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TLR1 (toll like receptor 1)

Identity

Other namesCD281
TIL
TIL. LPRS5
rsc786
HGNC (Hugo) TLR1
LocusID (NCBI) 7096
Atlas_Id 42580
Location 4p14
Location_base_pair Starts at 38797876 and ends at 38806412 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TLR1   11847
Cards
Entrez_Gene (NCBI)TLR1  7096  toll like receptor 1
AliasesCD281; TIL; TIL.; rsc786
GeneCards (Weizmann)TLR1
Ensembl hg19 (Hinxton)ENSG00000174125 [Gene_View]  chr4:38797876-38806412 [Contig_View]  TLR1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000174125 [Gene_View]  chr4:38797876-38806412 [Contig_View]  TLR1 [Vega]
ICGC DataPortalENSG00000174125
TCGA cBioPortalTLR1
AceView (NCBI)TLR1
Genatlas (Paris)TLR1
WikiGenes7096
SOURCE (Princeton)TLR1
Genomic and cartography
GoldenPath hg19 (UCSC)TLR1  -     chr4:38797876-38806412 -  4p14   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TLR1  -     4p14   [Description]    (hg38-Dec_2013)
EnsemblTLR1 - 4p14 [CytoView hg19]  TLR1 - 4p14 [CytoView hg38]
Mapping of homologs : NCBITLR1 [Mapview hg19]  TLR1 [Mapview hg38]
OMIM601194   613223   
Gene and transcription
Genbank (Entrez)AB445617 AK292982 AL050262 AW408740 BC089403
RefSeq transcript (Entrez)NM_003263
RefSeq genomic (Entrez)NC_000004 NC_018915 NG_016228 NT_006238 NW_004929317
Consensus coding sequences : CCDS (NCBI)TLR1
Cluster EST : UnigeneHs.654532 [ NCBI ]
CGAP (NCI)Hs.654532
Alternative Splicing GalleryENSG00000174125
Gene ExpressionTLR1 [ NCBI-GEO ]   TLR1 [ EBI - ARRAY_EXPRESS ]   TLR1 [ SEEK ]   TLR1 [ MEM ]
Gene Expression Viewer (FireBrowse)TLR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7096
GTEX Portal (Tissue expression)TLR1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15399 (Uniprot)
NextProtQ15399  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15399
Splice isoforms : SwissVarQ15399 (Swissvar)
PhosPhoSitePlusQ15399
Domaine pattern : Prosite (Expaxy)LRR (PS51450)    TIR (PS50104)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    L_dom-like    Leu-rich_rpt    TIR_dom    TLR1    Toll-like_receptor   
Domain families : Pfam (Sanger)LRR_8 (PF13855)    LRRCT (PF01463)    TIR (PF01582)   
Domain families : Pfam (NCBI)pfam13855    pfam01463    pfam01582   
Domain families : Smart (EMBL)LRRCT (SM00082)  TIR (SM00255)  
DMDM Disease mutations7096
Blocks (Seattle)TLR1
PDB (SRS)1FYV    2Z7X   
PDB (PDBSum)1FYV    2Z7X   
PDB (IMB)1FYV    2Z7X   
PDB (RSDB)1FYV    2Z7X   
Structural Biology KnowledgeBase1FYV    2Z7X   
SCOP (Structural Classification of Proteins)1FYV    2Z7X   
CATH (Classification of proteins structures)1FYV    2Z7X   
SuperfamilyQ15399
Human Protein AtlasENSG00000174125
Peptide AtlasQ15399
HPRD03119
IPIIPI00090764   IPI00968297   IPI00966563   IPI00966356   IPI00968008   
Protein Interaction databases
DIP (DOE-UCLA)Q15399
IntAct (EBI)Q15399
FunCoupENSG00000174125
BioGRIDTLR1
STRING (EMBL)TLR1
ZODIACTLR1
Ontologies - Pathways
QuickGOQ15399
Ontology : AmiGOtoll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  receptor activity  transmembrane signaling receptor activity  transmembrane signaling receptor activity  protein binding  Golgi apparatus  plasma membrane  integral component of plasma membrane  inflammatory response  immune response  signal transduction  membrane  phagocytic vesicle membrane  toll-like receptor 1 signaling pathway  Toll-like receptor 1-Toll-like receptor 2 protein complex  Toll-like receptor 2 binding  toll-like receptor TLR1:TLR2 signaling pathway  macrophage activation  detection of triacyl bacterial lipopeptide  positive regulation of tumor necrosis factor biosynthetic process  defense response to bacterium  innate immune response  membrane raft  positive regulation of interleukin-6 biosynthetic process  protein heterodimerization activity  regulation of cytokine secretion  lipopeptide binding  cellular response to triacyl bacterial lipopeptide  
Ontology : EGO-EBItoll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  receptor activity  transmembrane signaling receptor activity  transmembrane signaling receptor activity  protein binding  Golgi apparatus  plasma membrane  integral component of plasma membrane  inflammatory response  immune response  signal transduction  membrane  phagocytic vesicle membrane  toll-like receptor 1 signaling pathway  Toll-like receptor 1-Toll-like receptor 2 protein complex  Toll-like receptor 2 binding  toll-like receptor TLR1:TLR2 signaling pathway  macrophage activation  detection of triacyl bacterial lipopeptide  positive regulation of tumor necrosis factor biosynthetic process  defense response to bacterium  innate immune response  membrane raft  positive regulation of interleukin-6 biosynthetic process  protein heterodimerization activity  regulation of cytokine secretion  lipopeptide binding  cellular response to triacyl bacterial lipopeptide  
Pathways : KEGGToll-like receptor signaling pathway    Tuberculosis   
NDEx Network
Atlas of Cancer Signalling NetworkTLR1
Wikipedia pathwaysTLR1
Orthology - Evolution
OrthoDB7096
GeneTree (enSembl)ENSG00000174125
Phylogenetic Trees/Animal Genes : TreeFamTLR1
Homologs : HomoloGeneTLR1
Homology/Alignments : Family Browser (UCSC)TLR1
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerTLR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLR1
dbVarTLR1
ClinVarTLR1
1000_GenomesTLR1 
Exome Variant ServerTLR1
ExAC (Exome Aggregation Consortium)TLR1 (select the gene name)
Genetic variants : HAPMAP7096
Genomic Variants (DGV)TLR1 [DGVbeta]
Mutations
ICGC Data PortalTLR1 
TCGA Data PortalTLR1 
Broad Tumor PortalTLR1
OASIS PortalTLR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTLR1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMutasearch TLR1
DgiDB (Drug Gene Interaction Database)TLR1
DoCM (Curated mutations)TLR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TLR1 (select a term)
intoGenTLR1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)4:38797876-38806412  ENSG00000174125
CONAN: Copy Number AnalysisTLR1 
Mutations and Diseases : HGMDTLR1
OMIM601194    613223   
MedgenTLR1
Genetic Testing Registry TLR1
NextProtQ15399 [Medical]
TSGene7096
GENETestsTLR1
Huge Navigator TLR1 [HugePedia]
snp3D : Map Gene to Disease7096
BioCentury BCIQTLR1
ClinGenTLR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7096
Chemical/Pharm GKB GenePA36549
Clinical trialTLR1
Miscellaneous
canSAR (ICR)TLR1 (select the gene name)
Probes
Litterature
PubMed174 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTLR1
EVEXTLR1
GoPubMedTLR1
iHOPTLR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat May 28 11:24:32 CEST 2016

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