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TLL2 (tolloid like 2)

Identity

Other alias-
HGNC (Hugo) TLL2
LocusID (NCBI) 7093
Atlas_Id 74724
Location 10q24.1  [Link to chromosome band 10q24]
Location_base_pair Starts at 96364606 and ends at 96513926 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MED20 (6p21.1) / TLL2 (10q24.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TLL2   11844
Cards
Entrez_Gene (NCBI)TLL2  7093  tolloid like 2
Aliases
GeneCards (Weizmann)TLL2
Ensembl hg19 (Hinxton)ENSG00000095587 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000095587 [Gene_View]  chr10:96364606-96513926 [Contig_View]  TLL2 [Vega]
ICGC DataPortalENSG00000095587
TCGA cBioPortalTLL2
AceView (NCBI)TLL2
Genatlas (Paris)TLL2
WikiGenes7093
SOURCE (Princeton)TLL2
Genetics Home Reference (NIH)TLL2
Genomic and cartography
GoldenPath hg38 (UCSC)TLL2  -     chr10:96364606-96513926 -  10q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TLL2  -     10q24.1   [Description]    (hg19-Feb_2009)
EnsemblTLL2 - 10q24.1 [CytoView hg19]  TLL2 - 10q24.1 [CytoView hg38]
Mapping of homologs : NCBITLL2 [Mapview hg19]  TLL2 [Mapview hg38]
OMIM606743   
Gene and transcription
Genbank (Entrez)AB023149 AF059516 AK026106 AW452288 BC013871
RefSeq transcript (Entrez)NM_012465
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TLL2
Cluster EST : UnigeneHs.154296 [ NCBI ]
CGAP (NCI)Hs.154296
Alternative Splicing GalleryENSG00000095587
Gene ExpressionTLL2 [ NCBI-GEO ]   TLL2 [ EBI - ARRAY_EXPRESS ]   TLL2 [ SEEK ]   TLL2 [ MEM ]
Gene Expression Viewer (FireBrowse)TLL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7093
GTEX Portal (Tissue expression)TLL2
Human Protein AtlasENSG00000095587-TLL2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6L7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6L7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6L7
Splice isoforms : SwissVarQ9Y6L7
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
PhosPhoSitePlusQ9Y6L7
Domaine pattern : Prosite (Expaxy)CUB (PS01180)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)BMP_1/tolloid-like    CUB_dom    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    MetalloPept_cat_dom    Peptidase_M12A    Peptidase_Metallo    ZnMP_TLD/BMP1   
Domain families : Pfam (Sanger)Astacin (PF01400)    CUB (PF00431)    EGF_CA (PF07645)   
Domain families : Pfam (NCBI)pfam01400    pfam00431    pfam07645   
Domain families : Smart (EMBL)CUB (SM00042)  EGF (SM00181)  EGF_CA (SM00179)  ZnMc (SM00235)  
Conserved Domain (NCBI)TLL2
DMDM Disease mutations7093
Blocks (Seattle)TLL2
SuperfamilyQ9Y6L7
Human Protein Atlas [tissue]ENSG00000095587-TLL2 [tissue]
Peptide AtlasQ9Y6L7
HPRD05993
IPIIPI00465231   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6L7
IntAct (EBI)Q9Y6L7
FunCoupENSG00000095587
BioGRIDTLL2
STRING (EMBL)TLL2
ZODIACTLL2
Ontologies - Pathways
QuickGOQ9Y6L7
Ontology : AmiGOmetalloendopeptidase activity  serine-type endopeptidase activity  calcium ion binding  extracellular region  proteolysis  multicellular organism development  zinc ion binding  extracellular matrix disassembly  cell differentiation  negative regulation of skeletal muscle tissue growth  
Ontology : EGO-EBImetalloendopeptidase activity  serine-type endopeptidase activity  calcium ion binding  extracellular region  proteolysis  multicellular organism development  zinc ion binding  extracellular matrix disassembly  cell differentiation  negative regulation of skeletal muscle tissue growth  
NDEx NetworkTLL2
Atlas of Cancer Signalling NetworkTLL2
Wikipedia pathwaysTLL2
Orthology - Evolution
OrthoDB7093
GeneTree (enSembl)ENSG00000095587
Phylogenetic Trees/Animal Genes : TreeFamTLL2
HOVERGENQ9Y6L7
HOGENOMQ9Y6L7
Homologs : HomoloGeneTLL2
Homology/Alignments : Family Browser (UCSC)TLL2
Gene fusions - Rearrangements
Fusion: Tumor Portal TLL2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTLL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLL2
dbVarTLL2
ClinVarTLL2
1000_GenomesTLL2 
Exome Variant ServerTLL2
ExAC (Exome Aggregation Consortium)ENSG00000095587
GNOMAD BrowserENSG00000095587
Genetic variants : HAPMAP7093
Genomic Variants (DGV)TLL2 [DGVbeta]
DECIPHERTLL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTLL2 
Mutations
ICGC Data PortalTLL2 
TCGA Data PortalTLL2 
Broad Tumor PortalTLL2
OASIS PortalTLL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTLL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTLL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TLL2
DgiDB (Drug Gene Interaction Database)TLL2
DoCM (Curated mutations)TLL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TLL2 (select a term)
intoGenTLL2
Cancer3DTLL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606743   
Orphanet
MedgenTLL2
Genetic Testing Registry TLL2
NextProtQ9Y6L7 [Medical]
TSGene7093
GENETestsTLL2
Target ValidationTLL2
Huge Navigator TLL2 [HugePedia]
snp3D : Map Gene to Disease7093
BioCentury BCIQTLL2
ClinGenTLL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7093
Chemical/Pharm GKB GenePA36546
Clinical trialTLL2
Miscellaneous
canSAR (ICR)TLL2 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTLL2
EVEXTLL2
GoPubMedTLL2
iHOPTLL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 12:32:29 CET 2017

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