Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TLR3 (toll like receptor 3)

Identity

Alias_namestoll-like receptor 3
Alias_symbol (synonym)CD283
Other aliasIIAE2
HGNC (Hugo) TLR3
LocusID (NCBI) 7098
Atlas_Id 43628
Location 4q35.1  [Link to chromosome band 4q35]
Location_base_pair Starts at 186069155 and ends at 186085098 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TLR3   11849
LRG (Locus Reference Genomic)LRG_117
Cards
Entrez_Gene (NCBI)TLR3  7098  toll like receptor 3
AliasesCD283; IIAE2
GeneCards (Weizmann)TLR3
Ensembl hg19 (Hinxton)ENSG00000164342 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164342 [Gene_View]  chr4:186069155-186085098 [Contig_View]  TLR3 [Vega]
ICGC DataPortalENSG00000164342
TCGA cBioPortalTLR3
AceView (NCBI)TLR3
Genatlas (Paris)TLR3
WikiGenes7098
SOURCE (Princeton)TLR3
Genetics Home Reference (NIH)TLR3
Genomic and cartography
GoldenPath hg38 (UCSC)TLR3  -     chr4:186069155-186085098 +  4q35.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TLR3  -     4q35.1   [Description]    (hg19-Feb_2009)
EnsemblTLR3 - 4q35.1 [CytoView hg19]  TLR3 - 4q35.1 [CytoView hg38]
Mapping of homologs : NCBITLR3 [Mapview hg19]  TLR3 [Mapview hg38]
OMIM603029   609423   
Gene and transcription
Genbank (Entrez)AB445631 AK302143 AK314208 BC017954 BC043204
RefSeq transcript (Entrez)NM_003265
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TLR3
Cluster EST : UnigeneHs.657724 [ NCBI ]
CGAP (NCI)Hs.657724
Alternative Splicing GalleryENSG00000164342
Gene ExpressionTLR3 [ NCBI-GEO ]   TLR3 [ EBI - ARRAY_EXPRESS ]   TLR3 [ SEEK ]   TLR3 [ MEM ]
Gene Expression Viewer (FireBrowse)TLR3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7098
GTEX Portal (Tissue expression)TLR3
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15455   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15455  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15455
Splice isoforms : SwissVarO15455
PhosPhoSitePlusO15455
Domaine pattern : Prosite (Expaxy)LRR (PS51450)    TIR (PS50104)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    L_dom-like    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    TIR_dom    TLR3   
Domain families : Pfam (Sanger)LRR_6 (PF13516)    LRR_8 (PF13855)    TIR (PF01582)   
Domain families : Pfam (NCBI)pfam13516    pfam13855    pfam01582   
Domain families : Smart (EMBL)LRR_TYP (SM00369)  LRRCT (SM00082)  TIR (SM00255)  
Conserved Domain (NCBI)TLR3
DMDM Disease mutations7098
Blocks (Seattle)TLR3
PDB (SRS)1ZIW    2A0Z    2MK9    2MKA    3ULU    3ULV    5GS0   
PDB (PDBSum)1ZIW    2A0Z    2MK9    2MKA    3ULU    3ULV    5GS0   
PDB (IMB)1ZIW    2A0Z    2MK9    2MKA    3ULU    3ULV    5GS0   
PDB (RSDB)1ZIW    2A0Z    2MK9    2MKA    3ULU    3ULV    5GS0   
Structural Biology KnowledgeBase1ZIW    2A0Z    2MK9    2MKA    3ULU    3ULV    5GS0   
SCOP (Structural Classification of Proteins)1ZIW    2A0Z    2MK9    2MKA    3ULU    3ULV    5GS0   
CATH (Classification of proteins structures)1ZIW    2A0Z    2MK9    2MKA    3ULU    3ULV    5GS0   
SuperfamilyO15455
Human Protein AtlasENSG00000164342
Peptide AtlasO15455
HPRD04324
IPIIPI00019007   IPI01014524   IPI00964068   IPI00966006   
Protein Interaction databases
DIP (DOE-UCLA)O15455
IntAct (EBI)O15455
FunCoupENSG00000164342
BioGRIDTLR3
STRING (EMBL)TLR3
ZODIACTLR3
Ontologies - Pathways
QuickGOO15455
Ontology : AmiGOGolgi membrane  toll-like receptor signaling pathway  microglial cell activation involved in immune response  regulation of dendritic cell cytokine production  MyD88-independent toll-like receptor signaling pathway  double-stranded RNA binding  double-stranded RNA binding  receptor activity  transmembrane signaling receptor activity  protein binding  intracellular  cytoplasm  lysosomal membrane  early endosome  endoplasmic reticulum membrane  integral component of plasma membrane  inflammatory response  hyperosmotic response  signal transduction  I-kappaB kinase/NF-kappaB signaling  activation of NF-kappaB-inducing kinase activity  I-kappaB phosphorylation  male gonad development  detection of virus  cell surface  endosome membrane  positive regulation of gene expression  membrane  positive regulation of chemokine production  positive regulation of interferon-beta production  positive regulation of interleukin-12 production  positive regulation of interleukin-6 production  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  positive regulation of toll-like receptor signaling pathway  negative regulation of MyD88-independent toll-like receptor signaling pathway  toll-like receptor 3 signaling pathway  positive regulation of type III interferon production  cellular response to interferon-beta  TRIF-dependent toll-like receptor signaling pathway  cellular response to drug  endolysosome membrane  positive regulation of NF-kappaB import into nucleus  defense response to bacterium  identical protein binding  positive regulation of apoptotic process  response to exogenous dsRNA  positive regulation of interferon-gamma biosynthetic process  positive regulation of chemokine biosynthetic process  innate immune response  positive regulation of interferon-alpha biosynthetic process  positive regulation of interferon-beta biosynthetic process  positive regulation of interferon-beta biosynthetic process  negative regulation of osteoclast differentiation  positive regulation of transcription from RNA polymerase II promoter  positive regulation of JNK cascade  positive regulation of inflammatory response  positive regulation of NF-kappaB transcription factor activity  defense response to virus  necroptotic process  cellular response to mechanical stimulus  cellular response to interferon-gamma  cellular response to exogenous dsRNA  apoptotic signaling pathway  extrinsic apoptotic signaling pathway  necroptotic signaling pathway  
