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TLL1 (tolloid like 1)

Identity

Alias (NCBI)ASD6
TLL
HGNC (Hugo) TLL1
LocusID (NCBI) 7092
Atlas_Id 74723
Location 4q32.3  [Link to chromosome band 4q32]
Location_base_pair Starts at 165873237 and ends at 166104457 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TLL1   11843
Cards
Entrez_Gene (NCBI)TLL1    tolloid like 1
AliasesASD6; TLL
GeneCards (Weizmann)TLL1
Ensembl hg19 (Hinxton)ENSG00000038295 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000038295 [Gene_View]  ENSG00000038295 [Sequence]  chr4:165873237-166104457 [Contig_View]  TLL1 [Vega]
ICGC DataPortalENSG00000038295
TCGA cBioPortalTLL1
AceView (NCBI)TLL1
Genatlas (Paris)TLL1
SOURCE (Princeton)TLL1
Genetics Home Reference (NIH)TLL1
Genomic and cartography
GoldenPath hg38 (UCSC)TLL1  -     chr4:165873237-166104457 +  4q32.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TLL1  -     4q32.3   [Description]    (hg19-Feb_2009)
GoldenPathTLL1 - 4q32.3 [CytoView hg19]  TLL1 - 4q32.3 [CytoView hg38]
ImmunoBaseENSG00000038295
Genome Data Viewer NCBITLL1 [Mapview hg19]  
OMIM606742   613087   
Gene and transcription
Genbank (Entrez)AF282732 AK021908 BC016922 BC136429 BC136430
RefSeq transcript (Entrez)NM_001204760 NM_012464
Consensus coding sequences : CCDS (NCBI)TLL1
Gene ExpressionTLL1 [ NCBI-GEO ]   TLL1 [ EBI - ARRAY_EXPRESS ]   TLL1 [ SEEK ]   TLL1 [ MEM ]
Gene Expression Viewer (FireBrowse)TLL1 [ Firebrowse - Broad ]
GenevisibleExpression of TLL1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7092
GTEX Portal (Tissue expression)TLL1
Human Protein AtlasENSG00000038295-TLL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43897   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43897  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43897
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusO43897
Domaine pattern : Prosite (Expaxy)ASTACIN (PS51864)    CUB (PS01180)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)BMP_1/tolloid-like    CUB_dom    EGF-like_Ca-bd_dom    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    MetalloPept_cat_dom_sf    Peptidase_M12A    Peptidase_Metallo    Sperma_CUB_dom_sf    ZnMP_TLD/BMP1   
Domain families : Pfam (Sanger)Astacin (PF01400)    CUB (PF00431)    EGF_CA (PF07645)   
Domain families : Pfam (NCBI)pfam01400    pfam00431    pfam07645   
Domain families : Smart (EMBL)CUB (SM00042)  EGF (SM00181)  EGF_CA (SM00179)  ZnMc (SM00235)  
Conserved Domain (NCBI)TLL1
PDB (RSDB)3EDI   
PDB Europe3EDI   
PDB (PDBSum)3EDI   
PDB (IMB)3EDI   
Structural Biology KnowledgeBase3EDI   
SCOP (Structural Classification of Proteins)3EDI   
CATH (Classification of proteins structures)3EDI   
SuperfamilyO43897
AlphaFold pdb e-kbO43897   
Human Protein Atlas [tissue]ENSG00000038295-TLL1 [tissue]
HPRD07074
Protein Interaction databases
DIP (DOE-UCLA)O43897
IntAct (EBI)O43897
BioGRIDTLL1
STRING (EMBL)TLL1
ZODIACTLL1
Ontologies - Pathways
QuickGOO43897
Ontology : AmiGOskeletal system development  metalloendopeptidase activity  calcium ion binding  extracellular region  proteolysis  zinc ion binding  extracellular matrix disassembly  cell differentiation  collagen fibril organization  
Ontology : EGO-EBIskeletal system development  metalloendopeptidase activity  calcium ion binding  extracellular region  proteolysis  zinc ion binding  extracellular matrix disassembly  cell differentiation  collagen fibril organization  
NDEx NetworkTLL1
Atlas of Cancer Signalling NetworkTLL1
Wikipedia pathwaysTLL1
Orthology - Evolution
OrthoDB7092
GeneTree (enSembl)ENSG00000038295
Phylogenetic Trees/Animal Genes : TreeFamTLL1
Homologs : HomoloGeneTLL1
Homology/Alignments : Family Browser (UCSC)TLL1
Gene fusions - Rearrangements
Fusion : QuiverTLL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTLL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLL1
dbVarTLL1
ClinVarTLL1
MonarchTLL1
1000_GenomesTLL1 
Exome Variant ServerTLL1
GNOMAD BrowserENSG00000038295
Varsome BrowserTLL1
ACMGTLL1 variants
VarityO43897
Genomic Variants (DGV)TLL1 [DGVbeta]
DECIPHERTLL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTLL1 
Mutations
ICGC Data PortalTLL1 
TCGA Data PortalTLL1 
Broad Tumor PortalTLL1
OASIS PortalTLL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTLL1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTLL1
Mutations and Diseases : HGMDTLL1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTLL1
DgiDB (Drug Gene Interaction Database)TLL1
DoCM (Curated mutations)TLL1
CIViC (Clinical Interpretations of Variants in Cancer)TLL1
Cancer3DTLL1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606742    613087   
Orphanet14123    14120   
DisGeNETTLL1
MedgenTLL1
Genetic Testing Registry TLL1
NextProtO43897 [Medical]
GENETestsTLL1
Target ValidationTLL1
Huge Navigator TLL1 [HugePedia]
ClinGenTLL1
Clinical trials, drugs, therapy
MyCancerGenomeTLL1
Protein Interactions : CTDTLL1
Pharm GKB GenePA36545
PharosO43897
Clinical trialTLL1
Miscellaneous
canSAR (ICR)TLL1
HarmonizomeTLL1
DataMed IndexTLL1
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTLL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 16:25:36 CEST 2021

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