Identity
HGNC
LOCATION
1q41
LOCUSID
ALIAS
MELIOS,SLE1,SLEB1,TIL3
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7100
MIM: 603031
HGNC: 11851
Ensembl: ENSG00000187554
Variants:
dbSNP: 7100
ClinVar: 7100
TCGA: ENSG00000187554
COSMIC: TLR5
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000187554 | ENST00000407096 | B1AZ06 |
| ENSG00000187554 | ENST00000540964 | O60602 |
| ENSG00000187554 | ENST00000642603 | A0A2R8Y7Z4 |
| ENSG00000187554 | ENST00000645434 | A0A2R8Y4Q2 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164713366 | Tumor necrosis factor alpha (TNF-alpha) inhibitors | Chemical | VariantAnnotation | associated | PD | 28139755 | |
| PA166048654 | ustekinumab | Chemical | ClinicalAnnotation | associated | PD | 28696418 | |
| PA443815 | Crohn Disease | Disease | VariantAnnotation | associated | PD | 28139755 | |
| PA445451 | Psoriasis | Disease | ClinicalAnnotation | associated | PD | 28696418 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38482010 | 2024 | TLR5-deficiency controls dendritic cell subset development in an autoimmune diabetes-susceptible model. | 0 |
| 38482010 | 2024 | TLR5-deficiency controls dendritic cell subset development in an autoimmune diabetes-susceptible model. | 0 |
| 36608151 | 2023 | Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5. | 19 |
| 36645307 | 2023 | Endogenous Reverse Transcriptase Inhibition Attenuates TLR5-Mediated Inflammation. | 2 |
| 37118933 | 2023 | Upregulation of TLR5 indicates a favorable prognosis in prostate cancer. | 0 |
| 37277671 | 2023 | SPI1 Regulates the Progression of Ankylosing Spondylitis by Modulating TLR5 via NF-κB Signaling. | 2 |
| 37330637 | 2023 | Association between TLR2, TLR4, and TLR5 genetic variants and the risk of hepatocellular carcinoma in Moroccan population. | 0 |
| 37433685 | 2023 | Toll-like receptor 5 tunes hepatic and pancreatic stellate cells activation. | 1 |
| 37823415 | 2023 | Identification of toll-like receptor 5 and acyl-CoA synthetase long chain family member 1 as hub genes are correlated with the severe forms of COVID-19 by Weighted gene co-expression network analysis. | 1 |
| 36608151 | 2023 | Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5. | 19 |
| 36645307 | 2023 | Endogenous Reverse Transcriptase Inhibition Attenuates TLR5-Mediated Inflammation. | 2 |
| 37118933 | 2023 | Upregulation of TLR5 indicates a favorable prognosis in prostate cancer. | 0 |
| 37277671 | 2023 | SPI1 Regulates the Progression of Ankylosing Spondylitis by Modulating TLR5 via NF-κB Signaling. | 2 |
| 37330637 | 2023 | Association between TLR2, TLR4, and TLR5 genetic variants and the risk of hepatocellular carcinoma in Moroccan population. | 0 |
| 37433685 | 2023 | Toll-like receptor 5 tunes hepatic and pancreatic stellate cells activation. | 1 |
Citation
Dessen P
TLR5 (toll like receptor 5)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/42581/tlr5
