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TLR1 (toll like receptor 1)

Identity

Alias (NCBI)CD281
TIL
TIL. LPRS5
rsc786
HGNC (Hugo) TLR1
HGNC Alias symbrsc786
KIAA0012
CD281
HGNC Previous nametoll-like receptor 1
LocusID (NCBI) 7096
Atlas_Id 42580
Location 4p14  [Link to chromosome band 4p14]
Location_base_pair Starts at 38796255 and ends at 38804791 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TLR1   11847
Cards
Entrez_Gene (NCBI)TLR1    toll like receptor 1
AliasesCD281; TIL; TIL.; rsc786
GeneCards (Weizmann)TLR1
Ensembl hg19 (Hinxton)ENSG00000174125 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000174125 [Gene_View]  ENSG00000174125 [Sequence]  chr4:38796255-38804791 [Contig_View]  TLR1 [Vega]
ICGC DataPortalENSG00000174125
TCGA cBioPortalTLR1
AceView (NCBI)TLR1
Genatlas (Paris)TLR1
SOURCE (Princeton)TLR1
Genetics Home Reference (NIH)TLR1
Genomic and cartography
GoldenPath hg38 (UCSC)TLR1  -     chr4:38796255-38804791 -  4p14   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TLR1  -     4p14   [Description]    (hg19-Feb_2009)
GoldenPathTLR1 - 4p14 [CytoView hg19]  TLR1 - 4p14 [CytoView hg38]
ImmunoBaseENSG00000174125
Genome Data Viewer NCBITLR1 [Mapview hg19]  
OMIM601194   613223   
Gene and transcription
Genbank (Entrez)AB445617 AK292982 AL050262 AW408740 BC089403
RefSeq transcript (Entrez)NM_003263
Consensus coding sequences : CCDS (NCBI)TLR1
Gene ExpressionTLR1 [ NCBI-GEO ]   TLR1 [ EBI - ARRAY_EXPRESS ]   TLR1 [ SEEK ]   TLR1 [ MEM ]
Gene Expression Viewer (FireBrowse)TLR1 [ Firebrowse - Broad ]
GenevisibleExpression of TLR1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7096
GTEX Portal (Tissue expression)TLR1
Human Protein AtlasENSG00000174125-TLR1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15399   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15399  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15399
PhosPhoSitePlusQ15399
Domaine pattern : Prosite (Expaxy)LRR (PS51450)    TIR (PS50104)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    LRR_dom_sf    TIR_dom    TLR1    Toll-like_receptor    Toll_tir_struct_dom_sf   
Domain families : Pfam (Sanger)LRR_8 (PF13855)    LRRCT (PF01463)    TIR (PF01582)   
Domain families : Pfam (NCBI)pfam13855    pfam01463    pfam01582   
Domain families : Smart (EMBL)LRR_TYP (SM00369)  LRRCT (SM00082)  TIR (SM00255)  
Conserved Domain (NCBI)TLR1
PDB (RSDB)1FYV    2Z7X    6NIH   
PDB Europe1FYV    2Z7X    6NIH   
PDB (PDBSum)1FYV    2Z7X    6NIH   
PDB (IMB)1FYV    2Z7X    6NIH   
Structural Biology KnowledgeBase1FYV    2Z7X    6NIH   
SCOP (Structural Classification of Proteins)1FYV    2Z7X    6NIH   
CATH (Classification of proteins structures)1FYV    2Z7X    6NIH   
SuperfamilyQ15399
AlphaFold pdb e-kbQ15399   
Human Protein Atlas [tissue]ENSG00000174125-TLR1 [tissue]
HPRD03119
Protein Interaction databases
DIP (DOE-UCLA)Q15399
IntAct (EBI)Q15399
BioGRIDTLR1
STRING (EMBL)TLR1
ZODIACTLR1
Ontologies - Pathways
QuickGOQ15399
Ontology : AmiGOmicroglial cell activation  cell activation  toll-like receptor signaling pathway  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  transmembrane signaling receptor activity  protein binding  Golgi apparatus  plasma membrane  integral component of plasma membrane  inflammatory response  immune response  signal transduction  membrane  phagocytic vesicle membrane  positive regulation of interleukin-6 production  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  toll-like receptor 1 signaling pathway  positive regulation of toll-like receptor 2 signaling pathway  Toll-like receptor 1-Toll-like receptor 2 protein complex  Toll-like receptor 1-Toll-like receptor 2 protein complex  Toll-like