TLR2 (toll like receptor 2)

2007-02-01  

Identity

HGNC
LOCATION
4q31.3
LOCUSID
ALIAS
CD282,TIL4

Other Information

Locus ID:

NCBI: 7097
MIM: 603028
HGNC: 11848
Ensembl: ENSG00000137462

Variants:

dbSNP: 7097
ClinVar: 7097
TCGA: ENSG00000137462
COSMIC: TLR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137462ENST00000260010O60603
ENSG00000137462ENST00000260010A0A0S2Z4S4
ENSG00000137462ENST00000642580O60603
ENSG00000137462ENST00000642580A0A0S2Z4S4
ENSG00000137462ENST00000642700O60603
ENSG00000137462ENST00000642700A0A0S2Z4S4
ENSG00000137462ENST00000643087A0A0S2Z4L7
ENSG00000137462ENST00000643501A0A2R8Y7R7
ENSG00000137462ENST00000646219A0A2R8YHF6
ENSG00000137462ENST00000646900A0A2R8Y4N9

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Toll-like receptor signaling pathwayKEGGko04620
Toll-like receptor signaling pathwayKEGGhsa04620
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
MalariaKEGGko05144
MalariaKEGGhsa05144
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
MeaslesKEGGko05162
MeaslesKEGGhsa05162
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hepatitis BKEGGhsa05161
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Toll-like receptor signalingKEGGhsa_M00686
Toll-like receptor signalingKEGGM00686
DiseaseREACTOMER-HSA-1643685
Diseases of Immune SystemREACTOMER-HSA-5260271
Diseases associated with the TLR signaling cascadeREACTOMER-HSA-5602358
IRAK4 deficiency (TLR2/4)REACTOMER-HSA-5603041
MyD88 deficiency (TLR2/4)REACTOMER-HSA-5602498
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing-Cross presentationREACTOMER-HSA-1236975
ER-Phagosome pathwayREACTOMER-HSA-1236974
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
MyD88:Mal cascade initiated on plasma membraneREACTOMER-HSA-166058
Toll Like Receptor 2 (TLR2) CascadeREACTOMER-HSA-181438
Toll Like Receptor TLR1:TLR2 CascadeREACTOMER-HSA-168179
Toll Like Receptor TLR6:TLR2 CascadeREACTOMER-HSA-168188
DefensinsREACTOMER-HSA-1461973
Beta defensinsREACTOMER-HSA-1461957
Regulation of TLR by endogenous ligandREACTOMER-HSA-5686938
Antimicrobial peptidesREACTOMER-HSA-6803157
Neutrophil degranulationREACTOMER-HSA-6798695

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164713366Tumor necrosis factor alpha (TNF-alpha) inhibitorsChemicalClinicalAnnotationassociatedPD24776844, 28696418
PA443750Colitis, UlcerativeDiseaseClinicalAnnotationassociatedPD24776844
PA443815Crohn DiseaseDiseaseClinicalAnnotationassociatedPD24776844
PA445451PsoriasisDiseaseClinicalAnnotationassociatedPD24776844, 28696418
PA446116Inflammatory Bowel DiseasesDiseaseClinicalAnnotationassociatedPD24776844, 28696418

References

Pubmed IDYearTitleCitations
164978872006Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response.1029
178896512007Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide.406
118362572002Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4.388
162671052006High mobility group box 1 protein interacts with multiple Toll-like receptors.295
168780262006HMGB1 signals through toll-like receptor (TLR) 4 and TLR2.272
118420862002HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway.221
126637652003Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2.219
216733432011Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4.209
234630052013Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia.187
183694802008The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis.186

Citation

Dessen P

TLR2 (toll like receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45714/tlr2