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TLR5 (toll like receptor 5)

Identity

Alias_namesSLEB1
systemic lupus erythematosus susceptibility 1
toll-like receptor 5
Alias_symbol (synonym)TIL3
FLJ10052
MGC126430
MGC126431
Other aliasMELIOS
SLE1
HGNC (Hugo) TLR5
LocusID (NCBI) 7100
Atlas_Id 42581
Location 1q41  [Link to chromosome band 1q41]
Location_base_pair Starts at 223109406 and ends at 223143282 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HHIPL2 (1q41) / TLR5 (1q41)HHIPL2 1q41 / TLR5 1q41

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TLR5   11851
Cards
Entrez_Gene (NCBI)TLR5  7100  toll like receptor 5
AliasesMELIOS; SLE1; SLEB1; TIL3
GeneCards (Weizmann)TLR5
Ensembl hg19 (Hinxton)ENSG00000187554 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000187554 [Gene_View]  chr1:223109406-223143282 [Contig_View]  TLR5 [Vega]
ICGC DataPortalENSG00000187554
TCGA cBioPortalTLR5
AceView (NCBI)TLR5
Genatlas (Paris)TLR5
WikiGenes7100
SOURCE (Princeton)TLR5
Genetics Home Reference (NIH)TLR5
Genomic and cartography
GoldenPath hg38 (UCSC)TLR5  -     chr1:223109406-223143282 -  1q41   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TLR5  -     1q41   [Description]    (hg19-Feb_2009)
EnsemblTLR5 - 1q41 [CytoView hg19]  TLR5 - 1q41 [CytoView hg38]
Mapping of homologs : NCBITLR5 [Mapview hg19]  TLR5 [Mapview hg38]
OMIM601744   603031   608556   615557   
Gene and transcription
Genbank (Entrez)AB060695 AB445645 AF051151 AI628024 BC109118
RefSeq transcript (Entrez)NM_003268
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TLR5
Cluster EST : UnigeneHs.604542 [ NCBI ]
CGAP (NCI)Hs.604542
Alternative Splicing GalleryENSG00000187554
Gene ExpressionTLR5 [ NCBI-GEO ]   TLR5 [ EBI - ARRAY_EXPRESS ]   TLR5 [ SEEK ]   TLR5 [ MEM ]
Gene Expression Viewer (FireBrowse)TLR5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7100
GTEX Portal (Tissue expression)TLR5
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60602   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60602  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60602
Splice isoforms : SwissVarO60602
PhosPhoSitePlusO60602
Domaine pattern : Prosite (Expaxy)LRR (PS51450)    TIR (PS50104)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    L_dom-like    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    TIR_dom    TLR5   
Domain families : Pfam (Sanger)LRR_8 (PF13855)    TIR (PF01582)   
Domain families : Pfam (NCBI)pfam13855    pfam01582   
Domain families : Smart (EMBL)LRR_TYP (SM00369)  LRRCT (SM00082)  TIR (SM00255)  
Conserved Domain (NCBI)TLR5
DMDM Disease mutations7100
Blocks (Seattle)TLR5
PDB (SRS)1P95    3J0A   
PDB (PDBSum)1P95    3J0A   
PDB (IMB)1P95    3J0A   
PDB (RSDB)1P95    3J0A   
Structural Biology KnowledgeBase1P95    3J0A   
SCOP (Structural Classification of Proteins)1P95    3J0A   
CATH (Classification of proteins structures)1P95    3J0A   
SuperfamilyO60602
Human Protein AtlasENSG00000187554
Peptide AtlasO60602
HPRD04326
IPIIPI00298758   IPI00657896   
Protein Interaction databases
DIP (DOE-UCLA)O60602
IntAct (EBI)O60602
FunCoupENSG00000187554
BioGRIDTLR5
STRING (EMBL)TLR5
ZODIACTLR5
Ontologies - Pathways
QuickGOO60602
Ontology : AmiGOMyD88-dependent toll-like receptor signaling pathway  transmembrane signaling receptor activity  interleukin-1 receptor binding  plasma membrane  inflammatory response  male gonad development  integral component of membrane  positive regulation of interleukin-8 production  positive regulation of toll-like receptor signaling pathway  toll-like receptor 5 signaling pathway  defense response to bacterium  innate immune response  positive regulation of nitric oxide biosynthetic process  regulation of cytokine secretion  cellular response to lipopolysaccharide  cellular response to mechanical stimulus  
Ontology : EGO-EBIMyD88-dependent toll-like receptor signaling pathway  transmembrane signaling receptor activity  interleukin-1 receptor binding  plasma membrane  inflammatory response  male gonad development  integral component of membrane  positive regulation of interleukin-8 production  positive regulation of toll-like receptor signaling pathway  toll-like receptor 5 signaling pathway  defense response to bacterium  innate immune response  positive regulation of nitric oxide biosynthetic process  regulation of cytokine secretion  cellular response to lipopolysaccharide  cellular response to mechanical stimulus  
Pathways : KEGGToll-like receptor signaling pathway    Pathogenic Escherichia coli infection    Salmonella infection    Legionellosis    Inflammatory bowel disease (IBD)   
NDEx NetworkTLR5
Atlas of Cancer Signalling NetworkTLR5
Wikipedia pathwaysTLR5
Orthology - Evolution
OrthoDB7100
GeneTree (enSembl)ENSG00000187554
Phylogenetic Trees/Animal Genes : TreeFamTLR5
HOVERGENO60602
HOGENOMO60602
Homologs : HomoloGeneTLR5
Homology/Alignments : Family Browser (UCSC)TLR5
Gene fusions - Rearrangements
Fusion: TCGAHHIPL2 1q41 TLR5 1q41 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTLR5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLR5
dbVarTLR5
ClinVarTLR5
1000_GenomesTLR5 
Exome Variant ServerTLR5
ExAC (Exome Aggregation Consortium)TLR5 (select the gene name)
Genetic variants : HAPMAP7100
Genomic Variants (DGV)TLR5 [DGVbeta]
DECIPHERTLR5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTLR5 
Mutations
ICGC Data PortalTLR5 
TCGA Data PortalTLR5 
Broad Tumor PortalTLR5
OASIS PortalTLR5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTLR5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTLR5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Pharmacogenomics of Infectious Diseases (PGx_IfD )
BioMutasearch TLR5
DgiDB (Drug Gene Interaction Database)TLR5
DoCM (Curated mutations)TLR5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TLR5 (select a term)
intoGenTLR5
Cancer3DTLR5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601744    603031    608556    615557   
Orphanet
MedgenTLR5
Genetic Testing Registry TLR5
NextProtO60602 [Medical]
TSGene7100
GENETestsTLR5
Target ValidationTLR5
Huge Navigator TLR5 [HugePedia]
snp3D : Map Gene to Disease7100
BioCentury BCIQTLR5
ClinGenTLR5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7100
Chemical/Pharm GKB GenePA36553
Clinical trialTLR5
Miscellaneous
canSAR (ICR)TLR5 (select the gene name)
Probes
Litterature
PubMed194 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTLR5
EVEXTLR5
GoPubMedTLR5
iHOPTLR5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:59:31 CEST 2017

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