Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TLR1 (toll-like receptor 1)

Identity

Other namesCD281
TIL
TIL. LPRS5
rsc786
HGNC (Hugo) TLR1
LocusID (NCBI) 7096
Location 4p14
Location_base_pair Starts at 38797876 and ends at 38806412 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TLR1   11847
Cards
Entrez_Gene (NCBI)TLR1  7096  toll-like receptor 1
GeneCards (Weizmann)TLR1
Ensembl (Hinxton)ENSG00000174125 [Gene_View]  chr4:38797876-38806412 [Contig_View]  TLR1 [Vega]
ICGC DataPortalENSG00000174125
cBioPortalTLR1
AceView (NCBI)TLR1
Genatlas (Paris)TLR1
WikiGenes7096
SOURCE (Princeton)NM_003263
Genomic and cartography
GoldenPath (UCSC)TLR1  -  4p14   chr4:38797876-38806412 -  4p14   [Description]    (hg19-Feb_2009)
EnsemblTLR1 - 4p14 [CytoView]
Mapping of homologs : NCBITLR1 [Mapview]
OMIM601194   613223   
Gene and transcription
Genbank (Entrez)AB445617 AK292982 AL050262 AW408740 BC089403
RefSeq transcript (Entrez)NM_003263
RefSeq genomic (Entrez)AC_000136 NC_000004 NC_018915 NG_016228 NT_006238 NW_001838902 NW_004929317
Consensus coding sequences : CCDS (NCBI)TLR1
Cluster EST : UnigeneHs.654532 [ NCBI ]
CGAP (NCI)Hs.654532
Alternative Splicing : Fast-db (Paris)GSHG0023201
Alternative Splicing GalleryENSG00000174125
Gene ExpressionTLR1 [ NCBI-GEO ]     TLR1 [ SEEK ]   TLR1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15399 (Uniprot)
NextProtQ15399  [Medical]
With graphics : InterProQ15399
Splice isoforms : SwissVarQ15399 (Swissvar)
Domaine pattern : Prosite (Expaxy)LRR (PS51450)    TIR (PS50104)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C [organisation]   Leu-rich_rpt [organisation]   TIR_dom [organisation]   TLR1 [organisation]   Toll-like_receptor [organisation]  
Related proteins : CluSTrQ15399
Domain families : Pfam (Sanger)LRR_8 (PF13855)    TIR (PF01582)   
Domain families : Pfam (NCBI)pfam13855    pfam01582   
Domain families : Smart (EMBL)LRRCT (SM00082)  TIR (SM00255)  
DMDM Disease mutations7096
Blocks (Seattle)Q15399
PDB (SRS)1FYV    2Z7X   
PDB (PDBSum)1FYV    2Z7X   
PDB (IMB)1FYV    2Z7X   
PDB (RSDB)1FYV    2Z7X   
Human Protein AtlasENSG00000174125 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ15399
HPRD03119
IPIIPI00090764   IPI00968297   IPI00966563   IPI00966356   IPI00968008   
Protein Interaction databases
DIP (DOE-UCLA)Q15399
IntAct (EBI)Q15399
FunCoupENSG00000174125
BioGRIDTLR1
InParanoidQ15399
Interologous Interaction database Q15399
IntegromeDBTLR1
STRING (EMBL)TLR1
Ontologies - Pathways
Ontology : AmiGOMyD88-dependent toll-like receptor signaling pathway  receptor activity  transmembrane signaling receptor activity  plasma membrane  integral component of plasma membrane  inflammatory response  immune response  signal transduction  membrane  phagocytic vesicle membrane  toll-like receptor 1 signaling pathway  Toll-like receptor 1-Toll-like receptor 2 protein complex  macrophage activation  detection of triacyl bacterial lipopeptide  positive regulation of tumor necrosis factor biosynthetic process  innate immune response  positive regulation of interleukin-6 biosynthetic process  protein heterodimerization activity  regulation of cytokine secretion  cellular response to triacyl bacterial lipopeptide  
Ontology : EGO-EBIMyD88-dependent toll-like receptor signaling pathway  receptor activity  transmembrane signaling receptor activity  plasma membrane  integral component of plasma membrane  inflammatory response  immune response  signal transduction  membrane  phagocytic vesicle membrane  toll-like receptor 1 signaling pathway  Toll-like receptor 1-Toll-like receptor 2 protein complex  macrophage activation  detection of triacyl bacterial lipopeptide  positive regulation of tumor necrosis factor biosynthetic process  innate immune response  positive regulation of interleukin-6 biosynthetic process  protein heterodimerization activity  regulation of cytokine secretion  cellular response to triacyl bacterial lipopeptide  
Pathways : KEGGToll-like receptor signaling pathway    Tuberculosis   
Protein Interaction DatabaseTLR1
Wikipedia pathwaysTLR1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)TLR1
snp3D : Map Gene to Disease7096
SNP (GeneSNP Utah)TLR1
SNP : HGBaseTLR1
Genetic variants : HAPMAPTLR1
Exome VariantTLR1
1000_GenomesTLR1 
ICGC programENSG00000174125 
Somatic Mutations in Cancer : COSMICTLR1 
CONAN: Copy Number AnalysisTLR1 
Mutations and Diseases : HGMDTLR1
Mutations and Diseases : intOGenTLR1
Genomic VariantsTLR1  TLR1 [DGVbeta]
dbVarTLR1
ClinVarTLR1
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM601194    613223   
MedgenTLR1
GENETestsTLR1
Disease Genetic AssociationTLR1
Huge Navigator TLR1 [HugePedia]  TLR1 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneTLR1
Homology/Alignments : Family Browser (UCSC)TLR1
Phylogenetic Trees/Animal Genes : TreeFamTLR1
Chemical/Protein Interactions : CTD7096
Chemical/Pharm GKB GenePA36549
Clinical trialTLR1
Cancer Resource (Charite)ENSG00000174125
Other databases
Probes
Litterature
PubMed141 Pubmed reference(s) in Entrez
CoreMineTLR1
iHOPTLR1
OncoSearchTLR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 17:07:46 CEST 2014

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