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TLN1 (talin 1)

Identity

Alias_namesTLN
Alias_symbol (synonym)ILWEQ
Other aliastalin-1
HGNC (Hugo) TLN1
LocusID (NCBI) 7094
Atlas_Id 42578
Location 9p13.3  [Link to chromosome band 9p13]
Location_base_pair Starts at 35697337 and ends at 35732395 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
APAF1 (12q23.1) / TLN1 (9p13.3)FYCO1 (3p21.31) / TLN1 (9p13.3)MBD6 (12q13.3) / TLN1 (9p13.3)
NRCAM (7q31.1) / TLN1 (9p13.3)TLN1 (9p13.3) / EIF4G1 (3q27.1)TLN1 (9p13.3) / KCTD12 (13q22.3)
TLN1 (9p13.3) / NCOR2 (12q24.31)TLN1 (9p13.3) / RBM27 (5q32)TLN1 (9p13.3) / TLN1 (9p13.3)
TMEM8B (9p13.3) / TLN1 (9p13.3)NRCAM 7q31.1 / TLN1 9p13.3TLN1 9p13.3 / EIF4G1 3q27.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)TLN1   11845
Cards
Entrez_Gene (NCBI)TLN1  7094  talin 1
AliasesILWEQ; TLN; talin-1
GeneCards (Weizmann)TLN1
Ensembl hg19 (Hinxton)ENSG00000137076 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137076 [Gene_View]  chr9:35697337-35732395 [Contig_View]  TLN1 [Vega]
ICGC DataPortalENSG00000137076
TCGA cBioPortalTLN1
AceView (NCBI)TLN1
Genatlas (Paris)TLN1
WikiGenes7094
SOURCE (Princeton)TLN1
Genetics Home Reference (NIH)TLN1
Genomic and cartography
GoldenPath hg38 (UCSC)TLN1  -     chr9:35697337-35732395 -  9p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TLN1  -     9p13.3   [Description]    (hg19-Feb_2009)
EnsemblTLN1 - 9p13.3 [CytoView hg19]  TLN1 - 9p13.3 [CytoView hg38]
Mapping of homologs : NCBITLN1 [Mapview hg19]  TLN1 [Mapview hg38]
OMIM186745   
Gene and transcription
Genbank (Entrez)AB028950 AF078828 AF113217 AF177198 BC020881
RefSeq transcript (Entrez)NM_006289
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TLN1
Cluster EST : UnigeneHs.471014 [ NCBI ]
CGAP (NCI)Hs.471014
Alternative Splicing GalleryENSG00000137076
Gene ExpressionTLN1 [ NCBI-GEO ]   TLN1 [ EBI - ARRAY_EXPRESS ]   TLN1 [ SEEK ]   TLN1 [ MEM ]
Gene Expression Viewer (FireBrowse)TLN1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7094
GTEX Portal (Tissue expression)TLN1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y490   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y490  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y490
Splice isoforms : SwissVarQ9Y490
PhosPhoSitePlusQ9Y490
Domaine pattern : Prosite (Expaxy)FERM_1 (PS00660)    FERM_2 (PS00661)    FERM_3 (PS50057)    I_LWEQ (PS50945)   
Domains : Interpro (EBI)Band_41_domain    FERM/acyl-CoA-bd_prot_3-hlx    FERM_central    FERM_CS    FERM_domain    FERM_f0    FERM_N    ILWEQ_dom    PH_dom-like    Talin-1    Talin_cent    Ubiquitin-rel_dom    Vinculin-bd_dom    Vinculin/catenin   
Domain families : Pfam (Sanger)FERM_f0 (PF16511)    FERM_M (PF00373)    FERM_N (PF09379)    I_LWEQ (PF01608)    Talin_middle (PF09141)    VBS (PF08913)   
Domain families : Pfam (NCBI)pfam16511    pfam00373    pfam09379    pfam01608    pfam09141    pfam08913   
Domain families : Smart (EMBL)B41 (SM00295)  ILWEQ (SM00307)  
Domain structure : Prodom (Prabi Lyon)ILWEQ (PD011820)   
Conserved Domain (NCBI)TLN1
DMDM Disease mutations7094
Blocks (Seattle)TLN1
PDB (SRS)1SYQ    2MWN    4DJ9   
PDB (PDBSum)1SYQ    2MWN    4DJ9   
PDB (IMB)1SYQ    2MWN    4DJ9   
PDB (RSDB)1SYQ    2MWN    4DJ9   
Structural Biology KnowledgeBase1SYQ    2MWN    4DJ9   
SCOP (Structural Classification of Proteins)1SYQ    2MWN    4DJ9   
CATH (Classification of proteins structures)1SYQ    2MWN    4DJ9   
SuperfamilyQ9Y490
Human Protein AtlasENSG00000137076
Peptide AtlasQ9Y490
HPRD01726
IPIIPI00298994   IPI01014975   IPI00385946   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y490
IntAct (EBI)Q9Y490
FunCoupENSG00000137076
BioGRIDTLN1
STRING (EMBL)TLN1
ZODIACTLN1
Ontologies - Pathways
QuickGOQ9Y490