Ontology : EGO-EBIGolgi membrane  toll-like receptor signaling pathway  microglial cell activation involved in immune response  regulation of dendritic cell cytokine production  MyD88-independent toll-like receptor signaling pathway  double-stranded RNA binding  double-stranded RNA binding  receptor activity  transmembrane signaling receptor activity  protein binding  intracellular  cytoplasm  lysosomal membrane  early endosome  endoplasmic reticulum membrane  integral component of plasma membrane  inflammatory response  hyperosmotic response  signal transduction  I-kappaB kinase/NF-kappaB signaling  activation of NF-kappaB-inducing kinase activity  I-kappaB phosphorylation  male gonad development  detection of virus  cell surface  endosome membrane  positive regulation of gene expression  membrane  positive regulation of chemokine production  positive regulation of interferon-beta production  positive regulation of interleukin-12 production  positive regulation of interleukin-6 production  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  positive regulation of toll-like receptor signaling pathway  negative regulation of MyD88-independent toll-like receptor signaling pathway  toll-like receptor 3 signaling pathway  positive regulation of type III interferon production  cellular response to interferon-beta  TRIF-dependent toll-like receptor signaling pathway  cellular response to drug  endolysosome membrane  positive regulation of NF-kappaB import into nucleus  defense response to bacterium  identical protein binding  positive regulation of apoptotic process  response to exogenous dsRNA  positive regulation of interferon-gamma biosynthetic process  positive regulation of chemokine biosynthetic process  innate immune response  positive regulation of interferon-alpha biosynthetic process  positive regulation of interferon-beta biosynthetic process  positive regulation of interferon-beta biosynthetic process  negative regulation of osteoclast differentiation  positive regulation of transcription from RNA polymerase II promoter  positive regulation of JNK cascade  positive regulation of inflammatory response  positive regulation of NF-kappaB transcription factor activity  defense response to virus  necroptotic process  cellular response to mechanical stimulus  cellular response to interferon-gamma  cellular response to exogenous dsRNA  apoptotic signaling pathway  extrinsic apoptotic signaling pathway  necroptotic signaling pathway  
Pathways : BIOCARTAToll-Like Receptor Pathway [Genes]   
Pathways : KEGGToll-like receptor signaling pathway    Hepatitis C    Hepatitis B    Influenza A    Herpes simplex infection   
NDEx NetworkTLR3
Atlas of Cancer Signalling NetworkTLR3
Wikipedia pathwaysTLR3
Orthology - Evolution
OrthoDB7098
GeneTree (enSembl)ENSG00000164342
Phylogenetic Trees/Animal Genes : TreeFamTLR3
HOVERGENO15455
HOGENOMO15455
Homologs : HomoloGeneTLR3
Homology/Alignments : Family Browser (UCSC)TLR3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTLR3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLR3
dbVarTLR3
ClinVarTLR3
1000_GenomesTLR3 
Exome Variant ServerTLR3
ExAC (Exome Aggregation Consortium)TLR3 (select the gene name)
Genetic variants : HAPMAP7098
Genomic Variants (DGV)TLR3 [DGVbeta]
DECIPHERTLR3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTLR3 
Mutations
ICGC Data PortalTLR3 
TCGA Data PortalTLR3 
Broad Tumor PortalTLR3
OASIS PortalTLR3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTLR3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTLR3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
LOVD (Leiden Open Variation Database)Pharmacogenomics of Infectious Diseases (PGx_IfD )
BioMutasearch TLR3
DgiDB (Drug Gene Interaction Database)TLR3
DoCM (Curated mutations)TLR3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TLR3 (select a term)
intoGenTLR3
Cancer3DTLR3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603029    609423   
Orphanet3275   
MedgenTLR3
Genetic Testing Registry TLR3
NextProtO15455 [Medical]
TSGene7098
GENETestsTLR3
Target ValidationTLR3
Huge Navigator TLR3 [HugePedia]
snp3D : Map Gene to Disease7098
BioCentury BCIQTLR3
ClinGenTLR3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7098
Chemical/Pharm GKB GenePA36551
Clinical trialTLR3
Miscellaneous
canSAR (ICR)TLR3 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTLR3
EVEXTLR3
GoPubMedTLR3
iHOPTLR3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:16:59 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.