Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TLR2 (toll like receptor 2)

Identity

Alias_namestoll-like receptor 2
Alias_symbol (synonym)TIL4
CD282
Other alias
HGNC (Hugo) TLR2
LocusID (NCBI) 7097
Atlas_Id 45714
Location 4q31.3  [Link to chromosome band 4q31]
Location_base_pair Starts at 153684252 and ends at 153706260 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TLR2   11848
Cards
Entrez_Gene (NCBI)TLR2  7097  toll like receptor 2
AliasesCD282; TIL4
GeneCards (Weizmann)TLR2
Ensembl hg19 (Hinxton)ENSG00000137462 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137462 [Gene_View]  chr4:153684252-153706260 [Contig_View]  TLR2 [Vega]
ICGC DataPortalENSG00000137462
TCGA cBioPortalTLR2
AceView (NCBI)TLR2
Genatlas (Paris)TLR2
WikiGenes7097
SOURCE (Princeton)TLR2
Genetics Home Reference (NIH)TLR2
Genomic and cartography
GoldenPath hg38 (UCSC)TLR2  -     chr4:153684252-153706260 +  4q31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TLR2  -     4q31.3   [Description]    (hg19-Feb_2009)
EnsemblTLR2 - 4q31.3 [CytoView hg19]  TLR2 - 4q31.3 [CytoView hg38]
Mapping of homologs : NCBITLR2 [Mapview hg19]  TLR2 [Mapview hg38]
OMIM246300   603028   607948   
Gene and transcription
Genbank (Entrez)AB445624 AF051152 AF424049 AF424050 AF424051
RefSeq transcript (Entrez)NM_001318787 NM_001318789 NM_001318790 NM_001318791 NM_001318793 NM_001318795 NM_001318796 NM_003264
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TLR2
Cluster EST : UnigeneHs.519033 [ NCBI ]
CGAP (NCI)Hs.519033
Alternative Splicing GalleryENSG00000137462
Gene ExpressionTLR2 [ NCBI-GEO ]   TLR2 [ EBI - ARRAY_EXPRESS ]   TLR2 [ SEEK ]   TLR2 [ MEM ]
Gene Expression Viewer (FireBrowse)TLR2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7097
GTEX Portal (Tissue expression)TLR2
Human Protein AtlasENSG00000137462-TLR2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60603   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60603  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60603
Splice isoforms : SwissVarO60603
PhosPhoSitePlusO60603
Domaine pattern : Prosite (Expaxy)LRR (PS51450)    TIR (PS50104)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    L_dom-like    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    TIR_dom    TLR2    Toll-like_receptor   
Domain families : Pfam (Sanger)LRR_8 (PF13855)    LRRCT (PF01463)    TIR (PF01582)   
Domain families : Pfam (NCBI)pfam13855    pfam01463    pfam01582   
Domain families : Smart (EMBL)LRR_TYP (SM00369)  LRRCT (SM00082)  TIR (SM00255)  
Conserved Domain (NCBI)TLR2
DMDM Disease mutations7097
Blocks (Seattle)TLR2
PDB (SRS)1FYW    1FYX    1O77    2Z7X    2Z80   
PDB (PDBSum)1FYW    1FYX    1O77    2Z7X    2Z80   
PDB (IMB)1FYW    1FYX    1O77    2Z7X    2Z80   
PDB (RSDB)1FYW    1FYX    1O77    2Z7X    2Z80   
Structural Biology KnowledgeBase1FYW    1FYX    1O77    2Z7X    2Z80   
SCOP (Structural Classification of Proteins)1FYW    1FYX    1O77    2Z7X    2Z80   
CATH (Classification of proteins structures)1FYW    1FYX    1O77    2Z7X    2Z80   
SuperfamilyO60603
Human Protein Atlas [tissue]ENSG00000137462-TLR2 [tissue]
Peptide AtlasO60603
HPRD04323
IPIIPI00019006   IPI00954814   
Protein Interaction databases
DIP (DOE-UCLA)O60603
IntAct (EBI)O60603
FunCoupENSG00000137462
BioGRIDTLR2
STRING (EMBL)TLR2
ZODIACTLR2
Ontologies - Pathways
QuickGOO60603
Ontology : AmiGOlipopolysaccharide binding  response to hypoxia  microglial cell activation  cell activation  lipopolysaccharide receptor activity  toll-like receptor signaling pathway  cytokine secretion involved in immune response  MyD88-dependent toll-like receptor signaling pathway  receptor activity  protein binding  cytoplasm  Golgi apparatus  plasma membrane  plasma membrane  integral component of plasma membrane  leukotriene metabolic process  apoptotic process  inflammatory response  immune response  signal transduction  I-kappaB phosphorylation  learning  negative regulation of cell proliferation  signaling pattern recognition receptor activity  response to toxic substance  cell surface  positive regulation of gene expression  microglia development  positive regulation of Wnt signaling pathway  secretory granule membrane  phagocytic vesicle membrane  intrinsic component of plasma membrane  lipopolysaccharide-mediated signaling pathway  central nervous system myelin formation  protein complex binding  response to progesterone  interleukin-10 production  tumor necrosis factor production  positive regulation of chemokine production  positive regulation of interferon-beta production  positive regulation of interleukin-10 production  positive regulation of interleukin-12 production  positive regulation of interleukin-18 production  positive regulation of interleukin-6 production  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  response to insulin  positive regulation of toll-like receptor signaling pathway  toll-like receptor 2 signaling pathway  Toll-like receptor binding  Toll-like receptor 1-Toll-like receptor 2 protein complex  toll-like receptor TLR1:TLR2 signaling pathway  toll-like receptor TLR6:TLR2 signaling pathway  positive regulation of NF-kappaB import into nucleus  detection of triacyl bacterial lipopeptide  detection of diacyl bacterial lipopeptide  triacyl lipopeptide binding  peptidoglycan binding  cell projection  neutrophil degranulation  cell body  innate immune response  membrane raft  positive regulation of transcription by RNA polymerase II  nitric oxide metabolic process  protein heterodimerization activity  positive regulation of oligodendrocyte differentiation  positive regulation of inflammatory response  negative regulation of phagocytosis  defense response to Gram-positive bacterium  positive regulation of NF-kappaB transcription factor activity  positive regulation of nitric-oxide synthase biosynthetic process  negative regulation of synapse assembly  response to fatty acid  cellular response to bacterial lipopeptide  cellular response to lipoteichoic acid  cellular response to lipoteichoic acid  cellular response to diacyl bacterial lipopeptide  cellular response to triacyl bacterial lipopeptide  amyloid-beta complex  positive regulation of interleukin-8 secretion  
