancer of split 6
Alias_symbol (synonym)FLJ14009
GRG6
Other aliasPREMBL
HGNC (Hugo) TLE6
LocusID (NCBI) 79816
Atlas_Id 50289
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 2977538 and ends at 2995184 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PRMT1 (19q13.33) / TLE6 (19p13.3)PRMT1 19q13.33 / TLE6 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(19;19)(p13;q13) PRMT1/TLE6

External links

Nomenclature
HGNC (Hugo)TLE6   30788
Cards
Entrez_Gene (NCBI)TLE6  79816  TLE family member 6, subcortical maternal complex member
AliasesGRG6; PREMBL
GeneCards (Weizmann)TLE6
Ensembl hg19 (Hinxton)ENSG00000104953 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104953 [Gene_View]  ENSG00000104953 [Sequence]  chr19:2977538-2995184 [Contig_View]  TLE6 [Vega]
ICGC DataPortalENSG00000104953
TCGA cBioPortalTLE6
AceView (NCBI)TLE6
Genatlas (Paris)TLE6
WikiGenes79816
SOURCE (Princeton)TLE6
Genetics Home Reference (NIH)TLE6
Genomic and cartography
GoldenPath hg38 (UCSC)TLE6  -     chr19:2977538-2995184 +  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TLE6  -     19p13.3   [Description]    (hg19-Feb_2009)
GoldenPathTLE6 - 19p13.3 [CytoView hg19]  TLE6 - 19p13.3 [CytoView hg38]
ImmunoBaseENSG00000104953
Mapping of homologs : NCBITLE6 [Mapview hg19]  TLE6 [Mapview hg38]
OMIM612399   616814   
Gene and transcription
Genbank (Entrez)AK024071 AK308771 BC007215 BC007329 BC013986
RefSeq transcript (Entrez)NM_001143986 NM_024760
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TLE6
Cluster EST : UnigeneHs.334507 [ NCBI ]
CGAP (NCI)Hs.334507
Alternative Splicing GalleryENSG00000104953
Gene ExpressionTLE6 [ NCBI-GEO ]   TLE6 [ EBI - ARRAY_EXPRESS ]   TLE6 [ SEEK ]   TLE6 [ MEM ]
Gene Expression Viewer (FireBrowse)TLE6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79816
GTEX Portal (Tissue expression)TLE6
Human Protein AtlasENSG00000104953-TLE6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H808   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H808  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H808
Splice isoforms : SwissVarQ9H808
PhosPhoSitePlusQ9H808
Domaine pattern : Prosite (Expaxy)WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)Groucho_enhance    WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_dom    WD40_repeat_dom_sf   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)TLE6
DMDM Disease mutations79816
Blocks (Seattle)TLE6
SuperfamilyQ9H808
Human Protein Atlas [tissue]ENSG00000104953-TLE6 [tissue]
Peptide AtlasQ9H808
HPRD18195
IPIIPI00015529   IPI00903026   IPI00155552   IPI00925640   IPI00925076   IPI00642730   
Protein Interaction databases
DIP (DOE-UCLA)Q9H808
IntAct (EBI)Q9H808
FunCoupENSG00000104953
BioGRIDTLE6
STRING (EMBL)TLE6
ZODIACTLE6
Ontologies - Pathways
QuickGOQ9H808
Ontology : AmiGOtranscription corepressor activity  protein binding  nucleus  transcription factor complex  cytoplasm  regulation of transcription, DNA-templated  protein-containing complex  embryonic process involved in female pregnancy  repressing transcription factor binding  negative regulation of canonical Wnt signaling pathway  negative regulation of nucleic acid-templated transcription  
Ontology : EGO-EBItranscription corepressor activity  protein binding  nucleus  transcription factor complex  cytoplasm  regulation of transcription, DNA-templated  protein-containing complex  embryonic process involved in female pregnancy  repressing transcription factor binding  negative regulation of canonical Wnt signaling pathway  negative regulation of nucleic acid-templated transcription  
NDEx NetworkTLE6
Atlas of Cancer Signalling NetworkTLE6
Wikipedia pathwaysTLE6
Orthology - Evolution
OrthoDB79816
GeneTree (enSembl)ENSG00000104953
Phylogenetic Trees/Animal Genes : TreeFamTLE6
HOGENOMQ9H808
Homologs : HomoloGeneTLE6
Homology/Alignments : Family Browser (UCSC)TLE6
Gene fusions - Rearrangements
Fusion : MitelmanPRMT1/TLE6 [19q13.33/19p13.3]  [t(19;19)(p13;q13)]  
Fusion PortalPRMT1 19q13.33 TLE6 19p13.3 LAML
Fusion : QuiverTLE6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTLE6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLE6
dbVarTLE6
ClinVarTLE6
1000_GenomesTLE6 
Exome Variant ServerTLE6
ExAC (Exome Aggregation Consortium)ENSG00000104953
GNOMAD BrowserENSG00000104953
Varsome BrowserTLE6
Genetic variants : HAPMAP79816
Genomic Variants (DGV)TLE6 [DGVbeta]
DECIPHERTLE6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTLE6 
Mutations
ICGC Data PortalTLE6 
TCGA Data PortalTLE6 
Broad Tumor PortalTLE6
OASIS PortalTLE6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTLE6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTLE6
Mutations and Diseases : HGMDTLE6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TLE6
DgiDB (Drug Gene Interaction Database)TLE6
DoCM (Curated mutations)TLE6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TLE6 (select a term)
intoGenTLE6
Cancer3DTLE6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612399    616814   
Orphanet
DisGeNETTLE6
MedgenTLE6
Genetic Testing Registry TLE6
NextProtQ9H808 [Medical]
TSGene79816
GENETestsTLE6
Target ValidationTLE6
Huge Navigator TLE6 [HugePedia]
snp3D : Map Gene to Disease79816
BioCentury BCIQTLE6
ClinGenTLE6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79816
Chemical/Pharm GKB GenePA134948893
Clinical trialTLE6
Miscellaneous
canSAR (ICR)TLE6 (select the gene name)
DataMed IndexTLE6
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTLE6
EVEXTLE6
GoPubMedTLE6
iHOPTLE6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 18:11:51 CET 2019
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