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TLN2 (talin 2)

Identity

Alias (NCBI)ILWEQ
HGNC (Hugo) TLN2
HGNC Alias symbKIAA0320
ILWEQ
LocusID (NCBI) 83660
Atlas_Id 47537
Location 15q22.2  [Link to chromosome band 15q22]
Location_base_pair Starts at 62647311 and ends at 62844630 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NEDD4L (18q21.31) / TLN2 (15q22.2)TLN2 (15q22.2) / TLN2 (15q22.2)NEDD4L 18q21.31 / TLN2 15q22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TLN2   15447
Cards
Entrez_Gene (NCBI)TLN2    talin 2
AliasesILWEQ
GeneCards (Weizmann)TLN2
Ensembl hg19 (Hinxton)ENSG00000171914 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171914 [Gene_View]  ENSG00000171914 [Sequence]  chr15:62647311-62844630 [Contig_View]  TLN2 [Vega]
ICGC DataPortalENSG00000171914
TCGA cBioPortalTLN2
AceView (NCBI)TLN2
Genatlas (Paris)TLN2
SOURCE (Princeton)TLN2
Genetics Home Reference (NIH)TLN2
Genomic and cartography
GoldenPath hg38 (UCSC)TLN2  -     chr15:62647311-62844630 +  15q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TLN2  -     15q22.2   [Description]    (hg19-Feb_2009)
GoldenPathTLN2 - 15q22.2 [CytoView hg19]  TLN2 - 15q22.2 [CytoView hg38]
ImmunoBaseENSG00000171914
Genome Data Viewer NCBITLN2 [Mapview hg19]  
OMIM607349   
Gene and transcription
Genbank (Entrez)AB002318 AB621808 AF007154 AF070527 AF085910
RefSeq transcript (Entrez)NM_001394547 NM_015059
Consensus coding sequences : CCDS (NCBI)TLN2
Gene ExpressionTLN2 [ NCBI-GEO ]   TLN2 [ EBI - ARRAY_EXPRESS ]   TLN2 [ SEEK ]   TLN2 [ MEM ]
Gene Expression Viewer (FireBrowse)TLN2 [ Firebrowse - Broad ]
GenevisibleExpression of TLN2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)83660
GTEX Portal (Tissue expression)TLN2
Human Protein AtlasENSG00000171914-TLN2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y4G6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y4G6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y4G6
PhosPhoSitePlusQ9Y4G6
Domaine pattern : Prosite (Expaxy)FERM_2 (PS00661)    FERM_3 (PS50057)    I_LWEQ (PS50945)   
Domains : Interpro (EBI)Alpha-catenin/vinculin-like_sf    Band_41_domain    FERM/acyl-CoA-bd_prot_sf    FERM_2    FERM_central    FERM_CS    FERM_domain    FERM_f0    I/LWEQ_dom_sf    ILWEQ_dom    PH-like_dom_sf    Talin1/2-RS    Talin_cent    Talin_cent_sf    Ubiquitin-like_domsf    Vinculin-bd_dom   
Domain families : Pfam (Sanger)FERM_f0 (PF16511)    FERM_M (PF00373)    I_LWEQ (PF01608)    Talin_middle (PF09141)    VBS (PF08913)   
Domain families : Pfam (NCBI)pfam16511    pfam00373    pfam01608    pfam09141    pfam08913   
Domain families : Smart (EMBL)B41 (SM00295)  ILWEQ (SM00307)  
Conserved Domain (NCBI)TLN2
PDB (RSDB)6U4K   
PDB Europe6U4K   
PDB (PDBSum)6U4K   
PDB (IMB)6U4K   
Structural Biology KnowledgeBase6U4K   
SCOP (Structural Classification of Proteins)6U4K   
CATH (Classification of proteins structures)6U4K   
SuperfamilyQ9Y4G6
AlphaFold pdb e-kbQ9Y4G6   
Human Protein Atlas [tissue]ENSG00000171914-TLN2 [tissue]
HPRD09555
Protein Interaction databases
DIP (DOE-UCLA)Q9Y4G6
IntAct (EBI)Q9Y4G6
BioGRIDTLN2
STRING (EMBL)TLN2
ZODIACTLN2
Ontologies - Pathways
QuickGOQ9Y4G6
Ontology : AmiGOruffle  actin binding  integrin binding  structural molecule activity  structural constituent of cytoskeleton  protein binding  cytoplasm  plasma membrane  focal adhesion  focal adhesion  cytoskeleton organization  cell-cell junction assembly  cell adhesion  actin cytoskeleton  synapse  actin filament binding  cell-cell adhesion  
Ontology : EGO-EBIruffle  actin binding  integrin binding  structural molecule activity  structural constituent of cytoskeleton  protein binding  cytoplasm  plasma membrane  focal adhesion  focal adhesion  cytoskeleton organization  cell-cell junction assembly  cell adhesion  actin cytoskeleton  synapse  actin filament binding  cell-cell adhesion  
Pathways : KEGGRap1 signaling pathway    Focal adhesion    HTLV-I infection   
NDEx NetworkTLN2
Atlas of Cancer Signalling NetworkTLN2
Wikipedia pathwaysTLN2
Orthology - Evolution
OrthoDB83660
GeneTree (enSembl)ENSG00000171914
Phylogenetic Trees/Animal Genes : TreeFamTLN2
Homologs : HomoloGeneTLN2
Homology/Alignments : Family Browser (UCSC)TLN2
Gene fusions - Rearrangements
Fusion : MitelmanNEDD4L/TLN2 [18q21.31/15q22.2]  
Fusion : QuiverTLN2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTLN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLN2
dbVarTLN2
ClinVarTLN2
MonarchTLN2
1000_GenomesTLN2 
Exome Variant ServerTLN2
GNOMAD BrowserENSG00000171914
Varsome BrowserTLN2
ACMGTLN2 variants
VarityQ9Y4G6
Genomic Variants (DGV)TLN2 [DGVbeta]
DECIPHERTLN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTLN2 
Mutations
ICGC Data PortalTLN2 
TCGA Data PortalTLN2 
Broad Tumor PortalTLN2
OASIS PortalTLN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTLN2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTLN2
Mutations and Diseases : HGMDTLN2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTLN2
DgiDB (Drug Gene Interaction Database)TLN2
DoCM (Curated mutations)TLN2
CIViC (Clinical Interpretations of Variants in Cancer)TLN2
Cancer3DTLN2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607349   
Orphanet
DisGeNETTLN2
MedgenTLN2
Genetic Testing Registry TLN2
NextProtQ9Y4G6 [Medical]
GENETestsTLN2
Target ValidationTLN2
Huge Navigator TLN2 [HugePedia]
ClinGenTLN2
Clinical trials, drugs, therapy
MyCancerGenomeTLN2
Protein Interactions : CTDTLN2
Pharm GKB GenePA37958
PharosQ9Y4G6
Clinical trialTLN2
Miscellaneous
canSAR (ICR)TLN2
HarmonizomeTLN2
DataMed IndexTLN2
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTLN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:13 CEST 2021

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