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TLK1 (tousled like kinase 1)

Identity

Alias (NCBI)PKU-beta
HGNC (Hugo) TLK1
HGNC Alias symbKIAA0137
PKU-BETA
HGNC Previous nametousled-like kinase 1
LocusID (NCBI) 9874
Atlas_Id 43529
Location 2q31.1  [Link to chromosome band 2q31]
Location_base_pair Starts at 170990823 and ends at 171160893 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TLK1 (2q31.1) / CAT (11p13)TLK1 (2q31.1) / CNTN4 (3p26.3)TLK1 (2q31.1) / CREG2 (2q11.2)
TLK1 (2q31.1) / RABEP1 (17p13.2)TLK1 (2q31.1) / SSB (2q31.1)TLK1 (2q31.1) / TLK1 (2q31.1)
TLK1 (2q31.1) / TTLL13P (15q26.1)TLK1 2q31.1 / CAT 11p13TLK1 2q31.1 / CREG2 2q11.2
TLK1 2q31.1 / SSB 2q31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TLK1   11841
Cards
Entrez_Gene (NCBI)TLK1    tousled like kinase 1
AliasesPKU-beta
GeneCards (Weizmann)TLK1
Ensembl hg19 (Hinxton)ENSG00000198586 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198586 [Gene_View]  ENSG00000198586 [Sequence]  chr2:170990823-171160893 [Contig_View]  TLK1 [Vega]
ICGC DataPortalENSG00000198586
TCGA cBioPortalTLK1
AceView (NCBI)TLK1
Genatlas (Paris)TLK1
SOURCE (Princeton)TLK1
Genetics Home Reference (NIH)TLK1
Genomic and cartography
GoldenPath hg38 (UCSC)TLK1  -     chr2:170990823-171160893 -  2q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TLK1  -     2q31.1   [Description]    (hg19-Feb_2009)
GoldenPathTLK1 - 2q31.1 [CytoView hg19]  TLK1 - 2q31.1 [CytoView hg38]
ImmunoBaseENSG00000198586
Genome Data Viewer NCBITLK1 [Mapview hg19]  
OMIM608438   
Gene and transcription
Genbank (Entrez)AB004885 AF162666 AF246219 AK090779 AK091975
RefSeq transcript (Entrez)NM_001136554 NM_001136555 NM_012290
Consensus coding sequences : CCDS (NCBI)TLK1
Gene ExpressionTLK1 [ NCBI-GEO ]   TLK1 [ EBI - ARRAY_EXPRESS ]   TLK1 [ SEEK ]   TLK1 [ MEM ]
Gene Expression Viewer (FireBrowse)TLK1 [ Firebrowse - Broad ]
GenevisibleExpression of TLK1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9874
GTEX Portal (Tissue expression)TLK1
Human Protein AtlasENSG00000198586-TLK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKI8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKI8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKI8
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9UKI8
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)TLK1
SuperfamilyQ9UKI8
AlphaFold pdb e-kbQ9UKI8   
Human Protein Atlas [tissue]ENSG00000198586-TLK1 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q9UKI8
IntAct (EBI)Q9UKI8
BioGRIDTLK1
STRING (EMBL)TLK1
ZODIACTLK1
Ontologies - Pathways
QuickGOQ9UKI8
Ontology : AmiGOregulation of chromatin assembly or disassembly  regulation of chromatin assembly or disassembly  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleus  nucleoplasm  chromatin organization  protein phosphorylation  intracellular protein transport  cellular response to DNA damage stimulus  cell cycle  chromosome segregation  peptidyl-serine phosphorylation  intracellular signal transduction  intracellular signal transduction  protein serine kinase activity  protein threonine kinase activity  
Ontology : EGO-EBIregulation of chromatin assembly or disassembly  regulation of chromatin assembly or disassembly  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleus  nucleoplasm  chromatin organization  protein phosphorylation  intracellular protein transport  cellular response to DNA damage stimulus  cell cycle  chromosome segregation  peptidyl-serine phosphorylation  intracellular signal transduction  intracellular signal transduction  protein serine kinase activity  protein threonine kinase activity  
NDEx NetworkTLK1
Atlas of Cancer Signalling NetworkTLK1
Wikipedia pathwaysTLK1
Orthology - Evolution
OrthoDB9874
GeneTree (enSembl)ENSG00000198586
Phylogenetic Trees/Animal Genes : TreeFamTLK1
Homologs : HomoloGeneTLK1
Homology/Alignments : Family Browser (UCSC)TLK1
Gene fusions - Rearrangements
Fusion : MitelmanTLK1/CAT [2q31.1/11p13]  
Fusion : MitelmanTLK1/CREG2 [2q31.1/2q11.2]  
Fusion : MitelmanTLK1/SSB [2q31.1/2q31.1]  
Fusion : QuiverTLK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTLK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLK1
dbVarTLK1
ClinVarTLK1
MonarchTLK1
1000_GenomesTLK1 
Exome Variant ServerTLK1
GNOMAD BrowserENSG00000198586
Varsome BrowserTLK1
ACMGTLK1 variants
VarityQ9UKI8
Genomic Variants (DGV)TLK1 [DGVbeta]
DECIPHERTLK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTLK1 
Mutations
ICGC Data PortalTLK1 
TCGA Data PortalTLK1 
Broad Tumor PortalTLK1
OASIS PortalTLK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTLK1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTLK1
Mutations and Diseases : HGMDTLK1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTLK1
DgiDB (Drug Gene Interaction Database)TLK1
DoCM (Curated mutations)TLK1
CIViC (Clinical Interpretations of Variants in Cancer)TLK1
Cancer3DTLK1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608438   
Orphanet
DisGeNETTLK1
MedgenTLK1
Genetic Testing Registry TLK1
NextProtQ9UKI8 [Medical]
GENETestsTLK1
Target ValidationTLK1
Huge Navigator TLK1 [HugePedia]
ClinGenTLK1
Clinical trials, drugs, therapy
MyCancerGenomeTLK1
Protein Interactions : CTDTLK1
Pharm GKB GenePA36543
PharosQ9UKI8
Clinical trialTLK1
Miscellaneous
canSAR (ICR)TLK1
HarmonizomeTLK1
DataMed IndexTLK1
Probes
Litterature
PubMed64 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTLK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:35:13 CEST 2021

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