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TLN2 (talin 2)

Identity

Alias_symbol (synonym)KIAA0320
ILWEQ
Other alias
HGNC (Hugo) TLN2
LocusID (NCBI) 83660
Atlas_Id 47537
Location 15q22.2  [Link to chromosome band 15q22]
Location_base_pair Starts at 62647311 and ends at 62844630 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NEDD4L (18q21.31) / TLN2 (15q22.2)TLN2 (15q22.2) / TLN2 (15q22.2)NEDD4L 18q21.31 / TLN2 15q22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TLN2   15447
Cards
Entrez_Gene (NCBI)TLN2  83660  talin 2
AliasesILWEQ
GeneCards (Weizmann)TLN2
Ensembl hg19 (Hinxton)ENSG00000171914 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171914 [Gene_View]  chr15:62647311-62844630 [Contig_View]  TLN2 [Vega]
ICGC DataPortalENSG00000171914
TCGA cBioPortalTLN2
AceView (NCBI)TLN2
Genatlas (Paris)TLN2
WikiGenes83660
SOURCE (Princeton)TLN2
Genetics Home Reference (NIH)TLN2
Genomic and cartography
GoldenPath hg38 (UCSC)TLN2  -     chr15:62647311-62844630 +  15q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TLN2  -     15q22.2   [Description]    (hg19-Feb_2009)
EnsemblTLN2 - 15q22.2 [CytoView hg19]  TLN2 - 15q22.2 [CytoView hg38]
Mapping of homologs : NCBITLN2 [Mapview hg19]  TLN2 [Mapview hg38]
OMIM607349   
Gene and transcription
Genbank (Entrez)AB002318 AB621808 AF007154 AF070527 AF085910
RefSeq transcript (Entrez)NM_015059
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TLN2
Cluster EST : UnigeneHs.610975 [ NCBI ]
CGAP (NCI)Hs.610975
Alternative Splicing GalleryENSG00000171914
Gene ExpressionTLN2 [ NCBI-GEO ]   TLN2 [ EBI - ARRAY_EXPRESS ]   TLN2 [ SEEK ]   TLN2 [ MEM ]
Gene Expression Viewer (FireBrowse)TLN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)83660
GTEX Portal (Tissue expression)TLN2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y4G6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y4G6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y4G6
Splice isoforms : SwissVarQ9Y4G6
PhosPhoSitePlusQ9Y4G6
Domaine pattern : Prosite (Expaxy)FERM_2 (PS00661)    FERM_3 (PS50057)    I_LWEQ (PS50945)   
Domains : Interpro (EBI)Band_41_domain    FERM/acyl-CoA-bd_prot_3-hlx    FERM_central    FERM_CS    FERM_domain    FERM_f0    FERM_N    ILWEQ_dom    PH_dom-like    Talin-2    Talin_cent    Ubiquitin-rel_dom    Vinculin-bd_dom    Vinculin/catenin   
Domain families : Pfam (Sanger)FERM_f0 (PF16511)    FERM_M (PF00373)    FERM_N (PF09379)    I_LWEQ (PF01608)    Talin_middle (PF09141)    VBS (PF08913)   
Domain families : Pfam (NCBI)pfam16511    pfam00373    pfam09379    pfam01608    pfam09141    pfam08913   
Domain families : Smart (EMBL)B41 (SM00295)  ILWEQ (SM00307)  
Domain structure : Prodom (Prabi Lyon)ILWEQ (PD011820)   
Conserved Domain (NCBI)TLN2
DMDM Disease mutations83660
Blocks (Seattle)TLN2
SuperfamilyQ9Y4G6
Human Protein AtlasENSG00000171914
Peptide AtlasQ9Y4G6
HPRD09555
IPIIPI00219299   IPI00910010   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y4G6
IntAct (EBI)Q9Y4G6
FunCoupENSG00000171914
BioGRIDTLN2
STRING (EMBL)TLN2
ZODIACTLN2
Ontologies - Pathways
QuickGOQ9Y4G6
Ontology : AmiGOruffle  actin binding  structural molecule activity  structural constituent of cytoskeleton  protein binding  cytoplasm  plasma membrane  cell-cell junction  focal adhesion  cytoskeletal anchoring at plasma membrane  cell-cell junction assembly  cell adhesion  actin cytoskeleton  synapse  actin filament binding  
Ontology : EGO-EBIruffle  actin binding  structural molecule activity  structural constituent of cytoskeleton  protein binding  cytoplasm  plasma membrane  cell-cell junction  focal adhesion  cytoskeletal anchoring at plasma membrane  cell-cell junction assembly  cell adhesion  actin cytoskeleton  synapse  actin filament binding  
Pathways : KEGGRap1 signaling pathway    Focal adhesion    HTLV-I infection   
NDEx NetworkTLN2
Atlas of Cancer Signalling NetworkTLN2
Wikipedia pathwaysTLN2
Orthology - Evolution
OrthoDB83660
GeneTree (enSembl)ENSG00000171914
Phylogenetic Trees/Animal Genes : TreeFamTLN2
HOVERGENQ9Y4G6
HOGENOMQ9Y4G6
Homologs : HomoloGeneTLN2
Homology/Alignments : Family Browser (UCSC)TLN2
Gene fusions - Rearrangements
Fusion : MitelmanNEDD4L/TLN2 [18q21.31/15q22.2]  [t(15;18)(q22;q21)]  
Fusion: TCGANEDD4L 18q21.31 TLN2 15q22.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTLN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLN2
dbVarTLN2
ClinVarTLN2
1000_GenomesTLN2 
Exome Variant ServerTLN2
ExAC (Exome Aggregation Consortium)TLN2 (select the gene name)
Genetic variants : HAPMAP83660
Genomic Variants (DGV)TLN2 [DGVbeta]
DECIPHERTLN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTLN2 
Mutations
ICGC Data PortalTLN2 
TCGA Data PortalTLN2 
Broad Tumor PortalTLN2
OASIS PortalTLN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTLN2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTLN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TLN2
DgiDB (Drug Gene Interaction Database)TLN2
DoCM (Curated mutations)TLN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TLN2 (select a term)
intoGenTLN2
Cancer3DTLN2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607349   
Orphanet
MedgenTLN2
Genetic Testing Registry TLN2
NextProtQ9Y4G6 [Medical]
TSGene83660
GENETestsTLN2
Target ValidationTLN2
Huge Navigator TLN2 [HugePedia]
snp3D : Map Gene to Disease83660
BioCentury BCIQTLN2
ClinGenTLN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD83660
Chemical/Pharm GKB GenePA37958
Clinical trialTLN2
Miscellaneous
canSAR (ICR)TLN2 (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTLN2
EVEXTLN2
GoPubMedTLN2
iHOPTLN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Wed Jun 7 12:59:30 CEST 2017

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