receptor 2 binding  Toll-like receptor 2 binding  signaling receptor activity  toll-like receptor TLR1:TLR2 signaling pathway  macrophage activation  detection of triacyl bacterial lipopeptide  identical protein binding  innate immune response  membrane raft  NAD(P)+ nucleosidase activity  NAD+ nucleotidase, cyclic ADP-ribose generating  cellular response to bacterial lipopeptide  lipopeptide binding  cellular response to triacyl bacterial lipopeptide  cellular response to triacyl bacterial lipopeptide  cellular response to triacyl bacterial lipopeptide  
Ontology : EGO-EBImicroglial cell activation  cell activation  toll-like receptor signaling pathway  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  transmembrane signaling receptor activity  protein binding  Golgi apparatus  plasma membrane  integral component of plasma membrane  inflammatory response  immune response  signal transduction  membrane  phagocytic vesicle membrane  positive regulation of interleukin-6 production  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  toll-like receptor 1 signaling pathway  positive regulation of toll-like receptor 2 signaling pathway  Toll-like receptor 1-Toll-like receptor 2 protein complex  Toll-like receptor 1-Toll-like receptor 2 protein complex  Toll-like receptor 2 binding  Toll-like receptor 2 binding  signaling receptor activity  toll-like receptor TLR1:TLR2 signaling pathway  macrophage activation  detection of triacyl bacterial lipopeptide  identical protein binding  innate immune response  membrane raft  NAD(P)+ nucleosidase activity  NAD+ nucleotidase, cyclic ADP-ribose generating  cellular response to bacterial lipopeptide  lipopeptide binding  cellular response to triacyl bacterial lipopeptide  cellular response to triacyl bacterial lipopeptide  cellular response to triacyl bacterial lipopeptide  
Pathways : KEGGToll-like receptor signaling pathway    Tuberculosis   
NDEx NetworkTLR1
Atlas of Cancer Signalling NetworkTLR1
Wikipedia pathwaysTLR1
Orthology - Evolution
OrthoDB7096
GeneTree (enSembl)ENSG00000174125
Phylogenetic Trees/Animal Genes : TreeFamTLR1
Homologs : HomoloGeneTLR1
Homology/Alignments : Family Browser (UCSC)TLR1
Gene fusions - Rearrangements
Fusion : QuiverTLR1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTLR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLR1
dbVarTLR1
ClinVarTLR1
MonarchTLR1
1000_GenomesTLR1 
Exome Variant ServerTLR1
GNOMAD BrowserENSG00000174125
Varsome BrowserTLR1
ACMGTLR1 variants
VarityQ15399
Genomic Variants (DGV)TLR1 [DGVbeta]
DECIPHERTLR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTLR1 
Mutations
ICGC Data PortalTLR1 
TCGA Data PortalTLR1 
Broad Tumor PortalTLR1
OASIS PortalTLR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTLR1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTLR1
Mutations and Diseases : HGMDTLR1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTLR1
DgiDB (Drug Gene Interaction Database)TLR1
DoCM (Curated mutations)TLR1
CIViC (Clinical Interpretations of Variants in Cancer)TLR1
Cancer3DTLR1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601194    613223   
Orphanet
DisGeNETTLR1
MedgenTLR1
Genetic Testing Registry TLR1
NextProtQ15399 [Medical]
GENETestsTLR1
Target ValidationTLR1
Huge Navigator TLR1 [HugePedia]
ClinGenTLR1
Clinical trials, drugs, therapy
MyCancerGenomeTLR1
Protein Interactions : CTDTLR1
Pharm GKB GenePA36549
PharosQ15399
Clinical trialTLR1
Miscellaneous
canSAR (ICR)TLR1
HarmonizomeTLR1
DataMed IndexTLR1
Probes
Litterature
PubMed210 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTLR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:35:14 CEST 2021

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