Ontology : AmiGOruffle  phosphatidylserine binding  platelet degranulation  integrin binding  structural constituent of cytoskeleton  protein binding  extracellular region  cytosol  cytoskeleton  cell-cell junction  focal adhesion  focal adhesion  focal adhesion  movement of cell or subcellular component  muscle contraction  cytoskeletal anchoring at plasma membrane  cell-cell junction assembly  cell-substrate junction assembly  integrin-mediated signaling pathway  cell surface  viral process  vinculin binding  LIM domain binding  cortical actin cytoskeleton organization  ruffle membrane  integrin activation  phosphatidylinositol binding  IRE1-mediated unfolded protein response  cadherin binding  actin filament binding  extracellular exosome  platelet aggregation  
Ontology : EGO-EBIruffle  phosphatidylserine binding  platelet degranulation  integrin binding  structural constituent of cytoskeleton  protein binding  extracellular region  cytosol  cytoskeleton  cell-cell junction  focal adhesion  focal adhesion  focal adhesion  movement of cell or subcellular component  muscle contraction  cytoskeletal anchoring at plasma membrane  cell-cell junction assembly  cell-substrate junction assembly  integrin-mediated signaling pathway  cell surface  viral process  vinculin binding  LIM domain binding  cortical actin cytoskeleton organization  ruffle membrane  integrin activation  phosphatidylinositol binding  IRE1-mediated unfolded protein response  cadherin binding  actin filament binding  extracellular exosome  platelet aggregation  
Pathways : BIOCARTA [Genes]   
Pathways : KEGGRap1 signaling pathway    Focal adhesion    HTLV-I infection   
NDEx NetworkTLN1
Atlas of Cancer Signalling NetworkTLN1
Wikipedia pathwaysTLN1
Orthology - Evolution
OrthoDB7094
GeneTree (enSembl)ENSG00000137076
Phylogenetic Trees/Animal Genes : TreeFamTLN1
HOVERGENQ9Y490
HOGENOMQ9Y490
Homologs : HomoloGeneTLN1
Homology/Alignments : Family Browser (UCSC)TLN1
Gene fusions - Rearrangements
Fusion : MitelmanAPAF1/TLN1 [12q23.1/9p13.3]  [t(9;12)(p13;q23)]  
Fusion : MitelmanNRCAM/TLN1 [7q31.1/9p13.3]  [t(7;9)(q31;p13)]  
Fusion : MitelmanTLN1/EIF4G1 [9p13.3/3q27.1]  [t(3;9)(q27;p13)]  
Fusion : MitelmanTMEM8B/TLN1 [9p13.3/9p13.3]  [t(9;9)(p13;p13)]  
Fusion: TCGANRCAM 7q31.1 TLN1 9p13.3 LGG
Fusion: TCGATLN1 9p13.3 EIF4G1 3q27.1 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTLN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLN1
dbVarTLN1
ClinVarTLN1
1000_GenomesTLN1 
Exome Variant ServerTLN1
ExAC (Exome Aggregation Consortium)TLN1 (select the gene name)
Genetic variants : HAPMAP7094
Genomic Variants (DGV)TLN1 [DGVbeta]
DECIPHERTLN1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTLN1 
Mutations
ICGC Data PortalTLN1 
TCGA Data PortalTLN1 
Broad Tumor PortalTLN1
OASIS PortalTLN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTLN1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTLN1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TLN1
DgiDB (Drug Gene Interaction Database)TLN1
DoCM (Curated mutations)TLN1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TLN1 (select a term)
intoGenTLN1
Cancer3DTLN1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM186745   
Orphanet
MedgenTLN1
Genetic Testing Registry TLN1
NextProtQ9Y490 [Medical]
TSGene7094
GENETestsTLN1
Huge Navigator TLN1 [HugePedia]
snp3D : Map Gene to Disease7094
BioCentury BCIQTLN1
ClinGenTLN1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7094
Chemical/Pharm GKB GenePA36547
Clinical trialTLN1
Miscellaneous
canSAR (ICR)TLN1 (select the gene name)
Probes
Litterature
PubMed140 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTLN1
EVEXTLN1
GoPubMedTLN1
iHOPTLN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:41:07 CEST 2017

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