Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TLK2 (tousled like kinase 2)

Identity

Alias_namestousled-like kinase 2
Alias_symbol (synonym)PKU-ALPHA
MGC44450
Other aliasHsHPK
MRD57
HGNC (Hugo) TLK2
LocusID (NCBI) 11011
Atlas_Id 43530
Location 17q23.2  [Link to chromosome band 17q23]
Location_base_pair Starts at 62479025 and ends at 62615480 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FBXL20 (17q12) / TLK2 (17q23.2)TLK2 (17q23.2) / CA10 (17q21.33)TLK2 (17q23.2) / LAMC1 (1q25.3)
TLK2 (17q23.2) / LOC731275 ()TLK2 (17q23.2) / PPM1G (2p23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(17;17)(q12;q23) FBXL20/TLK2
t(17;17)(q23;q24) TLK2/CEP112

External links

Nomenclature
HGNC (Hugo)TLK2   11842
Cards
Entrez_Gene (NCBI)TLK2  11011  tousled like kinase 2
AliasesHsHPK; MRD57; PKU-ALPHA
GeneCards (Weizmann)TLK2
Ensembl hg19 (Hinxton)ENSG00000146872 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146872 [Gene_View]  ENSG00000146872 [Sequence]  chr17:62479025-62615480 [Contig_View]  TLK2 [Vega]
ICGC DataPortalENSG00000146872
TCGA cBioPortalTLK2
AceView (NCBI)TLK2
Genatlas (Paris)TLK2
WikiGenes11011
SOURCE (Princeton)TLK2
Genetics Home Reference (NIH)TLK2
Genomic and cartography
GoldenPath hg38 (UCSC)TLK2  -     chr17:62479025-62615480 +  17q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TLK2  -     17q23.2   [Description]    (hg19-Feb_2009)
GoldenPathTLK2 - 17q23.2 [CytoView hg19]  TLK2 - 17q23.2 [CytoView hg38]
ImmunoBaseENSG00000146872
Mapping of homologs : NCBITLK2 [Mapview hg19]  TLK2 [Mapview hg38]
OMIM608439   618050   
Gene and transcription
Genbank (Entrez)AA430024 AB004884 AF162667 AI381985 AI621235
RefSeq transcript (Entrez)NM_001112707 NM_001284333 NM_001284363 NM_001330418 NM_006852
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TLK2
Cluster EST : UnigeneHs.445078 [ NCBI ]
CGAP (NCI)Hs.445078
Alternative Splicing GalleryENSG00000146872
Gene ExpressionTLK2 [ NCBI-GEO ]   TLK2 [ EBI - ARRAY_EXPRESS ]   TLK2 [ SEEK ]   TLK2 [ MEM ]
Gene Expression Viewer (FireBrowse)TLK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11011
GTEX Portal (Tissue expression)TLK2
Human Protein AtlasENSG00000146872-TLK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86UE8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86UE8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86UE8
Splice isoforms : SwissVarQ86UE8
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ86UE8
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS    TLK2   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)TLK2
DMDM Disease mutations11011
Blocks (Seattle)TLK2
SuperfamilyQ86UE8
Human Protein Atlas [tissue]ENSG00000146872-TLK2 [tissue]
Peptide AtlasQ86UE8
HPRD10527
IPIIPI00385652   IPI00337659   IPI00337660   
Protein Interaction databases
DIP (DOE-UCLA)Q86UE8
IntAct (EBI)Q86UE8
FunCoupENSG00000146872
BioGRIDTLK2
STRING (EMBL)TLK2
ZODIACTLK2
Ontologies - Pathways
QuickGOQ86UE8
Ontology : AmiGOregulation of chromatin assembly or disassembly  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  intermediate filament  chromatin organization  protein phosphorylation  cellular response to DNA damage stimulus  cell cycle  chromosome segregation  negative regulation of autophagy  peptidyl-serine phosphorylation  negative regulation of proteasomal ubiquitin-dependent protein catabolic process  intracellular signal transduction  perinuclear region of cytoplasm  cellular response to gamma radiation  
Ontology : EGO-EBIregulation of chromatin assembly or disassembly  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  intermediate filament  chromatin organization  protein phosphorylation  cellular response to DNA damage stimulus  cell cycle  chromosome segregation  negative regulation of autophagy  peptidyl-serine phosphorylation  negative regulation of proteasomal ubiquitin-dependent protein catabolic process  intracellular signal transduction  perinuclear region of cytoplasm  cellular response to gamma radiation  
NDEx NetworkTLK2
Atlas of Cancer Signalling NetworkTLK2
Wikipedia pathwaysTLK2
Orthology - Evolution
OrthoDB11011
GeneTree (enSembl)ENSG00000146872
Phylogenetic Trees/Animal Genes : TreeFamTLK2
HOGENOMQ86UE8
Homologs : HomoloGeneTLK2
Homology/Alignments : Family Browser (UCSC)TLK2
Gene fusions - Rearrangements
Fusion : MitelmanFBXL20/TLK2 [17q12/17q23.2]  [t(17;17)(q12;q23)]  
Fusion Cancer (Beijing)TLK2 [17q23.2]  -  LOC731275 [FUSC000028]  [FUSC000028]  [FUSC000028]  [FUSC000028]
Fusion : QuiverTLK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTLK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLK2
dbVarTLK2
ClinVarTLK2
1000_GenomesTLK2 
Exome Variant ServerTLK2
ExAC (Exome Aggregation Consortium)ENSG00000146872
GNOMAD BrowserENSG00000146872
Varsome BrowserTLK2
Genetic variants : HAPMAP11011
Genomic Variants (DGV)TLK2 [DGVbeta]
DECIPHERTLK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTLK2 
Mutations
ICGC Data PortalTLK2 
TCGA Data PortalTLK2 
Broad Tumor PortalTLK2
OASIS PortalTLK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTLK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTLK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TLK2
DgiDB (Drug Gene Interaction Database)TLK2
DoCM (Curated mutations)TLK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TLK2 (select a term)
intoGenTLK2
Cancer3DTLK2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608439    618050   
Orphanet
DisGeNETTLK2
MedgenTLK2
Genetic Testing Registry TLK2
NextProtQ86UE8 [Medical]
TSGene11011
GENETestsTLK2
Target ValidationTLK2
Huge Navigator TLK2 [HugePedia]
snp3D : Map Gene to Disease11011
BioCentury BCIQTLK2
ClinGenTLK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11011
Chemical/Pharm GKB GenePA36544
Clinical trialTLK2
Miscellaneous
canSAR (ICR)TLK2 (select the gene name)
DataMed IndexTLK2
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTLK2
EVEXTLK2
GoPubMedTLK2
iHOPTLK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 7 18:19:47 CEST 2019
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