Ontology : EGO-EBIlipopolysaccharide binding  response to hypoxia  microglial cell activation  cell activation  lipopolysaccharide receptor activity  toll-like receptor signaling pathway  cytokine secretion involved in immune response  MyD88-dependent toll-like receptor signaling pathway  receptor activity  protein binding  cytoplasm  Golgi apparatus  plasma membrane  plasma membrane  integral component of plasma membrane  leukotriene metabolic process  apoptotic process  inflammatory response  immune response  signal transduction  I-kappaB phosphorylation  learning  negative regulation of cell proliferation  signaling pattern recognition receptor activity  response to toxic substance  cell surface  positive regulation of gene expression  microglia development  positive regulation of Wnt signaling pathway  secretory granule membrane  phagocytic vesicle membrane  intrinsic component of plasma membrane  lipopolysaccharide-mediated signaling pathway  central nervous system myelin formation  protein complex binding  response to progesterone  interleukin-10 production  tumor necrosis factor production  positive regulation of chemokine production  positive regulation of interferon-beta production  positive regulation of interleukin-10 production  positive regulation of interleukin-12 production  positive regulation of interleukin-18 production  positive regulation of interleukin-6 production  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  response to insulin  positive regulation of toll-like receptor signaling pathway  toll-like receptor 2 signaling pathway  Toll-like receptor binding  Toll-like receptor 1-Toll-like receptor 2 protein complex  toll-like receptor TLR1:TLR2 signaling pathway  toll-like receptor TLR6:TLR2 signaling pathway  positive regulation of NF-kappaB import into nucleus  detection of triacyl bacterial lipopeptide  detection of diacyl bacterial lipopeptide  triacyl lipopeptide binding  peptidoglycan binding  cell projection  neutrophil degranulation  cell body  innate immune response  membrane raft  positive regulation of transcription by RNA polymerase II  nitric oxide metabolic process  protein heterodimerization activity  positive regulation of oligodendrocyte differentiation  positive regulation of inflammatory response  negative regulation of phagocytosis  defense response to Gram-positive bacterium  positive regulation of NF-kappaB transcription factor activity  positive regulation of nitric-oxide synthase biosynthetic process  negative regulation of synapse assembly  response to fatty acid  cellular response to bacterial lipopeptide  cellular response to lipoteichoic acid  cellular response to lipoteichoic acid  cellular response to diacyl bacterial lipopeptide  cellular response to triacyl bacterial lipopeptide  amyloid-beta complex  positive regulation of interleukin-8 secretion  
Pathways : KEGGToll-like receptor signaling pathway   
NDEx NetworkTLR2
Atlas of Cancer Signalling NetworkTLR2
Wikipedia pathwaysTLR2
Orthology - Evolution
OrthoDB7097
GeneTree (enSembl)ENSG00000137462
Phylogenetic Trees/Animal Genes : TreeFamTLR2
HOVERGENO60603
HOGENOMO60603
Homologs : HomoloGeneTLR2
Homology/Alignments : Family Browser (UCSC)TLR2
Gene fusions - Rearrangements
Fusion : QuiverTLR2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTLR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLR2
dbVarTLR2
ClinVarTLR2
1000_GenomesTLR2 
Exome Variant ServerTLR2
ExAC (Exome Aggregation Consortium)ENSG00000137462
GNOMAD BrowserENSG00000137462
Genetic variants : HAPMAP7097
Genomic Variants (DGV)TLR2 [DGVbeta]
DECIPHERTLR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTLR2 
Mutations
ICGC Data PortalTLR2 
TCGA Data PortalTLR2 
Broad Tumor PortalTLR2
OASIS PortalTLR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTLR2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTLR2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
LOVD (Leiden Open Variation Database)Pharmacogenomics of Infectious Diseases (PGx_IfD )
BioMutasearch TLR2
DgiDB (Drug Gene Interaction Database)TLR2
DoCM (Curated mutations)TLR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TLR2 (select a term)
intoGenTLR2
Cancer3DTLR2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM246300    603028    607948   
Orphanet
DisGeNETTLR2
MedgenTLR2
Genetic Testing Registry TLR2
NextProtO60603 [Medical]
TSGene7097
GENETestsTLR2
Target ValidationTLR2
Huge Navigator TLR2 [HugePedia]
snp3D : Map Gene to Disease7097
BioCentury BCIQTLR2
ClinGenTLR2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7097
Chemical/Pharm GKB GenePA36550
Clinical trialTLR2
Miscellaneous
canSAR (ICR)TLR2 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTLR2
EVEXTLR2
GoPubMedTLR2
iHOPTLR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Feb 28 13:41:50 CET 2018
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