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TLK1 (tousled like kinase 1)

Identity

Alias_namestousled-like kinase 1
Alias_symbol (synonym)KIAA0137
PKU-BETA
Other aliasPKU-beta
HGNC (Hugo) TLK1
LocusID (NCBI) 9874
Atlas_Id 43529
Location 2q31.1  [Link to chromosome band 2q31]
Location_base_pair Starts at 170990823 and ends at 171231314 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TLK1 (2q31.1) / CAT (11p13)TLK1 (2q31.1) / CNTN4 (3p26.3)TLK1 (2q31.1) / CREG2 (2q11.2)
TLK1 (2q31.1) / RABEP1 (17p13.2)TLK1 (2q31.1) / SSB (2q31.1)TLK1 (2q31.1) / TLK1 (2q31.1)
TLK1 (2q31.1) / TTLL13P (15q26.1)TLK1 2q31.1 / CAT 11p13TLK1 2q31.1 / CREG2 2q11.2
TLK1 2q31.1 / SSB 2q31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TLK1   11841
Cards
Entrez_Gene (NCBI)TLK1  9874  tousled like kinase 1
AliasesPKU-beta
GeneCards (Weizmann)TLK1
Ensembl hg19 (Hinxton)ENSG00000198586 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198586 [Gene_View]  chr2:170990823-171231314 [Contig_View]  TLK1 [Vega]
ICGC DataPortalENSG00000198586
TCGA cBioPortalTLK1
AceView (NCBI)TLK1
Genatlas (Paris)TLK1
WikiGenes9874
SOURCE (Princeton)TLK1
Genetics Home Reference (NIH)TLK1
Genomic and cartography
GoldenPath hg38 (UCSC)TLK1  -     chr2:170990823-171231314 -  2q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TLK1  -     2q31.1   [Description]    (hg19-Feb_2009)
EnsemblTLK1 - 2q31.1 [CytoView hg19]  TLK1 - 2q31.1 [CytoView hg38]
Mapping of homologs : NCBITLK1 [Mapview hg19]  TLK1 [Mapview hg38]
OMIM608438   
Gene and transcription
Genbank (Entrez)AB004885 AF162666 AF246219 AK090779 AK091975
RefSeq transcript (Entrez)NM_001136554 NM_001136555 NM_012290
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TLK1
Cluster EST : UnigeneHs.744917 [ NCBI ]
CGAP (NCI)Hs.744917
Alternative Splicing GalleryENSG00000198586
Gene ExpressionTLK1 [ NCBI-GEO ]   TLK1 [ EBI - ARRAY_EXPRESS ]   TLK1 [ SEEK ]   TLK1 [ MEM ]
Gene Expression Viewer (FireBrowse)TLK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9874
GTEX Portal (Tissue expression)TLK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKI8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKI8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKI8
Splice isoforms : SwissVarQ9UKI8
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9UKI8
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)TLK1
DMDM Disease mutations9874
Blocks (Seattle)TLK1
SuperfamilyQ9UKI8
Human Protein AtlasENSG00000198586
Peptide AtlasQ9UKI8
IPIIPI00339361   IPI00333559   IPI00385779   IPI00942365   IPI00916637   IPI00915978   IPI00746072   IPI00917230   IPI00916464   IPI00941438   
Protein Interaction databases
DIP (DOE-UCLA)Q9UKI8
IntAct (EBI)Q9UKI8
FunCoupENSG00000198586
BioGRIDTLK1
STRING (EMBL)TLK1
ZODIACTLK1
Ontologies - Pathways
QuickGOQ9UKI8
Ontology : AmiGOregulation of chromatin assembly or disassembly  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleus  protein phosphorylation  intracellular protein transport  cellular response to DNA damage stimulus  cell cycle  covalent chromatin modification  intracellular signal transduction  
Ontology : EGO-EBIregulation of chromatin assembly or disassembly  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleus  protein phosphorylation  intracellular protein transport  cellular response to DNA damage stimulus  cell cycle  covalent chromatin modification  intracellular signal transduction  
NDEx NetworkTLK1
Atlas of Cancer Signalling NetworkTLK1
Wikipedia pathwaysTLK1
Orthology - Evolution
OrthoDB9874
GeneTree (enSembl)ENSG00000198586
Phylogenetic Trees/Animal Genes : TreeFamTLK1
HOVERGENQ9UKI8
HOGENOMQ9UKI8
Homologs : HomoloGeneTLK1
Homology/Alignments : Family Browser (UCSC)TLK1
Gene fusions - Rearrangements
Fusion : MitelmanTLK1/CAT [2q31.1/11p13]  
Fusion : MitelmanTLK1/CREG2 [2q31.1/2q11.2]  [t(2;2)(q11;q31)]  
Fusion : MitelmanTLK1/SSB [2q31.1/2q31.1]  [t(2;2)(q31;q31)]  
Fusion: TCGATLK1 2q31.1 CAT 11p13 BRCA
Fusion: TCGATLK1 2q31.1 CREG2 2q11.2 LUSC
Fusion: TCGATLK1 2q31.1 SSB 2q31.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTLK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLK1
dbVarTLK1
ClinVarTLK1
1000_GenomesTLK1 
Exome Variant ServerTLK1
ExAC (Exome Aggregation Consortium)TLK1 (select the gene name)
Genetic variants : HAPMAP9874
Genomic Variants (DGV)TLK1 [DGVbeta]
DECIPHERTLK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTLK1 
Mutations
ICGC Data PortalTLK1 
TCGA Data PortalTLK1 
Broad Tumor PortalTLK1
OASIS PortalTLK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTLK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTLK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TLK1
DgiDB (Drug Gene Interaction Database)TLK1
DoCM (Curated mutations)TLK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TLK1 (select a term)
intoGenTLK1
Cancer3DTLK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608438   
Orphanet
MedgenTLK1
Genetic Testing Registry TLK1
NextProtQ9UKI8 [Medical]
TSGene9874
GENETestsTLK1
Target ValidationTLK1
Huge Navigator TLK1 [HugePedia]
snp3D : Map Gene to Disease9874
BioCentury BCIQTLK1
ClinGenTLK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9874
Chemical/Pharm GKB GenePA36543
Clinical trialTLK1
Miscellaneous
canSAR (ICR)TLK1 (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTLK1
EVEXTLK1
GoPubMedTLK1
iHOPTLK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:35:09 CEST 2017

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